• BMB Reports
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• 제56권9호
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• pp.514-519
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• 2023

Methyltransferase-like 3 (METTL3), a key component of the m⁶A methyltransferase complex, regulates the splicing, nuclear transport, stability, and translation of its target genes. However, the mechanism underlying the regulation of METTL3 expression by alternative splicing (AS) remains unknown. We analyzed the expression pattern of METTL3 after AS in human tissues and confirmed the expression of an isoform retaining introns 8 and 9 (METTL3-IR). We confirmed the different intracellular localizations of METTL3-IR and METTL3 proteins using immunofluorescence microscopy. Furthermore, the endogenous expression of METTL3-IR at the protein level was different from that at the mRNA level. We found that 3'-UTR generation by intron retention (IR) inhibited the export of METTL3-IR mRNA to the cytoplasm, which in turn suppressed protein expression. To the best of our knowledge, this is the first study to confirm the regulation of METTL3 gene expression by AS, providing evidence that the suppression of METTL3 protein expression by IR is an integral part of the mechanism by which 3'-UTR generation regulates protein expression via inhibition of RNA export to the cytoplasm.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2022년도 춘계학술발표대회
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• pp.477-480
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• 2022

반도체 성능 향상으로 신호를 전달하는 회로의 단위가 마이크로 미터에서 나노미터로 미세화되어 선폭(linewidth)이 점점 좁아지고 있다. 이러한 변화는 검출해야 할 불량의 크기가 작아지고, 정상 공정상태와 비정상 공정상태의 차이도 상대적으로 감소되어, 공정오차 및 공정조건의 허용범위가 축소되었음을 의미한다. 따라서 검출해야 할 이상징후 탐지가 더욱 어렵게 되어, 높은 정밀도와 해상도를 갖는 검사공정이 요구되고 있다. 이러한 이유로, 미세 공정변화를 파악할 수 있는 신규 검사 및 계측 공정이 추가되어 TAT(Turn-around Time)가 증가하게 되었고, 웨이퍼가 가공되어 완제품까지 도달하는데 필요한 공정시간이 증가하여 제조원가 상승의 원인으로 작용한다. 본 논문에서는 웨이퍼의 검계측 데이터가 아닌, 제조공정 과정에서 발생하는 다양한 센서 및 장비 데이터를 기반으로 웨이퍼 제조 결과가 양품인지 그렇지 않으면 불량인지 구별할 수 있는 가상계측 모델을 제안한다. 기계학습의 여러 알고리즘 중에서 다양한 장점을 갖는 XGBoost 알고리즘을 이용하여 예측모델을 구축하였고, 데이터 전처리(data-preprocessing), 주요변수 추출(feature selection), 모델 구축(model design), 모델 평가(model evaluation)의 순서로 연구를 수행하였다. 결과적으로 약 94% 이상의 정확성을 갖는 모형을 구축하는데 성공하였으나 더욱 높은 정확성을 확보하기 위해서는 반도체 공정과 관련된 Domain Knowledge 를 반영한 모델구축과 같은 추가적인 연구가 필요하다.

• Asia pacific journal of information systems
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• 제32권3호
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• pp.684-705
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• 2022

A new trend has been emerging in recent years, with video game live streaming becoming a meeting ground for gamers, as well as a marketing strategy for game developers. In line with this trend, the emergence of the "Let's Play" culture has significantly changed the manner in which people enjoyed video games. In order to academically explore this new experience, this study seeks to answer the following research questions: (1) Does engaging in video game streaming offer the same feeling as playing the game? (2) If so, what are the factors that affect the feeling of telepresence from viewers' perspective? and (3) How does the feeling of telepresence affect viewers' learning experience of the streamed game? We generated and empirically tested a comprehensive research model based on the telepresence and consumer learning theories. The research findings revealed that the authenticity and pleasantness of the streamer and the interaction of viewers positively affect telepresence, which in turn is positively associated with the gained knowledge and a positive attitude toward the streamed game. Based on the research findings, various practical implications are discussed for game developers as well as platform providers.

• Geomechanics and Engineering
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• 제36권3호
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• pp.247-258
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• 2024

Tailings are waste materials of mining operations, consisting of a mixture of clay, silt, sand with a high content of unrecoverable metals, process water, and chemical reagents. They are usually discharged as slurry into the storage area retained by dams or earth embankments. Poor knowledge of the hydro-mechanical behaviour of tailings has often resulted in a high rate of failures in which static liquefaction has been widely recognized as one of the major causes of dam collapse. Many studies have dealt with the static liquefaction of coarse soils in saturated conditions. This research provides an extension to the case of silty tailings in unsaturated conditions. The static liquefaction resistance was evaluated in terms of stress-strain behavior by means of monotonic triaxial tests. Its dependency on the preparation method, the volumetric water content, the void ratio, and the degree of saturation was studied and compared with literature data. The static liquefaction response was proved to be dependent mainly on the preparation technique and degree of saturation that, in turn, controls the excess of pore pressure whose leading role is investigated by means of the relationship between the -B Skempton parameter and the degree of saturation. A preliminary interpretation of the static liquefaction response of Stava tailings is also provided within the Critical State framework.

