• 한국임상약학회지
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• 제26권4호
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• pp.324-329
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• 2016

Background: With the development of information and communication technology, there is a growing number of people looking for health information on the internet. This pilot study was performed to analyze the pattern of pharmacist consultation on the internet portal site. Methods: Questions and answers posted on the portal site "Naver Jisik-iN" from March 1st to 31th in 2016 were collected. Medications asked were categorized into prescription drugs, nonprescription drugs, sanitary aids, emergency drugs, functional health foods, and others. Medications were subcategorized into 14 according to the anatomical therapeutic chemical classification system. Questions were divided into 10 categories based on Hepler's drug-related problems. Results: Of the 955 cases, females accounted for 59.5% and inquirers from 11 to 40 years old, 89.4%. The number of prescription drugs, nonprescription drugs, sanitary aids, emergency drugs, functional health foods, and others were 428 (44.8%), 328 (34.3%), 31 (3.3%), 2 (0.2%), 122 (12.8%), and 44 (4.6%), respectively. Questions for drugs acting on alimentary tract and metabolism took up 27.4% followed by those on nervous system, 13.6% and anti-infectives for systemic use, 12.2%. Pharmacist consultation regarding drug information, drug interaction, and adverse reaction occupied 47.9%, 15.2%, and 12.3%, respectively. Conclusion: Health counseling through online is predicted to increase steadily, so pharmacists should broaden their boundaries beyond off-line pharmacies to meet social needs.

• Korean Chemical Engineering Research
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• 제48권4호
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• pp.534-539
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• 2010

메탄 속에 포함되어 있는 TBM, THT, DMS 등의 유기 황 화합물에 대한 흡착 제거가 NaY와 CuNaY 제올라이트를 이용하여 303 K, 대기압 조건하에서 수행되었다. 삼성분계 흡착시스템 실험을 통해, NaY에서는 THT의 선택적 흡착이 목격되었으며, CuNaY에서는 모든 유기 황 화합물의 동시 흡착이 일어났다. 이러한 현상은 파과흡착곡선, 승온탈착, 겉보기 탈착 활성화 에너지 등의 실험결과로 부터 설명될 수 있었다. 황에 대한 흡착능은 CuNaY(2.90~3.20 mmol/g)가 NaY(0.70~0.90 mmol/g)보다 매우 우수하였다. 본 연구결과는 CuNaY에 존재하는 $Cu^{1+}$ 흡착점과 강한 산의 세기가 황 원자와의 강한 상호작용을 유발하여 높은 황 흡착능을 갖게 하는 것으로 이해된다.

• 한국세라믹학회지
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• 제47권1호
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• pp.26-38
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• 2010

Degradation in Solid Oxide Fuel Cell performance can be ascribed to the following fundamental processes from the materials chemical point of view; that is, diffusion in solids and reaction with gaseous impurities. For SOFC materials, diffusion in solids is usually slow in operation temperatures $800\sim1000^{\circ}C$. Even at $800^{\circ}C$, however, a few processes are rapid enough to lead to some degradations; namely, Sr diffusion in doped ceria, cation diffusion in cathode materials, diffusion related with metal corrosion, and sintering of nickel anodes. For gaseous impurities, chromium containing vapors are important to know how the chemical stability of cathode materials is related with degradation of performance. For LSM as the most stable cathode among the perovskite-type cathodes, electrochemical reduction reaction of $CrO_3$(g) at the electrochemically active sites is crucial, whereas the rest of the cathodes have the $SrCrO_4$ formation at the point where cathodes meet with the gases, leading to rather complicated processes to the degradations, depending on the amount and distribution of reacted Cr component. These features can be easily generalized to other impurities in air or to the reaction of nickel anodes with gaseous impurities in anode atmosphere.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제29권4호
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• pp.249-256
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• 2003

The lack of sufficient oral mucosa available for intra-oral reconstruction has been dealt with by the use of skin or oral mucosa grafts harvested from donor sites but grafts requires more than one surgical procedures and could cause donor site morbidity. Many investigators have attempted to increase available soft tissue by tissue engineered skin or oral mucosa replacements for clinical applications. But, reconstructed mucosa by several methods have low physical properties such as rolling and contraction. The aims of this study were to develope an in vitro experimental model that maintains an epithelial-mesenchymal interaction by organotypic raft culture, and to characterize biologic properties of three-dimensionally cultured oral mucosa embedded with Polydioxanone mesh by histological and immunohistochemical analysis. The results were as follows; 1. Oral mucosa reconstructed by three-dimensional organotypic culture revealed similar morphologic characteristics to equvalent normal oral mucosa in the point that they show stratification and differentiation. 2. The expression of cytokeratin 10/13 and involucrin in the cultured tissue showed the same pattern with normal oral mucosa suggesting that organotypic co-culture condition is able to induce cellular differentiation. 3. After insertion of polydioxanone mesh, increased tensile strength were observed. These results suggest that three-dimensional organotypic co-culture of the oral mucosa cell lines with the dermal equvalent consisting type I collagen and fibroblasts reproduce the morphologic and immunohistochemical characteristics similar to those in vivo condition. And increased physical properties by use of polydioxanone mesh will helpful for clinical applications.

