• Title/Summary/Keyword: investigator

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Approaches to the Analysis of Case-Control Studies of the Efficacy of Screening for Cancer

  • Weiss Noel S.;Mcknight Barbara;Stevens Nancy G.
    • 대한예방의학회:학술대회논문집
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    • 1994.02b
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    • pp.188-195
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    • 1994
  • To an increasing extent, case-control studies are being undertaken to determine if use of early detection procedures is associated with reduced mortality from cancer. The authors recommend that in such studies the analysis focus on screening activity in cases that occurs during an interval prior to diagnosis in which the cancer is believed to be detectable and still curable and to a corresponding time period in controls. This approach places a heavy burden on the investigator to estimate accurately the period during which the tumor ought to be detectable using the test in question and to sort out reliably tests done in response to signs or symptoms of the cancer from screening tests per se. Nonetheless, the authors feel that it offers the greatest ability to discern a true benefit of screening, while minimizing the numerous potential biases that can be present in this type of study.

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Re-organization of Parametric epidermis (파라메트릭 표피 재 조직화)

  • Park, Jeong-Joo
    • Proceedings of the Korean Institute of Interior Design Conference
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    • 2008.05a
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    • pp.46-49
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    • 2008
  • This research does Complexity form, Interior epidermis cell re-organization, Object discovery that have correct numerical value concept by purpose. Research applied by Grid re-organization in form generation, Parameter variation of cell unit (morphor, tweener), Symbol, pattern of variation, self-organization cell substitution order. Representation through 3d digital modeler of polygon, Nurbs and street-sheet program(x,y,z coordinates & Network way of points) etc. of main work. Investigator specified numbers of U profiles*30, V point-20 that is 600 Paramaters individual in volume, and define circle radius of lighting in object, Projection size variously and tried difference. Transposition cell to point and Heightened brightness of color using pointillism of painting. Led lighting cell object is expressed being decoded by digital code.

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A Research of Legalization and Operating Methods for Preservation Districts of Historic Buildings -Case of Historic Districts in Japan- (전통마을보존사업의 시행방법 연구 -일본의 전통적건조물군보존지구제도(傳統的建造物群保存地區制度)와 비교-)

  • Kim, Ranky
    • Journal of the Korean Institute of Rural Architecture
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    • v.6 no.3
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    • pp.49-62
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    • 2004
  • This paper intends to analyze, present the problems in operating of conservation of the historic villages in Korea, in oder to improve the procedure and methods of restoration construction. Improvments are as follows. 1. Recognizing of historic village as cultural heritages to dewellers, 2. Understading of village to administraor and investigator, 3. Forming of mutual agreements with dewellers, 4. Establishing Conservation Act and making delibration organization in order to repair and restorate, 5. Minimalizing of inconvenences of dewellers. 6. Recognition of the individual specialities of the building in construction, and constructions, repairments, restorations in priceples of conservation. 7. Establishing the permission criterion, and managing by the Conservation Act.

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Estimation of Transition Probability on Two Successive Occasions Sampling with Randomized Response Technique

  • Lee, Kay-O
    • Communications for Statistical Applications and Methods
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    • v.6 no.3
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    • pp.761-770
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    • 1999
  • A combination procedure of successive occasions sampling and randomized response method is investigated. Randomized response technique is very simple for use in a telephone survey of a sensitive subject. In the suggested randomized response method. the interviewee replies "yes" or "no" to a randomly selected question and the investigator can estimate the proportion of "yes" or "no" answer. When this procedure is used on successive occasions, not only the proportion supporting a candidate and the time change in this supporting proportion can be derived but also the voters' swing in the trend of voters' support can be estimated. A numerical example is given to show how the suggested sampling strategy can be applied to a practical telephone survey.

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3 Cases of Postmenopausal Hot Flush Treated with Hwangryunhaedoktang-Gamibang (황연해독탕가미방(黃連解毒湯加味方)을 처방한 갱년기 안면홍조 환자 3례 증례 보고)

  • Lee, A-Rin;Son, Sang-Hyun;Park, Seon-Jeong
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.30 no.4
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    • pp.176-183
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    • 2017
  • Objectives : The purpose of this study is to report the effect of Hwangryunhaedoktang-Gamibang on Postmenopausal Hot Flushes. Methods : This case study was done on 3 Postmenopausal Hot Flush patients who have visited Korean Medicine Clinic. Hwangryunhaedoktang-Gamibang was prescribed to all 3 patients and evaluated the symptom change through photographs and questionnaire. Investigator's Global Assessment(IGA) was used to evaluate the objective symptom and Visual Analogue Scale(VAS) was used to evaluate the subjective change. Results & Conclusions : The IGA and VAS were decreased in all patients. Most symptoms of 3 patients were improved. As a result of examining IGA, VAS scores and photographs, Hwangryunhaedoktang-Gamibang can be effective on Postmenopausal hot flush.

