• Biomedical Science Letters
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• v.27 no.3
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• pp.121-133
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• 2021

Antibody-drug conjugates (ADCs) are drawing much interest due to its great potential to be one of the important options in cancer treatments. ADCs are acting like a magic bullet which delivers cytotoxic drugs specifically to cancerous cells throughout the body, thus attacks these cells, while not harming healthy cells. ADCs are complex molecules that are composed of an antibody having targeting capability and linked-payload or cytotoxic drug killing cancerous cells. The key factors of the success in the development of ADC are selection of appropriate antibody, cytotoxic payload and linker for conjugation. Recently there was considerable progress in ADCs development, and a large number of ADCs gained US FDA approval. About 80 new ADCs are under active clinical studies. In this review we present a brief introduction of the US-FDA approved ADCs and global situation in the clinical studies of ADC pipelines. We address an overview on each component of an ADC design such as target antigens, payloads, linkers, conjugation methods, drug antibody ratio. In addition, we discuss on the trend of ADC market where global big pharmas and domestic biopharmaceutical companies are competing to develop safer and more effective ADCs.

• Journal of the Korea Institute of Military Science and Technology
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• v.21 no.6
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• pp.894-903
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• 2018

In the case of helicopters, the development of parts technology is rapidly changing, and the complexity is rapidly increasing. Particularly, the surge of various electric and electronic systems is recognized as a problem that is directly related to the safety of the helicopter. Due to these problems, there is a growing interest in reliability evaluation in the face of the problem of confirming and certifying the reliability of parts in the development stage. In this paper, the analysis of the failure mechanism of the wiper system was carried out, and the priority and importance of each failure mode were checked by using the results, and major stress factors were derived and the corresponding acceleration model was selected. Also, the accelerated lifetime test time was calculated according to the life test time, acceleration status and acceleration level of the steady state by using the selected acceleration model and characteristic values.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2014.05a
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• pp.668-671
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• 2014

Wiress high-speed internet network and Mobile devices such as smartphones and tablets are popular, production and consumption of information is changing from the PC environment to mobile environment. Thus, the development of related programs in the development of mobile applications than PC is dramatically increasing. In particular, A tool that is very easy to manufacture mobile app are emergence, Professionals, as well as increasing the public's interest. In this paper, when create a moblie apps, copyright and software license to be considered are examined.

• PNF and Movement
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• v.17 no.2
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• pp.253-261
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• 2019

Purpose: The purpose of this study was to identify the causal relationship between workplace stress and working posture and the development of work-related neck pain in office workers. Methods: The study participants included 62 office workers who had not experienced neck pain in the previous 12 months. A battery of measures to evaluate potential workplace risk factors in an office setting were conducted at baseline, and the 12-month incidence of work-related neck pain was reported via monthly questionnaires. Survival analysis was used to evaluate the longitudinal relationship between the workplace risk factors and the development of work-related neck pain. Results: The incidence of work-related neck pain was 1.91 (95% CI: 1.06-3.45) per 100 person months. The incidence of neck pain was predicted to be less likely to happen when workers had a more upright thorax posture during computer work (hazard ratio, 0.94; 95% CI: 0.89-0.99). However, stress may deteriorate the preventative effects of other risk factors on neck pain and showed a positive relationship with episodes of neck pain (hazard ratio, 1.37; 95% CI: 1.03-1.84). Conclusion: Understanding the psychophysiological effects of neck pain may explain the development of neck pain in office workers. Our interest in prevention plans and treatments should therefore involve a multifactorial pathology of neck pain in the workplace.

• Advances in Energy Research
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• v.6 no.1
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• pp.17-33
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• 2019

This study aimed to observe trends in the literature on research, development, and innovation management in the energy sector, using performance assessment systems. The paper presented a bibliometric analysis of 40 studies on the subject. These materials come from ScienceDirect, Scopus and the Institute of Electrical and Electronics Engineers (IEEE) databases from 2006 to 2016. The results showed an increasing trend in the number of publications on the theme, showing the scientific community's interest in the subject. In addition, it was verified that the predominant language used to write the publications was English, the country that most published articles in the area was Brazil and most of the articles were produced through collaboration between researchers. It was found that the journal with the greatest number of publications on the subject was the Procedia - Social and Behavioral Sciences, while the Expert Systems with Applications journal presented the article with the greatest number of citations. This analysis allowed us to identify important points of the research and its future directions, in addition to enabling a better understanding of the world trend of the subject approached.

