• Title/Summary/Keyword: laboratory analysis

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Parallelization and application of SACOS for whole core thermal-hydraulic analysis

  • Gui, Minyang;Tian, Wenxi;Wu, Di;Chen, Ronghua;Wang, Mingjun;Su, G.H.
    • Nuclear Engineering and Technology
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    • v.53 no.12
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    • pp.3902-3909
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    • 2021
  • SACOS series of subchannel analysis codes have been developed by XJTU-NuTheL for many years and are being used for the thermal-hydraulic safety analysis of various reactor cores. To achieve fine whole core pin-level analysis, the input preprocessing and parallel capabilities of the code have been developed in this study. Preprocessing is suitable for modeling rectangular and hexagonal assemblies with less error-prone input; parallelization is established based on the domain decomposition method with the hybrid of MPI and OpenMP. For domain decomposition, a more flexible method has been proposed which can determine the appropriate task division of the core domain according to the number of processors of the server. By performing the calculation time evaluation for the several PWR assembly problems, the code parallelization has been successfully verified with different number of processors. Subsequent analysis results for rectangular- and hexagonal-assembly core imply that the code can be used to model and perform pin-level core safety analysis with acceptable computational efficiency.

A Study on the Rational Management of the Pre-Hazard Factors Analysis in the Laboratory (연구실 사전유해인자위험분석의 합리적 관리 개선 방안에 대한 연구)

  • Seo, Jae Shin;Oh, Tea Keun
    • Journal of the Korean Society of Safety
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    • v.34 no.4
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    • pp.85-94
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    • 2019
  • Through the survey on the current status of hazardous substances in laboratories, the research institute is designed to establish measures to improve the management of university laboratories and to create a safe laboratory. We intend to explore countermeasures by confirming and reviewing the recognition of the statutes in the "Guidelines for the Implementation of the Laboratory Pre-Hazard Factors Analysis" through the questionnaire. Although there are various parts to create a pleasant environment for a laboratory, the most important part is the role of a laboratory manager in the area where each and every one of the laboratory's directors is the "Act on the Establishment of a Safety Environment in a Laboratory", but if the laboratory is not to be accident-prone, the laboratory's responsibility is to be more secure. This research is intended to be funded by research to reasonably implement" Guidelines for the Implementation of the Laboratory Pre-Hazard Factors Analysis" before applying to universities and to protect field-based research activities and to reasonably reduce safety accident prevention and risk.

Current Evidence on the Association between rs3757318 of C6orf97 and Breast Cancer Risk: a Meta-Analysis

  • Hong, Yuan;Chen, Xue-Qin;Li, Jiao-Yuan;Liu, Cheng;Shen, Na;Zhu, Bei-Bei;Gong, Jing;Chen, Wei
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.19
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    • pp.8051-8055
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    • 2014
  • Background: A common genetic variant rs3757318, located in intron of C6orf97, was firstly identified to be associated with breast cancer (BC) risk by a genome-wide association (GWA) study. However, subsequent validation studies with different ethnicities have yielded conflicting results. Materials and Methods: We performed a meta-analysis to synthesize all available data for evaluating the precise effect of this variant on BC susceptibility. Results: A total of 8 articles containing 11 studies with 62,891 cases and 65,635 controls were included in this meta-analysis. When compared to the G allele, the rs3757318-A allele was significantly associated with BC risk with the pooled OR of 1.21 (95% CI=1.15 - 1.29, P<0.001) but with obvious between-study heterogeneity (P=0.040). Stratified analysis suggested that diversity of ethnicity along with control source may explain part of the heterogeneity. Similarly, significant associations were also identified in heterozygote, homozygote, dominant and recessive genetic models. Sensitivity and publication bias analyses indicated robust stability of our results. Conclusions: Our present meta-analysis demonstrated that the variant rs3757318 is associated with increased BC risk. Nevertheless, further studies are needed to clarify the underlying biological mechanisms.

A Study on Development of Pre-Hazards Risk Analysis Guide Tool (연구실 위험분석을 위한 사전유해인자 가이드 Tool 개발 연구)

  • Choi, Byeong Kyu;Rhie, Kwang Won
    • Journal of the Korea Safety Management & Science
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    • v.19 no.4
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    • pp.133-140
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    • 2017
  • The Ministry of Science, ICT and Future Planning made law for Pre-Hazard Risk Analysis in December 31, 2014 to protect researchers from continuing accidents in laboratory. Conducted before an experiment, Pre-Hazard Risk Analysis finds hazards of the experiment and rules to manage the hazards.So the Pre-Hazard Risk Analysis can support laboratory safety system by prevent accidents in laboratory. Pre-Hazards Risk Analysis is newly created system so that executors need Guidelines to perform this analysis properly. This study is to develop guide tool for Pre-Hazard Risk Analysis by analyzing other risk assessment systems; PSM, Off-site Consequence Assessment, laboratory safety system. Also, this study suggested how to establish database for Pre-Hazard Risk Assessment by analyse KRAS.