• Tuberculosis and Respiratory Diseases
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• 제69권6호
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• pp.456-464
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• 2010

Background: Synergistic antitumor effects of the combined chemoimmunotherapy based on dendritic cells have been reported recently. The aim of this study is to search new applicability of gefitinib into the combination treatment through the confirmation of gefitinib effects on the monocyte derived dendritic cells (moDCs); most potent antigen presenting cell (APC). Methods: Immature and mature monocyte-derived dendritic cell (im, mMoDC)s were generated from peripheral blood monocyte (PBMC) in Opti-MEM culture medium supplemented with IL-4, GM-CSF and cocktail, consisting of TNF-${\alpha}$ (10 ng/mL), IL-$1{\beta}$ (10 ng/mL), IL-6 (1,000 U/mL) and $PGE_2$ ($1{\mu}/mL$). Various concentrations of gefitinib also added on day 6 to see the influence on immature and mature MoDCs. Immunophenotyping of DCs under the gefitinib was performed by using monoclonal antibodies (CD14, CD80, CD83, CD86, HLA-ABC, HLA-DR). Supernatant IL-12 production and apoptosis of DCs was evaluated. And MLR assay with $[^3H]$-thymidine uptake assay was done. Results: Expression of CD83, MHC I were decreased in mMoDCs and MHC I was decreased in imMoDCs under gefitinib. IL-12 production from mMoDCs was decreased under $10{\mu}M$ of gefitinib sinificantly. Differences of T cell proliferation capacity were not observed in each concentration of geftinib. Conclusion: In spite of decreased expressions of some dendritic cell surface molecules and IL-12 production under $10{\mu}M$ of gefitinib, significant negative influences of gefitinib in antigen presenting capacity and T cell stimulation were not observed.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 2003년도 ISIS 2003
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• pp.439-442
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• 2003

In order to solve the difficulties of parameter settings in SA algorithm, an improved practical SA algorithm is proposed by employing the threading techniques, appropriate software structures, and dynamic adjustments of temperature parameters. Threads provide a mechanism to realize a parallel processing under a disperse environment by controlling the flux of internal information of an application. Thread services divide a process by multiple processes leading to parallel processing of information to access common data. Therefore, efficient search is achieved by multiple search processes, different initial conditions, and automatic temperature adjustments. The proposed are methods are evaluated, for three types of Traveling Salesman Problem (TSP) (random-tour, fractal-tour, and TSPLIB test data)are used for the performance evaluation. The experimental results show that the computational time is 5％ decreased comparing to conventional SA algorithm, furthermore there is no need for manual parameter settings. These results also demonstrate that the proposed method is applicable to real-world vehicle routing problems.

• 한국컴퓨터정보학회논문지
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• 제3권2호
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• pp.69-76
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• 1998

논리형 집적회로의 내부 결함을 검증하기 위해서는 설정된 초기 값을 전파하여 최종 출력 단에 나타난 값과 결함이 없을 경우의 출력 값을 비교함으로써 검증할 수 있다. 입력 단자의 수가 N인 회로에서 모든 내부신호 선의 결함을 검출하기 위해서는 최대 2N개의초기 입력 값들로 구성된 검증 패턴이 필요하다. 본 논문에서는 다 출력회로에서 2N개의 입력 패턴 중, 모든 신호선의 결함을 검출 할 수 있는 최소의 입력패턴 집합을 빠르고 정확하게 생성하기 위한 방법으로 다 출력회로를 출력과 연관된 세부회로로 분리하여 각각 검증함으로써 탐색공간을 줄이는 방법을 제안한다. 이는 입력 패턴의 길이가 상대적으로 줄어들 뿐 아니라 관련이 없는 신호 선을 탐색하지 않으므로 검증 패턴 생성 시간이 감소함으로써기존의 패턴 생성 알고리즘보다 효과적인 검증 패턴의 생성이 가능하다.

• 한국정보통신학회논문지
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• 제17권11호
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• pp.2486-2491
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• 2013

세라믹 소재 영상은 사람의 육안으로 판단하기 힘든 내부 기공이나 균열, 이물질 등의 결함들이 존재한다. 본 논문에서는 사람의 육안으로 검출하기 힘든 세라믹 소재로 이루어진 파이프 용접부에 있는 결함을 확인하기 위해 ART2 알고리즘을 이용하여 세라믹 영상에서 결함을 검출하는 방법을 제안한다. 비파괴 검사는 본질에 손상이 전혀 가지 않는 검사 방법이기 때문에 소재의 결함 검출에 대해서는 적절한 방법이다. 따라서 본 논문에서는 Ends-In Search Stretching 기법을 적용하여 명암 대비를 강조하고, 명암 대비가 강조된 영상에서 삼각형 타입의 소속 함수를 이용한 퍼지 이진화 기법을 적용한 후, 임의의 패턴 입력에 대해서도 효과적으로 특징을 분류하는 개선된ART2 알고리즘을 적용하여 결함 영역을 검출한다. 제안된 방법을 세라믹 소재 영상을 대상으로 실험한 결과, 기존의 방법보다 효율적으로 결함이 검출되는 것을 확인하였다.

