• The Korean Journal of Physiology and Pharmacology
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• v.16 no.6
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• pp.413-422
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• 2012

The purpose of this study is to investigated the mechanism of pharmacological action of local anesthetic and provide the basic information about the development of new effective local anesthetics. Fluorescent probe techniques were used to evaluate the effect of lidocaine HCl on the physical properties (transbilayer asymmetric lateral and rotational mobility, annular lipid fluidity and protein distribution) of synaptosomal plasma membrane vesicles (SPMV) isolated from bovine cerebral cortex, and liposomes of total lipids (SPMVTL) and phospholipids (SPMVPL) extracted from the SPMV. An experimental procedure was used based on selective quenching of 1,3-di(1-pyrenyl)propane (Py-3-Py) and 1,6-diphenyl-1,3,5-hexatriene (DPH) by trinitrophenyl groups, and radiationless energy transfer from the tryptophans of membrane proteins to Py-3-Py. Lidocaine HCl increased the bulk lateral and rotational mobility of neuronal and model membrane lipid bilayes, and had a greater fluidizing effect on the inner monolayer than the outer monolayer. Lidocaine HCl increased annular lipid fluidity in SPMV lipid bilayers. It also caused membrane proteins to cluster. The most important finding of this study is that there is far greater increase in annular lipid fluidity than that in lateral and rotational mobilities by lidocaine HCl. Lidocaine HCl alters the stereo or dynamics of the proteins in the lipid bilayers by combining with lipids, especially with the annular lipids. In conclusion, the present data suggest that lidocaine, in addition to its direct interaction with proteins, concurrently interacts with membrane lipids, fluidizing the membrane, and thus inducing conformational changes of proteins known to be intimately associated with membrane lipid.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.6 no.4
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• pp.413-420
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• 1994

Dynamics of the river plume is a very complicated non-linear problem with the free boundary changing in time and space. Mixing with the ambient water through the boundary makes the problem more complicated. In this paper we reduced 3-dimensional problem into 1-dimensional one by using the integral analysis method. Basic equations have been integrated over the lateral and vertical variations. For these integrations we adopted the well-established assumption that the flow-axis component of plume velocity and the density difference of the plume with the ambient water have Gaussian distributions in directions which are perpendicular to the flow-axis of the plume. We also used the result of our previous study on the lateral spreading velocity of the plume derived under the same assumption. And entrainment was included as a mixing process. The resultant 1-dimensional equations were solved by Runge-Kutta numerical method. Consequently, comparatively easy method of numerical analysis is presented for the 3-dimensional river plume. The method can also be used for the analysis of the thermal plume of cooling water of power plants.

• Structural Engineering and Mechanics
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• v.41 no.2
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• pp.183-204
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• 2012

Several issues regarding the structural idealization of steel buildings with perimeter moment resisting steel frames (MRSFs) and interior gravity frames (GFs) are studied. Results indicate that the contribution of GFs to the lateral structural resistance may be significant. The contribution increases when the stiffness of the connection of the GFs is considered and is larger for inelastic than for elastic behavior. The interstory shears generally increase when the connections stiffness is taken into account. Resultant stresses at some base columns of MRSFs also increase in some cases but to a lesser degree. For columns of the GFs, however, the increment is significant. Results also indicate that modeling the building as planes frames may result in larger interstory shears and displacements and resultant stresses than those obtained from the more realistic 3-D formulation. These differences may be much larger when semi-rigid (SR) connections are considered. The conservativism is more for resultant stresses. The differences observed in the behaviour of each structural representation are mainly due to a) the elements that contribute to strength and stiffness and b) the dynamics characteristics of each structural representation. It is concluded that, if the structural system under consideration is used, the three-dimensional model should be used in seismic analysis, the GFs should be considered as part of the lateral resistance system, and the stiffness of the connections should be included in the design of the GFs. Otherwise, the capacity of gravity frames may be overestimated while that of MRSFs may be underestimated.

• Journal of computational fluids engineering
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• v.20 no.3
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• pp.94-103
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• 2015

The turbulent flow characteristics in the channel flow are investigated using large eddy simulation(LES) of FDS code, built in NIST(USA), in which the near-wall flow is solved by Werner-Wengle wall function. The periodic flow condition is applied in streamwise direction to get the fully developed turbulent flow and symmetric condition is applied in lateral direction. The height of the channel is H=1m, and the length of the channel is 6H, and the lateral length is H. The total grid is $32{\times}32{\times}32$ and $y^+$ is kept above 11 to fulfill the near-wall flow requirement. The Smagorinsky model is used to solve the sub-grid scale stress. Smagorinsky constant $C_s$ is 0.2(default in FDS). Three cases of Reynolds number(10,700, 26,000, 49,000.), based on the channel height, are analyzed. The simulated results are compared with direct numerical simulation(DNS) and particle image velocimetry(PIV) experimental data. The linear low-Re eddy viscosity model of Launder & Sharma and non-linear low-Re eddy viscosity model of Abe-Jang-Leschziner are utilized to compare the results with LES of FDS. Reynolds normal stresses, Reynolds shear stresses, turbulent kinetic energys and mean velocity flows are well compared with DNS and PIV data.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.10 no.2
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• pp.64-72
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• 1998