• 대한토목학회논문집
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• 제10권2호
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• pp.103-112
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• 1990

본 연구는 내진설계시 많은 불확실성을 내포하는 지반의 거동특성을 규명하고, 적용대상지반의 확충 및 경제성 제고를 위하여 토사지반의 동적지반특성 평가 및 지반-구조물 거동 특성을 고찰하였다. 예제해석은 토사지반에 원전 containment 구조물이 설치된 경우를 가상하여 지진하중에 대한 지반-구조물 시스템의 거동을 반무한체해석과 유한요소해석으로 분석하였다. 이는 토사지반에 원전이 건설될 경우에 고려해야 할 안정성 및 경제성 분석의 일환으로 수행되었으며, 토사지반의 큰 비선형거동을 정확하게 해석에 반영하기 위한 해석 software와 지반입력 data의 합리적인 평가방안 등을 예제해석을 통하여 분석하였다. 예제해석결과를 종합해 볼 때 토사지반의 동적거동의 정확한 분석을 위하여 비선형 유한요소해석은 Seed & Idriss 모델이, 선형 유한요소해석은 지진하중에 대한 1차원 지반거동시 변형율에서의 동적지반특성을 이용한 방법이, 반무한체해석은 정적하중시 변형율에서의 동적지반특성을 이용한 방법이 가장 합리적으로 동적지반특성을 평가하는 것으로 추천할 수 있다.

• Molecules and Cells
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• 제43권4호
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• pp.331-339
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• 2020

Genetic modifications in noncoding regulatory regions are likely critical to human evolution. Human-accelerated noncoding elements are highly conserved noncoding regions among vertebrates but have large differences across humans, which implies human-specific regulatory potential. In this study, we found that human-accelerated noncoding elements were frequently coupled with DNase I hypersensitive sites (DHSs), together with monomethylated and trimethylated histone H3 lysine 4, which are active regulatory markers. This coupling was particularly pronounced in fetal brains relative to adult brains, non-brain fetal tissues, and embryonic stem cells. However, fetal brain DHSs were also specifically enriched in deeply conserved sequences, implying coexistence of universal maintenance and human-specific fitness in human brain development. We assessed whether this coexisting pattern was a general one by quantitatively measuring evolutionary rates of DHSs. As a result, fetal brain DHSs showed a mixed but distinct signature of regional conservation and outlier point acceleration as compared to other DHSs. This finding suggests that brain developmental sequences are selectively constrained in general, whereas specific nucleotides are under positive selection or constraint relaxation simultaneously. Hence, we hypothesize that human- or primate-specific changes to universally conserved regulatory codes of brain development may drive the accelerated, and most likely adaptive, evolution of the regulatory network of the human brain.

• 한국GIS학회:학술대회논문집
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• 한국GIS학회 1999년도 추계학술대회 발표요약문
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• pp.21-25
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• 1999

Planning support systems(PSS) add more advanced spatial analysis functions than Geographic information systems(GIS) and intertemporal functions to the functions of spatial decision support systems(SDSS). This paper reports the continuing development of a PSS providing a framework that facilitates urban planners and civil engineers in conducting coherent deliberations about planning, design and operation & maintenance(O&M) of water-distribution networks for urban growth management. The PSS using dynamic optimization model, modeling-to-generate-alternatives, value engineering(VE) and life-cycle cost(LCC) can generate network alternatives in consideration of initial cost and O&H cost. Users can define alternatives by the direct manipulation of networks or by the manipulation of parameters in the models. The water-distribution network analysis model evaluates the performance of the user-defined alternatives. The PSS can be extended to include the functions of generating sewer network alternatives, combining water-distribution and sewer networks, eventually the function of planning, design and O&H of housing sites. Capacity expansion by the dynamic water-distribution network optimization model using MINLP includes three advantages over capacity expansion using optimal control theory(Kim and Hopkins 1996): 1) finds expansion alternatives including future capacity expansion times, sizes, locations, and pipe types of a water-distribution network provided, 2) has the capabilities to do the capacity expansion of each link spatially and intertemporally, and 3) requires less interaction between models. The modeling using MINLP is limited in addressing the relationship between cost, price, and demand, which the optimal control approach can consider. Strictly speaking, the construction and O&M costs of water-distribution networks influence the price charged for the served water, which in turn influence the. This limitation can be justified in rather small area because price per unit water in the area must be same as that of neighboring area, i.e., the price is determined administratively. Planners and engineers can put emphasis on capacity expansion without consideration of the relationship between cost, price, and demand.

