• Childhood Kidney Diseases
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• 제22권1호
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• pp.1-6
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• 2018

Rituximab (RTX) is a chimeric monoclonal antibody that inhibits CD20-mediated B-cell proliferation and differentiation. Several studies have examined its use in intractable nephrotic syndrome (NS) with some positive results. However, those studies examined such effects for a short-term period of 1 year, and some patients continued to relapse after a lapse in RTX treatment. Our use of RTX as a maintenance therapy (RTX injection when the CD19 cell count exceeded $100-200/{\mu}L$ before relapse) showed some noticeable efficacy. We used RTX in 19 patients with steroid-dependent NS (SDNS). In 12 patients treated with RTX maintenance therapy, only one relapse occurred. The mean treatment period was $23.4{\pm}12.7months$, and the mean number of RTX administrations was $3.9{\pm}1.6$. The relapse rates were decreased (from 2.68/year to 0.04/year), and the drug-free period also increased (from 22.5 days/year to 357.1 days/year) during maintenance therapy. The other seven patients were treated with one cycle of RTX or additional cycles in case of relapse (non-maintenance therapy). Relapse rates were significantly decreased after RTX treatment (from 1.76/year to 0.96/year, P=0.017). The relapse-free period was $15.55{\pm}7.38$ (range, 5.3-30.7) months. No severe side effects of RTX were found except for a hypersensitivity reaction such as fever and chills during its infusion. In conclusion, RTX is considered an effective and safe option to reduce the relapse rate by a single- or maintenance-interval therapy in SDNS.

• Nuclear Engineering and Technology
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• 제52권2호
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• pp.296-307
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• 2020

Permanent magnet sodium flowmeter (PMSF) have been used to measure the sodium flow in fast breeder reactors. Due to the effects of irradiation, thermal cycling, time lapse, etc., the magnetic flux density of the PMSF will decrease after being used in the reactor for a period of time. Therefore, it must be calibrated regularly. But some flowmeters that immersed in sodium cannot be removed for an off-line calibration, so the on-line calibration is required. However, the best online calibration accuracy of PMSF using cross-correlation analysis method was 2.0-level without considering the repeatability. In order to further improve this work, the operational principle of the transducer in PMSF is analyzed and the design principle of the transducer is proposed. The transducers were tested on the sodium flow loop to collect the experimental data. The signal characteristics are analyzed from the time and frequency domains, respectively. The cross-correlation analysis method based on biased estimation is adopted to obtain the flow rate. The verification experimental results showed that the measurement accuracy is 1.0-level when the flow velocity is above 0.5 m/s, and the measurement accuracy is 3.0-level when the flow velocity is in the range of 0.2 m/s to 0.5 m/s.

• 생태와환경
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• 제53권2호
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• pp.195-207
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• 2020

난온대 동백나무군강의 한국 내 분포 북한계는 연평균 기온 13℃와 14℃, 한랭지수 -10℃로 제안된 바 있다. 본 연구는 이들 기후요소의 지리적 공간분포 실체를 검토하였다. 세 기후요소의 공간분포 양상은 티센망법과 크리깅법으로 분석하였으며, 세 가지 기후도를 생산하여 난온대 주요 상록활엽수종의 현존분포와 그 대응성을 비교·분석하였다. 결과로 난온대 식생의 분포 북한계는 한랭지수 -10℃가 연평균기온 14℃보다 일치하였으나, 연평균기온 13℃가 더욱 정교한 일치를 보여주었다. 한반도에서 연평균기온 13℃를 북한계로 한 난온대 식생역의 잠재 분포 면적은 20,334 ㎢로 다른 두 온도요소의 경우보다 넓었다. 본 연구는 가공하지 않은 직접 기후요소인 연평균기온 13℃가 가공으로부터 생겨난 간접 기후요소인 한랭지수 -10℃보다 난온대 식생 분포 북한계에 대응하는 특정 온도 요소인 것으로 밝혀졌다. 더불어 식물구계학적 특정종의 평가 기준으로 사용되는 난온대 경계선에 대한 학술적 재고의 필요성이 대두되었다.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2008년도 International Symposium on Remote Sensing
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• pp.293-296
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• 2008

Land surface Temperature (LST) is a very useful surface parameter for the wide range of applications, such as agriculture, numerical and climate modelling community. Whereas operational observation of LST is far from the needs of application community in the spatial Itemporal resolution and accuracy. So, we developed split-window type LST retrieval algorithm to estimate the LST from MTSAT-IR data. The coefficients of split-window algorithm were obtained by means of a statistical regression analysis from the radiative transfer simulations using MODTRAN 4 for wide range of atmospheric profiles, satellite zenith angle and lapse rate conditions including the surface inversions. The sensitivity analysis showed that the LST algorithm reproduces the LST with a reasonable quality. However, the LST algorithm overestimates and underestimates for the strong surface inversion and superadiabatic conditions especially for the warm temperature, respectively. And the performance of LST algorithms is superior when satellite zenith angle is small. The accuracy of the retrieved LST has been evaluated with the Moderate Resolution Imaging Spectroradiometer (MODIS) LST data. The validation results showed that the correlation coefficients and RMSE are about 0.83${\sim}$0.98 and 1.38${\sim}$4.06, respectively. And the quality of LST is significantly better during night and winter time than during day and summer. The validation results showed that the LST retrieval algorithm could be used for the operational retrieval of LST from MTSAT-IR and COMS(Communication, Ocean and Meteorological Satellite) data with some modifications.

