• 한국터널지하공간학회 논문집
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• 제19권2호
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• pp.143-159
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• 2017

지진하중으로 초래되는 지하터널 구조물의 손상에 대한 위험도를 예측하기 위해 이 논문에서 확률론적 취약도 평가절차를 개발하였다. 특히 지진취약도 평가에 필수 요소인 취약도곡선의 유도를 위하여 단순화된 방법론을 정립하는 데 중점을 두었다. 지반-구조물상호작용(SSI) 효과를 고려한 구조물의 동적응답거동을 추정하기 위해서 지중구조물에 대한 지반응답가속도법(GRAMBS)을 제안기법에 적용하였다. 또한, 푸시오버 해석을 통해 터널의 손상상태를 정의하고 라틴하이퍼큐브 샘플링(LHS) 기법을 사용하여 설계변수와 관련된 불확실성을 고려하였다. 적용된 기법의 개념을 보다 상세하게 설명하기 위하여 설계스펙트럼을 만족하도록 생성된 다수의 인공지진운동에 대해 수치해석을 수행하고 취약도곡선을 개발하였다. 두 매개변수 대수정규분포 함수로 지진 취약도곡선을 표현하는데, 여기서 두 매개변수인 중앙값과 대수표준편차는 최우추정(MLE)법을 사용하여 산정하였다.

• 대한토목학회논문집
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• 제34권2호
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• pp.355-365
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• 2014

원형 콘크리트 충전 강관(CFT)은 급속시공이 가능하고 뛰어난 좌굴 성능 및 콘크리트의 구속효과와 같은 여러 장점을 가지고 있어, 건축물의 기둥이나 교량의 교각으로 이용되고 있다. 하지만 CFT는 이러한 장점에도 불구하고 널리 이용되고 있지 않고 있다. 이러한 이유는 CFT의 설계기준들이 서로 상이하여 보수적인 설계가 이루어지고 있는 것에 일부 기인한다. 이 연구에서는 CFT설계에 널리 이용되는 AISC 및 EC4 설계기준의 타당성을 기존 연구자들이 수행한 실험 결과 및 이 연구에서 수행된 유한요소해석 결과를 이용하여 검증하였다. 특히 축력과 휨모멘트가 동시에 작용하는 CFT에 대하여 AISC 및 EC4에서 제안한 P-M 상관곡선의 타당성 검증에 초점을 두었다. 연구 결과, 기존의 P-M 상관곡선은 CFT의 강도를 상당히 보수적으로 예측하는 것을 알 수 있었다. 이 연구에서는 개선된 P-M 상관곡선을 제안하고 기존 실험 결과 및 이 연구에서 수행한 유한요소해석 결과를 이용하여 검증하였다.

• Bulletin of the Korean Chemical Society
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• 제33권8호
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• pp.2719-2723
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• 2012

A kinetic study is reported for nucleophilic substitution reactions of benzyl 4-pyridyl carbonate 6 with a series of alicyclic secondary amines in MeCN. The plot of pseudo-first-order rate constant ($k_{obsd}$) vs. [amine] curves upward, which is typical for reactions reported previously to proceed through a stepwise mechanism with two intermediates (i.e., a zwitterionic tetrahedral intermediate $T^{\pm}$ and its deprotonated form $T^-$). Dissection of $k_{obsd}$ into the second- and third-order rate constants (i.e., $Kk_2$ and $Kk_3$, respectively) reveals that $Kk_3$ is significantly larger than $Kk_2$, indicating that the reactions proceed mainly through the deprotonation pathway (i.e., the $k_3$ process) in a high [amine] region. This contrasts to the recent report that the corresponding aminolysis of benzyl 2-pyridyl carbonate 5 proceeds through a forced concerted mechanism. An intramolecular H-bonding interaction was suggested to force the reactions of 5 to proceed through a concerted mechanism, since it could accelerate the rate of leaving-group expulsion (i.e., an increase in $k_2$). However, such H-bonding interaction, which could increase $k_2$, is structurally impossible for the reactions of 6. Thus, presence or absence of an intramolecular H-bonding interaction has been suggested to be responsible for the contrasting reaction mechanisms (i.e., a forced concerted mechanism for the reaction of 5 vs. a stepwise mechanism with $T^{\pm}$ and $T^-$ as intermediates for that of 6).