Case Report of Facial Flush Treated by Gyejigamchoyonggolmoryeo-tang Based on Shanghanlun Provisions (『상한론(傷寒論)』 변병진단체계(辨病診斷體系)에 근거하여 계지감초용골모려탕(桂枝甘草龍骨牡蠣湯) 투여 후 호전된 안면홍조치험 1례)

  • Jung, Su-young;Kim, Yeon-ju;Lee, Sang-kee
    • 대한상한금궤의학회지
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    • v.12 no.1
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    • pp.91-99
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    • 2020
  • Objective: The aim of this study was to evaluate the effects of Gyejigamchoyonggolmoryeo-tang on facial flush. Methods: Facial flushwas evaluated using photographs and questionnaires. The (VAS) and investigator's global assessment were used to measure the improvement in facial flush symptoms. Results: The visual findings were. The VAS score decreased from 10 to 0 after administration of Gyejigamchoyonggolmoryeo-tang for 40 days. In addition, accompanying symptoms such as neck pain, palpitation, and insomnia were improved. These results indicated that Gyejigamchoyonggolmoryeo-tang was effective for emotional facial flush. Conclusions: This study shows the effective treatment of facial flush using Gyejigamchoyonggolmoryeo-tang based on the provisions of the Shanghanlun disease pattern identification diagnostic system.

Nummular Eczema Treated by Hoeyeok-tang Based on the Shanghanlun Disease Pattern Identification Diagnostic System (『상한론(傷寒論)』 변병진단체계(辨病診斷體系)에 근거하여 회역탕(回逆湯) 투여 후 호전된 화폐상 습진 증례 1례)

  • Lim, Eunkyo
    • 대한상한금궤의학회지
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    • v.13 no.1
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    • pp.155-164
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    • 2021
  • Objective: This study aimed to report the improvement of a patient with nummular eczema treated with Hoeyeok-tang based on Shanghanlun provisions. Methods: According to the disease pattern identification diagnostic system (DPIDS) based on the Shanghanlun provisions, the patient was diagnosed with lesser yin disease according to the 324th provision. The patient was treated with Hoeyeok-tang for 90 days. The severity of pruritus decreased, and changes in symptoms were estimated by a visual analog scale, Scoring Atopic Dermatitis Index and the Validated Investigator Global Assessment for Atopic Dermatitis. Results: The patient's symptoms were improved. The severity of pruritus decreased and they recovered from abrasions. Conclusions: This study suggests that the 324th provision of Shanghanlun refer directly to nummular eczema.

Improvement of Post-inflammatory Hyperpigmentation, Subsequent to Cold Atmospheric Plasma Treatment, in a Patient with Atopic Dermatitis

  • Lee, Mi Young;Won, Chong Hyun;Kim, Young Jae
    • Medical Lasers
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    • v.9 no.2
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    • pp.187-189
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    • 2020
  • Cold atmospheric plasma (CAP) is a material that generates free radicals through the ionization of air. Despite the application in various medical fields, the efficacy and safety of CAP on post-inflammatory hyperpigmentation due to atopic dermatitis have not been reported. Herein, we report the improvement in post-inflammatory hyperpigmentation of atopic dermatitis, after CAP treatment of three sessions weekly, 10 minutes per session. We examined the clinical severity indexes before and after treatment, including the Investigator's Global Assessment, modified Atopic Dermatitis Antecubital Severity, Eczema Area and Severity Index, and pruritus visual analogue scores. Our results indicate that CAP alleviates the post-inflammatory hyperpigmentation and clinical severity of atopic dermatitis, and effectively improves the atopic skin lesion without severe safety issues. We believe that the previously reported anti-bacterial effects and production of interleukin-6 after CAP treatment are probably responsible for the underlying mechanisms leading to clinical improvement.

