• 대한기계학회:학술대회논문집
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• 대한기계학회 2002년도 학술대회지
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• pp.39-42
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• 2002

The nuclear transmutation technology to Incinerate the long lived radioactive nuclides and produce energy during the incineration process is believed to be one or the best solutions. HYPER(${\underline{HY}}brid {\underline{P}}ower {\underline{E}}xtraction {\underline{R}}$eactor)is the accelerator driven transmutation system which is being developed by KAERI(Korea Atomic Energy Research Institute). Lead-bismuth(Pb-Bi) is adopted as a coolant and spallation target material. In this paper, we performed the thermal-hydraulic analysis of HYPER target using the commercial code FLUENT, and also calculated thermal and mechanical stress of the beam window using the commercial code ANSYS. It is found that there is an optimum value for the window diameter and the maximum allowable beam current can be increased to 17.3 mA for the inner diameter of windows, 40 cm. Finally, the other shapes such as uniform or scanned beam were considered. The results of FLUENT calculations show that the uniform type is preferable to the other shapes of the beam in terms of the window and target cooling and the maximum window temperature is lower than that of the parabolic beam by $58 ^{\circ}C$ for the beam current, 13 mA.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2005년도 생물공학의 동향(XVI)
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• pp.82-85
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• 2005

Doxorubicin is a highly-valuable anthracycline-family polyketide drug with a very potent anticancer activity, typically produced by a Gram-positive soil bacterium called Streptomyces peucetius. Thanks to the recent development of Streptomyces genomics-based technologies, the random mutagenesis approach for Streptomyces strain improvement has been switched toward the genomics-based technologies including the application of DNA microarray systems. In order to identify and characterize the genomics-driven potential target genes critical for doxorubincin overproduction, three different types of doxorubicin overproducing strains, a dnrI(doxorubicin-specific positive regulatory gene)-overexpressor, a doxA (gene involved in the conversion from daunorubicin to doxorubicin)-overexpressor, and a recursively-mutated industrial strain, were generated and examined their genomic transcription profiles using Streptomyces DNA microarray systems. The DNA microarray results revealed several potential target genes in S. peucetius genome, whose expressions were significantly either up- or down-regulated comparing with the wild-type strain. A systematic understanding of doxorubicin overproduction at the genomic level presented in this research should lead us a rational design of molecular genetic strain improvement strategy.

• 대한임베디드공학회논문지
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• 제5권2호
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• pp.93-102
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• 2010

The FMCW(Frequency Modulation Continuous Wave) radar possesses range-velocity ambiguity to identify the correct combination of beat frequencies for each target in the multi-target situation. It can lead to ghost targets and missing targets, and it can reduce the detection probability. In this pap er, we propose an effective identification algorithm for the correct pairs of beat frequencies and the signal processing hardware architecture to effectively support the algorithm. First, using the correlation of the detected up- and down-beat frequencies and Doppler frequencies, the possible combinations are determined. Then, final pairing algorithm is completed with the power spectrum density of the correlated up- and down-beat frequencies. The proposed hardware processor has the basic architecture consisting of beat-frequency registers, pairing table memory, and decision unit. This method will be useful to improve the radar detection probability and reduce the false alarm rate.

• E2M - 전기 전자와 첨단 소재
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• 제11권10호
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• pp.53-59
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• 1998

Paraelectric lead landthanum titanate(PLT) thin films have been prepared by a reactive dc magnetron sputtering system using a multicomponent metal target. The surface area control of each element on the target markedly facilitates the fabrication of thin films of complex ceramic compounds. A postdeposition heat-treatment was applied to all as-deposited PLT thin films at annealing temperatures up to 75$0^{\circ}C$ for crystalization. The composition of the PLT(28) thin filmannealed at $650^{\circ}C$ was: Pb, 0.73; La, 0.28; Ti, 0.88; O, 2.9. The dielectric constant and dissipation factor of the thin film(200 nm) at low filed measurements (500 Vcm-1) are 1216 and 0.018, respectively. The charge storage density using a typical Sawyer-Tower circuit with a 500 Hz sine wave was 12.5 $\mu$Ccm-2 at the electric field of 200 kVcm-1.

