• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2013년도 춘계학술대회 논문집
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• pp.881-882
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• 2013

• International Journal of Aeronautical and Space Sciences
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• 제17권3호
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• pp.409-422
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• 2016

A parametric study based on an unsteady mathematical model of a pyrotechnically actuated device was performed for design optimization. The model simulates time histories for the chamber pressure, temperature, mass transfer and pin motion. It is validated through a comparison with experimentally measured pressure and pin displacement. Parametric analyses were conducted to observe the detailed effects of the design parameters using a validated performance analysis code. The detailed effects of the design variables on the performance were evaluated using the one-at-a-time (OAT) method, while the scatter plot method was used to evaluate relative sensitivity. Finally, the design optimization was conducted by employing a genetic algorithm (GA). Six major design parameters for the GA were chosen based on the results of the sensitivity analysis. A fitness function was suggested, which included the following targets: minimum explosive mass for the uniform ignition (small deviation), light casing weight, short operational time, allowable pyrotechnic shock force and finally the designated pin kinetic energy. The propellant mass and cross-sectional area were the first and the second most sensitive parameters, which significantly affected the pin's kinetic energy. Even though the peak chamber pressure decreased, the pin kinetic energy maintained its designated value because the widened pin cross-sectional area induced enough force at low pressure.

• 한국미생물·생명공학회지
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• 제23권4호
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• pp.425-431
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• 1995

A kinetic model of the cyclodextrin formation in a heterogeneous enzyme reaction system using swollen extrusion starch as substrate was derived emphasing the structural features of extrusion starch. The degree of gelatinization, the ratio of accessible and inaccessible portion of extrusion starch, adsorption of CGTase on swollen starch, the structural transformation during reaction, and product inhibition caused by produced CDs were considered in deriving kinetic model. Various kinetic constants were also evaluated. The derived kinetic equation was numerically simulated, which result showed that the derived kinetic equations can be used to predict the experimental data reasonably well under the various experimental conditions. Kinetic model can be utilized for the optimization of enzyme reactor and the process development for CD production from swollen extrusion starch.

• KSBB Journal
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• 제9권2호
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• pp.108-114
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• 1994

분쇄마찰매치 함유 불균일상 효소반응계에서 생전분을 당공여체로 한 stevioside의 당전이 반응의 kinetics에 관한 연구를 수행하였다. 생전분으로부터 CD를 생서하는 과정과 생성된 CD와 stevioside가 random sequenrial bireactant ,echanism으로 반응하여 당전이 equation을 유도하였다. 또한 유도된 반응식의 각종 kinetic constants을 평가하였다. 유도된 반응식을 Runge-Kutta integration법으로 계산하였으며, 계산 결과를 실험치와 비교하여 유도식의 효용성을 검토하였다. 유도된 kinetic equations는 당공여체인 생전분의 농도, stevioside의 농도, 그리고 중간산물인 CD의 농도 변화를 비교적 정획히 표시할 수 있었으며, 고효율 당전이 효소반응기 개발에 활용될 것이다.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1993년도 한국자동제어학술회의논문집(국내학술편); Seoul National University, Seoul; 20-22 Oct. 1993
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• pp.582-588
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• 1993

A scheme of dynamic optimization for batch reactor his been developed and applied to a semi-batch esterification reactor. To obtain optimal operating conditions for the given semi-batch reactor system with complex reaction kinetic and process constraints, a general nonlinear programming solver and finite element techniques have been introduced. The optimization results for the complex reactor system have been compared with those of Kumar et al. [1984] to show better optimization performance. The proposed optimizing scheme has been applied to the free end time problem to obtain the realistic operating condition. The results can supply valuable information for economic operation of the given batch esterification reactor.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2015년도 제46회 하계학술대회
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• pp.179-180
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• 2015

High wind penetration might cause the frequency stability problem because a wind power plant (WPP) is operating in a maximum power tracking mode to extract the maximal energy from wind and thus does not react to the system frequency variation. Therefore, the system operators encourage a WPP to participate in frequency control, which includes inertia/orl and primary control. The frequency support capability of a WPP depends on the amount of kinetic energy (KE) and reserve. This paper formulates an optimization problem to maximize KE while retaining the required reserve. The proposed optimization problem would allow wind generators (WGs) with a smaller wind speed to retaine more KE. The performance of the proposed optimization problem was investigated in a 100-MW WPP consisting of 20 units of 5-MW permanent magnet synchronous generators using an EMTP-RV simulator. The results show that the proposed optimization problem successfully improves the frequency nadir more than a conventional reserve allocation that distributes WGs proportional to the current output.

