• 동의신경정신과학회지
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• 제26권4호
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• pp.357-364
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• 2015

Objectives: The purpose of this study was to examine the effects of Korean medical treatment for Restless Legs Syndrome (RLS). Methods: We examined the effects of Korean medical treatment for patients with RLS who visited the neuropsychiatric clinic of Korean medicine. We treated the patient with herbal-medication, acupuncture, oriental psychotherapy. IRLS, STAI-X1,X2, BDI-2, BAI, STAXI-S,T were compared before and after 4 and 8 weeks of treatment to determine whether the symptoms and mood of patients were improved. Results: After 4 weeks treatment (n=13), STAI-X1,X2, BDI-2, BAI, STAXI-S scores increased significantly; whereas, IRLS and STAXI-T scores decreased. After 8 weeks treatment (n=8), IRLS, STAI-X1,X2, BDI-2, BAI scores increased significantly; whereas, STAXI-S scores decreased.Conclusions The treatment of RLS with Korean medicine was clinically efficient and resulted in improvement of the symptoms as well as psychological problems.

• The Korean Journal of Pain
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• 제11권2호
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• pp.273-282
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• 1998

Background: Twelve years have passed since the Korean Pain Society was organized. Nowadays, there are so many problems to be solved in pain clinics including health insurance, pain education and public information etc. in Korea. The present study was designed to evaluate the current status of pain clinics in Korea. Methods: Eight hundred twenty regular members of Korean Pain Society were surveyed by questionnaire in October 1997. We compared the general characteristics, contents of diseases in pain clinic, treatment Methods, patients satisfaction, pain educations, problems in pain treatments, requests to Korean Pain Society among the 138 respondents. Results: Thirty seven percents of the respondents worked at university hospitals, 39% at non-university hospitals and 24% at private pain clinics. The most common diseases treated in pain clinics was low back pain(32% in university and non-university hospital and 28% in private pain clinic respectively). However, cancer pain was 10% in university and non-university hospital and 0.7% in private pain clinic. Epidural block was the most frequently used procedure in chronic pain treatments. And 74.6% of the respondents were studied and learned in Korea and Japan. And then, current problems in pain management and requests to Korean Pain Society were medical insurance problems, pain education and public information of pain clinics. Conclusions: These results suggest that the Korean Pain Society should make an effort to solve these current problems in order to activate pain medicine and increase the quality of life for those suffering from pain.

• Biomolecules & Therapeutics
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• 제27권5호
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• pp.492-501
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• 2019

Nitrogen-containing heterocycles such as quinoline, quinazolinones and indole are scaffolds of natural products and have broad biological effects. During the last years those structures have been intensively synthesized and modified to yield new synthetic molecules that can specifically inhibit the activity of dysregulated protein kinases in cancer cells. Herein, a series of newly synthesized isoquinolinamine (FX-1 to 8) and isoindoloquinazolinone (FX-9, FX-42, FX-43) compounds were evaluated in regards to their anti-leukemic potential on human B- and T- acute lymphoblastic leukemia (ALL) cells. Several biological effects were observed. B-ALL cells (SEM, RS4;11) were more sensitive against isoquinolinamine compounds than T-ALL cells (Jurkat, CEM). In SEM cells, metabolic activity decreased with $10{\mu}M$ up to 26.7% (FX-3), 25.2% (FX-7) and 14.5% (FX-8). The 3-(p-Tolyl) isoquinolin-1-amine FX-9 was the most effective agent against B- and T-ALL cells with IC50 values ranging from 0.54 to $1.94{\mu}M$. None of the tested compounds displayed hemolysis on erythrocytes or cytotoxicity against healthy leukocytes. Anti-proliferative effect of FX-9 was associated with changes in cell morphology and apoptosis induction. Further, influence of FX-9 on PI3K/AKT, MAPK and JAK/STAT signaling was detected but was heterogeneous. Functional inhibition testing of 58 kinases revealed no specific inhibitory activity among cancer-related kinases. In conclusion, FX-9 displays significant antileukemic activity in B- and T-ALL cells and should be further evaluated in regards to the mechanisms of action. Further compounds of the current series might serve as templates for the design of new compounds and as basic structures for modification approaches.

• 한방안이비인후피부과학회지
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• 제28권1호
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• pp.152-159
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• 2015

저자는 본 증례에서 한방치료를 통해 사지말단부인 손의 증상이 호전된 백반증 환자 증례를 경험하였기에 보고하는 바이다. 하지만 4례의 증례만으로 부족한 점이 많고 앞으로 더욱 많은 임상 증례와 연구가 필요할 것으로 사료된다.

