• 제목/요약/키워드: let-7

검색결과 331건 처리시간 0.038초

이압요법이 암환자의 불면증에 미치는 효능 : 무작위배정, 단일맹검, 위약대조군 연구 (Effect of Auricular Acupress Therapy on Insomnia of Cancer Patients : Randomized, Single Blinded, Placebo Controlled Trial)

  • 정인숙;김정선;유화승
    • 대한약침학회지
    • /
    • 제13권2호
    • /
    • pp.93-100
    • /
    • 2010
  • Background: Auricular acupressure is one of the traditional health care treatments in oriental medicine. Approximately, 30~40% of the cancer patients have said to be suffering from insomnia and half of them having chronic and severe insomnia at the same time. Insomnia caused cancer patients feel more pain, fatigue, depression and anxiety and it sometimes let the power to have the best of cancer pull down. Objective: To investigate how effective the auricular acupressure treatment to cancer patients suffering from insomnia. Methods: We recruited participants from East-West Cancer Center of Daejeon University. Finally, of the people whose age range from 20 to 75, 12 patients who got less than 40 points from the score of Oh's sleeping score (OSS) were recruited. Single-blind, randomized pilot study was performed. The treatment group received auricular acupressure treatment (AAT) on active points and the control group had received sham acupressure treatment (SAT) for five times. Sleep parameters were checked by using OSS and numeric rating scale (NRS). We checked the scale everytime, both before and after treatment. We analyzed the data statistically by using independent T-test, paired T-test and analysis of variance (ANOVA) test. (p<0.05) Results: Twelve cancer patients participated in this pilot study and there was no significant difference between control and treatment group. Only 7 of them had completed the whole treatment process, 4 patients of AAT group and 3 participants of SAT. The OSS of AAT group had increased from $34.0{\pm}4.3$ to $39.5{\pm}3.1$ and that of SAT group had increased from $38.3{\pm}3.5$ to $40.0{\pm}0.0$. There was no significant difference between them. The NRS of AAT group had increased from $6.3{\pm}2.9$, $04.8{\pm}2.1$ and that of SAT group had increased from $7.0{\pm}1.0$ to $5.0{\pm}2.6$. No significant difference was observed between them. Conclusion: Although both groups did not show significant differences, most of the experimental participants showed increasing OSS and NRS after treatments. Significant participants' number will be needed in the next study.

일부 특수학교 교직원의 구강관리실태 (A study on the state of oral care among some special school personnels)

  • 박정순;이선옥
    • 한국치위생학회지
    • /
    • 제11권5호
    • /
    • pp.659-670
    • /
    • 2011
  • Objectives : The purpose of this study was to examine the state of oral health care among special school personnels in an attempt to provide some information on the improvement of the oral health care of students with disabilities who would be under the first hand influence of school personnels. Methods : The subjects in this study were personnels who were selected by random selection in five different special schools located in the city of Jeonju, North Jeolla Province. A self-administered survey was conducted in person from July 5 to 14 after the purpose of this study was explained. Results : 1. Concerning their general characteristics, the level of oral health knowledge was high in the personnel whose career is 5 years more, and the younger personnels had a better oral health knowledge, and the men were more knowledgeable than the women. 2. As to oral health education experience, the rate of the respondents who ever received oral health education stood at 35.3 percent. In relation to the frequency of oral health education, the biggest group that accounted for 58.2 percent received that education once. As for the route of education, the largest group that represented 52.7 percent received that education at dental hospitals or clinics. In relation to satisfaction with oral health education, the greatest group that accounted for 38.5 percent were dissatisfied with that education. 3. As for an intention of receiving oral health education in the future, the biggest group that accounted for 60.9 percent intended to receive that education if they would have free time, and the largest group that represented 47.7 percent believed that oral health education should be conducted by dental hygienists. 4. Concerning their general characteristics, the level of oral health promotion behavior according to age in both bushing and supplies of oral health care was high in forties-1.89 point and 3.33 point, and that in regular visit to a dental clinic was the highest in twenties for 2.58 point, and that in dietary control was the highest in twenties for 2.59 point. 5. Their oral health knowledge had a significant positive correlation to their toothbrushing, regular dental clinic visit and dietary control that were the subfactors of oral health promotion behavior. 6. As for the impact of oral health promotion behavior on oral health knowledge, toothbrushing exerted the greatest influence on that(${\beta}$=0.306, p<0.001). Conclusions : Appropriate institutional measures should be taken to let dental hygienists who are expert in oral health care provide incremental oral health care for students and adults with disabilities in educational institutions and facilities for the disabled, and the development of oral health education programs is urgently required to offer systematic oral health education for not only students with disabilities but their teachers and guardians.