• 한국분말재료학회지
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• 제31권4호
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• pp.302-307
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• 2024

This study explored the process-structure-property (PSP) relationships in Ti-6Al-4V alloys fabricated through direct energy deposition (DED) additive manufacturing. A systematic investigation was conducted to clarify how process variables-specifically, manipulating the cooling rate and energy input by adjusting the laser power and scan speed during the DED process-influenced the phase fractions, pore structures, and the resultant mechanical properties of the samples under various processing conditions. Significant links were found between the controlled process parameters and the structural and mechanical characteristics of the produced alloys. The findings of this research provide foundational knowledge that will drive the development of more effective and precise control strategies in additive manufacturing, thereby improving the performance and reliability of produced materials. This, in turn, promises to make significant contributions to both the advancement of additive manufacturing technologies and their applications in critical sectors.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2015년도 제49회 하계 정기학술대회 초록집
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• pp.64-64
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• 2015

Control of plasma processing methodologies can only occur by obtaining a thorough understanding of the physical and chemical properties of plasmas. However, all plasma processes are currently used in the industry with an incomplete understanding of the coupled chemical and physical properties of the plasma involved. Thus, they are often 'non-predictive' and hence it is not possible to alter the manufacturing process without the risk of considerable product loss. Only a more comprehensive understanding of such processes will allow models of such plasmas to be constructed that in turn can be used to design the next generation of plasma reactors. Developing such models and gaining a detailed understanding of the physical and chemical mechanisms within plasma systems is intricately linked to our knowledge of the key interactions within the plasma and thus the status of the database for characterizing electron, ion and photon interactions with those atomic and molecular species within the plasma and knowledge of both the cross-sections and reaction rates for such collisions, both in the gaseous phase and on the surfaces of the plasma reactor. The compilation of databases required for understanding most plasmas remains inadequate. The spectroscopic database required for monitoring both technological and fusion plasmas and thence deriving fundamental quantities such as chemical composition, neutral, electron and ion temperatures is incomplete with several gaps in our knowledge of many molecular spectra, particularly for radicals and excited (vibrational and electronic) species. However, the compilation of fundamental atomic and molecular data required for such plasma databases is rarely a coherent, planned research program, instead it is a parasitic process. The plasma community is a rapacious user of atomic and molecular data but is increasingly faced with a deficit of data necessary to both interpret observations and build models that can be used to develop the next-generation plasma tools that will continue the scientific and technological progress of the late 20th and early 21st century. It is therefore necessary to both compile and curate the A&M data we do have and thence identify missing data needed by the plasma community (and other user communities). Such data may then be acquired using a mixture of benchmarking experiments and theoretical formalisms. However, equally important is the need for the scientific/technological community to recognize the need to support the value of such databases and the underlying fundamental A&M that populates them. This must be conveyed to funders who are currently attracted to more apparent high-profile projects.

• 한국지구과학회지
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• 제31권1호
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• pp.106-117
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• 2010

이 연구의 목적은 학생들의 논증을 인식론적 (사고과정) 및 심리학적 (사고유형) 관점에서 탐색하여 어떠한 사고과정 및 유형으로 교사가 학생들의 논증 형성 능력을 향상시키는지 알아보는 것이다. 35년의 교사경력을 지니고 있는 교사 및 그의 26명 학생의 과학수업 60시간을 관찰하고, 전사하였으며, 전사한 학생들의 논증이 어떻게 표현되는지를 두 개의 도구, 즉 인식론적 및 심리학적 관점으로 분석하였다. 이 연구 참여자인 교사는 학생들의 논증의 질을 향상 시키기 위하여 특별한 목적으로 개발한 명시적인 교수법 "주장-근거 교수법"을 수업 시간에 활용하였다. 논증을 두 개의 다른 관점으로 분석해 본 결과, "보기" 또는 "예"를 이용한 사고과정에서는 "정교성" 사고유형이 가장 빈번하게 사용되었다. 모든 탐구의 시작인 가설을 세우기 위해 학생들은 "귀납" 사고과정으로 "일반화" 사고유형을 통해 탐구의 시작단계인 본인들의 "주장"을 형성하였다. 좀 더 높은 수준의 논증은 다른 지식이나 경험을 통한 개념의 "일관성" 사고 과정을 통해 교사의 도움에 힘입어 학생들이 "설명"을 형성하였다. 이러한 높은 수준의 논증 기회에서 확인된 교사의 역할은 학생들이 스스로 논증을 형성할 수 잇도록 도와주는 조력자, 그리고 학생들의 논증을 평가하는 것이 아닌 좀더 학생들의 사고과정을 확장시켜 주는 정교자 (elaborator), 그리고 학생들의 논증 수준이 높아질 수 있도록 논증을 추적하여 발전시켜주는 멘토로 확인되었다. 논증 본성에 대한 이해를 바탕으로 교사들은 학생들이 과학의 참 의미를 이해 할 수 있도록, 논증 기회를 제공하는 명시적인 교수전략을 개발하는 것이 필수적이라 할 수 있겠다.

