• The Journal of Internal Korean Medicine
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• v.41 no.6
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• pp.1089-1099
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• 2020

Objective: The purpose of this study was to investigate the effect of cinnamon on the treatment of Parkinson's disease (PD) and to introduce its use in Korea. Method: We searched the experimental studies in electronic databases (PubMed, CNKI, Wanfang, CiNii, J-STAGE, Science ON, and OASIS) using the key search terms "cinnamic acid", "cinnamon", "cinnamomum", "Parkinson's disease", "Parkinson disease", "Parkinsonism", and "dopamine". This study only involved experimental studies (in vivo and in vitro) that adopted cinnamon as a single administration and measured indicators relating to Parkinson's disease, including parkin, tyrosine hydroxylase (TH), and dopamine. Results: A Total of 11 literature studies were selected, and they all showed that treatment with cinnamon has a neuroprotective effect. Cinnamon activated neuroprotective factors and restored neurotransmitters and it reduced the rate of oxidative stress and inflammation in neurons. As a result, cell viability was upregulated, while cell apoptosis and neurodegeneration were downregulated. Five in vivo studies, through behavioral tests, also confirmed that cinnamon recovers locomotor function in PD models. Conclusion: We identified that cinnamon is an effective neural protector and improves motor performance in behavioral testing in the experimental PD studies.

• The Journal of Internal Korean Medicine
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• v.41 no.6
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• pp.1078-1088
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• 2020

Objective: The purpose of this study was to investigate the effect of amorfrutin of licorice for Type2 diabetes mellitus. Method: The PubMed, CNKI, Wanfang, OASIS, NDSL, J-STAGE, and CiNii databases were searched from the beginning of the search to September 20, 2020, with no limits on language. Extractions and selections from the literature were made by two authors. The study included in vivo experiments with amorfrutins in high-fat diet-induced obesity C57BL/6 mice and leptin receptor-deficient db/db mice and in silico studies. Results & Conclusion: Four studies were finally selected. We confirmed that amorfrutin treatment considerably improved insulin sensitivity and glucose tolerance and reduced plasma insulin and glucose. Amorfrutins bind to and selectively activate Peroxisome Proliferator-Activated Receptor Gamma (PPARγ), which plays an important role in glucose metabolism. Amorfrutins also strongly bind to the glucagon receptor (GCGR) and work as antagonist. Using the amorfrutins from licorice could therefore be helpful in treating type2 diabetes mellitus.

• The Journal of Internal Korean Medicine
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• v.43 no.4
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• pp.720-737
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• 2022

Objectives: To compare the effectiveness and safety of East Asian traditional medicine treatments (EATMT) versus conventional management in patients following heart valve replacement surgery. Methods: We searched several databases, including the Korean Studies Information Service System, PubMed, China National Knowledge Infrastructure, and Citation Information by NII. The search range included randomized controlled trials from each first issue until June 27, 2021. Two review authors independently extracted the data. We assessed the risk of systematic errors by evaluating risk domains using the "Risk of bias" tool. Results: We included 5 trials in the review. In the EATMT, the investigators reported significant improvements in reshaping of the heart structure: left ventricular end diastolic diameter (MD -4.43, 95% CI -6.06 to -2.79; 130 participants; 2 studies; high evidence). Comparisons with usual care revealed a significant decrease in gastrointestinal complications rate (OR 0.30, 95% CI 0.20 to 0.47; 503 participants; 2 studies; high evidence). We assessed 4 studies as having a low risk of bias and 1 study as having a high risk of bias. Conclusion: This systematic review suggests that East Asian traditional medicine interventions may be effective in preventing and alleviating complications, but we found evidence of important trade-offs between known benefits and known adverse effects in cardiac dysfunction and inflammation following heart valve replacement. Consequently, additional high-quality studies should be conducted.