• The Korean Journal of Pain
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• 제18권1호
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• pp.10-14
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• 2005

Background: Previous studies have suggested synergistic analgesic drug interactions between NSAIDs and opioids in neuropathic and inflammatory pain models. The aim of this study was to investigate the analgesic drug interaction between intraperitoneal (IP) ketorolac and morphine in radiant thermal stimulation rat. Methods: Initially, we assessed the withdrawal latency time of the hindpaw to radiant thermal stimulation every 15 min for 1 hour and every 30 min for next 1 hour after IP normal saline 5 ml (control group). The latency time was changed into percent maximal possible effect (%MPE). Next, IP dose response curves were established for the %MPE of morphine (0.3, 1, 3, 10 mg/kg) and ketorolac (3, 10, 30 mg/kg) to obtain the $ED_{50}$ for each agent. And we confirmed that the IP morphine effect was induced by opioid receptor through IP morphine followed by IP naloxone. At last, we injected three doses of IP ketorolac (3, 10, 30 mg/kg) mixed with one dose of morphine (2 mg/kg) for fixed dose analysis. Results: IP morphine delayed the paw withdrawal latency time dose dependently, but not ketorolac. $ED_{50}$ of IP morphine was 2.1 mg/kg. And the IP morphine effect was reversed to control level by IP naloxone. IP ketorolac + morphine combination showed no further additional effects on paw withdrawal latency time over morphine only group. Conclusions: IP ketorolac did not produce antinociceptive effect during radiant thermal stimulation. There was neither additional nor synergistic analgesic interaction between IP morphine and ketorolac in thermal stimulation rat.

• Toxicological Research
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• 제20권2호
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• pp.89-100
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• 2004

The comet assay (also called the single-cell gel electrophoresis assay) has been widely used for detecting DNA damage and repair in individual cells. Since the conventional methods of evaluating comet assay data using frequency statistics are unsatisfactory we developed a new quantitative measure of DNA damage/repair that is based on all information residing in the dose/time-response curves of a comet experiment. Blood samples were taken from 25 breast cancer patients before undergoing radiotherapy. The comet assay was performed under alkaline conditions using isolated lymphocytes. Tail DNA, tail length, tail moment and tail inertia of the comet were measured for each patient at four doses of $\gamma$-rays (0, 2, 4 and 8 Gy) and at four time points after irradiation (0, 10, 20 and 30 min) using 100 cells each. The resulting three-dimensional dose-time response surface was modeled by multiple regression, and the second derivative, termed 2D, on dose and time was determined. A software module was programmed in SAS/AF to compute 2D values. We applied the new method successfully to data obtained from cancer patients to be assessed for their radiation sensitivity. We computed the 2D values for the four damage measures, i.e., tail moment, tail length, tail DNA and tail inertia, and examined the pairwise correlation coefficients of 2D both on the log scale and the unlogged scale. 2D values based on tail moment and tail DNA showed a high correlation and, therefore, these two damage measures can be used interchangeably as far as DNA repair is concerned. 2D values based on tail inertia have a correlation profile different from the other 2D values which may reflect different facets of DNA damage/repair. Using the dose-time response surface, other statistical models, e.g., the proportional hazards model, become applicable for data analysis. The 2D approach can be applied to all DNA repair measures, Le., tail moment, tail length, tail DNA and tail inertia, and appears to be superior to conventional evaluation methods as it integrates all data of the dose/time-response curves of a comet assay.

• Steel and Composite Structures
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• 제16권2호
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• pp.157-185
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• 2014

This paper examines the behaviour of two types of practical open beam-to-tubular column connection details subjected to combined moment, axial and/or shear loads. Detailed continuum finite element models are developed and validated against available experimental results, and extended to deal with flexural, axial and shear load interactions. A numerical investigation is then carried out on the behaviour of selected connections with different stiffness and strength characteristics under various load combination scenarios. The influence of applied levels of axial tensile or compressive loads on the bending stiffness and capacity is examined and discussed. Additionally, the interaction effects between shear forces and co-existing bending and axial loads are examined and shown to be comparatively insignificant in terms of stiffness and capacity in most cases. It is also shown that the range of connections considered in this paper can provide rotational ductility levels in excess of those required under typical design scenarios. Based on these findings, a simplified component-based representation is proposed and described, and its ability to represent the connection response under combined loading is verified using results from detailed numerical simulations.