추파 야생화초지의 생육특성, 계절개화분포 및 식생변화에 관한 연구 (Study on the Growth Characteristics, Seasonal Anthesis Distribution and Botanical Composition of Autumn Sown Wildflower Pastures)

  • 이인덕;이형석;이병철
    • 한국초지조사료학회지
    • /
    • 제30권3호
    • /
    • pp.217-226
    • /
    • 2010
  • 본 연구는 추파 야생화초지의 생육특성, 계절분포 및 식생비율을 구명하고자 충남대학교 내 초지시험포장에서 2007년 10월부터 2009년 12월까지 수행하였다. 공시초종은 기본초종인 잔디형 목초로 Sheep fescue (Azure)와 야생화 초종으로는 국내산 야생화 4종과 외국산 야생화 29종 등 총 33종을 공시하였다. 야생화의 초장은 7~52 cm 범위이었고, 꽃 색은 6~10가지로 다양하게 개화되었으나 8월부터 11월까지 개화초종, 꽃 색, 개화지속기간 등이 편중되는 양상이 나타났다. 이러한 양상은 월동 후 2년차(2009)에 더욱 뚜렷하게 나타나 야생화의 꽃색, 계절분포 및 영속성이 문제시 되었다. 야생화초지의 연평균 식생비율은 야생화, 잔디형 목초 및 잡초가 각각 파종 후 1년차(2008)에 20%, 67% 및 13%이었고, 2년차(2009)에는 각각 16%, 72% 및 12%로 조사되었다. 이상의 결과로 보아 추파 야생화초지의 경우, 파종당년은 물론이고 특히 월동 후 2년차에 일년생야생화의 감소로 인한 꽃 색의 다양성, 계절분포 및 영속성을 유지할 수 있는 방안이 시급하다고 하겠다.

끓는점 오름에 대한 내용표상화(Content Representation) 활동에서 나타난 예비교사의 PCK 특징 (Characteristics of Pre-service Teachers' PCK in the Activities of Content Representation of Boiling Point Elevation)

  • 이영민;허진휴
    • 한국과학교육학회지
    • /
    • 제33권7호
    • /
    • pp.1385-1402
    • /
    • 2013
  • 이 연구는 끓는점 오름에 대한 내용표상화 활동과 모의수업 실행을 통해서 예비교사의 PCK를 분석하였다. 예비교사의 지식을 PCK 요소에 따라 분석한 결과, 대부분의 예비교사는 끓는점 오름에 대한 개념적인 이해를 중시하였는데, 일부는 끓는점 오름 현상을 과학적인 시각으로 이해하고, 수식을 도구로 사용하며, 실생활에 적용되는 경험을 통해 학습 동기를 얻게하는 과학 교수 지향도 보였다. 예비교사는 끓는점 오름에 관하여 가르쳐야 할 중요한 내용의 대부분을 개념 이해를 위해 습득해야 할 지식으로 제시했으며, 과학적 사고나 탐구능력 신장을 위한 내용은 나타나지 않았다. 또한 교과서 내용의 수준과 전개 순서에 의존하는 경향을 보였으며 일부는 교과서 편집상 강조되어있는 용어나 자료를 학습할 내용으로 여기거나, 예제 문제의 풀이를 학습 목표로 보는 경우도 있었다. 학생 이해에 대한 지식은 부족한 것으로 나타났는데, 실제 교수 경험이 없는 예비교사들은 자신의 학습 경험을 바탕으로 학생 수준을 간접적으로 이해하려고 시도하므로, 예비교사교육과정에서 오개념 자료 등을 적극적으로 활용할 필요가 있다. 교수 전략과 평가에 대한 지식은 다른 요소에 비해 피상적으로 표현되었는데, 목표와 연계된 방법을 고민하기 보다는 순환학습과 발견학습 같은 모형의 적용만을 언급하거나 일반적인 평가 방법을 나열하는데 그쳤다.