• 대한간호
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• 제5권4호통권24호
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• pp.68-75
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• 1966

The status of visits and deliveries on 1218 expectant mothers who registered at prenatal clinic, maternal and child health centerm Chonnam University Hospital, during Jan. 1958 to Dec. 1965 has been studied, and the following result were obtaind: 1. The m

• 한국병원경영학회지
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• 제26권1호
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• pp.71-82
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• 2021

Purpose: The purpose of this study is to estimate incomes and costs of the medical clinics by using secondary data. Methodology: The medical incomes and costs were estimated from 405 clinics operated by sole practitioner providing out-patient services among all clinics subject to the Medical Cost Survey on National Health Insurance Patients in 2017, excluding dental clinics and oriental medical clinics. The incomes and costs of the medical clinics were reflected with incomes and costs of health insurance benefits and were calculated by types of medical services (i.e., basic care, surgery, general treatment, functional test, specimen test and imaging test). The costs were classified as follows: labor costs, equipment costs, material costs and overhead costs. Secondary data was used to estimate the incomes and costs of the medical clinics. For allocation bases for costs for each type of the medical service, the ratio of revenue from health insurance benefits by types of medical services was applied. However, labor costs were calculated with the activity ratio by types of medical services and occupations, using clinical expert panel data. Finding: The percentage of health insurance income for all medical income was 73.1%. The health insurance cost per clinic was 401,864 thousand won. Labor cost accounted for the largest portion of the health insurance income was 191,229 thousand won (47.6%), followed by management cost was 170,018 thousand won (42.3%), materials cost was 35,434 thousand won (8.8%), and equipment costs was 5,183 thousand won (1.3%). Practical Implications: This study suggests a method of estimating incomes and costs of medical clinic services by using secondary data. It could efficiently provide incomes and costs to assess an appropriate level of the health insurance fee to the clinics.

• 한방비만학회지
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• 제10권1호
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• pp.29-40
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• 2010

Objective The aim of this study was to evaluate the influence of Gamitaeeumjowi-tang(GTT) prescribed by doctors of korean(KMD) medicine on liver function. Methods For this single-center, prospective, observational study, we enrolled patients who wished to take GTT prescribed by KMD for losing weight. sixty(60) patients took GTT for 33.8 days and completed questionnaires. Liver function tests(LFTs) were performed bofore(first test) and after each GTT treatment(finish test). For LFT, T-bil, ALP, AST, ALT were measured. Result There were no significant changes in LFT data between the first and finish tests. At first test, levels of test seven(7) patients were more than twice of normal range of upper limit, levels of eight(8) patients were more than normal range of upper limit, less than twice of normal range of upper limit. At last test, levels of nine(9) patients were more than normal range of upper limit, less than twice of normal range of upper limit. Conclusion The current study showed that ingestion of GTT prescribed by KMD did not increase the frequency of abnormal LFTs, at least in the short term.

• 대한한의학회지
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• 제36권4호
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• pp.122-128
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• 2015

Objectives: The purpose of this study is to present effect of transtherapy which is treatment of Korean Medicine to acne scar patients. Methods: We used transtherapy to moderate and severe acne scar patients and evaluated by a Photo evaluation with 10-point score and Qualitative Global Acne Scarring Grading System. Results: After transtherapy treatment, mean of Qualitative Global Acne Scarring Grading System of patients changed from $3.5{\pm}0.71$ to $1.5{\pm}0.71$. Acne scar showed an improvement at least 8 up to 9 and mean of their acne scar improvement scores was $8.33{\pm}0.52$ on photo evaluation with 10-point score. Conclusions: This paper shows that transtherapy in the treatment of moderate to severe acne scars is beneficial for promoting skin regeneration.

• 대한한의학회지
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• 제38권3호
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• pp.170-184
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• 2017

Objectives: The objective of this study was to summarize randomized clinical trials (RCTs) that have assessed efficacy and safety of mahuang and ephedrine on treatment of obesity and to propose better process of study. Methods: NLM Medline (pubmed), the Cochrane library, Scopus, Science Direct, RISS, KISS were systemically searched for clinical trials investigating the efficacy, safety of mahuang and ephedrine on treatment of obesity from 2000 to 2017. Results: 16 RCTs met all the inclusion criteria. In most reports, mahuang and ephedrine significantly reduced body weight, body fat mass. There were no serious adverse events associated with mahuang and ephedrine in all studies. Conclusions: In appropriate dose of mahuang and ephedrine for healthy adult was safe, and weight loss effect of mahuang and ephedrine was better than control group. Improved clinical practice guidelines should be developed for safe use of mahuang and ephedrine.

• 한국한의학연구원논문집
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• 제13권3호
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• pp.53-67
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• 2007

Seoul Bochun Medical Clinic Examined Patient Table' is a statistical data that Kim Young-Boon [1882-1974] put together himself. A total of 59353 cases from 1914 to 1935 were classified according to year and month of examination, and gender. Of the cases 26497 (${\fallingdotseq}$45%) were women and the remaining 32856 (${\fallingdotseq}$55%) cases were men. The most frequent disease examined was cold, followed by diarrhea and stomachache. Of the 639 different kinds of diseases ever examined, 71 had occurred on more than 100 occasions. The percentage that these 71 diseases occupies is an overwhelming 88.75%.