• 통합자연과학논문집
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• 제3권1호
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• pp.49-53
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• 2010

Molecular docking is a critical event which mostly forms Van der waals complex in molecular recognition. Since the majority of developed drugs are small molecules, docking them into proteins has been a prime concern in drug discovery community. Since the binding pose space is too vast to cover completely, many search algorithms such as genetic algorithm, Monte Carlo, simulated annealing, distance geometry have been developed. Proper evaluation of the quality of binding is an essential problem. Scoring functions derived from force fields handle the ligand binding prediction with the use of potential energies and sometimes in combination with solvation and entropy contributions. Knowledge-based scoring functions are based on atom pair potentials derived from structural databases. Forces and potentials are collected from known protein-ligand complexes to get a score for their binding affinities (e.g. PME). Empirical scoring functions are derived from training sets of protein-ligand complexes with determined affinity data. Because non of any single scoring function performs generally better than others, some other approaches have been tried. Although numerous scoring functions have been developed to locate the correct binding poses, it still remains a major hurdle to derive an accurate scoring function for general targets. Recently, consensus scoring functions and target specific scoring functions have been studied to overcome the current limitations.

• 한방안이비인후피부과학회지
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• 제31권4호
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• pp.65-82
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• 2018

Objectives : The purpose of this study is 1) to explore the general tendency of the herbs or herbal formula for acne treatment in clinical practice 2) and to provide a basis for explaining the principles of acne treatment in Korean Medicine in order to make patients understand more easily based on pharmacological mechanism by analyzing the herbs or herbal formula using for acne treatment in clinical practice. Methods : In the domestic databases (Oriental medicine Advanced Searching Integrated System-OASIS, Korean Traditional Knowledge Portal-KTKP, National Discovery for Science Leader-NDSL, Research Information Sharing Service-RISS), we selected among the papers published using search terms related to "acne". Reports related to sasang constitutional medicine were excluded and a total of 23 papers were finally selected. Results : 29 prescriptions were retrieved from 23 papers. Chungan-tang (淸顔湯) notified formulas ranked first by Cheongsangbangpung- tang (淸上防風湯), Hwangnyeonhaedok-tang (黃連解毒湯), Dangguijakyaksan (當歸芍藥散) and Bipachungpe-eum (枇杷淸肺飮). Commonly used herbs are Forsythiae Fructus (連翹), Scutellariae Radix (黃芩), Gardeniae Fructus (梔子), Ligustici Rhizoma (川芎), and Angelicae Gigantis Radix (當歸). In most patients with inflammatory lesions or excessive flushing, exterior-releasing medicinal (解表藥) and heat-clearing medicinal (淸熱藥) were mainly prescribed for acne treatment, while in patients with acne accompanied hyperkeratinization, Excess sebum secretion, Dysmenorrhea or indigestion, qi-tonifying medicinal (補氣藥) or blood-tonifying medicinal (補血藥) were mainly used. KAGS (Korean Acne Grading System) was the most commonly used method for acne severity assessment. Conclusions : These findings suggest that the herbs or herbal formula for acne treatment in Korean Medicine is prescribed differently according to the cause and symptoms of acne in a unique way for control the whole body balance. Also, our findings could provide a basis for explaining the principles of acne treatment in Korean Medicine in order to make patients understand more easily based on pharmacological mechanism in clinical practice.

• 대한한방내과학회지
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• 제39권6호
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• pp.1105-1115
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• 2018

