• Archives of Pharmacal Research
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• v.22 no.1
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• pp.35-43
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• 1999

Overstimulation of both kainate (KA) and N-methyl-D-aspartate (NMDA) receptors has been reported to induce excitatoxicity which can be characterized by neuronal damage and formation of reactive oxygen free radicals. Neuroprotective effect of melatonin against KA-induced excitotoxicity have been documented in vitro and in vivo. It is, however, not clear whether melationin is also neuroportective against excitotoxicity mediated by NMDA receptors. In the present work, we tested the in vivo protective effects of striatally infused melatonin against the oxidative stress and neuronal damage induced by the injection of KA and NMDA receptors into the rat striatum. Melatonin implants consisting of 22-gauge stainless-steel cannule with melatonin fused inside the tip were placed bilaterally in the rat brain one week prior to intrastriatal injection of glutamate receptor subtype agonists. Melatonin showed protective effects against the elevation of lipid peroxidation induced by either KA or NMDA and recovered Cu, Zn-superoxide dismutase activities reduced by both KA and NMDA into the control level. Melatonin also clearly blocked both KA- and NMDA-receptor mediated neuronal damage assessed by the determination of choline acetyltransferase activity in striatal monogenages and by microscopic observation of rat brain section stained with cresyl violet. The protective effects of melatonin are comparable to those of DNQX and MK801 which are the KA- and NMDA-receptor antagonist, respectively. It is suggested that melatonin could protect against striatal oxidative damages mediated by glutamate receptors, both non-NMDA and NMDA receptors.

• Food Science and Preservation
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• v.6 no.3
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• pp.303-307
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• 1999

Compressive strength reduction characteristics of 4 different linerboards(SC, KA, SK and IK) as influenced by temperature and humidity were investigated by ring crush test. No significant effect of temperature on the reduction of compressive strength was found for samples prepared at 5$^{\circ}C$ and 30$^{\circ}C$. At the relative humidity of 66 percents, IK linerboard showed the lowest reduction of the compressive strength. At the relative humidity of 93 percents, KA linerboard lost 40 percents of its initial compressive strength while SK linerboard lost its strength up to 56 percents. The result indicated that KA linerboard was the most cost effective and material with the highest compressive strength among tested linerboards.

• The Journal of the Korea institute of electronic communication sciences
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• v.12 no.2
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• pp.267-272
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• 2017

In this paper, we suggested that a RF-front module of down-converter that represents the lowest noise figure to receive high quality video signals because the attenuation occurs in the atmosphere over 20GHz. By budget analysis of CDR, SFDR and CIP3 of RF-FEM, we also analyzed the parameters and linearity that presents high dynamic range. The total gain of designed Ka-band down-converter is 61.8dBand noise figure is 1.05dB, so gain and noise figures show excellent properties. In the future, the designed RF-FEM will be applied to the Ka-band satellite down-converter for UHD-class video transmission.

• Publications of The Korean Astronomical Society
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• v.30 no.2
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• pp.637-639
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• 2015

The Korean very-long-baseline interferometry (VLBI) network (KVN) and VLBI Exploration of Radio Astrometry (VERA) Array (KaVA) is the first international VLBI array dedicated to high-frequency (23 GHz (K-band) and 43 GHz (Q-band)) observations in East Asia. To evaluate the imagine capability of KaVA, we performed imaging observations of three bright active galactic nuclei (AGNs) known for their complex morphologies: 4C 39.25, 3C 273, and M87 by KaVA at K-/Q-band. Our KaVA images reveal extended outflows with complex substructure such as knots and limb brightening, in agreement with previous observations by other VLBI facilities. Angular resolutions are better than 1.4 and 0.8 milliarcsecond (max) at K-/Q-band, respectively. KaVA achieves a high dynamic range of ~1000, more than three times the value achieved by VERA. We conclude that KaVA is a powerful array with a great potential for the study of AGN outflows, at least comparable to the best existing radio interferometric arrays.

