• Journal of Microbiology and Biotechnology
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• 제28권12호
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• pp.2113-2120
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• 2018

Cross-reactive material 197 ($CRM_{197}$) is a non-toxic mutant of diphtheria toxin containing a single amino acid substitution of glycine 52 with glutamic acid. $CRM_{197}$ has been used as a carrier protein for poorly immunogenic polysaccharide antigens to improve immune responses. In this study, to develop a sandwich ELISA that can detect $CRM_{197}$ and $CRM_{197}$ conjugate vaccines, we generated a human anti-$CRM_{197}$ monoclonal antibody (mAb) 3F9 using a phage-displayed human synthetic Fab library and produced mouse anti-$CRM_{197}$ polyclonal antibody. The affinity ($K_D$) of 3F9 for $CRM_{197}$ was 3.55 nM, based on Bio-Layer interferometry, and it bound specifically to the B fragment of $CRM_{197}$. The sandwich ELISA was carried out using 3F9 as a capture antibody and the mouse polyclonal antibody as a detection antibody. The detection limit of the sandwich ELISA was <1 ng/ml $CRM_{197}$. In addition, the 3F9 antibody bound to the $CRM_{197}$-polysaccharide conjugates tested in a dose-dependent manner. This ELISA system will be useful for the quantification and characterization of $CRM_{197}$ and $CRM_{197}$ conjugate vaccines. To our knowledge, this study is the first to generate a human monoclonal antibody against $CRM_{197}$ and to develop a sandwich ELISA for $CRM_{197}$ conjugate vaccines.

• 산업경영시스템학회지
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• 제42권1호
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• pp.74-86
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• 2019

As many existing research fields are matured academically, researchers have encountered numbers of academic, social and other problems that cannot be addressed by internal knowledge and methodologies of existing disciplines. Earlier, pioneers of researchers thus are following a new paradigm that breaks the boundaries between the prior disciplines, fuses them and seeks new approaches. Moreover, developed countries including Korea are actively supporting and fostering the convergence research at the national level. Nevertheless, there is insufficient research to analyze convergence trends in national R&D support projects and what kind of content the projects mainly deal with. This study, therefore, collected and preprocessed the research proposal data of National Research Foundation of Korea, transforming the proposal documents to term-frequency matrices. Based on the matrices, this study derived detailed research topics through Latent Dirichlet Allocation, a kind of topic modeling algorithm. Next, this study identified the research topics each proposal mainly deals with, visualized the convergence relationships, and quantitatively analyze them. Specifically, this study analyzed the centralities of the detailed research topics to derive clues about the convergence of the near future, in addition to visualizing the convergence relationship and analyzing time-varying number of research proposals per each topic. The results of this study can provide specific insights on the research direction to researchers and monitor domestic convergence R&D trends by year.

• 대한토목학회논문집
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• 제39권1호
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• pp.155-163
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• 2019

가뭄 전이는 수문학적 가뭄 특성에 대한 정확한 평가 및 조기 경보 시스템 구축에서 매우 중요한 역할을 한다. 이에 따라, 본 연구에서는 베이지안 네트워크를 이용하여 한강 유역의 가뭄 전이의 확률론적 관계를 분석하였다. 이를 위하여 과거 관측자료와 기후변화 시나리오 RCP 8.5 자료를 활용하였다. 가뭄 전이 및 지체시간을 분석한 결과, 1967~2013년 기간에 비해 2014~2053년 기간에는 증가하는 경향을 나타냈으며, 2054~2100년 기간에는 감소하는 경향을 나타냈다. 또한 베이지안 네트워크를 적용하여 지체시간의 발생확률을 분석하였다. 그 결과, 1967~2013년 동안에 기상학적 가뭄이 보통가뭄에서 심한가뭄 또는 극한가뭄으로 변화함에 따라, 지체시간의 발생빈도가 공간적으로 변화하거나 감소하였다. 이러한 확률은 2014~2053년에 몇몇 유역에서 약간 증가하는 경향이 나타났으나, 2054~2100년에 다시 감소하였다. 본 연구에서 제안된 확률론적 가뭄 전이 결과는 향후 미래 가뭄 상태에 대한 정책에서 의사결정시에 유용할 것으로 판단된다.

