• Title/Summary/Keyword: interaction

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ABO Blood Group, Epstein-Barr virus Infection and Prognosis of Patients with Non-metastatic Nasopharyngeal Carcinoma

  • Zhang, Ya-Xiong;Kang, Shi-Yang;Chen, Gang;Fang, Wen-Feng;Wu, Xuan;You, Hua-Jing;He, Da-Cheng;Cao, Ya-Lin;Liang, Wen-Hua;Zhang, Li
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.17
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    • pp.7459-7465
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    • 2014
  • Background: A prior study showed blood type A/AB to be associated with an increased risk of nasopharyngeal carcinoma (NPC) compared to subjects with blood type O. However, the relationship between ABO blood groups and prognosis of NPC patients is still questionable. In addition, whether Epstein-Barr virus (EBV) infection is associated with prognosis of NPC patients with different ABO blood groups is unclear. Materials and Methods: We conducted univariate and multivariable Cox regression analyses based on a consecutive cohort of 1,601 patients to investigate the above issues. Results: There was no significant difference in overall survival (OS) between different ABO blood groups (p=0.629), neither between A vs. non-A blood groups (p=0.895) nor AB vs. non-AB blood group (p=0.309) in univariate analyses and after adjusting for other factors. Interaction tests revealed that high immunoglobulin A against Epstein-Barr virus viral capsid antigen (VcA-IgA) level was associated with a favorable prognosis in male patients with UICC stage II disease who had an A blood type (p=0.008), compared with those with non-A blood type. In addition, male patients with an A blood group with a high blood lymphocyte level showeda tendency towards better survival in UICC stage III (p=0.096). Conclusions: ABO blood group status is not associated with the prognosis of patients with NPC. Additionally, blood group A male NPC patients with high VcA-IgA level or high blood lymphocyte counts might be correlated with a favorable prognosis in UICC stage II or III, respectively.

Folate-Related Nutrients, Genetic Polymorphisms, and Colorectal Cancer Risk: the Fukuoka Colorectal Cancer Study

  • Morita, Makiko;Yin, Guang;Yoshimitsu, Shin-Ichiro;Ohnaka, Keizo;Toyomura, Kengo;Kono, Suminori;Ueki, Takashi;Tanaka, Masao;Kakeji, Yoshihiro;Maehara, Yoshihiko;Okamura, Takeshi;Ikejiri, Koji;Futami, Kitaroh;Maekawa, Takafumi;Yasunami, Yohichi;Takenaka, Kenji;Ichimiya, Hitoshi;Terasaka, Reiji
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.11
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    • pp.6249-6256
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    • 2013
  • One-carbon metabolism plays an important role in colorectal carcinogenesis. Meta-analyses have suggested protective associations of folate and vitamin $B_6$ intakes with colorectal cancer primarily based on studies in Caucasians, and genetic polymorphisms pertaining to the folate metabolism have been a matter of interest. Less investigated are the roles of methionine synthase (MTR) and thymidylate synthetase (TS) polymorphisms in colorectal carcinogenesis. In a study of 816 cases and 815 community controls in Japan, we investigated associations of dietary intakes of folate, methionine, vitamin $B_2$, vitamin $B_6$, and vitamin $B_{12}$ with colorectal cancer risk. The associations with MTR 2756A>G, MTRR 66A>G, and TSER repeat polymorphism were examined in 685 cases and 778 controls. Methionine and vitamin $B_{12}$ intakes were inversely associated with colorectal cancer risk, but the associations were totally confounded by dietary calcium and n-3 fatty acids. The other nutrients showed no association with the risk even without adjustment for calcium and n-3 fatty acids. The TSER 2R allele was dose-dependently associated with an increased risk. The MTR and MTRR polymorphisms were unrelated to colorectal cancer risk. There was no measurable gene-gene or gene-nutrient interaction, but increased risk associated with the TSER 2R allele seemed to be confined to individuals with high folate status. This study does not support protective associations for folate and vitamin $B_6$. The TSER 2R allele may confer an increased risk of colorectal cancer. The role of the TSER polymorphism in colorectal carcinogenesis may differ by ethnicity.