• Journal of KIBIM
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• v.10 no.4
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• pp.89-97
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• 2020

The purpose of this study is to identify the problems of the currently used 3D spatial information utilization system to realize a more accurate landscape and to establish a user-oriented environment to improve the utilization plan for future landscape evaluation. As citizens' interest in urban landscapes with strong public characteristics increases and the speed of urban development also increases, more suitable simulation methods for landscape management are required. Nevertheless, there are many cases of inconvenient correction according to development changes along with many errors in various steps for creating landscape simulation. Therefore, in performing landscape deliberation according to development, it is necessary to create more accurate and efficient landscape simulation, and if changes occur after the initial deliberation, a process that can quickly and conveniently correct and supplement data is needed. In addition, it is necessary to create landscape simulation so that the created modeling source can be used by being compatible with other application programs. In this study, a method of constructing a more accurate and efficient simulation at the time of initial deliberation and a method of creating a landscape simulation model for rapid response to a plan that is changed at the time of re-deliberation are described.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.3
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• pp.1113-1119
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• 2021

This study aims to determine the impact of the news coverage of the COVID-19 pandemic on the composite stocks' movement (IHSG) in Indonesia. This study used secondary data of daily time series with an observation range of March 2020-June 2020. This study used three main variables, namely, COVID-19 news, the daily price of a composite stock market index (IHSG), and interest rate. This study clarifies pandemic news into two forms to facilitate quantitative analysis, namely, good news and bad news. Both pandemic news conditions, which have been clarified, are then processed into the index and reprocessed along with two other variables using vector autoregressive (VAR). The results showed that the good news have a dominant effect on developing the composite stock price index (IHSG) in Indonesia during the COVID-19 pandemic. Although the good news dominates the composite stock price index (IHSG) movement in Indonesia, the bad news must also be anticipated. By implementing a series of macroeconomic policies that follow the conditions of the composite stock price index (IHSG) movements on the stock exchange floor, the bad news response can decrease the potential for a decline in investor confidence, so that the financial system's macroeconomic stability is maintained.

• The Research Journal of the Costume Culture
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• v.29 no.4
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• pp.538-553
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• 2021

As interest in the sustainable fashion industry continues to increase along with climate issues, it is necessary to identify research trends in sustainable fashion and seek new development directions. Therefore, this study aims to analyze research trends on sustainable fashion. For this purpose, related papers were collected from the KCI (Korean Citation Index) and Scopus, and 340 articles were used for the study. The collected data went through data transformation, data preprocessing, topic modeling analysis, core topic derivation, and visualization through a Python algorithm. A total of eight topics were obtained from the comprehensive analysis: consumer clothing consumption behavior and environment, upcycle product development, product types by environmental approach, ESG business activities, materials and material development, process-based approach, lifestyle and consumer experience, and brand strategy. Topics were related to consumption, production, and education of sustainable fashion, respectively. KCI analysis results and Scopus analysis results derived eight topics but showed differences from the comprehensive analysis results. This study provides primary data for exploring various themes of sustainable fashion. It is significant in that the data were analyzed based on probability using a research method that excluded the subjective value of the researcher. It is recommended that follow-up studies be conducted to examine social trends.

• Textile Coloration and Finishing
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• v.34 no.2
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• pp.127-133
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• 2022

With the increasing interest in the expression of individuality and appearance of modern people, it is time to conduct research and development of novel hair coloring from various angles. Therefore, taking into account the order of discoloration of hair pigments, we selected a creative and novel emulsion as a novel material for hair coloring, rather than a cosmetic material such as hot water extract using natural products dealt with in previous studies, commercially available hair manicure, and oxidation hair dye for hair. Thus, the change in tensile strength and elongation of hair samples by color was studied. As a result of the study, hair with green emulsion paint had a significantly higher maximum load, maximum stress, maximum elongation and breaking load, breaking stress, breaking elongation values are shown. Maximum in terms of modulus, green emulsion applied hair and the control group were higher in the 0-15s strain and 15-145s sections, respectively, and the tangential modulus value was much higher in the control group than the experimental group hairs in all the 0-145s sections. This study, which analyzes the dynamic changes of hair samples that extend the daily color gamut, will greatly contribute to the development of innovative hair coloring materials in the research and production of hair beauty works, and it is judged that it will also contribute to the development of the beauty industry.

• Journal of Biomedical Engineering Research
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• v.44 no.2
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• pp.99-108
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• 2023

According to the COVID-19, development of various medical software based on IoT(Internet of Things) was accelerated. Especially, interest in a central software system that can remotely monitor and control ventilators is increasing to solve problems related to the continuous increase in severe COVID-19 patients. Since medical device software is closely related to human life, this study aims to develop central monitoring system that can remotely monitor and control multiple ventilators in compliance with medical device software development standards and to verify performance of system. In addition, to ensure the safety and reliability of this central monitoring system, this study also specifies risk management requirements that can identify hazardous situations and evaluate potential hazards and confirms the implementation of cybersecurity to protect against potential cyber threats, which can have serious consequences for patient safety. As a result, we obtained medical device software manufacturing certificates from MFDS(Ministry of Food and Drug Safety) through technical documents about performance verification, risk management and cybersecurity application.