• Steel and Composite Structures
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• 제21권5호
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• pp.1045-1067
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• 2016

Concrete bridges with corrugated steel webs and prestressed by both internal and external tendons have emerged as one of the promising bridge forms. In view of the different behaviour of components and the large shear deformation of webs with negligible flexural stiffness, the assumption that plane sections remain plane may no longer be valid, and therefore the classical Euler-Bernoulli and Timoshenko beam models may not be applicable. In the design of this type of bridges, both the ultimate load and ductility should be examined, which requires the estimation of full-range behaviour. An analytical sandwich beam model and its corresponding beam finite element model for geometric and material nonlinear analysis are developed for this type of bridges considering the diaphragm effects. Different rotations are assigned to the flanges and corrugated steel webs to describe the displacements. The model accounts for the interaction between the axial and flexural deformations of the beam, and uses the actual stress-strain curves of materials considering their stress path-dependence. With a nonlinear kinematical theory, complete description of the nonlinear interaction between the external tendons and the beam is obtained. The numerical model proposed is verified by experiments.

• 대한기계학회논문집A
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• 제26권8호
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• pp.1487-1494
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• 2002

In this study, to propose the prediction method of the crack growth under flight-simulation loading, crack growth tests are conducted on 2124-7851 aluminum alloy specimens. The prediction of crack growth under flight-simulation loading is performed by the stochastic crack growth model which was developed in previous study. First of all, to reduce the complex load history into a number of constant amplitude events, rainflow counting is applied to the flight-simulation loading wave. The crack growth, then, is predicted by the stochastic crack growth model that can describe the load interaction effect as well as the variability in crack growth process. The material constants required in this model are obtained from crack growth tests under constant amplitude loading and single tensile overload. The curves predicted by the proposed model well describe the crack growth behavior under flight-simulation loading and agree with experimental data. In addition, this model well predicts the variability of fatigue lives.

• Biotechnology and Bioprocess Engineering:BBE
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• 제6권4호
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• pp.293-300
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• 2001

A polyrotaxane-biotin conjugate was synthesized and its interaction with streptavidin measured using surface plasmon resonance(SPR) detection. A biodegradable polyrotaxane in which ca, 22 molecules of ${\alpha}$-cyclodextrina(${\alpha}$-CDs) were threaded onto a poly(ethylene oxide) chain(M$\sub$n:4,000) capped with benzyloxycarbonyl-L-phenylalanine was conjugated with a biotin hydorazide and 2-aminoethanol after activing the hydroxyl groups of ${\alpha}$-CDs in the polyrotaxane using N, N'-carbonyldiimidazole. The results of the high-resolution $^1$H-nyclear lmagnetic resonance($^1$H-NMR)spectra and gel permeation chromatography of the conjugate showed that ca, 11 biotin molecules were actually introduced to the polyrotaxane scaffold. An SPR analysis showed that the binding curves of the biotin molecules in the conjugate on the streptavidin-deposited surface changed in a concentration dependent manner, indicating that the biotin in the conjugate was ac-tually recognized by streptavidin. The association equilibrium constant(K$\sub$a/) of the interaction be-tween the conjugate and steptavidin tetramer was of the order 10$\^$7/. These results suggest that polyrotaxane is useful for scaffolds as a polymeric ligand in biomedical fields.

• 한국정밀공학회지
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• 제19권8호
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• pp.100-107
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• 2002

The extruder screw is a part for extruding material in a injection molding machine. The screw's geometrical shape can mathematically be described by a sweep surface which is constructed by sweeping a section curve composed of a few circular arcs, along a helical guide curve. In the paper we developed a dedicated CAD system which basically is parametric in a sense that the system initially takes several design parameters to construct the geometric elements including the final sweep surface of the screw as well as section & guiding curves, along with feasibility check of the input parameter values, without further user interaction. The system has been developed as a built-in module onto a commercial CAD system, which can further incorporate additional NC-out functions with ease.