• Title/Summary/Keyword: lateral flow

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Influence of Intraventricular Bethanidine on the Renal Function of the Rabbit (가토의 신장 기능에 미치는 측뇌실내 Bethanidine의 영향)

  • 고석태
    • YAKHAK HOEJI
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    • v.23 no.1
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    • pp.31-39
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    • 1979
  • Bethanidine was administered into the lateral ventricle of the rabbit brain for the investigation of the effect on the renal function in doses ranging from 0.1 to 1.0mg/kg. In a dose of 0.1 mg/kg, bethanidine did not exhibit significant changes on the renal function of the rabbit, on the other hand, in the doses of 0.3 and 1.0mg/kg bethanidine elicited the reduction of renal plasma flow and glomerular filtration rate with a marked antidiuresis, at the same time bethanidine produced the decrement of urinary sodium and potassium excretion. After intravenous pretreatment of phentolamine, intraventricular bethanidine in a dose of 0.3mg/kg did not produced the antidiuresis and the decrement of urinary sodium and potassium excretion, wherease renal plasma flow and glomerular filtration rate reduced as before of phentolamine pretreatment although the durations of their reduction were shortened. These observations suggest that bethanidine induces the antidiuresis through the centrally mediated mechanism which interposed other factors in addition to sympathetic stimulation affected by phentolamine, alpha adrenergic blocking agent.

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Analyses of Large Deformation Problems in Geotechnical Engineering using Particle Method (입자법을 이용한 지반공학 대변형 문제 해석)

  • Park, Sung-Sik
    • Proceedings of the Korean Geotechical Society Conference
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    • 2009.09a
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    • pp.1090-1094
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    • 2009
  • Many problems in geotechnical engineering such as slop failure, debris flow, ground heaving due to embankment, and lateral flow caused by liquefaction are related to large deformation rather than small deformation. Traditional numerical methods such as finite element and finite difference methods have a difficulty to solve such large deformations because they use grids. A particle method was developed for fluid dynamics. The particle method can solve large deformation problems because it uses particles to discretize differential equations. It can also include soil constitutive model and thus solve soil behavior on various boundary conditions. In this study, a particle method, which is based on particles rather than grids, is introduced and used to simulate large deformation including soil failure. The developed method can be applied for various large deformation problems in geotechnical engineering because it incorporates soil constitutive models.

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Velocity Structure of Wall Jet Originating from Circular Orifices in Shallow Water (천해역에 방류되는 원형 다공바닥젵의 유속구조)

  • 김대근;서일원
    • Journal of Environmental Science International
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    • v.11 no.10
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    • pp.1039-1044
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    • 2002
  • In this study, breakwater model which has several outlet pipes to discharge water is settled in the experimental open channel and mean velocity distributions of multi wall jet are measured. The length of zone of flow establishment of wall jet is shorter than that of free jet and decay rate of jet centerline longitudinal velocity along x is linear in $0.3{leq}x/I_p{leq}17$. The rate of vertical width and lateral width spreading of multi wall jet is respectively 0.0753, 0.157.

Rotordynamic Analysis for Labyrinth Seals Used in Compressors (압축기용 라비린스 실의 동특성 해석)

  • 하태웅;이안성
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 1997.10a
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    • pp.138-144
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    • 1997
  • The analysis of lateral hydrodynamic forces from the compressor labyrinth seals is presented. The basic equations are derived using a two-control-volume model for compressible flow. Blasius' wall friction-factor formula and jet flow theory are used for the calculation of the wall shear stresses and the recirculation velocity in the cavity. Linearized zeroth-order and first-order perturbation equations are developed for small motion about a centered position by an expansion in the eccentricity ratio. Integration of the resultant first-order pressure distribution along and around the seal defines the rotordynamic coefficients of the labyrinth seal. The rotordynamic analysis for the balance drum labyrinth seal of an ethylene refrigeration compressor is carried out. The results of rotordynamic characteristic of the labyrinth seal and comparisons with other types of seal, honeycomb seal and smooth seal, are presented.