• 한국지능시스템학회논문지
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• 제24권3호
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• pp.251-258
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• 2014

신경계 영상 해석의 목적은 움직이는 미토콘드리아들을 추적하여 그 속도와 이동 방향 등을 추출하는 것인데, 미토콘드리아의 움직임은 축삭돌기 상에서만 이루어지는 특징이 있다. 축삭돌기 추출 작업은 일반적으로 수작업을 동반한 처리 과정을 통해 이루어지고 있는데, 본 논문에서는 자동화된 축삭돌기 추출 기법을 제안한다. 우선 전체 비디오 프레임 영상에서 각 픽셀의 최대값을 취해 통합영상을 구한다. 통합 영상에서 축삭돌기는 능선 구조를 보이는데, 능선을 검출하기 위해 본 연구에서는 능선 강화 필터링과 피크 검출 과정을 적용하였다. 또한 검출된 능선점에서 나타난 오류를 제거하기 위해 대해 각 능선점 주위에서 신뢰도 함수를 사용한 필터링을 적용한다. 실제 영상을 이용한 실험을 통해 제안된 방식은 높은 검출률과 정확도를 나타내는 것을 확인하였다.

• 한국의상디자인학회지
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• 제21권4호
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• pp.27-42
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• 2019

This paper tried a detailed approach to identify the correlation among basic elements that influenced the change of forms of the Po. To this end, the subjects were limited to the clothing from the 15th to the 18th century, which was found in the tombs of the period of Pyeonbokpo. The total number of excavated artifacts measured directly is 6 and other correctly described excavated artifacts for a total of 54 items. Per period and element, the types of collars and Seop were presented by classifying collars in 4 types, and Seop in 3 types. On the basis of the classification, the relics selected in this paper were analyzed considering the appearance, period, and rate per type of each element. The type and the change of forms of each element per period, with the focus on the appearance, were identified and the factors influencing the change of forms per element and the correlation between such factors were investigated. The representative type in the first period included dual collars, dual Seop and the representative type in the second period was characterized by a shawl collar and a dual Seop joining the pieces. The representative type in the third period was characterized by round collars and a short Seop. The elements determining the forms of Po, including collars and Seop, had a correlation to the lapse of time and had been systematically influencing each other. Furthermore, the overall change of form was caused due to the social functions as well as the supplementary function of keeping balance among the elements and accordingly, the change of forms was think characterized per period.

• Journal of Biosystems Engineering
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• 제26권1호
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• pp.39-46
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• 2001

This research conducted to investigate the variation of the moisture content, crack ratio, and hardness of the whole and cracked brown rice after conditioning at the initial moisture content of 13, 14, and 15% with time lapse. The conditioning was conducted by increasing the moisture content of the sample to 0.4 and 0.8%. For basic information and conditioning characteristics for the development of a conditioning machine for the brown rice, predicted models of above three properties were developed using a nonlinear regression analysis of SAS with Gauss-Newton, Gradient, and DUD methods. Results of this research could be summarized as follows. 1. No moisture variation occurred after 0.5 hour conditioning. 2. The increasement of the crack ratio was 7.6 and 17.5% with the sample increased the moisture content of 0.4 and 0.8%, respectively, after 8 hours conditioning. 3. The hardness of the conditioned whole grain of the brown rice decreased 0.82 and 1,000kg$\_$f/ with the sample increased moisture content 0.4 and 0.8%, respectively, after 8 hours conditioning with respect to the non-conditioned sample. 4. The hardness of the conditioned cracked grain of the brown rice decreased 0.54 and 0.81kg$\_$f/ with the sample increased moisture content 0.4 and 0.8%, respectively, after 8 hours conditioning with respect to the non-conditioned sample. The hardness of the broken grain was about 0.81∼1.88kg$\_$f/ lower than whole grain. 5. The moisture content variation, increasing rate of the crack ratio, and hardness of the cracked and whole grain was predicted as a negative exponential function. 6. Each predicted model with the nonlinear regression analysis, which was very accurate and had a very small amount of sum of square of error between experimental value and predicted value, which could be used for predicting the physical variation after conditioning.