• The Journal of Internal Korean Medicine
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• v.44 no.6
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• pp.1197-1211
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• 2023

Objectives: This study presents evidence by analyzing the research trends in acupuncture treatment for cluster headache in the last 10 years. Methods: Randomized controlled trials (RCTs) about acupuncture for cluster headache were searched from the China National Knowledge Infrastructure, PubMed, Cochrane Library, Oriental Medicine Advanced Searching Integrated System, ScienceON, Korean Studies Information Service System, and Research Information Sharing Service. The search terms were the combinations of "cluster headache", "acupuncture", and "needle therapy", and the articles were restricted to those published between 2013 and 2023. Only RCTs were selected. The risk of bias (RoB) was assessed according to the revised Cochrane RoB2 criteria. Results: Six RCTs were selected and analyzed in this review. All selected studies were conducted in China. All RCTs comprised 628 participants. Manual acupuncture was used in all studies. Acupuncture targeting the sphenopalatine ganglion was performed in two papers published after 2020. ST8, Ex-HIN3, and GB14 were the most frequently used acupoints in acupuncture treatment. The most commonly used indicators for evaluation were headache attack frequency, clinical efficacy, and the visual analog scale. In each study, adding acupuncture treatment to conventional therapy had significant effects in relieving the symptoms of cluster headaches. Conclusion: The results suggest that acupuncture is an effective treatment for cluster headache. To ensure objective evidence for the effectiveness of acupuncture treatment in cluster headache, it is important to continue large-scale case reports and RCTs.

• Tuberculosis and Respiratory Diseases
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• v.56 no.1
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• pp.67-76
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• 2004

Background : Pulmonary hypertension is a poor prognostic factor in patients with chronic respiratory disease. However, diagnosing pulmonary hypertension is a difficult procedure which often requires an invasive test. Thus new alternative biochemical markers would be useful in clinical field and are in search. We sought to assess the role of plasma N-terminal pro-brain natriuretic peptide(NT-proBNP) in patients with pulmonary hypertension. Method : We measured plasma NT-proBNP level in twenty nine patients suspected for pulmonary hypertension. Pulmonary hypertension was defined as being right ventricular systolic pressure more than 35 mm Hg estimated by Doppler echocardiography. Plasma NT-proBNP level was measured by electrochemiluminescence sandwich immunoassay. Results : The log-transformed values for plasma NT-proBNP levels showed a linear correlation (correlation coefficiency: 0.783, p-value <0.001) with right ventricular systolic pressure. Plasma NT-proBNP levels closely correlated with right ventricular systolic pressure, right ventricular hypertrophy, interventricular septal flattening and right ventricular dilatation. Conclusion : Our results suggest that the measurement of plasma NT-proBNP level is an useful marker of the presence of pulmonary hypertension.

• Journal of Oriental Neuropsychiatry
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• v.25 no.4
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• pp.333-350
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• 2014

Objectives: The purpose of this study was to research learning based on brain science and the learning methodology of Korean Medicine according to disparity of age. Through this, the study aimed to provide a guideline to related Korean Medicine treatments as well as the common nurturing/educational institutions. Methods: All journals and dissertations on brain science based learning methods studied in Korea to date that could be found in the National Assembly Library and the RISS were implemented in the analysis. The terminology used for search was as follows: 1st search, 'Brain'; 2nd search, 'Learning', 'Education'; 3rd search, 'Baby, 'Infant', 'Child'. For the learning methodology of Korean Medicine according to disparity of age, the related contents were extracted from Donguibogam and Liuyi, Sasang constitutional medicine. Results: A total of 30 studies, were collected as data. In the baby stage, the development and myelination of brain neurons are accelerated by experience and learning, highly influenced by social, cognitive and emotional movement. In infancy, the frontal lobe actively develops, so education for development of the prefrontal cortex is suggested. The brain of the infant at this stage can be developed by arts and physical education. In the child stage, the parietal and temporal lobe develop actively. Thus, programs to stimulate brain activity including brain respiration would be helpful in enhancing learning ability, concentration, etc. As evidence for learning and nurturing methodology according to disparity of age from Korean Medicine prospective, the following are listed: Location and time for sexual intercourse before pregnancy, stabilization during pregnancy, baby nurturing methods for nurturing from Donguibogam. Also Liuyi and Sasanag constitutional medicine can be the learning methodology according to disparity of age. And there are acupuncture points on each head section according to age in Donguibogam. Conclusions: Studies on 'brain-science based learning' are continuously being conducted. Based on these studies, diverse new brain-science based learning will be developed in the future. There is also a need to develop the learning methodology of Korean Medicine according to disparity of age in a more systematic and diverse way.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.1
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• pp.41.1-41.1
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• 2015