• 통상정보연구
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• 제13권3호
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• pp.229-248
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• 2011

본 연구는 선행 연구와 실증연구를 병행하여 글로벌 제휴활동이 제휴혁신에 미치는 영향을 실증하였다. 연구 개념 사이에 영향을 검증하기 위하여 가설 6개를 설정하였고, 글로벌 제휴나 협력을 공시한 업체 중 기준에 적합한 업체 114곳에서 설문자료를 수집하여 빈도분석, 신뢰도분석, 요인분석, 회귀분석, 확인 요인분석, 구조방정식 모형분석, 회귀분석을 각각 하였다. 연구결과를 요약하면 다음과 갈다. 첫째, 기업역량과 파트너 역량은 제휴창조활동에 영향을 미치는 것으로 나타났다. 제휴창조활동은 제휴활동에 고유한 체계와 문화를 확립하는 것으로서 기업역량과 파트너 역량을 결합하고 습득하기 위한 것이다. 따라서 제휴창조활동은 참여 업체 사이에 의사결정체계, 기업문화 등이 상이하여 발생하는 갈등을 방지하고, 제휴로써 기존 활동을 변모시키기 위하여 상호 학습하고 파트너에게 접근하기 위한 경로를 개척하는 것으로 볼 수 있다. 둘째, 기업역량과 파트너 역량은 제휴학습에 영향을 미치는 것으로 나타났다. 제휴학습은 지식이나 역량을 통합하고 개발하여 조직과 가치사슬에 확산시키는 것으로서 기어역량과 파트너 역량을 교환하고 모방하여 제휴지식을 확장하는 것이 작용하였다고 볼 수 있다. 셋째, 제휴창조활동과 제휴학습 중 제휴학습이 제휴혁신에 영향을 미치는 것으로 나타났다. 제휴학습은 다양한 조직수준에서 발생하는 상호작용과 제휴지식을 확장하고 습득하여 가치사슬과 조직에 확산되는 과정이기 때문에 제휴혁신에 영향을 미친다고 볼 수 있다. 결국 제휴혁신은 기업역량과 파트너 역량을 바탕으로 제휴활동에 고유한 지식을 창출하거나 기술을 개발하는 제휴학습이 중요한 것으로 나타났다.

• 보건교육건강증진학회지
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• 제2권1호
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• pp.3-50
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• 1984

