• Computers and Concrete
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• v.22 no.1
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• pp.101-116
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• 2018

As one of the most important engineering structures, arch dams are huge constructions built with human hands and have strategical importance. Because of the fact that long construction duration, water supply, financial reasons, major loss of life and material since failure etc., the design of arch dams is very important problem and should be done by expert engineers to determine the structural behavior more accurately. Finite element analyses and non-destructive experimental measurements can be used to investigate the structural response, but there are some difficulties such as spending a long time while modelling, analysis and in-situ testing. Therefore, it is more useful to conduct the research on the laboratory conditions and to transform the obtained results into real constructions. Within the scope of this study, it is aimed to determine the structural behavior of arch dams considering experimentally validated prototype laboratory model using similitude and scaling laws. Type-1 arch dam, which is one of five arch dam types suggested at the "Arch Dams" Symposium in England in 1968 is selected as reference prototype model. The dam is built considering dam-reservoir-foundation interaction and ambient vibration tests are performed to validate the finite element results such as dynamic characteristics, displacements, principal stresses and strains. These results are considered as reference parameters and used to determine the real arch dam response with different scales factors such as 335, 400, 416.67 and 450. These values are selected by considering previously examined dam projects. Arch heights are calculated as 201 m, 240 m, 250 m and 270 m, respectively. The structural response is investigated between the model and prototype by using similarity requirements, field equations, scaling laws etc. To validate these results, finite element models are enlarged in the same scales and analyses are repeated to obtain the dynamic characteristics, displacements, principal stresses and strains. At the end of the study, it is seen that there is a good agreement between all results obtained by similarity requirements with scaling laws and enlarged finite element models.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.3
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• pp.1583-1588
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• 2016

Background: Polycystic ovary syndrome (PCOS) is considered to be a multifactorial disorder resulting from the interaction of several predisposing and protective genetic variants. PCOS is associated with low-grade chronic inflammation. Elevated levels of inflammatory markers including intercellular adhesion molecule-1 (ICAM-1) are demonstrated in women with PCOS. Recent evidence indicates a significant linkage between a locus on chromosome 19p13 and multifactorial diseases that have an inflammatory component. The aim of the study was to assess the possible association of Gly241Arg polymorphism of ICAM-1 gene located on chromosome 19p13 in determining risk of PCOS in Kashmiri women. Materials and Methods: Gly241Arg SNP in DNA from peripheral blood leukocytes of 220 PCOS cases and 220 age matched non-PCOS healthy controls was analysed using allel specific PCR. Results: The genotype and allele frequency distributions of Gly241Arg SNP showed insignificant difference between the PCOS cases and control women, indicating no role of this SNP in PCOS susceptibility. The odds ratio for Arg/Arg genotype was 0.87 (95% CI=0.32-2.3) [P=0.79], for Gly/Arg genotype was 0.98 (95% CI= 0.66-1.47) [P=1] and for Arg/Arg+Gly/Arg genotype was 0.97 (95% CI=0.65-1.45) [P=0.92]. The genotypic frequencies of ICAM-1codon 241 showed statistically insignificant difference between cases and controls (${\chi}^2=0.07$; p=0.96) Nor the studied polymorphism was found to affect clinical and laboratory parameters significantly. Conclusions: Although Gly241Arg polymorphism have not shown significant association with PCOS. Further, specifically designed studies on large cohorts are required to conclusively establish any role of ICAM-1 gene polymorphisms in PCOS in our study.

• Proceedings of the Korean Association of Geographic Inforamtion Studies Conference
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• 1999.12a
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• pp.21-25
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• 1999

Planning support systems(PSS) add more advanced spatial analysis functions than Geographic information systems(GIS) and intertemporal functions to the functions of spatial decision support systems(SDSS). This paper reports the continuing development of a PSS providing a framework that facilitates urban planners and civil engineers in conducting coherent deliberations about planning, design and operation & maintenance(O&M) of water-distribution networks for urban growth management. The PSS using dynamic optimization model, modeling-to-generate-alternatives, value engineering(VE) and life-cycle cost(LCC) can generate network alternatives in consideration of initial cost and O&H cost. Users can define alternatives by the direct manipulation of networks or by the manipulation of parameters in the models. The water-distribution network analysis model evaluates the performance of the user-defined alternatives. The PSS can be extended to include the functions of generating sewer network alternatives, combining water-distribution and sewer networks, eventually the function of planning, design and O&H of housing sites. Capacity expansion by the dynamic water-distribution network optimization model using MINLP includes three advantages over capacity expansion using optimal control theory(Kim and Hopkins 1996): 1) finds expansion alternatives including future capacity expansion times, sizes, locations, and pipe types of a water-distribution network provided, 2) has the capabilities to do the capacity expansion of each link spatially and intertemporally, and 3) requires less interaction between models. The modeling using MINLP is limited in addressing the relationship between cost, price, and demand, which the optimal control approach can consider. Strictly speaking, the construction and O&M costs of water-distribution networks influence the price charged for the served water, which in turn influence the. This limitation can be justified in rather small area because price per unit water in the area must be same as that of neighboring area, i.e., the price is determined administratively. Planners and engineers can put emphasis on capacity expansion without consideration of the relationship between cost, price, and demand.