Dynamic response analysis is carried out for slender marine structures such as tensioned risers and tethers of tension leg platform, which are subjected to floating vessel motions as well as environmental forces arising from ocean waves. A mumerical analysis procedure is developed by using finite element model of the structural member. Dynamic analses are performed in the time domain for regular waves. Parameter studies are carried out to highlight the effects of surface vessel motions on the lateral dynamics of the structures. Example results of displacements, bending stresses are compared for various in water depth, environmental condition and vessel motion. Some instability conditions of the structures due to time-varying tension by vessel heave motion are discussed through the example analyses. As the results, the interaction between vessel surge and heave motions amplifies the total structural response of a riser. In the case of a tether, the effect of vessel heave motion during heavy storm is seemed to be quite significant to lateral response of the structure.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.31 no.10
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• pp.79-88
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• 2003

The paper presented here covers the work associated with the flight control law design, ground based and in flight simulation and handling qualities assessment of the Fly-by-Wire type Aircraft (FBWA). The FBWA configurations are of the same generic form of the Korean advanced trainer. The normal acceleration (Nz) and pitch rate (q) feedback control system is employed for longitudinal axis and roll rate (p) and lateral acceleration (Ny) feedback flight control law is developed in lateral/ directional axis. The flight tests for the FBW A dynamics evaluation were executed for the target aircraft (FBWA) on the IFS (In-Flight-Simulator) aircraft . The test results showed that Level 1 handling qualities for the most unstable flight regime and Level 1/2 for the landing approach flight regime were achieved. And the designed FBWA flight control law has revealed acceptable CHR (Cooper-Harper handling qualities Ratings).

• Journal of the Korean Society for Railway
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• v.16 no.2
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• pp.110-116
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• 2013

Track irregularities is one of the key factors influencing the running behavior of trains. In order to ensure safety and ride comfort of train, the criteria for track irregularities should be adequately established regarding vehicle velocity, vehicle characteristics, characteristics of the track recording car, and measurement interval. Also, track maintenance should be carried out thoroughly according to the criteria for managing track irregularities. Numerical analysis was conducted to investigate the influence of track alignment on the running behavior of Korean high speed train(KTX). Various wavelengths and amplitudes of lateral alignment were considered as parameters for this study using the Vampire program, a vehicle dynamics modeling package in railway environment. Derailment, lateral load, bogie acceleration and body acceleration of numerical analysis results due to alignment were investigated. Finally, the influence of the alignment on safety and ride comfort for the KTX was evaluated. This study indicates that alignment irregularities have significant impacts on running safety, and that the criteria used to manage alignment irregularities should be restrictive to ensure the running safety of the KTX.

• Smart Structures and Systems
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• v.18 no.2
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• pp.355-374
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• 2016

This paper presents and compares a one-dimensional (1D) bending theory for piezoelectric thin beam-type structures with resistive-inductive electrodes to ANSYS$^{(R)}$ three-dimensional (3D) finite element (FE) analysis. In particular, the lateral deflections and vibrations of slender piezoelectric beams are considered. The peculiarity of the piezoelectric beam model is the modeling of electrodes in such a manner that is does not fulfill the equipotential area condition. The case of ideal, perfectly conductive electrodes is a special case of our 1D model. Two-coupled partial differential equations are obtained for the lateral deflection and for the voltage distribution along the electrodes: the first one is an extended Bernoulli-Euler beam equation (second-order in time, forth order in space) and the second one the so-called Telegrapher's equation (second-order in time and space). Analytical results of our theory are validated by 3D electromechanically coupled FE simulations with ANSYS$^{(R)}$. A clamped-hinged beam is considered with various types of electrodes for the piezoelectric layers, which can be either resistive and/or inductive. A natural frequency analysis as well as quasi-static and dynamic simulations are performed. A good agreement between the extended beam theory and the FE results is found. Finally, the practical relevance of this type of electrodes is shown. It is found that the damping capability of properly tuned resistive or resistive-inductive electrodes exceeds the damping performance of beams, where the electrodes are simply linked to an optimized impedance.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.4
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• pp.632-638
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• 2019

This paper presents the conceptual design and reaction force analysis of a bogie structure for an inter-modal automated transportation system, including road and rail transportation. The proposed system was based on a train with rotation-aligning bogie mechanism that can save significant time and cost. One of the critical issues in conceptual design is the lateral forces applied to the rail caused by the characteristic shapes and structure of the rails and bogie. In particular, the lateral forces are significant in the transition section between the driving and platform sections. This paper provides design guidance for the transition section through reaction force analysis. Based on the analysis result, it was confirmed that the proposed concept can be a valid design candidate of a practical system, and the radius of the rail and the distance between rails are major factors for reaction force generation.

• Journal of Power System Engineering
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• v.17 no.3
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• pp.72-81
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• 2013

Many articles have been published about a 2-degree of freedom model that includes the lateral and yaw motions for controller synthesis in intelligent transport system applications. In this paper, a 3-degree of freedom linear model that includes the roll motion is developed to design a robust steering controller for lane following maneuvers using ${\mu}$-synthesis. This linear perturbed system includes a set of parametric uncertainties in cornering stiffness and unmodelled dynamics in steering actuators. The state-space model with parametric uncertainties is represented in linear fractional transformation form. Design purpose can be obtained by properly choosing the frequency dependent weighting functions. The objective of this study is to keep the tracking error and steering input energy small in the presence of variations of the cornering stiffness coefficients. Furthermore, good ride quality has to be achieved against these uncertainties. Frequency-domain analyses and time-domain numerical simulations are carried out in order to evaluate these performance specifications of a given vehicle system. Finally, the simulation results indicate that the proposed robust controller achieves good performance over a wide range of uncertainty for the given maneuvers.