• Biomolecules & Therapeutics
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• v.29 no.1
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• pp.98-103
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• 2021

The demand for natural substances with anti-melanogenic activity is increasing due to the recent interest in skin whitening. Intensive investigation on the culture broth of Streptomyces sp. SCO-736, a marine bacterium from the Antarctica coast, has led to the isolation of a new natural product named antaroide (1). The chemical structure was established through the interpretation of MS, UV, and NMR spectroscopic data. Antaroide is a nine-membered macrolide with lactone and lactam moieties. To investigate its applicability in skin whitening cosmetics, its anti-melanogenic activity in B16F10 murine melanoma cells was examined. As a result, antaroide displayed strong inhibitory activities against melanin synthesis and also attenuated the dendrite formation induced by the α-melanocyte stimulating hormone (α-MSH). Antaroide suppressed the mRNA expression of the melanogenic enzymes such as tyrosinase, TRP-1 and TRP-2. This suggests that it may serve as a transcriptional regulator of melanogenesis. Collectively, the discovery of this novel natural nine-membered macrolide and its anti-melanogenic activity could give new insights for the development of skin whitening agents.

• Research in Community and Public Health Nursing
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• v.32 no.4
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• pp.477-484
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• 2021

Purpose: Various intervention strategies are needed to reduce the suicide rate among late adolescents. Therefore, we aimed to investigate the factors that can help overcome suicidal tendencies in late adolescents from the perspective of case managers. Methods: This qualitative study explored the reinforcing factors that can help overcome suicidal behaviors in late adolescents, by conducting focus group interviews with case managers from the local community. Interviews with 10 case managers were recorded and transcribed, and the data were analyzed using the content analysis method. Results: The main theme of this study was "a step in a new direction". Three categories were derived: "inner changes", "another possibility opened up by the interest of significant others", and "connecting with community resources to help overcome". Each category had subcategories that influenced the intention and course of action of behaviors to overcome the suicide crises. Conclusion: Our findings, from the exploration of the experiences of case managers, provide an in-depth understanding of the reinforcing factors for overcoming suicide among late adolescents. They provide useful preliminary data for the development of effective suicide prevention programs for the adolescents.

• Journal of the Korean Electrochemical Society
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• v.25 no.1
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• pp.13-21
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• 2022

There is an increasing interest in monitoring of specific biomarker for determining progression of a disease or efficacy of a treatment. Conventional method for quantification of specific biomarkers as enzyme linked immunosorbent assay (ELISA) has high material costs, long incubation periods, requires large volume of samples and involves special instruments, which necessitates clinical samples to be sent to a lab. This paper reports on the development of an electrochemical biosensor to measure total immunoglobulin E (IgE), a marker of asthma disease that varies with age, gender, and disease in concentrations from 0.3-1000 ng/mL with consuming 20 µL volume of whole blood sample. The sensor provides rapid, accurate, easy, point-of-care measurement of IgE, also, sequential monitoring of total IgE with ovalbumin (OVA) induced mice is another application of sensor. Taken together, these results provide an alternative way for detection of biomarkers in whole blood with low volumes and long-term ex-vivo assessments for understanding the progression of a disease.

• New & Renewable Energy
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• v.18 no.2
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• pp.26-39
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• 2022

Considering the recent substantial increase in national research and development (R&D) budgets in the energy sector there has been increased Interest in the effectiveness of government R&D investments. We conducted a case study to calculate the allowable scale and effectiveness of R&D investment by calculating the direct performance improvement effect resulting from R&D investment as an economic value. Using conditions that existed prior to R&D investments as a reference, five cases in which performance improved due to R&D investments were compared and analyzed. The government's financial investment is increasing rapidly in line with the establishment of the national hydrogen roadmap. R&D is needed to enhance the current low technology readiness level of hydrogen fuel cells compared to solar and wind energy fields. Therefore, an R&D project to improve the performance of the fuel cell system was selected as this case study's subject. Using the results in this study, the allowable level of investment in the task unit of national R&D projects could be calculated. Moreover, it is advisable to provide a standard for rational decision making for new R&D investments since it is possible to determine investment priorities among a large number of candidates.

• International Journal of Computer Science & Network Security
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• v.22 no.3
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• pp.252-258
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• 2022

Globalization, development of the information society, intensification of migration processes, and internationalization of education in recent years have significantly affected the international labour market and increased competition between professionals in various fields. Academic, research and teaching staff are currently facing rapid changes and growing demand for quality educational services. Under such conditions, educational institutions around the world pay particular attention to improving the quality of the educational process in order for their graduates to be able to compete in the international labour market. The study of the experience of teachers' professional training in advanced countries opens new opportunities for improving the system of pedagogical training in Ukraine in order to adapt it to the requirements of the European educational space. The progressive achievements of countries demonstrating a high level of teachers' professional training in accordance with international standards, having rich historical educational traditions are of considerable scientific interest; consequently, this contributes to their leadership in science and education at the regional and global levels. The purpose of the present academic paper lies in analysing the latest trends in exploring teaching experience in the European countries and performance review of passing by students and teachers of the program on studying of pedagogical practice and experience of teaching in the countries of Europe. Methodology. Analytical and empirical (questionnaire) methods were used in the research process. Results. According to the obtained results of the research, the advantages, the most common areas of educational programs and the wishes of the participants regarding the practical implementation of the experience were identified.