• 한국식품영양과학회지
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• 제28권1호
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• pp.126-131
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• 1999

We have got the following results from tests in the course of time retrogradation and taste change in bread with added flour of Angelica keiskei Koidz, which had been stored in room temperature (27±2oC), refrigerating(2±1oC) and freezing( 20±1oC), respectively. Bread with the added flour showed a little lower degree of retrogradation than control group, and every group in room temperature retrograded from the very first day. The degree of retrogradation of the group in refrigerating was far greater comparing with the group in room temperature. The longer bread was stored, the lower the degree of retrogradation was, and the higher the adding rate of the flour got, the later its retrogradation happened. Especially the flour of this vegetable's stem turned out to be the most effective in retarding its retrogradation. Group stored 30 days in freezing didn't show a wide difference in retrograde comparing with the group before storage. Preference for color and shape of the flour added bread stored in room temperatue, refrigerating and freezing did not change significantly from the group before storage. Although preference decreased for flavor, texture, mouth feel and overall quality with the lapse of time, flour added group improved in preference for these factors comparing with the control group. Above all, added flour of pretreated stem proved to be the most effective in the sensory tests. With respect to the storing method, the group stored in refrigerating showed greater preference for the texture and mouth feel over the groups in room temperature and freezing. Flavor preference of the group in freezing was the lowest of all.

• 한국식품조리과학회지
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• 제32권2호
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• pp.178-187
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• 2016

Purpose: This study investigated the quality characteristics of Jeungpyun prepared with brown rice and sea tangle powder. Methods: The pH, volume, and spreadability of the dough and moisture content, color, texture and sensory evaluation of the Jeungpyun were performed. Results: The results showed that the pH of the dough decreased in all sample groups with the lapse of fermentation time, and ultimately revealed a pH ranging from 4.55-4.65. The spreadability of the dough significantly decreased as the substitute amount of the brown rice flour increased; the sample group with 1% sea tangle powder showed a significantly larger spreadability than the sample group with 2% sea tangle powder (p<0.05). The moisture content in the Jeungpyun showed a significantly lower result as the substitute amount of brown rice flour increased (p<0.05). Lightness (L) was reduced as the substitute amount of brown rice flour increased, and redness (a) and yellowness (b) also appeared to increase. As a result of measuring the texture, the 50% sample group with a high substitute rate of brown rice flour was observed to have high characteristics of hardness, gumminess and chewiness, and was low in cohesiveness. The result of the acceptance test showed that the sample group that substituted 25% brown rice flour and added 1% sea tangle powder was evaluated to have a significantly higher acceptance than the sample group that added 2% sea tangle powder in terms of color, texture and overall acceptance. Conclusion: The result of the acceptance test showed that the sample group that substituted 25% of brown rice flour and added 1% of sea tangle powder showed higher tendency in all acceptance attributes than the sample group that did not substitute the brown rice flour to show the possibility of developing the Jeungpyun with brown rice.

• Journal of Pharmaceutical Investigation
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• 제16권2호
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• pp.43-54
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• 1986

To increase the bioavailability of clonixin, clonixin argininate was prepared and compared with clonixin by determining solubility, pKa, lipid-water partition coefficient, dissolution rate and in vivo tests. The results are summerized as followings; 1) The solubility of clonixin argininate was increased by 20 times in water, about 1.2 times in pH 1.2 and pH 8.0 buffer solution, and about 1.8 times in pH 6.8 buffer solution compared with that of clonixin. 2) pKa values of clonixin, clonixin lysinate and clonixin argininate were 6.32, 7.20 and 7.45, respectively. 3) The lipid-water partition coefficient of clonixin argininate was increased more than that of the clonixin in n-hexane, carbon tetrachloride, chloroform, methylene chloride, and n-butanol, but the partition coefficient of clonixin was increased more than that of clonixin argininate in benzene/pH 1.2 buffer solution, ether/pH 8.0 buffer solution, and 3-methylbutyl acetate/pH 1.2, pH 8.0 buffer solution. 4) The time required to dissolve 60% $(T_{60%},\;min.)$ of clonixin argininate was about 1.5 min. in water and pH 1.2 buffer solution, and about 5 min. in pH 6.8 buffer solution. $T_{60%}$ of clonixin lysinate was about 1.5 min. in water, about 1.8 min. in pH 6.8 buffer solution, and about 8 min. in pH 1.2 buffer solution. But $T_{60%}$ of clonixin was about 96 min. in pH 6.8 buffer solution, over 2 hours in water and pH 1.2 buffer solution. 5) Anti-inflammatory effect of clonixin argininate was increased more than that of clonixin over 6 hours, and that of clonixin lysinate was followed by lapse of time. 6) Analgesic effect of clonixin argininate was increased by 1.5 times more than that of clonixin and the effect of clonixin argininate was nearly identical with that of clonixin lysinate. 7) The absorption rates (Ka) of clonixin, clonixin lysinate and clonixin argininate were $0.169\;hr^{-1},\;0.652\;hr^{-1}$ and $0.723\;hr^{-1}$ in situ, respectively.