Objectives: The aim of this review is to investigate clinical studies on Oriental medicine treatment for aphasia after cerebrovascular disease. Methods: Using the keywords 'Aphasia', 'Oriental medicine', 'Stroke' 'Cerebral infarction', 'Cerebral hemorrhage', and 'Clinic', we searched domestic databases, including "NDSL (National Discovery for Science Leaders)", "Korean Traditional Knowledge Portal", "OASIS (Oriental Medicine Advanced Searching Integrated System)", and "RISS (Research Information Sharing Service)". Each keyword was not searched individually, but combined in various ways. To investigate recent trends, we limited our search to papers published after 2000. Papers that did not include a specific treatment method or did not match the subject "Aphasia after stroke" were excluded. Results: Using the searching method, 13 studies were found. Of these, 12 studies were in the form of case reports, while one was in the form of a non-randomized controlled trial. These studies showed positive results for the use of Oriental medicine in terms of the Korean version of the Western Aphasia Battery (K-WAB), the evaluation form on functional performance capability and accuracy of articulatory organs developed by Lee, aphasia screening test refered in 'Assessment in Speech-Language Pathology' and adapted properly to Korean, the Communicative Ability in Daily Living Test (CADLT), the Korean Version-Boston Naming Test (K-BNT), and language assessment items included in CNS, and NIHSS. Conclusions: Of the 12 case reports, 11 studies showed positive results of the use of Oriental medicine for treatment of aphasia after cerebrovascular disease. However, more sophisticated and large-scale clinical research on aphasia should be conducted.

• 대한한방내과학회지
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• 제40권3호
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• pp.295-311
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• 2019

Objectives: This research aimed to investigate Chinese clinical studies on the treatment of central post-stroke pain (CPSP) and thalamic syndrome after stroke with traditional herbal medicine (THM). Methods: Randomized controlled trials verifying the effects of herbal medicine on treating CPSP and thalamic syndrome after stroke were included in the study. Electrical and hand search were conducted in the China National Knowledge Infrastructure (CNKI), National Discovery for Science Leaders (NDSL), Research Information Sharing Service (RISS), Oriental Medicine Advanced Searching Integrated System (Oasis) for CPSP and thalamic syndrome after stroke. A literature search was performed in the Chinese and Korean databases for papers published from January 1, 2010 to October 1, 2018. The selected literature was assessed by Cochrane's risk of bias. Results: Twelve reports on randomized controlled trials met the inclusion criteria from the 227 identified reports. Effective rate, comparison of visual analogy scale, present pain intensity, pain grading index, recurrence rate, follow-up, and a 36-item short form survey instrument were used to evaluate the treatments. The effective rate of the treatment group was significantly higher than that of the control group in all papers. Side effects occurred less frequently in the treatment group than in the western medicine control group. Conclusions: The treatment of CPSP and thalamic syndrome after stroke with THM was shown to be highly effective. Additional well-designed clinical trials are needed. This study can be used as a basis for further research on the treatment of CPSP and thalamic syndrome after stroke.

• Journal of the Korean Data and Information Science Society
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• 제27권2호
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• pp.353-362
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• 2016

데이터 마이닝은 빅 데이터에 내재되어 있는 새로운 법칙이나 잠재되어 있는 지식을 탐색한 후, 이를 근거로 하여 의사결정에 활용하고자 하는 것이다. 위키 백과사전에 의하면 데이터 마이닝 기법 중의 하나인 연관성 규칙은 연관성 평가 기준에 의해 관심 있는 항목들 간에 관련성을 찾아내는 기법으로 많은 연구자들에 의해 연관성 평가를 위한 흥미도 측도들이 개발되어 왔다. 이들 중에서 헬링거 측도는 여러 가지 흥미도 측도들에 비해 많은 장점이 있으나 연관성의 방향을 판단하기가 곤란한 문제를 내포하고 있다. 이 문제를 해결하기 위해 본 논문에서는 부호를 가지는 헬링거 측도를 제안하고 몇 가지 예제를 통하여 유용성을 고찰하였다. 그 결과, 본 논문에서 제안하는 부호 헬링거 측도는 양의 연관성을 가지는 경우에는 양의 값으로 나타나고 음의 연관성을 가지는 경우에는 음의 값을 갖는 것으로 나타났다. 또한 동시발생빈도, 동시 비 발생빈도, 그리고 불일치 빈도가 증가함에 따라 기본적인 연관성 평가 기준들과 부호 헬링거 측도는 증감 여부가 동일한 것을 알 수 있었다.

