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The Inhibitory Effects of Glycyrrhiza uralensis on human Platelet Aggregation and Thrombus Formation

  • Seung Na Ko;Ji Won Son;Gyu Ri Kim;Min Seon Kim;Yea Jin Lee;Seung Ju Kim;Ji Hyeon Shin;Da In Jo;Woo Young Bok;Hye Gyo Oh;Hyuk-Woo Kwon
    • Biomedical Science Letters
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    • v.29 no.4
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    • pp.242-248
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    • 2023

  • Platelets are activated at the sites of vascular injury by a number of molecules, including adenosine diphosphate, collagen and thrombin. The full platelet aggregation is absolutely essential for the normal hemostasis. Glycyrrhiza glabra is a well-known medicinal herb that grows in various parts of the world and is known to have various effects such as antioxidant, anti-inflammatory, anti-atherogenic, anti-osteoporotic and skin-whitening. However, the platelet inhibitory effect of Glycyrrhiza glabra extract (GGE) has not been identified. In this study, we investigated if GGE inhibited platelet aggregation. We observed that GGE inhibited collagen-induced platelet aggregation, Ca2+ mobilization, and thromboxane A2 generation. In addition, GGE suppressed phosphorylation of phosphatidylinositol-3 kinase (PI3K), Akt and elevated phosphorylation of inositol 1,4,5-trisphosphate receptor (IP3R), vasodilator stimulated phosphoprotein (VASP). Taken together, GGE showed strong antiplatelet effects and may be used to block platelet-mediated cardiovascular diseases.

  • https://doi.org/10.15616/BSL.2023.29.4.242 인용 PDF

Effect of Pr Doping in La-Sn-Mn-O

  • Kumar, Neeraj;Tripathi, Rahul;Dogra, Anjana;Awana, V.P.S.;Kishan, H.
    • Proceedings of the Korean Magnestics Society Conference
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    • 2008.12a
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    • pp.156.2-156.2
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    • 2008

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Carbon-Nanotube Based Field-Emission Displays for Large Area and Color Applications

  • Choi, Won-Bong;Lee, Nae-Sung;Yi, Whi-Kun;Jin, Yong-Wan;Choi, Yong-Soo;Han, In-Taek;Jang, Hyeong-Yong;Kim, Hoonn-Young;Kang, Jung-Ho;Yun, Min-Jae;Park, Sang-Hyeun;Yu, Se-Gi;Jang, Jae-Eun;You, Jang-Hun;Kim, Jong-Min
    • Journal of Information Display
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    • v.1 no.1
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    • pp.59-62
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    • 2000

  • The first 9-inch carbon nanotube based color field emission displays (FEDs) are integrated using a paste squeeze technique. The panel is composed of 576 x 242 lines with implementation of low voltage phosphors. The uniform and moving images are achieved only at $2V/{\mu}m$, This demonstrates a turning point of nanotube for large area and full color applications.

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