Hierarchical galaxy formation models under LCDM cosmology predict that the most massive structures such as galaxy clusters (M > $10^{14}M_{\odot}$) appear late (z < 1) in the history of the universe through hierarchical clustering of small objects. Galaxy formation is also expected to be accelerated in overdense environments, with the star formation rate-density relation to be established at z ~ 2. In this talk, we present our search of massive structures of galaxies at 0.7 < z < 4, using the data from GOODS survey and our own imaging survey, Infrared Medium-deep Survey (IMS). From these studies, we find that there are excess of massive structures of galaxies at z > 2 in comparison to the Millennium simulation data. At 1 < z < 2, the number density of massive structures is consistent with the simulation data, but the star formation history is more or less identical between field and cluster. The star formation quenching process is dominated by internal process (stellar mass). The environmental effect becomes important only at z < 1, which contributes to create the well known star formation-density relation in the local universe. Our results suggest that galaxy formation models under LCDM cosmology may require further refinements to match the observation.

• Korean Journal of Adult Nursing
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• v.23 no.6
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• pp.527-542
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• 2011

Purpose: This paper is a report of an analysis of the concept of pro-environmental health behavior. Methods: Rodgers' method of evolutionary concept analysis was used to analyze the concept. A literature search using keywords 'pro-environmental health behavior, 'environmental health behavior', and 'eco-friendly health behavior' was conducted using PubMed, CINAHL, PsychINFO, and RISS and utilizing the results published from 1983 to 2011. Database and bibliographic searches yielded 84 records. Results: Four critical attributes of pro-environmental health behavior were identified as 'prevention and protection', 'internal process', 'altruism', and 'alternative'. Antecedents to pro-environmental health behavior were climate change, environmental pollution, and health risk. The consequences of pro-environmental health behavior were individual and social behavioral changes. Conclusion: The concept of pro-environmental health behavior developed in this project may offer information to be considered as the concept is further develop and efforts are made to measure the attributes of pro-environmental health behavior.

• Proceedings of the Korea Contents Association Conference
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• 2006.11a
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• pp.213-217
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• 2006

4 panels Comic Strips spreads it's story with introduction, development, turn and conclusion. The structure of introduction, development, turn and conclusion adds to the fun of story through the envelopment of deduction, induction so in the work the narrative structure is unfolded so many evolutions in order to communicating with further effective and funny. Therefore the study is mostly mended deduction, induction unfolding on the 4 panels comic strips. The purpose of this study is based on search for formation of the story and comparison of humor comic strips and satire comic strips through analysis of the narrative structure on 4 panels comic strips in internal and external.

• Journal of the Korean Society of Costume
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• v.52 no.4
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• pp.75-85
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• 2002

The degree of involvement was known to shape the types of decision- process behavior of consumers. The types of information search would be influenced according to the degree of involvement. The purpose of this study was to find out the fashion information sources used in clothing purchase, and to clarify the interrelationship of clothing involvement and information sources. The middle and high school girls in Seoul were the subjects of the study. The information sources were classified into three types; marketer-oriented, internal and personal sources. Fashion informations spreaded by mass media were the most diversely used by teens. Among fashion information sources, ‘my own thoughts and experiences’ was counted as the most important one. And ‘interior and display of the shop’ was more important than the other marketer-oriented informations. Clothing involvement in the aspect of pleasure/symbol showed meaningful correlation with the information of ‘street fashion’, but in the aspect of fashion consciousness, ‘fashion of movie stars and celebrities’was the most significant information source. It seemed that ‘fashion articles in the magazines’ was used to reduce perceived risk in clothing purchase.