• 동의신경정신과학회지
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• 제23권1호
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• pp.17-29
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• 2012

Objectives : The study was designed to evaluate the effects of scalp acupuncture treatment on patients with insomnia in China. Methods : A journal search was performed using China National Knowledge Infrastructure(CNKI) from 1994 to 2011. Key words used within the search were 'insomnia' and 'scalp acupuncture'. Results : 19 studies were selected. 9 RCTs and 2 case control studies showed that scalp acupuncture therapy reported better results than routine acupuncture, western medicine, and herbal medicine therapy. 8 case reports described a significant improvement in patients with insomnia by scalp acupuncture. Conclusions : There have been many studies regarding scalp acupuncture on patients with insomnia in China and these studies can be applied to clinical practices within Korea.

• Journal of Acupuncture Research
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• 제31권1호
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• pp.35-42
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• 2014

Objectives : Type analysis and comparison among three decades are done on papers published in The Journal of Korean Acupuncture and Moxibustion from the inaugural issue to the last issue of 2013, Vol 30(5). Methods : Journal search engine at 'theacpuncture' and 'kamms' were used. Issues not searched in these two search engines were not included in the analysis. Results : The number of journals in the thirty years of the journal history included 2081 articles. For type analysis of the articles, experiment articles outnumbered other types with 743 papers followed by 564 review articles, 601 clinical articles, and 156 case articles. In comparison among three decades, recent ten years outnumbered the other types with 1060 papers followed by 853 papers in the middle decade and 168 papers at the initial decade. Conclusion : In the thirty years of the journal history, the research has become more actively done in the recent decade.

• 한국정보통신학회논문지
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• 제18권11호
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• pp.2691-2696
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• 2014

SNOMED CT는 전자의무기록(EMR) 및 전자건강기록(EHR) 시스템에서 표준화된 용어를 사용하여 진로기록을 작성하고 관리하기 위한 표준 의학용어 체계이다. 이 용어체계는 용어의 방대함 및 설계 구조로 인해 용어 체계가 매우 복잡한 특징이 있다. SNOMED CT에서 제공하는 의학 용어를 검색하기 위해 진료 과정에서 사용하는 기존의 브라우저들은 용어체계의 복잡성을 반영하지 못하여 진료기록의 작성 단계에서 그 효용성이 떨어지는 문제가 있다. 본 연구에서는 SNOMED CT 브라우저에 내재된 문제점을 제시하고 용어체계의 분석을 통해 의학 용어를 빠르고 효율적으로 검색하기 위한 검색 브라우저의 요건을 분석하고 개선안을 제시한다.

• 대한전기학회논문지
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• 제45권1호
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• pp.113-122
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• 1996

As integrity of semiconductor device is increased, accurate and efficient modeling and recipe generation of semiconductor fabrication procsses are necessary. Among the major semiconductor manufacturing processes, dry etc- hing process using gas plasma and accelerated ion is widely used. The process involves a variety of the chemical and physical effects of gas and accelerated ions. Despite the increased popularity, the complex internal characteristics made efficient modeling difficult. Because of difficulty to determine the control input for the desired output, the recipe generation depends largely on experiences of the experts with several trial and error presently. In this paper, the optimal control of the etching is carried out in the following two phases. First, the optimal neural network models for etching process are developed with genetic algorithm utilizing the input and output data obtained by experiments. In the second phase, search for optimal control inputs in performed by means of using the optimal neural network developed together with genetic algorithm. The results of study indicate that the predictive capabilities of the neural network models are superior to that of the statistical models which have been widely utilized in the semiconductor factory lines. Search for optimal control inputs using genetic algorithm is proved to be efficient by experiments. (author). refs., figs., tabs.

• 대한한방내과학회지
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• 제39권3호
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• pp.338-349
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• 2018

Objective: The purpose of this study is to investigate recent clinical studies on the effects of acupuncture on dementia. Method: We searched RCTs (randomized controlled trials) using the database PubMed (2000-2018). Clinical RCT studies of acupuncture used to treat dementia in humans were included. Nine randomized controlled trials were included. Results: Various acupoints such as Baihui (GV20), Sishencong (EX-HN1), Fengchi (GB20), and Shenting (GV24) were used to treat symptoms. The studies reported a decrease in evaluation criteria, such as the Mini Mental State Examination (MMSE) and activities of daily living (ADL), for measuring cognitive ability. The acupuncture process, the results for outcome measure, and the effectiveness of studies were analyzed. We then assessed "risk of bias." Conclusions: Through this review, we found that acupuncture is applicable for the treatment of dementia. This can be used for future study.

• 대한한방내과학회지
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• 제33권2호
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• pp.160-171
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• 2012

Background and Objective : Warfarin is the standard anticoagulation treatment for atrial fibrillation, venous thromboembolism (VTE), and mechanical heart valves. Close monitoring of the International Normalized Ratio (INR) is required due to the drug's very narrow therapeutic window. Many factors can affect INR levels. Drug and food interactions are frequently cited as causes of adverse events with warfarin. We discussed interactions between herbs and warfarin studied in this research. Methods : In this review, PubMed was used to search medical journals. Keywords "warfarin AND interaction" were applied. Results : 55 articles were included. The possibility of correlation between warfarin and single herbal medicines such as Salviae Miltiorrhizae Radix, Angelicae Gigantis Radix, Ginseng Radix Alba, Lycii Fructus, Ginkgo Folium, Menthae Herba, Trigonellae semen was suggested. Furthermore, some herbal compounds interacting with warfarin were reported. The conclusion of studies reporting the effect of herbal medicine on warfarin were controversial due to small size or quality of research. Conculsions : We suggest that we should prescribe therapeutic herbal medicines to patients using warfarin more carefully and do INR follow-up regularly.