• The Journal of Korean Society of Virology
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• v.26 no.1
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• pp.67-76
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• 1996

The methods that make Hantavirus grow consist of inoculation into the experimental animals and cultured cells. The cultured cells, such as Vero-E6 and A549 cells, have been usually used for isolation of the virus and the animals, such as mice and rats, are used for large scale preparation of the virus so far. Furthermore, the cell can be used to maintain the virus and assay the infectivity and the animals can be used for the experiment of viral pathogenicity and challenge for assessment of vaccine. Apodemus mice, the own natural host of the virus, has been used for challenge test of Hantaan virus. However it has been pointed out to difficult handling and breeding the animal in laboratory. Therefore, we attempted to establish a new animal model for challenge test at the time of isolation of Maaji virus which is a new hantavirus similar but distinct to Hantaan virus. In suckling hamster, the titer of Maaji virus and the lethality to mice of the virus were increased gradually in the titer and lethality through passage by intracerebral (IC) inoculation. We tried to re-adapt this brain virus to lung of weanling hamster. The brain passaged virus was inoculated into weanling hamster intramuscularly. Again, the titer of the virus in lung was also increased by continuous passage of this virus. This facts could regarded as adaptation to new environment in which the virus proliferates. To identity the virus passaged in hamster with Maaji virus, both of the virus passaged in hamster brain and lung were compared with Maaji virus (MAA-I) and Hantaan virus (HTN 76-118) by means of restriction fragment length polymorphism (RFLP) and slingle strand conformation polymophism (SSCP). As a result, we conclude that Maaji virus could be adapted successfully to weanling hamster through this passage strategy. Utilizing this adapted Maaji virus strain, hamster model is able to be used for challenge test in hantaviral vaccinology and further experiments utilizing hamster system as a rather available and convenient lab animal are expected.

• Land and Housing Review
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• v.2 no.3
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• pp.287-297
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• 2011

This paper presents the results of performance verification tests of the isolated flat plate apartment building with the laminated rubber bearings. The shaking table test is carried out in CABR(China Academy of Building Research) with two 1/10 scale isolation and non-isolation models under 4 excitation waves. The shaking table test is proceeding from x axis, y axis and x+y axis with different amplitude of acceleration values. The results show that, to non-isolated model, the natural vibration period is remarkably decreased and entered non-linear condition after moderate earthquake. Its accelerations become lager with increasing storey number and completely collapsed under large earthquake. The inter-storey shifts largely exceed the limit values of regulated displacement angles. But to isolated model, the natural vibration period of isolated modal is almost the same in all conditions and still in its elastic condition. The earthquake loading is greatly reduced and the accelerations of superstructure are greatly reduced. The inter-storey drifts are very small and can be neglected. The isolated model is in translational state and can be seen as a rigid whole. The displacements of isolation layer are in the allowable range. This experiment demonstrates that the seismic isolation is very effective to mitigate the influence of earthquake on structures and it is possible to increase the serviceability due to decrease the floor acceleration. facilities from their good states that is superior to non-isolated structure.

• Journal of Ocean Engineering and Technology
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• v.32 no.1
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• pp.1-8
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• 2018

In order to analyze the response of the offshore structure numerically, the linear potential theory is generally applied for simplicity, and only the radiation damping is considered among various damping forces. Therefore, the results of a numerical simulation can be different from the motion of the structure in a real environment. To reduce the differences between the simulation results and experimental results, the viscous damping, which affects the motion of the structure, is also taken into account. The appropriate damping model is essential for the numerical simulation in order to obtain precise responses of the offshore structure. In this study, various damping models such as linear or quadratic damping and the nonlinear drag force from numerous slender bodies were used to simulate the free decay motion of the platform, and its characteristics were confirmed. The optimized damping model was found by comparing the simulation results to the experimental results. The hydrodynamic forces and wave exciting forces of the structure were obtained using WAMIT, and the free decay test was simulated using OrcaFlex. A free decay test of the scale model was performed by KRISO.

