• Journal of Veterinary Science
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• 제21권3호
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• pp.42.1-42.22
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• 2020

Regenerative medicine using stem cells from various sources are emerging treatment modality in several refractory diseases in veterinary medicine. It is well-known that stem cells can differentiate into specific cell types, self-renew, and regenerate. In addition, the unique immunomodulatory effects of stem cells have made stem cell transplantation a promising option for treating a wide range of disease and injuries. Recently, the medical demands for companion animals have been rapidly increasing, and certain disease conditions require alternative treatment options. In this review, we focused on stem cell application research in companion animals including experimental models, case reports and clinical trials in dogs and cats. The clinical studies and therapeutic protocols were categorized, evaluated and summarized according to the organ systems involved. The results indicate that evidence for the effectiveness of cell-based treatment in specific diseases or organ systems is not yet conclusive. Nonetheless, stem cell therapy may be a realistic treatment option in the near future, therefore, considerable efforts are needed to find optimized cell sources, cell numbers and delivery methods in order to standardize treatment methods and evaluation processes.

• Journal of Yeungnam Medical Science
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• 제40권4호
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• pp.435-441
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• 2023

Pheochromocytomas and paragangliomas (PPGLs) may secrete hormones or bioactive neuropeptides such as interleukin-6 (IL-6), which can mask the clinical manifestations of catecholamine hypersecretion. We report the case of a patient with delayed diagnosis of paraganglioma due to the development of IL-6-mediated systemic inflammatory response syndrome (SIRS). A 58-year-old woman presented with dyspnea and flank pain accompanied by SIRS and acute cardiac, kidney, and liver injuries. A left paravertebral mass was incidentally observed on abdominal computed tomography (CT). Biochemical tests revealed increased 24-hour urinary metanephrine (2.12 mg/day), plasma norepinephrine (1,588 pg/mL), plasma normetanephrine (2.27 nmol/L), and IL-6 (16.5 pg/mL) levels. ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography/CT showed increased uptake of FDG in the left paravertebral mass without metastases. The patient was finally diagnosed with functional paraganglioma crisis. The precipitating factor was unclear, but phendimetrazine tartrate, a norepinephrine-dopamine release drug that the patient regularly took, might have stimulated the paraganglioma. The patient's body temperature and blood pressure were well controlled after alpha-blocker administration, and the retroperitoneal mass was surgically resected successfully. After surgery, the patient's inflammatory, cardiac, renal, and hepatic biomarkers and catecholamine levels improved. In conclusion, our report emphasizes the importance of IL-6-producing PPGLs in the differential diagnosis of SIRS.

• Tuberculosis and Respiratory Diseases
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• 제63권5호
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• pp.423-429
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• 2007

연구배경: 급성폐손상과 급성호흡곤란증후군 대상자에서 폐포모집술의 적절한 방법에 대해서는 정해진 것이 없다. 이 연구를 통해 폐포모집술들 중 압력조절환기법을 이용한 폐포모집술의 효과와 안정성을 확인하고자 하였다. 방 법: 급성폐손상 및 급성호흡곤란증후군에 해당하는 대상자들을 대상으로 압력조절환기 방식에서 $30cmH_2O$의 흡입압력과 $20cmH_2O$의 호기말양압으로 2분 동안 폐포모집술을 시행하였다. 동맥혈 산소분압, 정맥혈 산소포화도, 혈압과 맥박, 중심정맥압, 폐탄성, 호기말양압, 흉부 X-ray를 시술 전 후로 확인하였다. 결 과: 16명의 대상자들 중에서, 3명은 폐외 급성폐손상 및 급성호흡곤란증후군 대상자였고 나머지 13명은 폐내 급성폐손상 및 급성호흡곤란증후군 대상자였다. 평균 나이는 $61.0{\pm}11.8$세였고, 평균 APACHE II score는 $21.6{\pm}11.9$이었으며, SAPS score는 $44.6{\pm}14$이었다. 폐포모집술 시행 전, 평균 호기말양압은 $11.3{\pm}1.5mmHg$이었으며 평균 동맥혈산소분압/흡입산소분율은 $130.3{\pm}60.2$이었다. 폐포모집술 시행 20분 후, 동맥혈산소분압/흡입산소분율의 비를 측정하여 50% 이상 상승한 경우를 반응군으로 50% 이하로 상승하거나 감소한 경우를 비반응군으로 분류하였다. 8명의 대상자들은 반응군이었고 8명의 대상자들은 비반응군이었다. 두 군간의 인구학적인 특성과 기계호흡의 패턴, APACHE II score, SAPS score, 동맥혈산소분압/흡입산소분율과 혈역동학적 특성 사이에는 차이가 없었다. 폐포모집술 이후, 동맥혈산소분압/흡입산소분율의 비는 상승하였다(p<0.001). 그 최대치는 폐포모집술 이후 60분에서 관찰되었다. 동맥혈 이산화탄소분압은 상승하는 경향을 보였다(p=0.05). 폐포모집술 전 후의 평균동맥압의 차이는 없었다(p=0.08). 기흉 등의 압력 손상에 의한 합병증은 없었으며, 단 한 예에서만 혈압 저하로 인해 폐포모집술을 중단하였으나 수액 공급 후 바로 회복되었다. 결 론: 본 연구를 통해서, 압력조절환기를 이용한 폐포모집술은 급성폐손상 및 급성호흡곤란증후군 대상자에서 산소화의 개선을 보였다. 또한 혈역학적 부작용은 거의 없었으며 고압력에 의한 합병증은 없었다. 따라서 압력조절환기를 이용한 폐포모집술은 폐보호전략과 더불어 임상적인 유용성과 안전성이 있을 것으로 기대된다.