The levels of health knowledge, attitude and practice of housewives considerably effect to the health of households, communities and the nation. This study was designed to grasp the levels of health knowledge, attitude and practice of houswives and analyse the various factors effecting to health in order to provide health education services as well as materials for effective formulation and implementation of health policy to improve the health of the nation. This study has been conducted through interviews by trained surveyers for 4,281 housewives selected from 4,500 households throughout the country for 40 days during July 11-August 20, 1983. The results of survey were analysed by stepwise multiple regression and path analysis are summarized as follows; 1. Based on the measurement instrument applied to this study, the levels of health knowledge, attitude and practice of housewives were extremely low with 54.5 points out of 100 points in full. Higher level with 72 points and above was approximately 21 percent and lower level with 39 points and below was approx. 24 percent. The middle level was approx. 55 percent. In order to implement health programs successively, health education should be more strengthened and to improve the level of health knowledge, attitude and practice (KAP) of the nation, political consideration as a part of spiritual reformation must be concentrated on health. 2. The level of health knowledge indicated the highest points with 57.3 the level of attitude was the second with 55.0 points and the practice level was the lowest with 50.0 point. Therefore, planning and implementation of health education program must be based on the persuasion and motivation that health knowledge turn into practice. 3. Housewives who had higher level of health knowledge, showed their practice level was relatively lower and those who had middle or low level of it practice level was the reverse. 4. Correlations among health knowledge, attitude and practice (KAP) were generally higher and statistically significant at 0.1 percent level. Correlation between total health KAP level and health knowledge was the highest with r=.8092. 5. Health KAP levels showed significant differences according to the age, number of children, marital status, self-assessed health status and concern on health of the housewives interviewed (p<0.001) 6. Health KAP levels also showed significant differences according to the education level, economic status, employment before marriage and grown-up area of the housewives interviewed. (p<0.001) 7. Heath KAP levels showed significant differences according to health insurance benificiary and the existence of patients in the family. (p<0.001). 8. Health KAP levels showed significant differences according to distance to government organizations, schools, distance to health facilities, telephone possession rate, television possession rate, newspaper reading rate and activities of Ban meeting and Women's club. (p<0.001) 9. Health KAP levels showed significant differences according to electric mass communication media such as television, radio and village broadcasting etc. and printed media such as newspaper, magazine and booklets etc., IEC variables such as individual consultation and husband-wife communication, however, there was no significance with group training. 10. Health KAP of the housewives showed close correlation with personal characteristics variables, i.e., education level (r=.5302), age (r=-.3694) grown-up area (r=.3357) and employment before marriage. In general, correlation of health knowledge level was higher than the levels of attitude or practice. In case of health concern and health insurance, correlation of practice level was higher than health knowledge level. 11. Health KAP levels showed higher correlation with community environmental characteristics, Ban meeting and activity of Women's club, however, no correlation with New-village movement. 12. Among IEC variables, husband-wife communication showed the highest correlation with health KAP levels and printed media, electric mas communication media and health consultation in order. Therefore, encouragement of husband-wife communication and development of training program for men should be included in health education program. 13. Mass media such as electric mass com. and printed media were effective for knowledge transmission and husband-wife communication and individual consultation were effective for health practice. Group training was significant for knowledge transmission, however, but not significant for attitude formation or turning to health practice. To improve health KAP levels, health knowledge should be transmitted via mass media and health consultation with health professionals and field health workers should be strengthened. 14. Correlation of health KAP levels showed that knowledge level was generally higher than that of practice and recognized that knowledge was not linked with attitude or practice. 15. The twenty-five variables effecting health KAP levels of housewives had 41 per cent explanation variances among which education level had great contribution (β=.2309) and electric mass com. media (β=.1778), husband-wife communication (β=.1482), printed media, grown-up area, and distance to government organizations in order. Variances explained (R²) of health KAP were 31%, 15%, and 30% respectively. 16. Principal variables contributed to health KAP were education level (β=.12320, β=.1465), electric mass comm. media (β=.1762, β=.1839), printed media, (β=.1383, β=.1420) husband-wife communication (β=.1004, β=.1067), grown-up area and distance to government organizations, in order. Since education level contributes greatly to health KAP of the housewives, health education including curriculum development in primary, middle and high schools must be emphasized and health science must be selected as one of the basic liberal arts subject in universities. 17. Variences explained of IEC variables to health KAP were 19% in total, 14% in knowledge, 9% in attitude, and 10% in health practice. Contributions of IEC variables to health KAP levels were printed media (β=.3882), electric mass comm media (β=.3165), husb-band wife com. (β=.2095,) and consultation on health (β=.0841) in order, however, group training showed negative effect (β=-.0402). National fund must be invested for the development of Health Program through mass media such as TV and radio etc. and for printed materials such as newspaper, magazines, phamplet etc. needed for transmission of health knowledge. 18. Variables contributed to health KAP levels through IEC variables with indirect effects were education level (Ind E=0.0410), health concern (Ind E=.0161), newspaper reading rate (Ind E=.0137), TV possession rate and activity of Ban meeting in order, however, health facility showed negative effect (Ind E=-.0232) and other variables showed direct effect but not indirect effect. 19. Among the variables effecting health KAP level, education level showed the highest in total effect (TE=.2693) then IEC (TE=.1972), grown-up city (TE=.1237), newspaper reading rate (TE=.1020), distance to government organization (TE=.095) in order. 20. Variables indicating indirect effects to health KAP levels were; at knowledge level with R²=30%, education level (Ind E=.0344), newspaper reading rate (Ind E=.0112), TV possession rate (Ind E=.0689), activity of Ban meeting (Ind E=.0079) in order and at attitude level with R²=13%, education level (Ind E=. 0338), activity of Ban meeting (Ind E=.0079), and at practice level with R²=29%. education level (Ind E=.0268), health facility (Ind E=.0830) and concern on health (Ind E=.0105). 21. Total effect to health KAP levels and IEC by variable characteristics, personal characteristics variables indicated larger than community characteristics variables. 22. Multiple Correlation Coefficient (MCC) expressed by the Personal Characteristic Variable was .5049 and explained approximately 25% of variances. MCC expressed by total Community environment variable was .4283 and explained approx. 18% of variances. MCC expressed by IEC Variables was .4380 and explained approx. 19% of variances. The most important variable effected to health KAP levels was personal characteristic and then IEC variable, Community Environment variable in order. When the IEC effected with personal characteristic or community characteristic, the MCC or the variances were relatively higher than effecting alone. Therefore it was identified that the IEC was one of the important intermediate variable.