• 한방안이비인후피부과학회지
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• 제31권3호
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• pp.12-25
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• 2018

Objectives : The purpose of this study is to analyze the use of herbal medicine for the treatment of urticaria in case studies and to find the general tendency of herbal medicine treatment and to establish the primary treatment direction of urticaria. Methods : In the domestic databases, Oriental medicine Advanced Searching Integrated System (OASIS), Korean Traditional Knowledge Portal (KTKP), National Discovery for Science Leader (NDSL), Research Information Sharing Service (RISS), we selected among the case study papers published in the last 20 years using search terms related to "urticaria". Reports related to Sasang Constitutional medicine were excluded and total of 15 papers were finally selected. Results : 23 prescriptions were retrieved from 15 papers. The most commonly used prescription was Seungmagalgeun-tang (升麻葛根湯), and Bangpoongtongsung-san (防風通聖散) and Pyeongwi-san (平胃散) were presented twice. Commonly used herbs are Glycyrrhizae Radix et Rhizoma (甘草), Zingiberis Rhizoma Recens (生薑), and Scutellariae Radix (黃芩). 18 out of 78 herbs are belonging to heat-clearing medicinal (淸熱藥) and 16 out of 78 herbs are belonging to exterior-releasing medicinal (解表藥). Concurrent therapies such as acupuncture, pharmacoacupuncture, moxibustion, cupping therapy, ice pack applying therapy were performed and several evaluation methods were used, patient's subjective remission rate was the most used. Conclusions : Through this study, we were able to discover the tendency of herbal medicine prescription for the treatment of urticaria.

• 정보처리학회논문지D
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• 제15D권2호
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• pp.179-186
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• 2008

위치 기반 장치의 발전과, GIS 기능의 확장 그리고 위치 정보기술들의 정확성과 가용성이 증가함에 따라서 위치 기반 서비스들의 새로운 영역에 대한 새로운 가능성이 나타나게 되었다. 데이터의 시간과 공간 형태에 따라서 정의되는 Relationship에 기인하여 시공간 데이터 마이닝 영역에서 공간에 대한 지식 검색이 증가할 경우 매우 큰 문제에 직면한다. 이 논문에서는 모바일 환경에서 시공간 패턴 마이닝을 위한 알고리즘들을 제안한다. 이동 패턴들은 All_MOP와 Max_MOP 두 개의 알고리즘을 활용하여 생성된다. 이 알고리즘들은 먼저 모든 빈발 패턴들을 탐사한 후 오직 최대의 빈발 패턴만을 탐사한다. 아울러, 제안한 기법과 기존의 DFS_MINE 기법의 수행 시간 비교를 통하여 제안한 기법이 수행시간에서 다소 우수한 것을 나타낸다. 이러한 제안접근법은 관광 서비스, 교통 서비스 등과 같은 위치 기반 서비스 등에 활용할 수 있다.

• 대한한방내과학회지
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• 제39권3호
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• pp.372-388
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• 2018

Objective: This study evaluates the effectiveness and safety of moxibustion for benign prostatic hyperplasia (BPH). Methods: Using the keywords "benign prostatic hyperplasia", "benign prostatic hypertrophy", "benign prostatic enlargement", "prostatic hyperplasia", and "moxibustion", we searched papers in numerous databases, including National Discovery for Science Leaders (NDSL), Korean Traditional Knowledge Portal (KTKP), Oriental Medicine Advanced Searching Integrated System (OASIS), Research Information Sharing Service (RISS), PubMed, Embase, and CENTRAL. The search range included randomized controlled trials (RCTs). Papers not matched with inclusion criteria were excluded. The methodological quality of each RCT was assessed using the Cochrane risk-of-bias tool. Where appropriate, meta-analyses were performed. Results: Initially, 77 studies were found. Of these, 11 duplicate studies were removed and 27 were excluded following title and abstract screening. After the remaining 39 papers were scanned, 13 RCTs were selected and analyzed. Among these 13 RCTs, five compared moxibustion therapy and oral medication, seven compared moxibustion plus acupuncture therapy and oral medication, and one compared moxibustion plus acupuncture therapy and sham-moxibustion. The meta-analysis showed positive results for the use of moxibustion therapy in terms of International Prostate Symptom Score (IPSS), Quality Of Life (QOL), Maximum Flow Rate (Qmax), Prostate Volume (PV), and the efficacy rate. The meta-analysis showed positive results for the use of moxibustion plus acupuncture therapy in terms of IPSS, QOL, and the efficacy rate. Conclusions: This meta-analysis of clinical trials suggests that moxibustion is effective intreating BPH patients. The results of this study could be applied to clinical treatment of BPH. However, additional large-scale clinical researches should be conducted.

