• 아동학회지
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• 제26권6호
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• pp.287-303
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• 2005

The purpose of this study was to describe infant and mother behaviors across situations. And, it was to examine the associations between infant's temperament and infant's patterns of attachment to their mother with mother-infant interaction. Results showed that there were significant main effects for the attentional focus of the situation and the level of regulatory challenge on observed mother-infant interaction behaviors. Also, mother and infant showed significant differences in their interaction behaviors depending on the patterns of infant temperzment and the patterns of infant-mother attachment.

• 대한인간공학회지
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• 제35권4호
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• pp.263-275
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• 2016

Objective: This paper introduces the regulatory oversight approaches and issues to consider in the course of safety culture oversight model development in the nuclear field. Common understanding on regulatory oversight and present practices of international communities are briefly reviewed. The nuclear safety culture oversight model of Korea is explained focusing on the development of safety culture definition and components, and their basic meanings. Oversight components are identified to represent the multiple human and organizational elements which can affect and reinforce elements of defense in depth system for nuclear safety. Result of validation study on safety culture components is briefly introduced too. Finally, the results of the application of the model are presented to show its effectiveness and feasibility. Background: The oversight of nuclear licensee's safety culture has been an important regulatory issue in the international community of nuclear safety regulation. Concurrent with the significant events that started to occur in the early 2000s and that had implications about safety culture of the operating organizations, it has been natural for regulators to pay attention to appropriate methods and even philosophy for intervening the licensee's safety culture. Although safety culture has been emphasized for last 30 years as a prerequisite to ensure high level of nuclear safety, it has not been of regulatory scope and has a unique dilemma between external oversight and the voluntary nature of culture. Safety culture oversight is a new regulatory challenge that needs to be approached taking into consideration of the uncontrollable aspects of cultural changes and the impacts on licensee's safety culture. Although researchers and industrial practitioners still struggle with measuring, evaluating, managing and changing safety culture, it was recognized that efforts to observe and influence licensees' safety culture should not be delayed. Method: Safety culture components which regulatory oversight will have to focus on are developed by benchmarking the concept of physical barriers and introducing the defense in depth philosophy into organizational system. Therefore, this paper begins with review of international regulatory oversight approaches and issues associated with the regulatory oversight of safety culture, followed by the development of oversight model. The validity of the model was verified by statistical analysis with the survey result obtained from survey administration to NPP employees in Korea. The developed safety culture oversight model and components were used in the "safety culture inspection" activities of the Korean regulatory body. Results: The developed safety culture model was confirmed to be valid in terms of content, construct and criterion validity. And the actual applicability in the nuclear operating organization was verified after series of pilot "safety culture inspection" activities. Conclusion: The application of the nuclear safety culture oversight model to operating organization of NPPs showed promising results for regulatory tools required for the organizations to improve their safety culture. Application: The developed oversight model and components might be used in the inspection activities and regulatory oversight of NPP operating organization's safety culture.

• 방사성폐기물학회지
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• 제20권4호
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• pp.533-540
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• 2022

Because of the massive development of nuclear power plants in China in recent years, China is facing the challenge of radioactive waste disposal. China has established complete regulatory requirements for radioactive waste disposal, but it also has encountered problems and challenges in low-level radioactive waste disposal in terms of management, selection of disposal facility sites, and implementation of a site selection plan. Three low-level radioactive waste disposal facilities that have been operated in China are described, and their activity limits, locations, and capacities are also outlined. The connotations of "regional" and "centralized" disposal policies are discussed in light of the characteristics of the radioactive waste. The characteristics and advantages of the regional and centralized disposal policies are compared. It is concluded that the regional disposal policy adopted in 1992 can no longer meet the current disposal needs, and China should adopt a combination of the two disposal policies to solve the problem of radioactive waste disposal.