• Journal of Ginseng Research
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• 제39권4호
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• pp.304-313
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• 2015

Background: Ginsenoside Rg3 is a promising anticancer agent. It is usually produced by heat treatment of ginseng, in which ginsenoside Rb1 is the major ginsenoside. A kinetic study was conducted to optimize ginsenoside Rg3 production by the heat treatment of ginsenoside Rb1. Methods: Ginsenoside Rb1 was heated using an isothermal machine at $80^{\circ}C$ and $100^{\circ}C$ and analyzed using HPLC. The kinetic parameters were calculated from the experimental results. The activation energy was estimated and used to simulate the process. The optimized parameters of ginsenoside Rg3 production are suggested based on the simulation. Results: The rate constants were $0.013h^{-1}$ and $0.073h^{-1}$ for the degradation of ginsenosides Rb1 and Rg3 at $80^{\circ}C$, respectively. The corresponding rate constants at $100^{\circ}C$ were $0.045h^{-1}$ and $0.155h^{-1}$. The estimated activation energies of degradation of ginsenosides Rb1 and Rg3 were 69.2 kJ/mol and 40.9 kJ/mol, respectively. The rate constants at different temperatures were evaluated using the estimated activation energies, and the kinetic profiles of ginsenosides Rb1 and Rg3 at each temperature were simulated based on the proposed kinetic model of consecutive reaction. The optimum strategies for producing ginsenoside Rg3 from ginsenoside Rb1 are suggested based on the simulation. With increased temperature, a high concentration of ginsenoside Rg3 is formed rapidly. However, the concentration decreases quickly after the reaching the maximal concentration value. Conclusion: The optimum temperature for producing ginsenoside Rg3 should be the highest temperature technically feasible below $180^{\circ}C$, in consideration of the cooling time. The optimum reaction time for heat treatment is 30 min.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2005년도 BIOINFO 2005
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• pp.272-277
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• 2005

We introduce a new approach to optimize the parameters in biological kinetic models by quantifier elimination (QE), in combination with numerical simulation methods. The optimization method was applied to a model for the inhibition kinetics of HIV proteinase with ten parameters and nine variables, and attained the goodness of fit to 300 points of observed data with the same magnitude as that obtained by the previous optimization methods, remarkably by using only one or two points of data. Furthermore, the utilization of QE demonstrated the feasibility of the present method for elucidating the behavior of the parameters in the analyzed model. The present symbolic-numeric method is therefore a powerful approach to reveal the fundamental mechanisms of kinetic models, in addition to being a computational engine.

• KSBB Journal
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• 제16권1호
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• pp.11-14
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• 2001

Techniques for protein refolding from inclusion body are discussed in view of its engineering application to large scale protein purification. Among the techniques, dilution and dialysis are mainly utilized due to simple operation. Membrane reactor, gel filtration chromatography, and continuous tank operation are emerging tools for their process-scale possibility in refolding. Reaction engineering approaches could be used to analyze the kinetic behaviour in the process scale refolding reactor. The kinetic analysis is helpful in the optimization of refolding yield in the refolding reactor.

• 한국미생물·생명공학회지
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• 제19권2호
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• pp.186-192
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• 1991

It is very important to have a good kinetic model which considers the effects of both ammonium and glucose for the control and optimization of the poly-${\beta}$-hydroxybutyrate (PHB) fermentation. A kinetic model for the growth of Alcaligenes eutrophus and the biosynthesis of PHB under both ammonium and glucose limitation was proposed. Growth rate of residual biomass was expressed as a function of concentrations of residual biomass, glucose and ammonium having glucose inhibition. PHB production rate was expressed as a function of concentrations of residual biomass, glucose, ammonium and PHB content having ammonium and product inhibitions. Novel approaches were made to estimate the parameters in the model equations which considered two limiting substrates. Model parameters were evaluated by graphical and simplex methods. The proposed kinetic model fitted the data very well.