• 한국해안·해양공학회논문집
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• 제22권4호
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• pp.248-257
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• 2010

본 연구에서는 조석과 해일이 결합된 범람모의 적용에 앞서 적용모형인 MIKE21 모형의 실시간 조석 및 조석-해일 결합모의에 대한 적용성을 검토하였다. 실시간 조석모의에 대한 적용성 검토결과, 한반도 주변해역을 모두 포함하는 광대역에 대한 모의결과임에도 만족스러운 결과를 보였다. 조석-해일 결합모의에 있어서도 전반적으로 높은 정도로 태풍 MAEMI(0314) 내습 당시의 수위 상승 양상의 재현이 가능하였을 뿐 아니라 태풍 MAEMI가 상륙한 통영, 마산, 부산 해역의 경우 관측조위와 정량적으로 매우 근접한 모의 결과를 획득할 수 있었다. 또한 조석의 영향이 강하고 수심이 복잡한 목포해역 일대에서는 조석과 해일 상호간의 비선형 효과가 크게 작용하고 있음을 확인할 수 있었고, 이에 따라 특히 서남해안에서의 조석-해일 결합모형의 효용성을 입증할 수 있었다.

• Molecular & Cellular Toxicology
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• 제3권3호
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• pp.208-213
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• 2007

With the help of a development and popularization of microarray technology that enable to us to simultaneously investigate the expression pattern of thousands of genes, the toxicogenomics experimenters can interpret the genome-scale interaction between genes exposed in toxicant or toxicant-related environment. The ultimate and primary goal of toxicogenomics identifies functional context among the group of genes that are differentially or similarly coexpressed under the specific toxic substance. On the other side, public reference databases with transcriptom, proteom, and biological pathway information are needed for the analysis of these complex omics data. However, due to the heterogeneous and independent nature of these databases, it is hard to individually analyze a large omics annotations and their pathway information. Fortunately, several web sites of the public database provide information linked to other. Nevertheless it involves not only approriate information but also unnecessary information to users. Therefore, the systematically integrated database that is suitable to a demand of experimenters is needed. For these reasons, we propose SOP (Search of Omics Pathway) database system which is constructed as the integrated biological database converting heterogeneous feature of public databases into combined feature. In addition, SOP offers user-friendly web interfaces which enable users to submit gene queries for biological interpretation of gene lists derived from omics experiments. Outputs of SOP web interface are supported as the omics annotation table and the visualized pathway maps of KEGG PATHWAY database. We believe that SOP will appear as a helpful tool to perform biological interpretation of genes or proteins traced to omics experiments, lead to new discoveries from their pathway analysis, and design new hypothesis for a next toxicogenomics experiments.

• 한국지반환경공학회 논문집
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• 제10권7호
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• pp.135-141
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• 2009

지진원 및 구조물과 지반상호간의 동적 특성을 보다 신뢰성 있게 도출하기 위해 지반의 증폭특성은 반드시 고려되어야하는 요소이다. 지반증폭 특성을 분석할 때 여러 가지 방법이 제시되어 있으나 본 연구에서는 Nakamura(1989)에 의해 제시된 방법을 적용하였다. 본 방법은 얕은 지반의 상시미동의 표면파 특성을 이해하기 위해 제시되어 한계점이 존재하나 근래에 와서 S파 등에 적용되어 지반의 동적인 증폭 특성연구에 많이 이용되고 있다. 일반적으로 S파가 이용되고 있으나 본 연구에서는 지진파 에너지인 Coda 파에 새로이 적용하였다. 최근 국내에 설치된 지진 관측기에 관측된 5개 지진(규모 3.6-5.1)의 약 60 여개의 관측자료를 이용하여 지진관측소 각각 지반의 동적인 증폭 특성을 분석하였다. 관측소마다 저진동수, 고진동수 및 우월주파수가 서로 다른 증폭특성을 보여주었다. 본 연구 결과 관측지반진동에서 지반 고유의 증폭특성을 제거하면 지진원 변수를 보다 신뢰성 있게 도출할 수 있다.