• 한국발생생물학회지:발생과생식
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• 제20권2호
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• pp.91-99
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• 2016

Lipopolysaccharide (LPS), an endotoxin, elicits strong immune responses in mammals. Several lines of evidence demonstrate that LPS challenge profoundly affects female reproductive function. For example, LPS exposure affects steroidogenesis and folliculogenesis, resulting in delayed puberty onset. The present study was conducted to clarify the mechanism underlying the adverse effect of LPS on the delayed puberty in female rats. LPS was daily injected for 5 days ($50{\mu}g/kg$, PND 25-29) to treated animals and the date at VO was evaluated through daily visual examination. At PND 39, animals were sacrificed, and the tissues were immediately removed and weighed. Among the reproductive organs, the weights of the ovaries and oviduct from LPS-treated animals were significantly lower than those of control animals. There were no changes in the weights of uterus and vagina between the LPS-treated and their control animals. immunological challenge by LPS delayed VO. Multiple corpora lutea were found in the control ovaries, indicating ovulations were occurred. However, none of corpus luteum was present in the LPS-treated ovary. The transcription level of steroidogenic acute regulatory protein (StAR), CYP11A1, CYP17A1 and CYP19 were significantly increased by LPS treatment. On the other hand, the levels of $3{\beta}$-HSD, $17{\beta}$-HSD and LH receptor were not changed by LPS challenge. In conclusion, the present study demonstrated that the repeated LPS exposure during the prepubertal period could induce multiple alterations in the steroidogenic machinery in ovary, and in turn, delayed puberty onset. The prepubertal LPS challenge model used in our study is useful to understand the reciprocal regulation of immune (stress) - reproductive function in early life.

• 한국수산과학회지
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• 제50권3호
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• pp.302-310
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• 2017

Interferon regulatory factor 8 (IRF8) is essential for the development of B and T cells, as well as for the activity of dendritic cells and macrophages. We performed molecular characterization of IRF8 from rock fish, Sebastes schlegelii (Ss), and investigated the spatial and temporal profile of mRNA expression after challenge with lipopolysaccharide (LPS), polyinosinic:polycytidylic acid (poly I:C), or Streptococcus iniae. The full-length cDNA sequence of SsIRF8 was 1,657 bp, containing an ORF of 1,266 bp. The gene had a predicted molecular mass of 47.7 kDa and an isoelectric point of 5.99. The amino acid sequence coded by this gene showed the highest degree of identity (90.8%) and similarity (96.2%) with IRF8 from Oplegnathus fasciatus. The SsIRF8 mRNA was expressed ubiquitously, at varying levels, with the highest level of expression observed in the spleen. To confirm the role of SsIRF8 in mediating the immune response, we measured SsIRF8 mRNA expression in the splenic tissue at different time points after injection with LPS, poly I:C, or S. iniae. The qRT-PCR results showed that SsIRF8 mRNA expression in the poly I:C-injected group was highly upregulated 6 hr after exposure (P<0.05). Expression of SsIRF8 mRNA in the S. iniae-injected group peaked at 24 hr. These results suggest that SsIRF8 might be important in regulating the strength of the rockfish immune response to immunostimulatory agents.

• 법제연구
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• 제44호
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• pp.155-184
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• 2013

본 연구는 방송과 통신, 영화나 게임 등 이용매체별 수직적 규제체계로 고착화되어 있는 현행 정책과 규제로는 새로운 융합미디어 환경을 따라가지 못한다는 비판적 시각에서 출발한다. 미디어 융합은 방송의 특수성을 완화하고, 그 동안 방송보다 약한 규제를 받아 왔던 다른 매체와 방송의 차별성을 상쇄시키고 있다. 그럼에도 불구하고 점차 확대되어 가고 있는 융합서비스와 기존 미디어에 대해 비대칭적인 현 규제정책을 그대로 유지한다면 그 충돌로 야기된 혼란은 끊임없이 지속될 수밖에 없다. 새로운 미디어환경에 적합한 규제방향과 관련하여 '동일한 서비스에 동일한 규제'라는 원칙에 기초한 '수평적 규제체계'가 도입되어야 한다는 것에 대한 사회적 합의는 사실상 모아져 있다. 다만 무엇과 무엇을 동일하게 취급해야 하는가에 대해서는 여전히 많은 이견이 있다. 이 연구는 콘텐츠 규제와 관련된 법률을 구체적으로 분석하고, 이를 기초로 융합시대에 적합한 콘텐츠 규제체제를 모색하는 원칙과 방향을 제안하고자 하였다. 이를 위해 매체별로 차별된 현행 규제가 근거들로 제시되고 있는 이유를 비판적으로 분석하여 현행 비대칭적 규제가 그 정당성을 상실하고 있음을 밝혀냄과 동시에, 여기서 도출된 논거를 토대로 향후 더욱 가속화될 미디어 융합 환경에 부합하는 규제기준으로써 "자율규제 원칙"을 제시하였다. 장기적으로는 콘텐츠 심의는 모든 콘텐츠에 대해서 하나의 심의기관이 동일한 심의기준과 등급분류를 적용하는 방향으로 개편되어야 한다고 본다. 콘텐츠의 상호호완의 정도가 높아지고 플랫폼을 넘나드는 새로운 기술의 발달은 서비스, 디바이스와 상관없이 동일한 미디어 콘텐츠는 동일하게 규제하는 플랫폼 중립적인 규제로 나아갈 수밖에 없기 때문이다. 그러나 심의정책이 자율규제를 기반으로 한 통합심의에 안전하게 다다르기 위해서는 중단기적인 준비가 필요하다. 본 연구에서는 이를 단계적으로 시행할 수 있는 콘텐츠 심의규제방안으로 심의기준의 통일화, 등급분류체계의 일원화, 자율규제의 범위 확정 및 상호인증제의 도입을 제안하였다.