The Crystal Structure of a Bromine Sorption Complex of Dehydrated Fully $Ca^{2+}$-Exchanged zeolite A (칼슘이온으로 완전히 치환한 제올라이트 A를 탈수한 후 브롬을 흡착한 결정구조)

  • Jang, Se-Bok;Han, Young-Wook;Moon, Sung-Doo;Kim, Yang
    • Journal of the Korean Chemical Society
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    • v.35 no.6
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    • pp.630-635
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    • 1991
  • The crystal structure of a bromine sorption complex of dehydrated fully $Ca^{2+}$-exchanged zeolite A (a = 12.211(2) ${\AA}$) has been determined by single-crystal X-ray diffraction techniques in the cubic space group, Pm3m at $21(1)^{\circ}C$. The crystal was prepared by dehydration at $360^{\circ}C$ and 2 ${\times}$ $10^{-6}$ Torr for 2 days, followed by exposure to about 180 Torr of bromine vapor at $24^{\circ}C$ for 30 min. In the resulting structure, six $Ca^{2+}$ ions are located on two different threefold axes associated with 6-ring oxygens. A total of six dibromine molecules are sorbed per unit cell. Each $Br_2$ molecule approaches a framework oxide ion axially, with O-Br = 3.12(7) ${\AA}$, Br-Br = 2.64(9) ${\AA}$ and O-Br-Br = $178(2)^{\circ}$, indicating a charge-transfer interaction. Full-matrix least-squares refinement converged to a conventional R index of 0.104 using the 103 independent reflections for which I > 3${\sigma}$ (I).

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자화수에서 염류의 용해속도 변화와 자화수에 의한 NaCl, KCl 및 석고의 결정화 양상에 대한 연구

  • Jeon, Sang Il;Kim, Dong Ryul;Lee, Suk Keun
    • Journal of the Korean Chemical Society
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    • v.45 no.2
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    • pp.116-120
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    • 2001
  • In order to know the physicochemical properties of magnetized water, the experimental methods of column assay, crystalization of saltsand gypsom have been explored to elucidate the effects of magnetized water on the solubility speed of salts, crystal pattern from salt squeous solutions, and gypsom crystal pattern, respectively. In the column assay for salt solubility the magnetized water showed the decreased initial solubility speed of NaCl and slightly increased initial solubility spped of KCI, however, the maximum solugilities of NaCl and KCI in the magnetized aster were almost same in the double distilled water, respectively. The column assay also indicated that the magnetized water showed the decreased initial solubility speed of urea (CH$_4$N$_2$O), sodium citrate (HOC(CO$_2$Na)-(CH$_2$CO$_2$Na)$_2$-2H$_2$O) and (NH$_4$)$_2$compared to the double distilled water, while slightly increased solubility speed of glycine (NH$_2$CH$_2$COOH), boric acid (H$_3$BO$_3$), MgSO$_4$. Crystalization of 1% or 5% salt aqueous solutions by rapid evaporation disclosed that the magnetized water produced more condensed and bigger crystal structure than the control water. The pattern of gypsom crystal formation also indicated that the magntized water enhanced the crystal formation in the hydration reaction of gypsom plaster compared to the double distilled water. Taken together, it was presumed that the magnetized water showed the different physicochemical properties in the interaction with various salts, especially showed the contrast results between NaCl and KCI.

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A Hand Gesture Recognition System using 3D Tracking Volume Restriction Technique (3차원 추적영역 제한 기법을 이용한 손 동작 인식 시스템)