• Bulletin of the Korean Chemical Society
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• v.26 no.2
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• pp.285-291
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• 2005

The nonstructural protein 5B (NS5B) of hepatitis C virus (HCV) is the viral RNA-dependent RNA polymerase (RdRp), which is the essential catalytic enzyme for the viral replication and is an appealing target for the development of new therapeutic agents against HCV infection. A small amount of serum from a single patient with hepatitis C was used to get the genome of a Korean HCV isolate. Sequence analysis of NS5B 1701 nucleotides showed the genotype of a Korean isolate to be subtype 1b. The soluble recombinant HCV NS5B polymerase lacking the C-terminal 24 amino acids was expressed and purified to homogeneity. With the highly purified NS5B protein, we established in vitro systems for RdRp activity to identify potential polymerase inhibitors. The rhodanine family compounds were found to be potent and specific inhibitors of NS5B from high throughput screening (HTS) assay utilizing the scintillation proximity assay (SPA) system. The binding mode of an inhibitor was analyzed by measuring various kinetic parameters. Lineweaver-Burk plots of the inhibitor suggested it binds not to the active site of NS5B polymerase, but to an allosteric site of the enzyme. The activity of NS5B in in vitro polymerase reactions with homopolymeric RNA requires interaction with multiple substrates that include a template/primer and ribonucleotide triphosphate. Steady-state kinetic parameter, such as Km, was determined for the ribonucleotide triphosphate. One of compounds found interacts directly with the viral polymerase and inhibits RNA synthesis in a manner noncompetitively with respect to UTP. Furthermore, we also investigated the ability of the compound to inhibit NS5B-directed viral RNA replication using the Huh7 cell-based HCV replicon system. The investigation is potentially very useful for the utility of such compounds as anti-hepatitic agents.

• Journal of the Korean Magnetics Society
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• v.26 no.3
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• pp.86-91
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• 2016

The cogging torque of a brushless dc (BLDC) motor results from the interaction between permanent magnets and iron core, and it causes noise and induce vibrations. During a manufacturing process, assembly tolerances lead to the change of the electromagnetic structure of a BLDC motor where permanent magnets are not properly glued to the surface of rotor core. In this paper, the effect of magnet separation from the surface of rotor core on the cogging torque is investigated due to assembly tolerance. The relationship with key design parameters is considered such as separation between magnets and rotor core, the number of magnets having separation, as well as the several types of arrangements among neighboring magnets. Finite element method (FEM) has been used to analyze a BLDC motor, and the allowable assembly tolerance is proposed to prevent generating noise and vibrations. Within proposed assembly tolerance, it is concluded that the cogging torque of a BLDC motor is decreased, and hence noise and vibrations.

• The Plant Pathology Journal
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• v.33 no.3
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• pp.329-336
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• 2017

An experiment was conducted to evaluate the tolerance of micropropagated and mycorrhized alpinia plants to the parasite Meloidogyne arenaria. The experimental design was completely randomized with a factorial arrangement of four inoculation treatments with arbuscular mycorrhizal fungi (AMF) (Gigaspora albida, Claroideoglomus etunicatum, Acaulospora longula, and a non-inoculated control) in the presence or absence of M. arenaria with five replicates. The following characteristics were evaluated after 270 days of mycorrhization and 170 days of M. arenaria inoculation: height, number of leaves and tillers, fresh mass of aerial and subterranean parts, dry mass of aerial parts, foliar area, nutritional content, mycorrhizal colonization, AMF sporulation, and the number of galls, egg masses, and eggs. The results indicated a significant interaction between the treatments for AMF spore density, total mycorrhizal colonization, and nutrient content (Zn, Na, and N), while the remaining parameters were influenced by either AMF or nematodes. Plants inoculated with A. longula or C. etunicatum exhibited greater growth than the control. Lower N content was observed in plants inoculated with AMF, while Zn and Na were found in larger quantities in plants inoculated with C. etunicatum. Fewer galls were observed on mycorrhized plants, and egg mass production and the number of eggs were lower in plants inoculated with G. albida. Plants inoculated with A. longula showed a higher percentage of total mycorrhizal colonization in the presence of the nematode. Therefore, the association of micropropagated alpinia plants and A. longula enhanced tolerance to parasitism by M. arenaria.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.22 no.5
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• pp.480-488
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• 2012

