• Journal of the Korean Geotechnical Society
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• v.36 no.12
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• pp.7-16
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• 2020

This study presents an acoustic technique to estimate the hydraulic conductivity of soils. Acoustic attenuation and propagation velocity spectra were measured for dry and saturated sandy specimens to confirm that the relationship between Biot's characteristic frequency and its associated hydraulic conductivity exists only for saturated soils. From the experiments presented in this paper, both attenuation-based and propagation-velocity-based techniques resulted in almost identical characteristic frequencies for saturated soils. The propagation velocity based measurements, however, show a a a slightly clearer trend compared to the attenuation based measurements. The results also show that the acoustically estimated hydraulic conductivities of soils agree well with constant head laboratory test results, demonstrating that this acoustic technique can be a useful nondestructive tool to estimate the hydraulic conductivity of sandy or silty soils.

• Biomolecules & Therapeutics
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• v.29 no.2
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• pp.184-194
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• 2021

Histone acetylation is a well-characterized epigenetic modification controlled by histone acetyltransferases (HATs) and histone deacetylases (HDACs). Imbalanced histone acetylation has been observed in many primary cancers. Therefore, efforts have been made to find drugs or small molecules such as HDAC inhibitors that can revert acetylation levels to normal in cancer cells. We observed dose-dependent reduction in the endogenous and exogenous protein expression levels of KAT8 (also known as human MOF), a member of the MYST family of HATs, and its corresponding histone acetylation at H4K5, H4K8, and H4K16 in chemotherapy drug gemcitabine (GEM)-exposed T24 bladder cancer (BLCA) cells. Interestingly, the reduction in MOF and histone H4 acetylation was inversely proportional to GEM-induced γH2AX, an indicator of chemotherapy drug effectiveness. Furthermore, pGL4-MOF-Luc reporter activities were significantly inhibited by GEM, thereby suggesting that GEM utilizes an MOF-mediated anti-BLCA mechanism of action. In the CCK-8, wound healing assays and Transwell® experiments, the additive effects on cell proliferation and migration were observed in the presence of exogenous MOF and GEM. In addition, the promoted cell sensitivity to GEM by exogenous MOF in BLCA cells was confirmed using an Annexin V-FITC/PI assay. Taken together, our results provide the theoretical basis for elucidating the anti-BLCA mechanism of GEM.

• Tunnel and Underground Space
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• v.30 no.6
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• pp.519-539
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• 2020

We reviewed numerical approaches to assess a hydraulic properties of excavation-disturbed zone (EDZ)created in argillaceous sedimentary rocks. It has been reported that fractures in the sedimentary rocks containing expansive clays are gradually closing due to swelling and their permeabilities are evolving to the level of in-tact rock, which is known as a self-healing or self-sealing process. The numerical approaches introduced here are capable of simulating spatio-temporal variation of EDZ permeability during long-term operation of a repository by including the self-healing characteristics of fractures, which wa observed in laboratory as well as in-situ experiments, The applicability of the numerical approaches was verified from the comparison to in-situ measurements of EDZ permeability at underground research laboratories.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.7
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• pp.2496-2512
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• 2021

The requirements for powerful computing capability, high capacity, low latency and low energy consumption of emerging services, pose severe challenges to the fifth-generation (5G) network. As a promising paradigm, mobile edge networks can provide services in proximity to users by deploying computing components and cache at the edge, which can effectively decrease service delay. However, the coexistence of heterogeneous services and the sharing of limited resources lead to the competition between various services for multiple resources. This paper considers two typical heterogeneous services: computing services and content delivery services, in order to properly configure resources, it is crucial to develop an effective offloading and caching strategies. Considering the high energy consumption of 5G base stations, this paper considers the hybrid energy supply model of traditional power grid and green energy. Therefore, it is necessary to design a reasonable association mechanism which can allocate more service load to base stations rich in green energy to improve the utilization of green energy. This paper formed the joint optimization problem of computing offloading, caching and resource allocation for heterogeneous services with the objective of minimizing the on-grid power consumption under the constraints of limited resources and QoS guarantee. Since the joint optimization problem is a mixed integer nonlinear programming problem that is impossible to solve, this paper uses deep reinforcement learning method to learn the optimal strategy through a lot of training. Extensive simulation experiments show that compared with other schemes, the proposed scheme can allocate resources to heterogeneous service according to the green energy distribution which can effectively reduce the traditional energy consumption.

• Applied Chemistry for Engineering
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• v.22 no.2
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• pp.203-208
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• 2011

Dumping of wastes at sea will be strongly prohibited from 2012 by London Dumping Convention. So, finding the method for treatment of food waste at ground is needed urgently. The solution for above mentioned problem is the resource development from food waste leachate by using Upflow Anaerobic Sludge Blanket (UASB) process. In this research, we try to find out the effect of effluent recirculation and internal return influence on organic removal efficiency and biogas production. Laboratory investigation was conducted for 25 days with only internal recycling, and then, effluent recirculation was performed. As the result of experiments, the organic removal efficiency was above 90%, and the content of methane was 78~80% during operating time. Also, when UASB reactor was operated to over the 3 Q effluent recirculation, there was not 1 N-NaOH consumption any more, therethrough the experiment was economically and stably carried out.

