• 제목/요약/키워드: intermediates

검색결과 669건 처리시간 0.031초

헤테로환성 아민기를 갖는 신규 택솔유도체의 합성 (Synthesis of Novel Taxol Analogues with Heterocylclic Amino Moieties)

  • 박해일
    • 약학회지
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    • 제45권4호
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    • pp.321-327
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    • 2001
  • The synthesis of novel taxol analogues with an amine moiety at the 7- and 10-positions to examine the BBB penetration was described. The analogues were synthesized from 2'-O-(tert-butyldim-ethylsilyl)taxol and 2'-0-(tert-butyldimethylsilyl) -7-O-(triethylsilyl)-10-deacetyltaxol, the key intermediates, in 2 steps via the esterification with heterocyclic amino acids and the subsequent desilylation reaction.

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효소를 이용한 광학분할 (Chiral Resolution Using Enzymes)

  • 이은교;정봉현
    • KSBB Journal
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    • 제15권5호
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    • pp.415-422
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    • 2000
  • Enzymatic resolution is becoming increasingly important in the production of optically active pharmaceutical drugs and is now challenging the traditional synthetic methods for production of a variety of chiral intermediates and products. This article reviews the recent advances in chirotechnology using enzymes as a catalyst to resolve chiral compounds. The review focuses on the recent trends in chirotechnology and the application of enzymes to the production of industrially valuable pharmaceutical drugs.

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