The Relationship between MRO E-Commerce System and Purchase Effects

  • Kwon, Soon-Won;Kim, Young-Ei;Youn, Myoung-Kil;Jeon, Ta-Sik
    • Journal of Distribution Science
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    • v.8 no.3
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    • pp.5-15
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    • 2010
  • Business corporations have become specialized and on the basis of various interests try to strengthen their competitiveness through a cooperative system of purchase, distribution, service and IT technology. And an advanced Internet-based electronic commerce has witnessed explosive growth and a business-to-business (B2B) electronic commerce. Through E-marketplace. business corporations achieve such diverse utilities as expenditure curtailment, process reduction and prime cost reduction. And with business depression worldwide and soaring prices of materials, many business corporations consider the introduction of comprehensive purchase of MRO (maintenance, repair and operation) materials. The Purpose of this study was to examine the definition of B2B E-marketplace and the utilities of MRO commerce correctly focusing on an empirical analysis of cases of MRO supply and purchase business corporations. The indications acquired from this research results are as follows. Firstly, as for MRO integrated purchase under the characteristics of the market environment, it had to use the supplier obligatorily through the integrated purchase on the level of CEO's decision-making or the group rather than the voluntary will of the purchasing department or the procurement department. Secondly, as for the present B2B E-marketplace MRO purchase, the purchasing agency business has formed the mainstream, but it is aiming at the diversification of the benefit by supplementing/correcting the business model such as category type, mediation business type, MRO-type advancing in the store inclusive of the purchasing agency business, keeping pace with the potential market of MRO. Thirdly, as for analysis of the products, the purchaser wants more various products and assortment of goods than those of the present time, and also to be provided with the precise product information. Especially, as the importance of the product sourcing becomes high, the whole energy has been bestowed on acquirement of the excellent suppliers. Fourth, as for use of B2B E-marketplace MRO integrated purchasing system, there are the purchasing companies complaining the inconvenience even until now, and there is the demerit spending the long time during the image move and the process treatment. It shall try to shorten the searching time and the process treatment time as the system is centered on the purchaser. In order to enhance the efficiency of MRO E-marketplace purchase, followings must be considered: First, because the importance of product sources ever increases, an excellent supplier must be secured earnestly. Second, the time of process must be reduced focusing on purchasers. B2B E-marketplace will increase and diversify electronic commerce continuously. Through MRO E-marketplace, business corporations will reduce expenditure, achieve a transparent and speedy trade, and purchase products of fine quality, thus establishing a most effective market. In addition, in this study the investigator brings focus into MRO which has not been clearly discussed in the academic and business world so far and intensively highlights an indirect material-oriented expenditure curtailment effect. By taking all the aspects of supplier, purchaser and practical economical value into account, the investigator presents a strategic direction for the successful comprehensive purchase of B2B MRO.

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A Proposal for Research Process of Botanical Drug based Clinical Traditional Korean Medicine - Historical Evidence-Based Medicine II - (한의학임상에 기초를 둔 천연물신약 연구과정에 대한 소고 - 역사적 근거 발굴부터 천연물신약 임상시험계획승인신청까지 -)

  • Eom, Seok-ki;Kim, Se-hyun;Kim, Kyung-suk;Park, Sang-jae;Eo, Wan-kyu;Choi, Won-cheol
    • Journal of Korean Medical classics
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    • v.23 no.4
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    • pp.63-102
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    • 2010
  • Purpose : To propose various types of clinical research which is feasible for botanical new drug (IND) development processes, and suggest essential steps to development of study protocol for IND. Methods : Literature-based discussions and one research group's experience is given regarding domestic act, regulation, and system. Results : In order to get an approval of IND for botanical drug in Korea there are several types of clinical research to conduct. In quality control steps for standardized medicinal herbs, case reports or case series can be conducted, and for good manufacturing practice(GMP) steps, we can conduct case reports, case series, and retrospective cohort studies. In addition, as long as we gathered good laboratory practice(GLP) data we can conduct up to quasi-experimental studies and clinical trials including investigator initiated trials. In order to conduct these studies development of study protocol is essential. First, we obtain historical evidence including target disease and indication, efficacy, safety, and endpoints by reviewing medical classics. Second, we obtain clinically and statistically important data by conducting non-clinical studies, observation studies, and quasi-experimental studies. Third, we generate research hypotheses and purposes and explore methodologies, endpoints, clinical practice guidelines, cost-effectiveness, and commercial potential. Finally, we develop study protocol with aid of biostatistician or expert in contract research organization. Discussions and conclusions : This study have obvious limitations in that most thoughts, suggestions, and proposes are from one research group's experience. Therefore, we hope to see various types of research in this topic and process from other research group as well.