• Journal of Ginseng Research
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• v.45 no.4
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• pp.510-518
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• 2021

Background: Gintonin is a newly derived glycolipoprotein from the roots of ginseng. The purpose of this study is to investigate the anti-arthritic efficacy of Gintonin on various proteases and inflammatory mediators that have an important role in arthritis. Methods: Fibroblast-like synoviocytes (FLS) were treated with Gintonin and stimulated with interleukin (IL)-1β 1 hour later. The antioxidant effect of Gintonin was measured using MitoSOX and H₂DCFDA experiments. The anti-arthritic efficacy of Gintonin was examined by analyzing the expression levels of inflammatory mediators using RT-PCR, western blot, and ELISA. The phosphorylation of mitogen-activated protein kinase (MAPK) pathways and translocation of nuclear factor kappa B (NF-κB)/p65 into the nucleus were also analyzed using western blot, ELISA, and immunocytochemistry. Collagen-induced arthritis (CIA) mice model was used. Mice were orally administered with Gintonin (25, 50, and 100 mg/kg) every 2 days for 45 days. The body weight, arthritis score, squeaking score, and paw volume were measured as the behavioral parameters. After sacrifice, H&E and safranin-O staining were performed for histological analysis. Results: Gintonin significantly inhibited the expression of inflammatory intermediates. Gintonin prevented NF-κB/p65 from moving into the nucleus through the JNK and ERK MAPK phosphorylation in FLS cells. Moreover, Gintonin suppressed the symptoms of arthritis in the CIA mice model. Conclusion: As a result, the antioxidant and anti-inflammatory effects of Gintonin were demonstrated, and ultimately the anti-arthritic effect was proved. Collectively, Gintonin has a great potential as a therapeutic agent for arthritis treatment.

• Journal of the Korean Geotechnical Society
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• v.37 no.1
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• pp.5-15
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• 2021

The areas consisting of frost susceptible soils in cold regions, such as the Arctic area, have problems of frost heave and thaw settlement due to the seasonal air temperature changes and internal temperature of installed structures. Ground stabilization methods for preventing frost heave and thaw settlement of frost susceptible soils include trenching, backfilling and thermo-syphon. The thermo-syphon is the method in which refrigerant can control the ground temperature by transferring the ground temperature to atmosphere in the from of two-phase flow through the heat circulation of the internal refrigerant. This numerical study applied the function of these thermo-syphon as the boundary condition through user-subroutine coding inside ABAQUS and compared and analyzed the temperature results of laboratory experiments.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.23 no.11
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• pp.1330-1336
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• 2019

As the Fourth Industrial Revolution era began, a variety of devices are running on the cloud. These various devices continue to generate various types of data or large amounts of multimedia data. To handle this situation, a large amount of storage is required, and big data technology is required to process stored data and obtain accurate information. NAS (Network Attached Storage) or SAN (Storage Area Network) technology is typically used to build high-speed, high-capacity storage in a network-based environment. In this paper, we propose a method to construct a mass storage device using Network-DAS which is an extension technology of DAS (Direct Attached Storage). Benchmark experiments were performed to verify the scalability of the storage system with 76 HDD. Experimental results show that the proposed high performance mass storage system is scalable and reliable.

• Journal of radiological science and technology
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• v.45 no.2
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• pp.159-164
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• 2022

The study developed a radiation dose measurement program in the radiology laboratory to measure how much exposure the students are exposed to during the radiology class, to request for the improvement and the revision of the current Nuclear Safety Act. The experimental program is shown in the following figure, and experiments were conducted to determine the degree of radiation exposure in the control room with a lead gown at a distance of 1 m, 2 m, and 1 m, and in a control room with a radiographic lead glass wall. The duration of the experiment was 3 months from April to June, when radiation imaging practice classes were conducted, and 128 hours of imaging practice per month were conducted. In order to find out the dose of radiation dose during radiology imaging practice class, the experiment was carried out from April to June for 3 months, and according to the program, the results of exposure dose were 0.34 mSv at 1 m distance, 0.01 mSv at shielding of lead gown at 1 m distance, 0.16 mSv at 2 m distance, and 0.01 mSv at control room with radiation lead glass wall. The exposure dose from the test results was much below the annual general public limit dose of 1 mSv. The restriction on the operation of the radiation equipment in the practice of the students is a regulation that infringes the right of students to learn, and amendments or exemptions of Nuclear Safety Act should be enacted to ensure that it does not violate the fundamental right to learn for students in radiology.

• Nuclear Engineering and Technology
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• v.54 no.1
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• pp.61-71
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• 2022

Pool boiling heat transfer is widely applied in nuclear engineering fields. The influence of heating surface orientation on the pool boiling heat transfer has received extensive attention. In this study, the heating surface with different roughness was adopted to conduct pool boiling experiments at different inclination angles. Based on the boiling curves and bubble images, the effects of inclination angle on the pool boiling heat transfer and critical heat flux were analyzed. When the inclination angle was bigger than 90°, the bubble size increased with the increase of inclination angle. Both the bubble departure frequency and critical heat flux decreased as the inclination angle increased. The existing theoretical models about pool boiling heat transfer and critical heat flux were compared. From the perspective of bubble agitation model and Hot/Dry spot model, the experimental phenomena could be explained reasonably. The enlargement of bubble not only could enhance the agitation of nearby liquid but also would cause the bubble to stay longer on the heating surface. Consequently, the effect of inclination angle on the pool boiling heat transfer was not conspicuous. With the increase of inclination angle, the rewetting of heating surface became much more difficult. It has negative effect on the critical heat flux. This work provides experimental data basis for heat transfer and CHF performance of pool boiling.