  • Kim, Kyung-Ho;Jung, Da-Un;Lee, Seok-Han;Choi, Jong-Soo
    • Journal of the Institute of Electronics and Information Engineers
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    • v.50 no.6
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    • pp.201-211
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    • 2013
  • In this paper, we propose a hand tracking and gesture recognition system. Our system employs a depth capture device to obtain 3D geometric information of user's bare hand. In particular, we build a flexible tracking volume and restrict the hand tracking area, so that we can avoid diverse problems caused by conventional object detection/tracking systems. The proposed system computes running average of the hand position, and tracking volume is actively adjusted according to the statistical information that is computed on the basis of uncertainty of the user's hand motion in the 3D space. Once the position of user's hand is obtained, then the system attempts to detect stretched fingers to recognize finger gesture of the user's hand. In order to test the proposed framework, we built a NUI system using the proposed technique, and verified that our system presents very stable performance even in the case that multiple objects exist simultaneously in the crowded environment, as well as in the situation that the scene is occluded temporarily. We also verified that our system ensures running speed of 24-30 frames per second throughout the experiments.

Interaction Contents for Reconsidering Visually Disabled Parents

  • Hong, Joo-Bong;Lee, Chan-Kyu;Lim, Chan
    • International journal of advanced smart convergence
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    • v.9 no.1
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    • pp.54-62
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    • 2020
  • According to the Ministry of Health and Welfare, "Status of Registered Persons with Disabilities", the number of people with disabilities is 2,494,460 as of 2015. The lowest rates of children with disabilities were intellectual disabilities (23%) and mental disorders (33.3%). The highest rates of screening were blindness (97%), heart failure (94.4%), and hearing impairment (92.7%). 65.2% of visually impaired people who have already had a disability at the time of marriage, and the remaining 34.8% can be thought to be the cause of high incidence of disability after marriage. 'SID (Seed in the Dark)' project was designed to recapture the visually impaired parent's desire for attachment and the space difficulties of the blind who want to be a normal parent to their children through a visual impairment of a father with 7-year-old daughter. Using Gear VR(Virtual Reality), the general public was able to feel the surroundings as if they had no vision and focused on the hearing. Especially, We expressed the sound wave visually and added the hilarious game element which grasps the terrain of the maze by sound wave like a 'blind person who perceives the surroundings by sound' and catches up with daughter. People with disabilities who are far from mental illness often have a form of family with children. The fact that the rate of childbirth is high means that there is relatively little problem in daily life. It is wondered that the rate of blindness among the visually impaired, which accounts for 10% of the total disabled, is the highest at 97%. This is because, in the case of the visually impaired, the obstacle is often caused by aging, accidents, or diseases due to inherited causes rather than the visual disorder. In particular, However, the fact that there is an obstacle in vision that accounts for 83% of the body's sensory organs causes other difficulties in the nursing process of children who are non-disabled. Parents do not know the face of child when their visual impairment is severe. Parents are extremely anxious about worry that they will be lost or abducted if their children are not by their side. And that the child recognizes the disability of his or her parents other than the other parents easily and takes it as a deficiency. Since visually impaired parents are mentally mature parents with non-disabled people, they may want their children not to feel deprived of their disability. The number of people with visual impairments has been increasing since 2001, and people with impairments often become disabled. In addition, there is much research on the problem of nondisabled parents who have children with disabilities, while there is relatively little interest and research on the problem of nondisabled child rearing of parents with disabilities.

The Threshold of 0.5% Salt-water Taste and Risk of Stomach Cancer (0.5% 소금물에 대한 역치와 위암발생의 위험도)

  • Ohrr, Hee-Chul;Lee, Kang-Hee;Yi, Sang-Wook
    • Journal of agricultural medicine and community health
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    • v.25 no.2
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    • pp.293-302
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    • 2000
  • The relationship between sodium intake and stomach cancer risk has been studied much in Japan but a great portions still remain controversial. There has been few studies on relationship between sodium intake and stomach cancer in Korea. The goal of this nested case-control study is to investigate the association between sodium intake and stomach cancer risk in a rural county of Korea We estimated sodium intake indirectly by the threshold of salt-water taste of patients. This study was based on both of the data from 'Kangwha Cohort Study' which had been conducted from March 1985 and 'Kangwha Community Cancer Registry' which had been launched on July in 1982 by the College of Medicine, Department of Preventive Medicine. Yonsei University. A total of 145 patients who developed stomach cancer in Kangwha County were initially recruited as the case group. We tried to get two community-controls per stomach cancer case by matching age and gender. Finally we got information from 90 cases and 146 controls about the threshold of the salt taste and preference of salty food and so on. Some 79% of the information about ease group came from proxy respondents and 56% among controls. Risk ratios of developing stomach cancer adjusted for smoking, body mass index and self-stated health level were estimated. No statistically significant association between the threshold of salt taste and stomach cancer risk found in this study. We recommend some further studies utilizing urinary salt excretion, diet record method for better estimating of salt intake with a paticular emphasis on interaction effect between salty and spicy food in hospital-based case-control study designs.