자주복 Takifugu rubripes 자어의 성장 생존 및 섭이율에 미치는 기아의 영향 (Effects of Starvation on Growth, Surival and Feeding Incidence of Tiger Puffer(Takifugu rubripes) Larvae)

  • 한경남
    • 한국양식학회지
    • /
    • 제11권4호
    • /
    • pp.521-528
    • /
    • 1998
  • 자주복 Takifugu rubripes 자어의 섭이상태에 관한 기초 지식을 얻기 위하여 수온 16.5~18.5${\circ}C$ 범위의 급이와 무급이 조건하에서 초기자어의 성장, 생존율 그리고 섭이율 등을 비교, 조사하였다. 자주복 자어는 부화후 5일 전후에서 난황흡수의 내부영양에서 외부영양으로의 전환이 시작되고, 이 시기에 있어 섭이의 유무는 그후 자어의 성장, 생존율에 큰 영향을 미치는 것이 사육실험 결과 밝혀졌다. 무급이 자어는 부화후 16일에 전 개체가 사망하나, 초기사망의 출발점은 유구가 흡수되는 부화후 9일(기아 5일)경부터 추측된다. 급이구와 무급이구 자어의 성장을 비교한 결과, 무급이구에서는 부화후 4일경부터 성장이 정지되고, 부화후 7일이후는 성장 감소를 보였다. 기아상태에 놓여있는 자어의 섭이율 변화는 기아일수 경과에 따른 자어의 유영력과 깊은 관계가 있는 것으로 생각된다. 따라서 자주복 종묘생산시급이 개시시기는 가능한 빨리 결정하는 것이 건강한 종묘의 생산과 높은 생존율을 향상시킬 수 있다.

  • PDF

Distribution and differential expression of microRNAs in the intestinal mucosal layer of necrotic enteritis induced Fayoumi chickens

  • Rengaraj, Deivendran;Truong, Anh Duc;Ban, Jihye;Lillehoj, Hyun S.;Hong, Yeong Ho
    • Asian-Australasian Journal of Animal Sciences
    • /
    • 제30권7호
    • /
    • pp.1037-1047
    • /
    • 2017
  • Objective: Despite an increasing number of investigations into the pathophysiology of necrotic enteritis (NE) disease, etiology of NE-associated diseases, and gene expression profiling of NE-affected tissues, the microRNA (miRNA) profiles of NE-affected poultry have been poorly studied. The aim of this study was to induce NE disease in the genetically disparate Fayoumi chicken lines, and to perform non-coding RNA sequencing in the intestinal mucosal layer. Methods: NE disease was induced in the Fayoumi chicken lines (M5.1 and M15.2), and non-coding RNA sequencing was performed in the intestinal mucosal layer of both NE-affected and uninfected chickens to examine the differential expression of miRNAs. Next, quantitative real-time polymerase chain reaction (real-time qPCR) was performed to further examine four miRNAs that showed the highest fold differences. Finally, bioinformatics analyses were performed to examine the four miRNAs target genes involvement in the signaling pathways, and to examine their interaction. Results: According to non-coding RNA sequencing, total 50 upregulated miRNAs and 26 downregulated miRNAs were detected in the NE-induced M5.1 chickens. While 32 upregulated miRNAs and 11 downregulated miRNAs were detected in the NE-induced M15.2 chickens. Results of real-time qPCR analysis on the four miRNAs (gga-miR-9-5p, gga-miR-20b-5p, ggamiR-196-5p, and gga-let-7d) were mostly correlated with the results of RNAseq. Overall, ggamiR-20b-5p was significantly downregulated in the NE-induced M5.1 chickens and this was associated with the upregulation of its top-ranking target gene, mitogen-activated protein kinase, kinase 2. Further bioinformatics analyses revealed that 45 of the gene targets of gga-miR-20b-5p were involved in signal transduction and immune system-related pathways, and 35 of these targets were predicted to interact with each other. Conclusion: Our study is a novel report of miRNA expression in Fayoumi chickens, and could be very useful in understanding the role of differentially expressed miRNAs in a NE disease model.