• Economic and Environmental Geology
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• v.50 no.2
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• pp.159-170
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• 2017

The temporal and spatial temperature distribution of the heat storage mortar made of porous feldspar was measured and the thermal properties and electricity consumption were analyzed. For the experiment, two real size chambers (control model and test model) with hot water pipes were constructed. Two large scale models with hot water pipes were constructed. The surface temperature change of the heat storage layer was remotely monitored during the heating and cooling process using infrared thermal imaging camera and temperature sensor. The temperature increased from $20^{\circ}C$ to $30^{\circ}C$ under the heating condition. The temperature of the heat storage layer of the test model was $2.0-3.5^{\circ}C$ higher than the control model and the time to reach the target temperature was shortened. As the distance from the hot water pipe increased, the temperature gap increased from $4.0^{\circ}C$ to $4.8^{\circ}C$. The power consumed until the surface temperature of the heat storage layer reached $30^{\circ}C$ was 2.2 times that of the control model. From the heating experiment, the stepwise temperature and electricity consumption were calculated, and the electricity consumption of the heat storage layer of the test model was reduced by 66%. In the cooling experiment, the surface temperature of the heat storage layer of the test model was maintained $2^{\circ}C$ higher than that of the control model. The heat storage effect of the porous feldspar mortar was confirmed by the temperature experiment. With considering that the time to reheat the heat storage layer is extended, the energy efficiency will be increased.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.14 no.4
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• pp.953-963
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• 1994

Treatment techniques of soft clay layers is needed sophisticated technology in civil engineering. Especially, dredged and reclaimed clay has high liquid limit and water content, so it is difficult to use. Now it comes to the applicability as good construction materials by predicting the behaviors. This paper is to evaluate the characteristics of sedimentation and self-weight consolidation of extremely soft clay, and is to find the way of applying model test result of reconstructing the in-situ condition to design. The consolidation properties of soft clay layers changing the size of the cell are investigated by large-scale consolidation test apparatus and the behaviors of self-weight consolidation are predicted by numerical analysis.

• Journal of Nutrition and Health
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• v.45 no.6
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• pp.600-612
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• 2012

Nutritional researchers world-wide are using large-scale sample survey methods to study nutritional health epidemiology and services utilization in general, non-clinical populations. This article provides a review of important statistical methods and software that apply to descriptive and multivariate analysis of data collected in sample surveys, such as national health and nutrition examination survey. A comparative data analysis of the Korea National Health and Nutrition Examination Survey (KNHANES) was used to illustrate analytical procedures and design effects for survey estimates of population statistics, model parameters, and test statistics. This article focused on the following points, method of approach to analyze of the sample survey data, right software tools available to perform these analyses, and correct survey analysis methods important to interpretation of survey data. It addresses the question of approaches to analysis of complex sample survey data. The latest developments in software tools for analysis of complex sample survey data are covered, and empirical examples are presented that illustrate the impact of survey sample design effects on the parameter estimates, test statistics, and significance probabilities (p values) for univariate and multivariate analyses.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.36 no.1
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• pp.17-24
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• 2018

DEM (Digital Elevation Model) is a useful dataset which represents the earth surface. Beside many applications, production and frequent update of DEM is a costly task. Recently global satellite based DEMs are available which has huge potential for application. To check the accuracy, this study compares two global DEMs: AW3D30 (Advanced Land Observing Satellite World 3D 30m) and SRTM30 (Shuttle Radar Topography Mission Global 30m) with reference resampled LiDAR DEM 30m in a test area around Chuncheon, Korea. The comparison analysis was based on statistics of each DEM, their difference, profiles, slope, basin and stream orders. As a result, it is found that SRTM30 and AW3D30 were much similar but inconsistent in the test area compared to the LiDAR30 DEM. In addition, SRTM30 shows less difference with LiDAR30 compared to the AW3D30 DEM. But, DEMs should be very carefully examined for area which has temporal or season changes. For basin and stream analysis, global DEMs can be used only for regional scale analysis not local large scales.