• Journal of Genetic Medicine
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• 제4권1호
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• pp.1-5
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• 2007

Unprecedented amount of genetic information being generated from the result of Human Genome Project (HGP) and advances in genetic research is already forcing changes in the paradigm of health and disease. The ultimate goal of genetic medicine is to use genetic information and technology to develop new ways of treatment or even prevention of the disease on an individual level for 'personalized medicine'. Genetics is play ing an increasingly important role in the diagnosis, monitoring and management of common multifactorial diseases in addition to rare single-gene disorders. While wide range of genetic testing have provided benefits to patients and family, uncertainties surrounding test interpretation, the current lack of available medical options for the diseases, and risks for discrimination and social stigmatization may remain to be resolved. However an increasing number of genetic tests are becoming commercially available, including direct to consumer genetic testing, yet public is often unaw are of their clinical and social implications. The personal nature of information generated by a genetic test, its power to affect major life decisions and family members, and its potential misuse raise important ethical considerations. Therefore appropriate genetic counseling is needed for patient to be informed with the benefits, limitations and risks of genetic tests, prior to informed consent for the tests. Physician also should be familiar with the legal and ethical issues involved in genetic testing to tell patients how w ell a particular genetic risk factor relates with likelihood of disease, and be able to provide appropriate genetic counseling. Genetic counseling become a mandatory requirement as global standard for many genetic testing such as prenatal diagnosis, presymtomatic DNA diagnostic tests and cancer susceptibility gene test for familial cancer syndrome. In oder to meet the challenge of genetic medicine of 21 century in korean health care system, professional education program and certification board for medical genetics specialist including non-MD genetic counselors should be addressed by medical society and regulatory policy of national health insurance reimbursement for genetic counseling to be in place to promote the implementation of clinical genetic service including genetic counseling for proper genetic testing.

• 방사성폐기물학회지
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• 제8권4호
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• pp.311-318
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• 2010

공학적 안전설비 공기정화계통의 규제지침인 Reg. Guide 1.52(Rev.3)의 변경사항중 성능시험과 관련한 운전가능성 시험시간 단축, HEPA 필터 현장누설시험용 시험물질 변경 및 활성탄 성능시험 Methyl Iodidie 투과허용율 상향 변경을 영광 5,6호기에 적용하고자, 모사실험장치와 현장 설비를 활용하여 기술적 타당성을 확인하는 실험을 수행하였다. 10시간 이상의 장시간 운전가능성 시험을 통해 계통내 습분을 제거하여도 시험후 1~4일만에 회복됨을 확인하여 운전가능성 시험은 기기적 운전가능성 점검에 적합한 매월 15분 이상의 시험을 수행하는 것이 타당함을 확인하였다. HEPA 필터 현장누설시험용 시험물질 변경을 위해 DOP와 PAO의 에어로졸 입자크기, 발생량, 누설인지도를 비교한 결과 PAO는 원전에서도 DOP 대체시험물질로 사용 가능함을 확인하였다. 베드깊이 4 인치 이상의 활성탄여과기에 대한 Methyl Iodide의 투과율 허용치가 0.175 %에서 0.5 %로 상향 변경된 것은, ASTM D3803(1989)으로의 활성탄 성능시험 방법 변경에 따른 것으로서, $30^{\circ}C$ 상대습도 95 %에서의 Methyl Iodide 투과허용율 0.5 %가 사용 중 활성탄의 성능을 시험하기에 충분히 보수적인 시험방법임을 확인하였다. 본 실험 결과를 바탕으로 영광 5,6호기는 인허가변경을 완료하였다.