• 한국컴퓨터정보학회논문지
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• 제23권11호
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• pp.159-165
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• 2018

In this study, it is analyzed that keywords of the interest in the 4th industrial revolution for science and Technician K women's university students, areas to prioritize in the strategy of 4th industry revolution, to research compare analyze the recognition of science technology such as the most necessary education, human resource development of universities and companies in Korea and abroad according to the technology trend required in the 4th Industrial revolution era and which area to prepare for the 4th industrial revolution. The survey result shows different thoughts of science and Technician(KOFST) and the women university students. In the 1) 4th industrial revolution, the 96% of former are interested, while 60% of latter are interested. And in the most used keywords, the former group used AI(24%), Fusion new industry(21%) the most, while the latter group used AI(34%), Robot(18%). And, 3) in the strategic priority, the science technology experts are interested in education, R&D system innovation(27%), IoT, Information and Communication(26%) and the university students are interested in IoT, Information and Communication(31%), AI(28%). Finally, 4) the science technology experts thought of Autonomous Vehicle(20%), 3D Printer(7%), AI(16%) important, while the women university students thought of AI(27%), VR/Augmented Reality(17%), and Autonomous Vehicle(16%) the most necessary education. In the 4th industrial revolution, we need people with ability to solve complicated problems with creativity based on understanding and absorbing new knowledge and thinking of converged idea.

• Journal of Contemporary Eastern Asia
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• 제18권1호
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• pp.7-29
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• 2019

This study describes an approach for comparative bibliometric analysis of scientific publications related to (i) individual or several departments comprising a university, and (ii) broader integrated subject areas using multiple disciplinary schemes. It uses a custom dataset of scientific publications (ca. 15,000 articles and reviews, published during 2009-2013, and recorded in the Web of Science Core Collections) with author affiliations to the research departments, dedicated to science, technology, engineering, mathematics, and medicine (STEMM), of a comprehensive university. The dataset was subjected, at first, to the department level and discipline level analyses using the newly available KAKEN-L3 classification (based on MEXT/JSPS Grants-in-Aid system), hierarchical clustering, correspondence analysis to decipher the major departmental and disciplinary clusters, and visualization of the department-discipline relationships using two-dimensional stacked bar diagrams. The next step involved the creation of subsets covering integrated subject areas and a comparative analysis of departmental contributions to a specific area (medical, health and life science) using several disciplinary schemes: Essential Science Indicators (ESI) 22 research fields, SCOPUS 27 subject areas, OECD Frascati 38 subordinate research fields, and KAKEN-L3 66 subject categories. To illustrate the effective use of the science mapping techniques, the same subset for medical, health and life science area was subjected to network analyses for co-occurrences of keywords, bibliographic coupling of the publication sources, and co-citation of sources in the reference lists. The science mapping approach demonstrates the ways to extract information on the prolific research themes, the most frequently used journals for publishing research findings, and the knowledge base underlying the research activities covered by the publications concerned.

• 한국의사학회지
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• 제31권2호
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• pp.91-101
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• 2018

Over the past 100 years, since the establishment of the modern medical education system in the early 1900s, the results of extensive field research and practice in North American medical schools and professional education have led the flow of medical education around the world. In this study, the direction of medical education in North America over the past 100 years were examined through major literature review, leading to implications and suggestions for Korean medicine education. The "Medical Education in the United States and Canada" published by the Carnegie Educational Foundation in 1910, which is considered to have laid the foundation for modern health care education, was reviewed. Next, "Educating physician: A Call for Reform of Medical School and Residency", published in 2010, which is known to have proposed a future-oriented goal for the training of medical professionals has been analyzed. The results of this study are as follows: 1) Acquisition and utilization of biomedical knowledge which is the basis of clinical competence, is a basic competency that should be provided to future medical professionals. 2) Beyond education to cultivate clinical competence of individuals directly affecting the medical treatment, various professionalism education programs that capture the specificity of Korean Medicine doctors should be established and strengthened.

• 융합정보논문지
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• 제9권6호
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• pp.75-82
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• 2019

ICT와 융합 등이 강조되는 4차 산업혁명 시대에 기업들은 전공지식 뿐만 아니라 복합적 문제해결역량, 시스템적 역량 등 다양한 역량을 갖춘 인재를 원하고 있다. 본 연구는 미래 회계담당자에게 필요한 역량의 인식차이를 알아보기 위하여 선행연구에 바탕을 둔 4개의 요인으로 작성된 166장의 유효한 설문지를 회수하여 경험적 연구를 하였다. 그 결과 기업에서 회계업무를 담당하고 있는 경력 5년 이상의 회계전공자 및 기업의 최고경영자는 사회역량을 가장 중요하게 생각하는 것으로 나타난 반면 회계학 교수들은 전공역량을 가장 중요한 자질로 생각하는 것으로 나타났다. 이러한 연구결과는 미래인재를 양성하는 대학에서는 업계의 요구를 반영하기 위해 전공내용 뿐만 아니라 사회역량 등 다양한 역량을 발휘할 수 있는 교과과정으로 개편하여야 함을 시사하고 있으며, 향후 연구에서는 다양한 지역의 대학과 기업을 대상으로 표본 범위 확장을 통한 연구가 필요하다.