• 대한족부족관절학회지
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• 제17권3호
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• pp.174-181
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• 2013

Distal tibia fractures were mainly caused by high energy trauma and the lower legs were enveloped in poor soft tissue. Therefore, there are many open fractures and concomitant soft tissue injuries in distal tibia fractures. For the restoration of ankle function, the surgical treatment was performed in distal tibia fractures. However, it is difficult to treat the distal tibia fracture surgically. There are many complications in distal tibia fracture due to highly comminuted fracture and poor soft tissue condition. There are many surgical methods for distal tibia fractures, such as, external fixator, intramedulary nailling, open reduction & internal fixation, and minimally invasive plate osteosynthesis. We reviewed the surgical treatments of distal tibia fractures.

• Clinics in Shoulder and Elbow
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• 제1권1호
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• pp.128-131
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• 1998

Fracture of the clavicle and dislocation of the acromioclavicular joint occur commonly as separate injuries. However, complete acromioclavicular dislocation with an ipsilateral clavicle fracture is quite rare. We experienced a case of acromioclavicular joint dislocation associated with fracture of clavicle and brachial plexus injury treated by open reduction and internal fixation.

• Journal of Korean Neurosurgical Society
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• 제56권6호
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• pp.537-539
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• 2014

Penetrating cerebral injuries caused by foreign bodies occur rarely due to the substantial mechanical protection offered by the skull. Throughout most of history, the brain, residing in a "closed box" of bone, has not been vulnerable to external aggression. Recently, we encountered a serious penetrating craniocerebral injury caused by a nail gun. Total excision of the offending nail via emergency craniotomy was performed, but the patient's neurologic status was not improved in spite of aggressive rehabilitative treatment. Here, we report on this troublesome case in light of a review of the relevant literature.

• Journal of Chest Surgery
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• 제17권3호
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• pp.488-491
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• 1984

Vascular injuries from gun shot wound is rare in these days, in Korea. A Case of false aneurysm of the right common carotid artery due to penetrating injury to the neck by carbine. The confirmatory diagnosis was made by right carotid angiogram which revealed bean-sized aneurysmal sac at the mid-portion of the right common carotid artery. Despite of no symptoms, emergency false aneurysmectomy and reconstruction with on-lay vein patch graft using left greater saphenous vein for threat of rupture and embolization from mural thrombi. During repair of common carotid artery, cerebral circulation was maintained with internal shunt. The postoperative course was uneventful except limit of motion of right upper extremity due to initial injury.

• Journal of Korean Neurosurgical Society
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• 제45권1호
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• pp.32-34
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• 2009

The common carotid artery generally bifurcates into the internal and external carotid arteries at the level of C3-4. Injury to the common carotid artery during anterior cervical discectomy is a complication that is very much feared but encountered rarely. Knowing the anatomic variations of the common carotid artery and using an operating microscope during the anterior cervical approach for cases with low-lying bifurcation of the common carotid artery would prevent injuries to this artery. We present a 42-year-old female who has successfully undergone anterior cervical discectomy at the level of C5-6 and C6-7. She had a low-lying bifurcation of the common carotid artery.

• 대한관절경학회지
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• 제2권2호
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• pp.173-176
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• 1998

Isolated posterior cruciate ligament injuries are rare and their management is controversial. But, there is general concept that a bony avulsion of posterior cruciate ligament should be repaired. The treatments for the bony avulsion of posterior cruciate ligament were conservative treatment, open reduction and internal fixation and arthroscopic fixation. We report 2 cases of posterior cruciate ligament avulsion fractures, which were arthroscopically reduced and stabilized with cannulated screws and Kirschner wires, and introduce the arthroscopic fixation technique.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2005년도 춘계 국제심포지엄 및 학술대회
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• pp.153-154
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• 2005