• 산업공학
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• 제21권4호
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• pp.418-434
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• 2008

This paper studied issues in decision making on the production control policy of a cathode plate manufacturing process in zinc refining plant. The present production system has a long lead time from raw materials (aluminum plate) to products (cathode plate) due to many WIP inventories. Because WIP inventories are stocked at each process and moved from one place to another frequently, they are the main cause of inefficiency in the process. In this paper, to solve this problem, several production control policies have been identified and studied. Several simulation models are used to compare the performances of these production control policies. The output lead time and WIP (Work In Process) of real production system are compared with those of simulation models. PUSH, CONWIP, DBR, KANBAN and CONWIP-DBR models have been used to simulate and review the optimized production control policy that achieves the target output quantities with decreased lead time and WIP. The simulation results of each production control policy show that CONWIP and CONWIP-DBR models are the good production control policy under the present production system. Especially in present production system, CONWIP with one parameter is easier control policy than CONWIP-DBR with two parameters. Therefore CONWIP has been selected as the best optimum production control policy. With CONWIP, lead time has been reduced by 97% (from 6,653 to 187 minute) and WIP has been reduced from 1,488 to 53, compared to the present system.

• 한국식품과학회지
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• 제26권6호
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• pp.745-749
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• 1994

녹차음료가 음용수나 식품에 오염된 중금속의 장내흡수 및 체내 축적 억제와 같은 생리적 기능이 있는지를 조사하기 위해 동물실험을 실시하였다. 쥐에게 3주간 수질기준의 5,000배와 500배 수준으로 납과 카드뮴을 오염시킨 음료수를 부여했을 때 식이섭취량과 체중증가량은 카드뮴 고농도 부여군을 제외한 모든 군에서 중금속 투여로 인한 유의적 차이를 나타내지 않았다. 표적장기의 무게는 신장과 대퇴골에서 중금속 투여에 의한 유의적 차이를 나타냈으며 녹차 투여로 인한 장기무게에는 영향을 나타내지 않았다. 표적장기의 중금속 함량에 있어서는 녹차 음용에 의한 장기의 축적억제 효과를 나타냈는데 특히 대퇴골에서 납은 $25{\sim}45%$, 카드뮴은 고농도 투여군에서 42%의 뚜렷한 감소효과를 보였다. 대퇴골의 칼슘함량은 중금속 투여로 크게 낮아졌으나 녹차 투여 군에서는 그 함량이 증가하였으므로 녹차 투여로 중금속의 축적이 방해되어 칼슘흡수가 증가했음을 확인할수 있었다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제11권11호
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• pp.5459-5473
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• 2017

Recently, a tracking algorithm called the spatial-temporal context model has been proposed to locate a target by using the contextual information around the target. This model has achieved excellent results when the target undergoes slight occlusion and appearance changes. However, the target location in the current frame is based on the location in the previous frame, which will lead to failure in the presence of fast motion because of the lack of a prediction mechanism. In addition, the spatial context model is updated frame by frame, which will undoubtedly result in drift once the target is occluded continuously. This paper proposes two improvements to solve the above two problems: First, four possible positions of the target in the current frame are predicted based on the displacement between the previous two frames, and then, we calculate four confidence maps at these four positions; the target position is located at the position that corresponds to the maximum value. Second, we propose a target reliability criterion and design an adaptive threshold to regulate the updating speed of the model. Specifically, we stop updating the model when the reliability is lower than the threshold. Experimental results show that the proposed algorithm achieves better tracking results than traditional STC and other algorithms.

