• 대한약침학회지
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• 제15권2호
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• pp.11-14
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• 2012

Objectives: The purpose of this study was to compare the antioxidant and anti-inflammatory effects of Alum (AL) and Burnt Alum (BAL), which are commonly used as external ointments. Methods: Extracts of AL and BAL were classified into three groups: 20, 50, and $100mg/{\mu}{\ell}$. The cytotoxicity was measured by using MTT assays in human keratinocyte cell line (HaCaT). The anti-oxidant effect was measured by using the DPPH (1, 1-diphenyl-2-picryl-hydrazyl-hydrate) radical scavenger. The anti-inflammatory effect was measured by using the inhibitory efficacy for the amount of nitric-oxide (NO) produced in mouse macrophage cell line (RAW 264.7). Results: BAL showed a higher level of cytotoxicity than AL. The AL groups showed a concentration-dependent scavenging effect on DPPH radicals, but no significant relevance was found. The BAL groups showed a concentration-dependent scavenging effect on DPPH radicals. The scavenging effects of the BAL groups were almost insignificant, but the values for the 20, 50, and $100{\mu}g/m{\ell}$ trials were different. The BAL groups showed significant concentration-dependent inhibitory effects on NO production, but the AL groups did not. Conclusions: AL showed an anti-oxidant effect more efficiently than BAL did, which demonstrated a superior anti-inflammatory effect. Therefore, for external usage, AL must be distinguished from BAL.

• 보건행정학회지
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• 제25권2호
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• pp.80-89
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• 2015

Background: This study aims to identify the monthly average medical expenses of public pension recipients, and analyze the determinants of total health and medical expenses and Western and Oriental medicine expenses, medical service expenses, and medical supplies expenses. Methods: This study used the fifth year data of 2013 out of the raw data of the Korean Retirement and Income Study collected by the National Pension Research Institute. This study conducted t-test, analysis of variance, and linear regression to verify publicly the relevance between pension recipients' general characteristics and health and medical expenses status using IBM SPSS ver. 21.0 for data analysis. Results: It was analyzed that there is a difference in the spending of expenditure and health care costs according to public pension recipients. Medical expenses of the national pensioners was higher compared to the special corporate pensioners. The national pensioner is related expenditure size, education level, family members living together, residential areas, status of spouse, number of chronic illness, and status of limitation in daily life with psychological health status. Conclusion: Therefore, fairness does not occur fire to the medical use between the special corporate pensioners and national pensioners, aggressive of government such as health policy and financial support for the retiree pension policy that reflects the reality intervention would be required.

• Structural Engineering and Mechanics
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• 제39권4호
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• pp.599-620
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• 2011

The investigation on possible causes of failures related to documented collapses is a complicated issue, primarily due to the scarcity and inadequacy of information available. Although several studies have tried to understand which are the inherent structural deficiencies or circumstances associated to failure of the main structural elements in a reinforced concrete frame, to the authors knowledge a uniform approach for the evaluation building static vulnerability, does not exist yet. This paper investigates, by means of a detailed case study, the potential failure mechanisms of an existing reinforced concrete building. The linear elastic analysis for the three-dimensional building model gives an insight on the working conditions of the structural elements, demonstrating the relevance of a number of structural faults that could sensibly lower the structure's safety margin. Next, the building's bearing capacity is studied by means of parametric nonlinear analysis performed at the element's level. It is seen that, depending on material properties, concrete strength and steel yield stress, the failure hierarchy could be dominated by either brittle or ductile mechanisms.

• The Journal of Asian Finance, Economics and Business
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• 제7권11호
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• pp.33-43
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• 2020

This study aims to investigate the importance of earnings quality as a determinant of companies' performance. It provides some empirical evidences from an emerging market, specifically from the Jordanian market. This study developed an econometric model for the effect of earnings quality on the companies' performance using empirical evidence. The study employs a panel data analysis method by using a sample of all Jordanian industrial public shareholding companies listed on Amman Stock Exchange (ASE) during 2010-2018. The results reveal that Return on Assets (ROA), Return on Equity (ROE), and Earnings Per Share (EPS) as proxies of company's performance are affected by the earnings quality. This provides the importance of positive earnings quality that eventually influences the companies' performance. The results of this study suggest that the higher control level on the managers' behavior and its outcome will have an effect on earnings quality, and thus the company's performance increases. As well as, high relevance of accounting information will improve earnings quality, and thus earnings quality with the interaction factors of the company's environment work on improving performance. As a conclusion, this study can work as a reference to assist standard setters, security analysts, regulators and other accounting-information users in appraising relation between the earnings quality and companies' performance.