• 한국철학논집
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• 제32호
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• pp.215-249
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• 2011

본고는 서양 근대 문명 수용 초기(1890~1910)에 발생한 신구 관념의 대립과 충돌을 중심으로 전통 지식 체계의 변용을 역사의미론적으로 탐색함으로써 한국의 근대를 성찰하는 데 목적이 있다. 한국에서 신구 관념을 놓고 벌어진 주체 간의 투쟁은 전통개신론자들과 문명개화론자들의 주장에서 첨예하게 드러났다. 서양의 충격에서 비롯된 신구 관념의 대립과 충돌은 우주 자연으로부터 사회 정치체제, 학술?문화 등 모든 부문에서 인식의 전환을 요구하였지만, 전통 지식 체계를 이해하는 시각에는 다소 차이가 있었다. 신구 관념에 따른 전통 지식 체계의 구축과 변용과정에서 문명개화론자들에게 '구(舊)'는 단순히 과거의 '지나간', '오래된' 것이 아니라 파괴하고 제거하지 않으면 새로운 문명 건설을 방해하는 장애물이었다. 그러나 전통개신론자들에게 '구(舊)'는 '온고지신(溫故知新)'의 이념 속에서 다시 '신(新)'으로 거듭날 수 있는 가능성을 내함하고 있는 '개신(改新)'의 대상이었다. 박은식의 "유교구신론(儒敎求新論)"이나 한용운의 "조선불교유신론(朝鮮佛敎維新論)"은 전통 지식 체계를 '신학(新學)'으로 재편하려한 대표적인 시도였다. 보편성과 객관성, 합리성을 추구하는 과학적 방법을 수용함으로써 전통 지식 체계는 근대적인 학문으로 변화할 수 있었다. 그러나 신학(新學)으로 변화하는 과정에서 성학(聖學)으로서의 위상은 탈각되었고, 신앙과 종교적 전통 또한 약화될 수밖에 없었다. 이러한 전통 지식 체계의 변용과 '구학의 신학화' 과정에서 신구 관념의 교차가 발생하였다. 여기서 특히 신구 관념의 교차를 가능하게 한 '실(實)(학(學))' 개념에 주목할 필요가 있다. 20세기 전후 발간된 다종의 근대 매체는 신구 관념의 다층적 전개 양상을 여실히 보여주는데, 전통 지식 체계가 신학(新學)으로 변용될 수 있었던 계기로서 '실학'이라는 개념적 준거틀이 작동하였음을 확인할 수 있다. 물론 이 시기 실학이 지칭하는 대상은 대체로 서양의 학문인 '신학(新學)'을 표상하고 심지어 등치되기도 했지만, 전통개신론자들은 문명개화론자들이 점유하였던 '실학' 개념과 그 의미를 재해석함으로써 전통 지식 체계를 신학으로 바꿀 수 있었다. 이들은 과학 기술에 압도되어 점차로 거세되어가던 전통적 가치를 '신학' 수용의 토대로 인식하고, '실학(實學)'을 개념을 준거로 하여 '신학(新學)'을 재전유(再專有)(re-appropriation)하였다. 일제의 강점이 구체화 되어 전통 지식 체계의 주체적 변용 시도는 일정한 한계에 직면할 수밖에 없었지만 '구학의 신학화'는 '동도서기(東道西器)' 논리가 지닌 모순과 문명개화론의 탈주체성을 넘어서는 것으로 평가할 수 있다. 도덕 원리와 경쟁 원리가 충돌하고 '진화'와 '진보'가 대세인 현실에 대응하려했던 '동도서기(東道西器)' 논리는 이미 분리될 수 없는 도(道)와 기(器)를 분리 가능한 것으로 상정해야만 성립되는 모순을 안고 있었고, 문명개화론은 서양을 내면화하여 자기 비하와 멸시로 주체의 균열을 야기하고 전통 지식 체계로부터 단절됐다는 비판에서 자유로울 수 없기 때문이다.