• Journal of The Geomorphological Association of Korea
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• v.26 no.2
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• pp.55-67
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• 2019

This study tries to reveal and compare uplift rates in the southern coast of the Korean Peninsula, based on absolute ages from coastal terrace on the coast. The uplift rate in the East Coast from previous study ranges from 0.258 to 0.357 m/ka with a median rate of 0.262 m/ka and shows an increase trend from north to south. Median uplift rate of 0.082 m/ka with minimum and maximum rates of 0.053 m/ka and 0.127 m/ka, respectively, is calculated in the South Coast from previous and this studies. The uplift rate in the West Coast from 3 absolute ages in this study is 0.082~0.112 m/ka with a median rate of 0.090 m/ka. Based on these uplift rates in the southern coast of the Korean Peninsula, it can be concluded that since MIS 5, the East Coast has experienced 3 to 4 times faster uplift rate than the West and South Coasts. However, this study suggests that more discussion on whether these uplift rates are long-term tectonic movement associated with tilted warping movement since the Tertiary or short-term tectonic movement associated with isostatic rebound due to sea level change since the Last Interglacial is needed.

• Journal of Life Science
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• v.29 no.7
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• pp.755-761
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• 2019

Kojic acid (KA) is produced by Aspergillus oryzae-sort of like mushrooms, which is commonly called as koji in Japan. KA is used as a chelation agent and a preservative preventing oxidative browning of fruits. KA also shows antibacterial and antifungal properties. Because KA stops the production of melanin by inhibiting tyrosinase in the biosynthetic pathway from tyrosine to melanin in skin, it has been applied as a skin lightening ingredient in cosmetics. Since some animal studies have shown that high amounts of KA had side effects such as in liver, kidney, reproductive, cardiovascular, gastrointestinal, respiratory, brain, and nervous system, more efficient KA derivatives are needed to be developed in order to safely apply as a skin lightening ingredient. A series of KA derivatives via conjugated with triazole by click reaction were synthesized and their in vitro tyrosinase inhibitory activities were evaluated. Most of all KA derivatives have shown in moderate tyrosinase inhibitory activities. In case of KA-hybrid compound, 1~3 have shown tyrosinase inhibitory activities about 50~10,000 times more effective tyrosinase inhibitor compared to KA itself. Specifically, the $IC_{50}$ value of KA-hybrid compound, 2 was $0.0044{\pm}0.74{\mu}M$ against tyrosinase. It is about 10,000 times more effective tyrosinase inhibitor compared to KA itself ($IC_{50}=45.2{\pm}4.6{\mu}M$).

• Archives of Pharmacal Research
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• v.15 no.3
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• pp.229-233
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• 1992

The pKa value of histidine-51 residue was determined by the pH dependency of contents of NADH bound to the active site in the orse liver alcohol dehydrogenase and % inactivation with diethyl pyrocarbonate treatment of the enzyme. The pKa for His-51 was -7.15 in the ternary complex and -6.7 in the enzyme itself.

• International Journal of Aeronautical and Space Sciences
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• v.4 no.2
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• pp.88-94
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• 2003

This paper describes the design of the Ka-band Antenna/RF system, which was developed for the experiment of the high-speed satellite communications with geostationary satellite. The design issues described here are the ka-band characteristics for having an optimum performance. and the system characteristic for having a reliable and an extensional operation.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.21 no.11
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• pp.2932-2941
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• 1996

Conventional non-regenerative satellite repeaters do not provide anti-jamming capability enough to provide communications between small terminals in jamming environment. In this paper, we analyze the budget and system requirements for Ka-band satellite communication. For the analysis, we modeled and simulated the Ka-band satellite system based on downlink power limited repeater. Assuming that a spread spectrum is applied for anti-jamming purpose, we also analyzed a tolerable jammer-to-signal power ratio under strong up-link jamming in the bit rates of 2.4Kbps and 19.6Kbps.

• Proceedings of the IEEK Conference
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• 1999.11a
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• pp.829-832
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• 1999

KORTASAT-III is planning to provide Ka-band broadband communication service, including eastsouth Asia area. In this paper, we calculate the link budget for Ka-band KOREASAT-III multimedia service and describe the performance of multimedia services according to link design parameters. There are Trunk service, Television receive only service, Two-way point-to-multipoint service, Tele-education service in the service scenario.