Enrichment and verification of differentially expressed miRNAs in bursa of Fabricius in two breeds of duck

  • Luo, Jun;Liu, Junying;Liu, Hehe;Zhang, Tao;Wang, Jiwen;He, Hua;Han, Chunchun
    • Asian-Australasian Journal of Animal Sciences
    • /
    • 제30권7호
    • /
    • pp.920-929
    • /
    • 2017
  • Objective: The bursa of Fabricius (BF) is a central humoral immune organ belonging specifically to avians. Recent studies had suggested that miRNAs were active regulators involved in the immune processes. This study was to investigate the possible differences of the BF at miRNA level between two genetically disparate duck breeds. Methods: Using Illumina next-generation sequencing, the miRNAs libraries of ducks were established. Results: The results showed that there were 66 differentially expressed miRNAs and 28 novel miRNAs in bursa. A set of abundant miRNAs (i.e., let-7, miR-146a-5p, miR-21-5p, miR-17~92) which are involved in immunity and disease were detected and the predicted target genes of the novel miRNAs were associated with duck high anti-adversity ability. By gene ontology analysis and enriching KEGG pathway, the targets of differential expressed miRNAs were mainly involved in immunity and disease, supporting that there were differences in the BF immune functions between the two duck breeds. In addition, the metabolic pathway had the maximum enriched target genes and some enriched pathways that were related to cell cycle, protein synthesis, cell proliferation and apoptosis. It indicted that the difference of metabolism may be one of the reasons leading the immune difference between the BF of two duck breeds. Conclusion: This data lists the main differences in the BF at miRNAs level between two genetically disparate duck breeds and lays a foundation to carry out molecular assisted breeding of poultry in the future.

소매 업태에 따른 판촉활동에 관한 이론적 연구 (A Theoretical Study of Promotion Activities by Types of Retailing)

  • 박진호;이수동
    • 서비스연구
    • /
    • 제7권4호
    • /
    • pp.15-38
    • /
    • 2017
  • 본 연구에서는 상표전환과 반복구매의 소비 형태를 보이는 소비자를 대상으로 그들의 상표전환과 반복구매의 결정 요인은 무엇인지 알아보고자 하며 그러한 상표전환의 과정과 반복구매에서 기업의 촉진활동으로 대표되는 마케팅 반응변수별 차이를 분석하여 그 결과를 마케팅에 적용시키기 위한 시사점을 제공하고자 한다. 이는 유통업계간 과다경쟁과 외형을 중시한 판매경쟁의 결과로 밀어내기식의 마케팅을 전개하고 있는 기업에게 소비자를 개개인의 실체로 인식시켜 이에 맞는 효율적인 촉진활동을 제시함으로써 자사상표에 대한 상표 충성도를 높여 지속적인 반복구매를 하게하고 경쟁상표 소비자의 상표전환을 유도하는데 도움을 주고자 한다. 본 연구 결과를 살펴보면 다음과 같다. 첫 번째 이벤트와 가격할인과 샘플이나 견본상표 혹은 로고(logo) 등이 새겨진 것을 일컫는 제품 프리미엄 등을 선호하는 고객들은 반복구매를 하는 특징이 있다. 두 번째 서비스 혜택과 포인트 형 판촉 그리고 비용절감 만족도가 상표전환에는 아무런 영향을 미치지 못했으며 쿠폰 형 판촉을 선호하는 사람들만이 상표전환을 하는 것으로 나타났다. 세 번째 반복구매와 쿠폰 형 판촉 사이에서는 소매 업태가 긍정적인 조절효과를 보이고 있으며 상표전환과 서비스혜택 사이에서도 소매 업태가 긍정적인 조절효과를 보이고 있는 것을 알 수 있었다.