• Geosystem Engineering
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• v.21 no.6
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• pp.326-334
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• 2018

Underground water-sealed gas storage caverns have become the primary method for strategic storage of LPG. Previous studies of excavation blasting effects on large-scale underground water-sealed gas storage caverns are rare at home and abroad. In this paper, the blasting excavation for underground water-sealed propane storage caverns in Yantai was introduced and field tests of blasting vibration were carried out. Field test data showed that the horizontal radial velocity had a major controlling effect in the blasting vibration and frequencies would not cause the vibration velocity concentration effects. In terms of the influence of blasting vibration on adjacent caverns, the dynamic finite element model in LS-DYNA soft was established, whose reliability was verified by field test data. The numerical results indicated the near-blasting side was primary zone for the structural failure and tensile failure tended to occur in the middle of the curved wall on the near-blasting side. Meanwhile, the safety criterions for adjacent caverns based on stress wave theory and according to statistic relationship between peak effective tensile stress and peak particle velocities were obtained, respectively. Finally, with Safety Regulations for Blasting in China (GB6722-2014) taken into account, a final safety criterion was proposed.

• Journal of Society of Preventive Korean Medicine
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• v.25 no.3
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• pp.1-14
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• 2021

Objectives : This study aimed to investigate the perception level of Telemedicine among Korean medical doctors. Methods : The on-line survey was administered for Korean Medicine doctors. The survey consisted of 46 questions, addressing issues on concepts and adoption model of Telemedicine. Data were collected from 528 Korean medical doctors, and were analyzed using frequency analysis, t-test, ANOVA, and Kruskalwallis test. Results : The results showed that more than half of respondents had positive attitude towards implementation of Telemedicine in Korean Medicine and conventional medicine areas. Respondents were most positive about the aspect that Telemedicine could reduce 'hospital use by people with disabilities', while they were most concerned about the possibility that patients could be concentrated in large-scale hospitals. As prerequisites for the introduction of Telemedicine, accurate information delivery during remote communication between doctors and patients, clarification of responsibility for Telemedicine at the policy level, and development of equipment for accurate information delivery at the technical level received high responses. Conclusions : Korean Medicine doctors were positive about the implementation of Telemedicine, and they preferred to remote monitoring between doctors and patients. The development of medical equipment for accurate patient information delivery and the establishment of an institutional basis for clarifying responsibilities in case of medical accidents are required.

• Dementia and Neurocognitive Disorders
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• v.22 no.1
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• pp.1-15
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• 2023

The Seoul Neuropsychological Screening Battery (SNSB) is known as a representative comprehensive neuropsychological evaluation tool in Korea since its first standardization in 2003. It was the main neuropsychological evaluation tool in the Clinical Research Center for Dementia of South Korea, a large-scale multi-center cohort study in Korea that was started in 2005. Since then, it has been widely used by dementia clinicians, and further solidified its status as a representative dementia evaluation tool in Korea. Many research results related to the SNSB have been used as a basis for the diagnosis and evaluation of patients in various clinical settings, especially, in many areas of cognitive assessment, including dementia evaluation. The SNSB version that was updated in 2012 provides psychometrically improved norms and indicators through a model-based standardization procedure based on a theoretical probability distribution in the norm's development. By providing a score for each cognitive domain, it is easier to compare cognitive abilities between domains and to identify changes in cognitive domain functions over time. Through the development of the SNSB-Core, a short form composed of core tests, which also give a composite score was provided. The SNSB is a useful test battery that provides key information on the evaluation of early cognitive decline, analysis of cognitive decline patterns, judging the severity of dementia, and differential diagnosis of dementia. This review will provide a broad understanding of the SNSB by describing the test composition, contents of individual subtests, characteristics of standardization, analysis of the changed standard score, and related studies.