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Prediction of Outflow Hydrograph caused by Landslide Dam Failure by Overtopping

  • Do, XuanKhanh;Kim, Minseok;Nguyen, H.P.T;Jung, Kwansue
    • Proceedings of the Korea Water Resources Association Conference
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    • 2016.05a
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    • pp.196-196
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    • 2016
  • Landslide dam failure presents as a severe natural disaster due to its adverse impact to people and property. If the landslide dams failed, the discharge of a huge volume of both water and sediment could result in a catastrophic flood in the downstream area. In most of previous studies, breaching process used to be considered as a constructed dam, rather than as a landslide dam. Their erosion rate was assumed to relate to discharge by a sediment transport equation. However, during surface erosion of landslide dam, the sediment transportation regime is greatly dependent on the slope surface and the sediment concentration in the flow. This study aims to accurately simulate the outflow hydrograph caused by landslide dam by overtopping through a 2D surface flow erosion/deposition model. The lateral erosion velocity in this model was presented as a function of the shear stress on the side wall. The simulated results were then compared and it was coherent with the results obtained from the experiments.

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MEASUREMENT OF PULPAL BLOOD FLOW USING A LASER DOPPLER FLOWMETER (Laser Doppler flowmeter를 이용한 치수혈류 측정)

  • Ban, Tae-Whan;Lee, Jae-Sang;Kim, Sung-Kyo
    • Restorative Dentistry and Endodontics
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    • v.24 no.4
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    • pp.560-569
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    • 1999
  • Blood supply rather than nerve supply implies pulp vitality. To evaluate pulp vitality clinically, electric pulp test and thermal test which are based on sensory nerve response have been used in addition to many auxiliary data such as past dental history, visual inspection, radiographic examination, percussion, palpation and transillumination test. However, reactivity of the nerves to the stimulation is not synonymous with normalcy. Therefore measurement of pulpal blood flow using a laser Doppler flowmeter became a new trial to test the pulp vitality. The purpose of the present study was to evaluate normal pulpal blood flow level of maxillary teeth in adult to provide a guideline in determining the vitality of dental pulp. Pulpal blood flow was measured in maxillary central and lateral incisors, canines, first and second premolars and first molars of seventy nine adults of 22 - 30 years old using a laser Doppler flowmeter (PeriFlux 4001, Perimed Co., Stockholm, Sweden, 780 nm infrared laser, 1mW). For directly-made splints, silicone rubber impressions were taken directly from the mouth. For indirectly-made splints, alginate impressions were taken from the mouth and stone cast were made. After making depressions on the buccal surfaces of the cast teeth to indicate the hole positions, second impressions with vinyl polysyloxane putty were taken from the cast. Holes for the laser probes were made at the putty impressions 4mm above the gingival level. Laser probe (PF416 dental probe, 1.5mm) was inserted in the prepared hole and the splint was set in the mouth. After 10 minutes of patient relaxing, pulpal blood flow was recorded for 5 minutes on each tooth. The recorded flow was saved in the computer and calculated with a software 'Perisoft' version 5.1. Pulpal blood flow was also recorded in six teeth of five individuals with no response to electric pulp test and cold test, with periapical radiolucency, or with history of root canal treatment to compare with nonvital teeth. The difference between the mean flow values of each group of teeth were analyzed using one-way ANOVA and Duncan's Multiple Range test. The results were as follows: 1. The average pulpal blood flow values of all the tested teeth of each location were between 9 - 16 Perfusion Unit. Pulpal blood flow value was highest in maxillary lateral incisors, followed by first premolars, second premolars, canines, central incisors, and then first molars (p<0.01). 2. In six anterior teeth, indirectly-made splint group showed higher pulpal blood flow values than directly-made splint group (p<0.01). In posterior teeth, however, there was no significant flow value difference between directly-made splint group and indirectly-made splint one (p>0.05). 3. Teeth with vital pulps showed higher signal values than teeth with nonvital pulps (p<0.01), and the flow photographs showed heartbeat-synchronous fluctuations and vasomotions, while those were absent in non vital tooth.

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Prevalence of Cryptosporidium-Associated Diarrhea in a High Altitude-Community of Saudi Arabia Detected by Conventional and Molecular Methods