기름으로 오염된 토양에서 작물생육을 위한 계면활성제 생산 Bacteria의 활용에 관한 연구 (The Study of Application of Bio-Surfactant Producing Bacteria for Growing Crop in Oil Spilled Soil)

  • 황철원;장혜원;최용락
    • 생명과학회지
    • /
    • 제17권7호통권87호
    • /
    • pp.944-947
    • /
    • 2007
  • Bacillus LPO3 (계면활성제와 같이 유화물질을 생산하는)을 hydrocarbon을 감소시키는 bio-control agent로 사용했다. 토양 (시중구입)은 gasoline을 섞어 오염시킨 토양을 사용하였다. 13일 동안 bacteria의 성장, hydrocarbon의 감소, 그리고, Bacillus LP03 의 작물 성장에 미친 요인(식물의 싹과 뿌리의 길이를 포함한)을 관찰하였다. 우리는 이 bacteria의hydrocarbon을 감소 시키는 물질로서 이 균이 생산하는 계면활성제일 것이라는 가능성을 이미 확인 하였으며 이는 식물의 싹과 뿌리의 생장을 촉진하였고, 회색 곰팡이에 대하여항 진균 활성을 보였다. 본 연구에서는 bacteria를 넣지 않은 기름으로 오염된 토양 실험 군에서는 식물이 자라나지 않았을 뿐 아니라 살아남지도 못했다. 실험 결과로 볼 때, gasoline의 hydrocarbon이 시간이 지남에 따라 감소되었고, RNA blotting실험에서는 오염된 토양에서 균의 증식과 더불어 계면활성제관련 유전자 산물의 증가를 확인하였다 결과적으로, 이 bacteria (계면활성제를 생산하는)는 회색 곰팡이에 감염된 토양이나 기름으로 오염된 토양에서 작물이 자랄 수 있게 하기 위한 bio-control agent로서 유효한 균으로 생각된다.

일부 대학생들의 흡연실태 및 지식도 (The Realities of Smoking among Some College Students and Their Relevant Knowledge)

  • 김진;임선아
    • 한국치위생학회지
    • /
    • 제6권4호
    • /
    • pp.283-294
    • /
    • 2006
  • The purpose of this study was to examine the state of smoking among some college students, the smoking motivation of smoker students, what made them quit smoking and how they got ready for giving up smoking, as smoking had a huge impact on national health and there was a desperate necessity for preventive antismoking education programs to let students keep away from smoking. After a survey was conducted with self-administered questionnaires from October 1 through November 1, 2006, the responses from 400 students were gathered, and 384 answer sheets were analyzed except 16 incomplete ones. The findings of the study were as follows: 1. By gender, 62.4% of the male students and 28.6% of the female students were smokers, and the state of smoking was statistically significantly different according to their gender(p<0.05). 2. The largest number of the male students, which accounted 44.1%, started smoking in their high school days, and 39.5% of the females did that in middle school. As for a daily mean amount of smoking, 41.8% of the male students, the greatest percentage, smoked 10 to 19 cigarettes a day, and one to nine cigarettes were most common among the females, which represented 57.9 %. But the gap between the two was insignificant(p>0.05). As many as 83.6% of the males and 86.8% of the females had ever attempted to quit it. 3. Concerning awareness of antismoking policies, they felt that a raise in cigarette price would lead to less smoking, and that antismoking advertisement or posters through television or newspaper would deliver the same results as well. There was a statistically significant difference among their awareness(p<0.05). 4. Regarding preparation stage for quitting smoking, 31.3% of the male smokers had no intention to give it up, and 23.2% considered it. 36.7%, the largest percentage, got ready to refrain from it. Among the female smokers, 34.2% had no plans to abstain from smoking, and 36.8% took it into consideration. 23.7% got ready to do that. The females who got ready for that were outnumbered the males who did. 5. As to connections between the state of smoking and relevant knowledge, the students didn't have a good knowledge on that, and a statistically significant difference existed between the smokers and nonsmokers in smoking knowledge. 6. As for knowledge about oral diseases, they were highly cognizant of the relationship of smoking to tooth discoloration, nicotine stomatitis and bad breath, but they didn't know well about its relationship to delayed recovery from dental treatment, implant failure and ozena. Their smoking condition made a statistically significant difference to their knowledge(p<0.05). In the future, sustained research efforts should be channeled into determining how much smoking affects health and concerns oral diseases, and antismoking counseling programs should be prepared to bolster people's awareness of oral health.

  • PDF