The aircrafts with high aspect ratio wings made by a composite material have been developed, which enable high energy efficiency and long-term flight by reducing air resistance and structural weight. However, they have difficulties in securing the aeroelastic stability such as the flutter because of their long and flexible wings. The flutter is unstable self-excited-vibration caused by interaction between the structural dynamics and the aerodynamics. It should be verified analytically prior to first flight test that the flutter does not happen in the range of flight mission. Normally, the finite element model is used for the flutter analysis. So it is important to construct the finite element model representing dynamic characteristics similar to those of a real aircraft. Accordingly, in this research, to acquire dynamic characteristics experimentally the modal test of the aircraft with high aspect ratio composite wings was conducted. And then the modal parameters from the finite element analysis(FEA) were compared with those from the modal test. To make analysis results closer to test results, the finite element model was updated by means of the sensitivity analysis on variables and the optimization. Finally, it was proved that the updated finite element model is reliable as compared with the results of the modal test.

• International Journal of Industrial Entomology and Biomaterials
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• v.7 no.2
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• pp.221-229
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• 2003

Ten multivoltine female parental lines were crossed with popular bivoltine male silkworm breed NB$_4$D$_2$. Three types of heterosis parameters viz., heterosis over mid-parental value (hybrid vigour), heterobeltiosis (useful heterosis) and standard heterosis (standard check) were estimated for 15 economically important quantitative traits. The interaction among the hybrids and parents indicated significant effect for maximum characters. The heterotic effect of new hybrid combination was compared with popular hybrids viz., Pure Mysore${\times}$NB$_4$D$_2$ and Nistari${\times}$NB$_4$D$_2$. Varied heterotic effect was observed for different traits for different hybrid combination. The results inferred that the crosses viz., BL$_{23}$${\times}$NB$_4$D$_2$ ranked top for 14 traits followed by Hosa Mysore${\times}$NB$_4$D$_2$ for 11 traits; PA$_{12}$${\times}$NB$_4$D$_2$ for 9 traits; BL$_{24}$${\times}$NB$_4$D$_2$ for 8 traits; Kolar Gold${\times}$NB$_4$D$_2$ for 7 traits; WAI$_1$${\times}$NB$_4$D$_2$ for 6 traits and MU$_{11}$${\times}$NB$_4$D$_2$ for 5 traits. Among these, the best hybrids Kolar Gold${\times}$NB$_4$D$_2$ and MU$_{11}$${\times}$NB$_4$D$_2$ were identified for longer filament length and fine denier. Similarly for higher cocoon yield and silk productivity BL$_{223}$${\times}$NB$_4$D$_2$ and BL$_{24}$${\times}$NB$_4$D$_2$ were found to be superior. These hybrid combinations are suitable for commercial exploitation at large scale.e.e.e.

• The Bulletin of The Korean Astronomical Society
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• v.35 no.1
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• pp.75.2-75.2
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• 2010

We investigate the dependence of occurrence of bar in galaxies on galaxy properties and environment. The environmental conditions considered include the large-scale background density and distance to the nearest neighbor galaxy. We use a volume-limited sample of 33,296 galaxies brighter than $M_r$=-19.5+5logh at $0.02{\leqq}z{\leqq}0.05489$, drawn from the Sloan Digital Sky Survey Data Release 7. We classify the galaxies into early and late types, and identify bars by visual inspection. We find that the fraction of barred galaxies ($f_{bar}$) is 18.2% on average in the case of late-type galaxies, and depends on both u-r color and central velocity dispersion $(\sigma);f_{bar}$ is a monotonically increasing function of u-r color, and has a maximum value at intermediate velocity dispersion (${\sigma}{\simeq}170km\;s^{-1}$). This trend suggests that bars are dominantly hosted by systems having intermediate-mass with no recent interaction or merger history. We also find that $f_{bar}$ does not directly depend on the large-scale background density as its dependence disappears when other physical parameters are fixed. We discover the bar fraction decreases as the separation to the nearest neighbor galaxy becomes smaller than 0.1 times the virial radius of the neighbor regardless of neighbor's morphology. These results imply that it is difficult for bars to be maintained during strong tidal interactions, and that the source for this phenomenon is gravitational and not hydrodynamical.

• Journal of the Korean GEO-environmental Society
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• v.10 no.7
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• pp.135-141
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• 2009

For more reliable estimation of soil-structure interaction and seismic source and attenuation properties, site amplification function should be considered. This study use the Nakamura's method (1989) for estimating site amplification though various methods for the same purpose have been proposed. This method was originally applied to the surface waves of background noise and therefore there are some limitation for applications to general wave energy. However, recently this method has been extended and applied to the S wave energy successfully. This study applied the method to the coda wave energy which is equivalent to the backscattered S wave energy. We used more than 60 observed ground motions from 5 earthquakes which occurred recently, with magnitude range from 3.6 to 5.1 Each station showed characteristic site amplification property in low-, high- and resonance frequency ranges. In the case of comparing these results to those from S wave energy, lots of information to the site classification work can be gained. Moreover, removal of site amplification can give us more reliable seismic source parameters.