• International Journal of Naval Architecture and Ocean Engineering
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• 제9권1호
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• pp.77-99
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• 2017

Offshore oscillating water columns (OWC) represent one of the most promising forms of wave energy converters. The hydrodynamic performance of such converters heavily depends on their interactions with ocean waves; therefore, understanding these interactions is essential. In this paper, a fully nonlinear 2D computational fluid dynamics (CFD) model based on RANS equations and VOF surface capturing scheme is implemented to carry out wave energy balance analyses for an offshore OWC. The numerical model is well validated against published physical measurements including; chamber differential air pressure, chamber water level oscillation and vertical velocity, overall wave energy extraction efficiency, reflected and transmitted waves, velocity and vorticity fields (PIV measurements). Following the successful validation work, an extensive campaign of numerical tests is performed to quantify the relevance of three design parameters, namely incoming wavelength, wave height and turbine damping to the device hydrodynamic performance and wave energy conversion process. All of the three investigated parameters show important effects on the wave-pneumatic energy conversion chain. In addition, the flow field around the chamber's front wall indicates areas of energy losses by stronger vortices generation than the rear wall.

• Archives of Pharmacal Research
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• 제27권2호
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• pp.127-135
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• 2004

Multiple drug administration is common in elderly, HIV, and cancer patients. Such treatments may result in drug-drug interactions due to interference at the metabolic enzyme level, and due to modulation of transporter protein functions. Both kinds of interference may result in altered drug distribution and toxicity in the human body. In this review, we have dealt with drug-drug interactions related to the most studied human transporter, P-glycoprotein. This transporter is constitutively expressed in several sites in the human body. Its function can be studied in vitro with different cell lines expressing P-glycoprotein in experiments using methods and equipment such as flow cytometry, cell proliferation, cell-free ATP as activity determination and Transwell culture equipment. In vivo experiments can be carried out by mdr1a(-/-) animals and by noninvasive methods such as NMR spectrometry. Some examples are also given for determination of possible drug-drug interactions using the above-mentioned cell lines and methods. Such preclinical studies may influence decisions concerning the fate of new drug candidates and their possible dosages. Some examples of toxicities obtained in clinics and summarized in this review indicate careful consideration in cases of polypharmacy and the requirement of preclinical studies in drug development activities.

• Design & Manufacturing
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• 제10권2호
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• pp.6-11
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• 2016

Designed patterns of slit are introduced to the uni-directional (UD) prepreg in order to enhance the formability of the carbon/epoxy composites without wrinkling and laddering. Three different types of the slit alignment along the thickness direction are applied to analyse the deformation behavior during the compression moulding process of laminates. Degrees of the slit open and the mechanical strength are evaluated based on the level of the compaction pressure in the course of forming process. Results have shown that the mechanical strength of laminates having slits could attain at least 80% of the conventional ones without slits. However, further studies are required to identify the direct relevance of the slit alignment in laminate to the mechanical properties.

• 한국학교ㆍ지역보건교육학회지
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• 제20권1호
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• pp.113-126
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• 2019

Objectives: The purpose of this study is to understand the relevance of chronic disease conditions and fall experience among people aged 65 and older. and use them as basic data to reduce the risk of falling. Methods: The study selected 26,122 men and 37,777 women aged 65 and over as final subjects of the study, using raw data from the Community Health Survey in 2015. The statistical analysis used SAS 9.4 USA. Results: About 20% of those aged 65 and older experienced a fall, with one in five elderly people experiencing a fall, and the ratio of men to women was 3:7, women higher than men. As the age grew, the lower the level of education, the more senior citizens who lived alone occurred falls. In addition, the incidence of falls was higher when the number of chronic diseases was more than three. The incidence of falls was 1.1-1.5 times higher depending on chronic diseases. Conclusion: The development of education and exercise programs for preventing fall of senior citizens aged 65 and older is required and further study is needed.

• International Journal of Computer Science & Network Security
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• 제21권9호
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• pp.86-90
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• 2021

The article assesses the level of navigation safety, in theoretical terms, defines the complexity of managing navigational risks in practice. The issues of assessing the navigational safety have been studied due to the importance and relevance of the issue in question, however, due to the great complexity of the problem under consideration, the article considers and indicates the directions for the development of the solution of the given direction, where, first of all, it became necessary to analyze the issue of assessing the levels of navigation risks when navigating vessels of various types in difficult navigation conditions.

• 한국항해항만학회지
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• 제45권2호
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• pp.75-86
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• 2021

This paper intends to evaluate the policies which are considered necessary to enhance the T/S competitiveness of Busan's port, and thereby present suggestions to the government which would best implement the results of this research. This research first raises the claim that the majority of the following four conditions: location of the port, port productivity/service level, status of network with overseas ports, and cost competitiveness, should be satisfied in order to maintain a competitive T/S port. Based on these four conditions, seven policies, which are individually pertinent to the four conditions, have been drawn up for proposal, and they are also analyzed in the survey, where all the eligible samples participate to ensure if they are effective in enhancing the T/S competitiveness of Busan. Proposed important policies are a) Terminal operator integration, b) port infrastructure expansion, c) global carriers owned terminal operation, d) enhancement of national carrier's competitiveness, e) feeder carriers' owned terminal operation in new port, f) institutional support for effective and convenient environments for handling T/S cargo, and g) volume incentive expansion. From the analysis by which all the relevant parties (Carriers, Terminal Operators, Port Authority) are answered, it was found that all the seven policies have relevance in strengthening the transshipment competitiveness of Busan's port. Whereas in the analysis that uses AHP methodology to compare the significance among the different policies, it was found that terminal operator integration has the highest priority in terms of increasing transshipment competitiveness.