• 한국정보과학회논문지:데이타베이스
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• 제28권3호
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• pp.279-300
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• 2001

지식탐사 프로세스의 핵심적인 역할을 담당하는 데이터마이닝 단계에서는 여러 가지 목적에 따라 알고리즘을 선택하여 사용한다. 최근 통계, 비즈니스, 전자 상거래, 의학, 생물학 등의 분야에서 데이터마이닝 기술아 적극적으로 활용되고 있으며, 이를 위해 다양한 알고리즘들이 계속해서 연구.개발되고 있다. 그러나 시간이 지나면 이들 중 각 분야 별로 우수한 응용성을 보이는 알고리즘이나 방대한 양의 데이터를 다루는데 있어 좋은 성능을 보이는 몇몇 알고리즘만이 남게 될 것이며 또한 앞으로는 이러한 알고리즘들만을 선별하여 집중 연구할 필요가 있다. 따라서 본 논문에서는 데이터마이닝에 널리 사용되고 활발한 연구가 진행중인 알고리즘들 중에서 연관규칙(association rule), 클러스터링(clustering), 신경망(neural network), 결정트리(decision tree), 유전자 알고리즘(genetic algorithm), 베이지안 네트워크(bayesian network), 메모리 기반 추론(memory-based reasoning)등 7가지 카테고리에 속하는 알고리즘들을 선정하여 분류.분석하였다. 우선 각 알고리즘의 계통과 특성들을 분석하였고 이를 토대로 비교.분석을 위한 14가지의 분류 기준을 제시하였다. 이러한 분류 기준에 근거하여 세부 알고리즘들을 분석해 보고 비교 가능한 일부 알고리즘은 여러 특징과 성능을 중심으로 각각 최상의 알고리즘을 도출해 보았다. 본 연구 결과는 데이터마이닝 분야의 흔재된 알고리즘들을 분류.분석함으로써 마이닝 기술 적용시 사용자에게 알고리즘 선택의 지표를 제시할 수 있을 것이다.

• 대한한방내과학회지
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• 제40권3호
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• pp.409-424
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• 2019

Objectives: This research aimed to confirm the efficacy of oriental medicine in sixth cranial nerve palsy and to evaluate the quality of the studies. Methods: Using the medical subject heading (MeSH) keywords "abducens nerve palsy", "abducens nerve paralysis", "sixth nerve palsy", "herbal medicine", "Chinese medicine", "oriental medicine" and "acupuncture", we collected the research papers through an electronic database search in Oriental Medicine Advanced Searching Integrated System (OASIS), National Discovery for Science Leaders (NDSL), PubMed, Cochran Library, and China National Knowledge Infrastructure (CNKI). Results: A total of 136 papers were searched from the databases. Among these, 15 case reports and 8 randomized controlled trials (RCTs) met our criteria. 17 articles were found on the use of acupuncture as the main intervention, 11 on the use of herbal medicine as the main intervention, and 9 on the use of electroacupuncture as the main intervention. The frequently used acupoints were LI4, EX-HN5, GB1, BL2, TE23, LR3, BL1, ST2, GB20, and ST36. All 23 studies confirmed the efficacy of Korean medicine. According to the assessment using the risk of bias, the overall quality of the RCTs was low. Conclusions: Twenty-three papers suggested that Korean medicine treatment for abducens nerve palsy was effective in many cases. Analyzing the potential bias was difficult.