• 한국콘텐츠학회논문지
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• 제20권3호
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• pp.73-80
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• 2020

본 연구는 국내 상장기업의 국민연금 지분 투자가 기부금 지출에 미치는 영향을 규명하기 위해 2014년부터 2018년까지 5년간 1,878개 기업의 8,499건의 관측 자료를 대상으로 실증분석을 실시하였다. 실증분석 결과, 첫째, 국민연금 지분율은 투자대상 기업의 기부금 지출(인당 기부금, 매출 대비, 자산 대비)에 정(+)의 유의적인 영향을 미치는 것으로 나타났다. 본 결과는 국민연금은 투자대상 기업의 장기적인 기업가치를 높이기 위해 기부금 지출을 늘리도록 영향력을 행사하는 것으로 해석할 수 있다. 둘째, 국민연금이 5% 이상의 지분을 보유하는 주요주주일 때 투자대상 기업의 기부금 지출(인당 기부금, 자산 대비)이 유의적으로 증가하는 것으로 나타났다. 본 결과는 국민연금이 주요 주주인 경우 투자대상 기업의 장기적인 가치 제고를 위해 기부금 지출을 촉진하도록 감시 활동을 전개하는 것으로 해석할 수 있다. 전체적으로 본 실증결과는 국내 상장기업에서 국민연금 지분투자가 투자대상 기업의 기부금 지출을 촉진하도록 영향력을 행사하고 있음을 보여준다. 이는 환경·사회·지배구조 등의 요소를 고려한 국민연금의 사회적 책임투자(Socially Responsible Investment)가 국내 상장기업의 사회적 책임활동에 긍정적 영향을 미칠 수 있음을 시사한다.

• 감성과학
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• 제17권4호
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• pp.3-18
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• 2014

본 연구에서는 2D 화면과 3D화면으로 각각 제시된 운전 시뮬레이션 환경에서 운전자의 종적 차량통제, 주관적 피로감 및 지각된 현실감에서의 차이를 비교하였다. 본 연구의 결과들을 요약하면 다음과 같다. 첫째, 실험참가자들은 미리 정해진 네 가지 수준의 목표속도(60, 80, 100 및 120km/h)를 유지할 때 3D 조건보다는 2D 조건에서, 그리고 목표속도가 낮을수록 목표속도에 비해 더 빠르게 운전하였고, 이러한 경향은 목표속도 조건과 상관없이 일정하였다. 둘째, 선행차량과의 차간거리 유지수행에 대한 분석 결과, 2D 조건에 비해 3D 조건에서 실험참가자들은 선행차량과 더 근접한 차간거리를 유지하며 주행하였는데, 특히 선행차량의 주행속도가 비교적 느렸던 조건(즉, 60km/h)에 비해 비교적 빨랐던 조건(즉, 80 및 100km/h)에서 이러한 경향이 두드러졌다. 셋째, 속도 유지 과제와 선행차량과의 차간거리 유지수행 모두에서 2D 조건에 비해 3D 조건에서 실험참가자들이 경험하는 피로감의 수준이 더 높았으나 주관적 현실감에 대한 평가에서는 두 가지 과제 모두에서 2D와 3D 조건에 따라 유의한 차이가 관찰되지 않았다.

• BMB Reports
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• 제42권11호
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• pp.737-742
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• 2009

Hypoxia-inducible factor-$1{\alpha}/{\beta}$ (HIF-$1{\alpha}/{\beta}$) is a heterodimeric transcriptional activator that mediates gene expression in response to hypoxia. HIF-$1{\alpha}$ has been noted as an effective therapeutic target for ischemic diseases such as myocardiac infarction, stroke and cancer. By using a yeast two-hybrid system and a random peptide library, we found a 16-mer peptide named F29 that directly interacts with the bHLH-PAS domain of HIF-$1{\alpha}$. We found that F29 facilitates the interaction of the HIF-$1{\alpha/\beta}$ heterodimer with its target DNA sequence, hypoxia-responsive element (HRE). The transient transfection of an F29-expressing plasmid increases the expression of both an HRE-driven luciferase gene and the endogenous HIF-1 target gene, vascular endothelial growth factor (VEGF). Taken together, we conclude that F29 increases the DNA-binding ability of HIF-$1{\alpha}$, leading to increased expression of its target gene VEGF. Our results suggest that F29 can be a lead compound that directly targets HIF-$1{\alpha}$ and increases its activity.