  • Hawash, Yousry;Dorgham, Laila Sh.;Al-Hazmi, Ayman S.;Al-Ghamdi, Mohammed S.
    • Parasites, Hosts and Diseases
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    • v.52 no.5
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    • pp.479-485
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    • 2014
  • Cryptosporidium diarrhea represents a relevant clinical problem in developing countries. In Al-Taif, a city of Saudi Arabia that lies at an altitude of an around 2 km above the sea level, Cryptosporidium infection seems to be undiagnosed in nearly all clinical laboratories. Furthermore, nothing was published regarding Cryptosporidium-associated diarrhea in this area. The objectives of this research were to (1) determine the Cryptosporidium prevalence among patients with diarrhea and (2) to estimate the performances of 3 different diagnostic methods. Total 180 diarrheal fecal samples, 1 sample per patient, were collected between January and August 2013. Samples were screened for Cryptosporidium with modified Zeihl Neelsen (ZN) microscopy, $RIDA^{(R)}$ Quick lateral flow (LF) immunotest, and a previously published PCR. The Cryptosporidium prevalence rate was 9.4% (17/180), 10% (18/180), and 11.6% (21/180) by microscopy, LF, and PCR test, respectively. Infection was significantly (P=0.004) predominant among children <5 years (22%) followed by children 5-9 years (11.1%). Although infection was higher in males than in females (16.2% males and 8.5% females), the difference was not statistically significant (P=0.11). Compared to PCR, the sensitivity of microscopy and the LF test were 80.9%, 85.7%, respectively. To conclude, high Cryptosporidium-associated diarrhea was found in this area especially in children ${\leq}9$ years. The PCR test showed the best performance followed by the LF test and ZN staining microscopy. The primary health care providers in Al-Taif need to be aware of and do testing for this protozoon, particularly for children seen with diarrhea.

The Effect of the Variation of Pressure Ratio on the Characteristics of Lateral Forces in an Over-Expanded Nozzle (압력비 변화과정이 과팽창 노즐에서 발생하는 횡력 변동 특성에 미치는 영향)

  • Lee, Jong-Sung;Kim, Heuy-Dong
    • Journal of the Korean Society of Propulsion Engineers
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    • v.14 no.6
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    • pp.38-44
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    • 2010
  • The shock wave and boundary layer interaction patterns in an over-expanded rocket nozzle are associated with the production of undesirable side-forces during the start-up and shut-down processes of the engine. In the present work, a computational study is carried out to investigate the effect of the transient nozzle pressure ratio (NPR) on the flow fields inside the nozzle. The unsteady, compressible, axisymmetric, Navier-Stocks equations with SST k-${\omega}$ turbulence model are solved using a fully implicit finite volume scheme. NPR is varied from 2.0 to 10.0, in order to simulate the start-up and shut-down processes of the rocket engine. It is observed that the interaction patterns and the hysteresis phenomenon strongly depend on the time variation of NPR, leading to significantly different characteristics in the lateral forces.

Development of a Method for Rapid Analysis of DNA Hybridization (측방유동방식 신속 DNA 교잡 분석법의 개발)

  • 정동석;최의열
    • Korean Journal of Microbiology
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    • v.39 no.2
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    • pp.114-117
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    • 2003
  • In molecular biology, it is necessary to develop an easy and rapid method to identify a specific DNA sequence. Though Southern and Northern blot techniques have been used widely for the analysis of gene structure and function, those methods are inconvenient in the points that we need to control incubation temperature, time, and other parameters to get the final result. In this study, we report a new method for the rapid analysis of specific DNA sequence with the modification of an immunochromatographic method. The lateral flow DNA analysis strip is composed of a sample pad, a nitrocellulose membrane for the separation and propagation of analytes, and an absorption pad for the generation of capillary action. Capture DNA was immobilized on the membrane by UV cross-linking and target DNA was labeled with Cy-5 for signaling. The samples containing target DNA were applied onto the sample pad, incubated for 15 min for separation, and scanned with a GSI fluorescence scanner. Though the hybridization reaction occurs in a short time without any washing steps, there appears to be little cross hybridization between the different sequences. The result showed a possibility that the new method can be used for the rapid identification of specific DNA sequence among the samples.

Interpretation of Soft Ground Deformation under Embankment using the Electrical Resistivity Survey (전기비저항탐사를 이용한 성토하부 연약지반의 변형 해석)

  • Kim, Jae-Hong;Hong, Won-Pyo;Kim, Gyoo-Bum
    • The Journal of Engineering Geology
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    • v.21 no.2
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    • pp.117-124
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    • 2011
  • Soil deformations such as settlement, heaving and lateral flow have frequently happened on marine reclaimed soft grounds due to embankment filling or banking. The electrical resistivity survey was applied to investigate on ground surface such soil deformation without disturbance of ground. A test embankment was performed to assess soil deformation in marine reclaimed soft grounds, where was located at Sihwa area in western coast of Korean peninsula. The soft ground was composed of clayey sediments. After embankment filling, the boundary of soil deformation affected by the filling could be investigated with application of the electrical resistivity survey. The result of electric resistivity survey shows that the extent of deformation is about 5 m laterally to the southern direction of embankment and about 5~6 m vertically in depth, which is about 1-1.2 times of embankment height. This shows that the electric resistivity survey can be applied to interpret the ground deformation in a soft ground region.