• 인터넷정보학회논문지
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• 제19권6호
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• pp.83-89
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• 2018

워크플로우 프로세스 인텔리전스와 시스템에서 워크플로우 프로세스 마이닝 및 분석 문제가 중요해지고 있다. 워크플로우 프로세스 인텔리전스의 품질을 향상시키기 위해서는 워크플로우 프로세스 마이닝 및 분석을 수행할 때, 워크플로우 실행 이벤트 로그를 저장하는 효율적이고 효과적인 데이터 센터가 필수적이다. 본 논문에서는 워크플로우 이벤트 로그 데이터 센터를 효율적으로 구성하고 XES 형식으로 워크플로우 프로세스 실행 이벤트 로그를 효과적으로 저장하기 위한 3차원 프로세스 기반 데이터 큐브를 제안한다. 이의 검증 단계로서, 프로세스 기반 데이터 큐브가 워크플로우 프로세스 패턴과 해당 워크플로우 프로세스 실행 이벤트 내역에서 실행 비율 및 업무전달관계와 같은 분석적 지식을 발견하는데 얼마나 적합한지를 보여주기 위해 프로세스 마이닝 실행 예제를 제시한다. 결과적으로, 프로세스 기반 데이터 큐브와 이를 활용한 프로세스 마이닝 시스템의 구현을 통해, 워크플로우 프로세스의 기본적 제어흐름 패턴을 성공적으로 발견할 수 있음을 확인했다.

• International Journal of Computer Science & Network Security
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• 제21권6호
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• pp.304-311
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• 2021

The relevance of the research involves outlining the need for modern professionals to acquire new competencies. In the conditions of rapid civilizational progress, in order to meet the requirements of the labor market in the knowledge society, there is a readiness for continuous training as an indicator of professional success. The purpose of the research is to identify the impact of various forms of application of information technologies for lifelong learning in order to provide the continuous self-development of each person without cultural or age restrictions and on the basis of rapid digital progress. A high level (96%) of need of the adult population in continuing education with the use of digital technologies has been established. The most effective ways to implement the concept of "lifelong learning" have been identified (educational camps, lifelong learning, mass open online courses, Makerspace activities, portfolio use, use of emoji, casual game, scientific research with iVR game, implementation of digital games, work in scientific cafes). 2 basic objectives of continuing professional education for adults have been outlined (continuous improvement of qualifications and obtaining new qualifications). The features of ICT application in adult education have been investigated by using the following methods, namely: flexibility in terms of easy access to ideas, solving various problems, orientation approach, functional learning, group or individual learning, integration of leisure, personal and professional activities, gamification. The advantages of application of information technologies for continuous education (economic, time, and adaptive) have been revealed. The concept of continuous adult learning in the context of digitalization has been concluded. The research provides a description of the structural principles of the concept of additional education; a system of information requests of the applicant, as well as basic technologies for lifelong learning. The research indicates the lack of comprehensive research in the relevant field. The practical significance of the research results lies in the possibility of using the obtained results for a wider acquaintance of the adult population with the importance of the application of lifelong learning for professional activities and the introduction of methods for its implementation in the educational policy of the state.

• 한국도서관정보학회지
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• 제51권4호
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• pp.231-247
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• 2020

인공지능(AI)이 4차 산업혁명 중에서도 미래유망기술로 부각됨에 따라 도서관을 포함한 사회 전 분야에 걸쳐 인공지능기술을 적용하고 확대하고자 노력하고 있다. 이 연구는 인공지능이 대학도서관 서비스에 미치고 있는 영향과 이슈, 그리고 시사점에 대해 조사하였다. 연구방법은 북미지역 대학도서관 IT전문가들과의 심층인터뷰를 수행하였으며, 인터뷰결과와 국내외 관련 문헌들을 통해 결론과 논의점을 도출하였다. 본 연구는 연구결과로 북미지역 대학도서관들은 인공지능 시스템을 기반으로 정보 접근과 검색을 효율화하는 인프라구축에 노력하고, 대학내 인공지능 연구소들과도 협업하여 새로운 서비스 제공을 시도하고 있음을 밝혔다. 또한 향후 도서관과 사서의 역할 변화, 프라이버시, 그리고 데이터품질에 대한 이슈들을 제기하였다. 논의를 통해 대학의 사서들이 지식을 보급하는 역할을 수행하는 소프트웨어 엔지니어가 되기 위한 사서 재교육의 필요성과 대학 도서관의 정보시스템 구축을 위한 투자와 도서관에 인공지능 연구소를 세우는 방안을 제시하였다. 연구환경 변화에 따른 연구의 제한점과 향후 연구에 대한 제안도 논의되었다.