• BMB Reports
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• v.53 no.1
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• pp.47-55
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• 2020

Alzheimer's disease (AD) is a multifactorial neurodegenerative disease and has become a major socioeconomic issue in many developed countries. Currently available therapeutic agents for AD provide only symptomatic treatments, mainly because the complete mechanism of the AD pathogenesis is still unclear. Although several different hypotheses have been proposed, mitochondrial dysfunction has gathered interest because of its profound effect on brain bioenergetics and neuronal survival in the pathophysiology of AD. Various therapeutic agents targeting the mitochondrial pathways associated with AD have been developed over the past decade. Although most of these agents are still early in the clinical development process, they are used to restore mitochondrial function, which provides an alternative therapeutic strategy that is likely to slow the progression of the disease. In this mini review, we will survey the AD-related mitochondrial pathways and their small-molecule modulators that have therapeutic potential. We will focus on recently reported examples, and also overview the current challenges and future perspectives of ongoing research.

• Journal of the Korean Society of Costume
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• v.58 no.9
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• pp.142-150
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• 2008

A universal design means a progressive and challenging design in the 21st century which can satisfy the demands from not only aged people and disabled people but also numerous members of our society. This research aims to apply a universal design commonly used in architecture (environment) and products to costumes, so as to convert the design into a universal fashion which can meet the aesthetic values, desires, and functionality of aged people and disabled women. After applying the said five universal fashion principles and design factors, a total of 20 pieces of universal fashion prototype products are produced through functional designs and designs utilizing knit materials and health & functionality materials. In addition, a direction to develop universal fashion products is suggested for costume manufacturers, for the purpose of facilitating the practical use of a universal fashion. The present author expects that human-centered universal fashion costumes shall propose the orientation of the interest in future new designs, beyond the scope of a jump in the quality of simple functional costumes.

• Fashion & Textile Research Journal
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• v.22 no.4
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• pp.446-455
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• 2020

In order to develop high value fashion culture products capable of reaching the global market, this study developed the original traditional clothing design of Northeast Asian countries according to a global perspective. This study applied the structural formality of traditional clothing to fashion cultural products. This study developed designs using Deel of Mongolia, Makap of China Korean Dang-ui / Dan-ryung, and Haori of Japan. The research methods are theoretically examined using literature on traditional clothing in Northeast Asia. First, it designed a shirt design using Adobe Illustrator CS6 and created a pattern with the Yuka program as well as applied CLO 5.0 (a 3D virtual dressing system from CLO Virtual Fashion Co.). A survey was also conducted on individual interest for the developed fashion cultural products. The design method obtained various design effects by applying the method of adding point detail parts of the clothes to the shirt that represented each country among their traditional clothes. This research can be used as basic data for the global fashion cultural products market that can contribute to maintaining the originality of each country in the global era, expanding tourism income to succeed and develop culture and tradition.

• Journal of the Korean Society of Propulsion Engineers
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• v.17 no.5
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• pp.132-139
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• 2013

Liquid-propellant rocket engines are widely used all over the world, thanks to their high performances thrust, in particular high thrust-to-weight ratio. The sucess rate of the launching of the liquid propulsion is similar to the solid one even though it has more complex mechanical system. In general, liquid propulsion is seemed as a mature technology, the requirements of a renewed interest for space exploration has led to the development of a family of new engines, with more design margins, simpler to use and to produce associated with a wide variety of thrust and life requirements.

• Journal of the Korean Society of Marine Environment & Safety
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• v.23 no.1
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• pp.56-66
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• 2017

This paper investigates university-level curriculum by comparing education systems among maritime universities, fishery universities and naval academy. It was found that maritime university programs are full of effective courses related to the concept of Sea Power along with the duties of maritime officers. It is recommended that more interest be paid to on the increase of national sea power by renovating current educational systems and adding more national supports by providing additional maritime policies to establish sustainable development goals for Sea Power.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2005.05a
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• pp.441-445
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• 2005

In the resent years, as the research and the development of micro and precision machinery become active, the interest of micro actuators using SMA(Shape Memory Alloy) has been increased. But, no detailed researches between the thermo-dynamic property in Nitinol alloy have been done yet. In this study, the thermal property of high temperature Nitinol shape memory alloy were evaluated using differential scanning calorimeter(DSC). The structure property was investigated using X-ray diffraction(XRD). A dynamic mechanical analyzer(DMA) with three point bending mode was used to study storage and loss modulus of shape memory alloy according to the thirteen frequencies in the temperature range between 30 and $200^{\circ}C$. The effects of the temperature heating/cooling rate, the frequency on the damping capacity have been systematically investigated. Such a frequency and temperature changes also influenced significantly to the damping behavior of the shape memory alloy. It was also found that Nitinol exhibited high damping capacity during phase transformation.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2005.05a
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• pp.48-53
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• 2005