• Journal of Information Technology Services
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• v.20 no.5
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• pp.177-187
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• 2021

The global economy has been very difficult due to the recent impact of COVID-19. Korea is also pushing for strong quarantine policies such as K- quarantine and social distancing, but the economy is hardly recovering. In particular, the economic situation began to change rapidly depending on the export and domestic market, the public's interest in the economy increased, and companies became more sensitive. In order to estimate this rapidly changing economic situation, major advanced countries have also developed models that can periodically monitor the economy at the government level. Through this, by periodically reporting the economic trends, the public and companies can be aware of the economic trends to some extent. This study analyzed the cases of weekly business trends in advanced countries and developed a model of weekly economic activity suitable for Korea. To verify this, indices closely related to the economy such as mobility, industrial activity, face-to-face consumption, and psychology were discovered and estimated. As a result of the study, the weekly economic activity index was judged to be very useful in capturing short-term real economic activity. In the future, in order to secure the robustness and stability of the index and to increase the reflection of reality, model improvement and parameter estimation should be performed regularly.

• Proceedings of the National Institute of Ecology of the Republic of Korea
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• v.3 no.3
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• pp.129-138
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• 2022

Reintroduction programs have been promoted across the world to recover and rehabilitate endangered birds through ex situ captive breeding and releasing to the nature. The ultimate aims of these reintroduction programs are recovery of sustainable populations in natural habitats. To ensure the success of the reintroduction programs, it is necessary to examine the followings in order to increase the success rate of releasing along with the development of captive breeding techniques: 1) Adequate habitat provision, 2) adaptability of captive-bred individuals, 3) survivability of released individuals, and 4) social interest and will. Before releasing captive-bred individuals, it should be reviewed whether there are habitats in which the limiting factor is removed, and assessed their long-term safety. The quantity and quality of the released individuals must be considered to increase the chances for mate selection, maintain genetic diversity, and acquire the ability to adapt to the wild. The release method must be decided in consideration of characteristics of the target habitats and individuals, and rational means such as careful observation, evaluation, and feedback must be provided throughout the release process. For the long-term success of recovery projects, social awareness, sustainable support, and related experts are needed. Satisfying these criteria can help to increase the success rates of reintroduction programs. For the bird reintroduction program in the future, the feasibility of the methods and procedures must be closely reviewed before starting.

• International Journal of Computer Science & Network Security
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• v.22 no.7
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• pp.421-426
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• 2022

This study aimed to determine the effectiveness of the Moodle system in the organization of independent work of students of pedagogical profile.The purpose of the article is to analyze the Moodle platform as an innovative element of educational and pedagogical strategies and a component of the educational and methodological content for the self-study of students.Methodology is divided into clusters: general scientific (analysis, classification), ICT methods (modeling, informatization), and philosophical (synergetics). The study revealed the reorientation of Moodle from an auxiliary element to an alternative format in the organization of independent work of student teachers. Prospects for further scientific research determined in the interest of all participants in the educational process in the further development of Moodle as an effective tool for self-education of future teachers.

• Journal of Korea Society of Digital Industry and Information Management
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• v.18 no.3
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• pp.83-95
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• 2022

A technology can be newly formed through technological convergence achieved by the intersection of two or more technological fields. As the complexity of technology development increases, related interest is increasing. Researches have been carried out on the concept, related indicators and analysis of technology convergence including method of social networks. This paper intends to suggest an analysis method of technology convergence using social networks based on the company's possessing technologies. According to the similarity of technologies among companies, a social network was constructed and the technology convergence was analyzed using k-core, a social network subgroup method. Using the result of k-core, base and element technologies for convergence was identified with their relations. Using the suggested method, technology convergence was analyzed on real technology data of defense-industry companies. When the minimum technology similarity is 0, the overall technology convergence relations between technology elements can be identified. In the scope of data in this paper, technologies of defense S/W, aircraft structure and structural materials are identified as important base technology for convergence.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.35 no.5
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• pp.509-515
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• 2022

As the 4th industrial revolution based on ICT is progressing in the manufacturing field, interest in building smart factories that can be flexible and customized according to customer demand is increasing. To this end, it is necessary to maximize the efficiency of factory by performing an automated process in real time through a network communication between engineers and equipment to be able to link the established IT system. It is also necessary to collect and store real-time data from heterogeneous facilities and to analyze and visualize a vast amount of data to utilize necessary information. Therefore, in this study, four types of controllers such as PLC, Arduino, Raspberry Pi, and embedded system, which are generally used to build a smart factory that can connect technologies such as artificial intelligence (AI), Internet of Things (IoT), and big data, are configured. This study was conducted for the development of a program that can collect and store data in real time to visualize and manage information. For communication verification by controller, data communication was implemented and verified with the data log in the program, and 3D monitoring was implemented and verified to check the process status such as planned quantity for each controller, actual quantity, production progress, operation rate, and defect rate.