The world, coming into the 21st century, is preparing a new revolution called a knowledge-based society after the industrial society. The interest of the world is concentrated on information technology, nano-technology and biotechnology. In particular, the nano-technology of which study was originally started from an alternative for overcoming semiconductor micro-technology. It can be applied to most industry subject such as electronics, information and communication, machinery, chemistry, bioengineering, energy, etc. They are emerging into the technology that can change civilization of human beings. Specially, ultra precision machining is quickly applied to nano-technology in the field of machinery. Lately, with rapid development of electronics industry and optic industry, there are needs for super precision finishing of various core parts required in such related apparatuses. This paper handles stability of a super precision micro cutting machine that is a core unit of such a super precision finisher, and analyzes the results depending on the hinge type and material change, using FEM analysis. By reviewing the stability, it is possible to achieve the effect of basic data collection for unit control and to reduce trials and errors in unit design and manufacturing.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.21 no.1
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• pp.175-181
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• 2012

This paper presents a novel dynamic vibration absorber (DVA) to suppress the unbalance response of flexible rotor-bearing systems. The DVA unit consists of two DVAs, an adapter to place the DVAs and an adapter frame to locate the adapter. The essential feature of the proposed DVA unit is to place itself on any desirable location of the shaft without disassembling the rotor-bearing system under consideration. A simulation with a 3D element based commercial rotor dynamic software is made to test the possibility of the proposed DVA on the suppression of unbalance response in rotor-bearing systems. Experiments are performed to validate the proposed DVA unit. The simulation and experiments show that the proposed DVA unit is very effective to suppress the unbalance response in rotor-bearing system at designated rotational speeds of interest.

• Journal of Fisheries and Marine Sciences Education
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• v.27 no.3
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• pp.614-624
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• 2015

Traditionally, fathers have been a bread earner and responsible for external matters as the head of household. However, the interest of today's fathers in their children has changed from that of the traditional fathers due to the increased employment of female, decreased birth rate and the trend of shared role in parenting. The purpose of this study was to identify the perception type of fathers of preschool children regarding obesity and the characteristics of the type by applying Q-methodology, and to create the basic data for the development of education programs for fathers or policy-making to prevent child obesity. Data were collected by applying 38 Q statements to 24 fathers of preschool children. Collected data were analyzed with the PC QUANL program. Results indicate that fathers' perception of obesity was divided into three types: 'management of physical activity and diet,' 'generous acknowledgment of reality' and 'compromised emphasis on homemade meal.' The 'compromised emphasis on homemade meal' type is those who consider homemade food important, although they sometimes suggest conditions to make their children cooperative for food. It was found that the subject of the study uniformly recognized that processed foods, fast foods or chocolates are harmful to health. The type of fathers' perception of obesity in preschool children was discussed, focusing on the perception type identified in this study.

• Journal of Institute of Control, Robotics and Systems
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• v.12 no.6
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• pp.573-579
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• 2006

Most of the recently developed robots are human friendly robots which imitate an animal or human such as entertainment robot, biomimetic robot and humanoid robot. Interest in these robots is increased because the social trend is focused on health, welfare, and graying. By these social backgrounds, robots become more human friendly and suitable or home or personal environment. The more biomimetic robots resemble living creature, the more human feels familiarity. Human feels close friendship not only when feeding a pet, but also when watching a pet having the food. Most of entertainment robots and pet robots use internal-type batteries and have a self-recharging function. Entertainment robots and pet robots with internal-type batteries are not able to operate during charging the battery. So far there have been a few robots that do not depend on an internal battery. However, they need a bulky energy conversion unit and a slug or foods as an energy source, which is not suitable for home or personal application. In this paper, we introduce a new biomimetic entertainment robot with autonomous eating functionality, called EPRO-1(Eating Pet RObot version 1). The EPRO-1 is able to eat a food (a small battery), by itself and evacuate. We describe the design concept of the autonomous eating mechanism of the EPRO-1, characteristics of sub-parts of the manufactured mechanism and its control system.