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NEONATAL BEHAVIORAL CHARACTERISTICS AND DOPAMINE TRANSPORTER GENE AND DOPAMINE D2, D3, D4 RECEPTOR GENE POLYMORPHISMS (신생아 행동 특성과 Dopamine Transporter 유전자 및 Dopamine D2, D3, D4 수용체 유전자의 다형성)

  • Park, Young-Nam;Kim, Dae-Kwang;Kim, Sung-Wook
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.12 no.2
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    • pp.179-191
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    • 2001
  • Objectives:This study evaluated the association between behavioral characteristics and polymorphisms in DAT1, DRD2, DRD3, and DRD4 genes. Methods:The subjects were 114 neonates, who were born by normal spontaneous vaginal delivery and had no physical problems. The behavioral characteristics were evaluated using Neonatal Behavioral Assessment Scale(NBAS) at $17.8{\pm}7.0$ hours after their birth to minimize environmental influences, and cord blood was used to analyze the gene polymorphisms. Results:In comparison to DAT1 gene 10/10 genotype group(N=93), other genotype group(N=19) showed significantly high NBAS scores on social-interaction, state organization, and state regulation. DRD2 gene Ser311/Cys311, TaqI A, and TaqI B polymorphisms showed no significant differences on NBAS scores when they were grouped by genotypes. DRD3 gene polymorphism and DRD4 gene promotor polymorphism showed no significant difference on NBAS scores when they were grouped by genotypes. In comparison to the short repeats(N=102), long repeats(N=10) in DRD4 gene showed significantly high habituation score of NBAS. Conclusion:These results suggest that the genetic effects of the neonatal behavioral characteristics may be mediated via DAT1 and DRD4 genes.

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System Diagnosis and MEMS Driving Circuits Design using Low Power Sensors (저 전력 센서를 이용한 MEMS 회로의 구현과 시스템 효율의 진단)

  • Kim, Tae-Wan;Ko, Soo-Eun;Jabbar, Hamid;Lee, Jong-Min;Choi, Sung-Soo;Lee, Jang-Ho;Jeong, Tai-Kyeong
    • Journal of the Institute of Electronics Engineers of Korea SC
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    • v.45 no.1
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    • pp.41-49
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    • 2008
  • Many machineries and equipments are being changing to various and complicated by development of recent technology and arrival of convergence age in distant future. These various and complicate equipments need more precise outcomes and low-power consumption sensors to get close and exact results. In this paper, we proposed fault tolerance and feedback theorem for sensor network and MEMS circuit which has a benefit of energy efficiency through wireless sensor network. The system is provided with independent sensor communication if possible as unused action, using idle condition of system and is proposed the least number of circuits. These technologies compared system efficiency after examining product of each Moving Distance by developed sensor which gives effects to execution of system witch is reduced things like control of management side and requirement for hardware, time, and interaction problems. This system is designed for practical application; however, it can be applied to a normal life and production environment such as "Ubiquitous City", "Factory Automata ion Process", and "Real-time Operating System", etc.

전이금속 (Ru$^{3+}$, Ni$^{2+}$, Cu$^{2+}$, Pd$^{2+}$)-Polyaza(N$_4$) 착물의 합성과 올레핀 산화반응에 대한 촉매적 활성

  • Park, Yu Cheol;Kim, Seong Su;Na, Hun Gil;Lee, Dong Cheol;Sin, Sang Hui;Byeon, Jong Cheol
    • Journal of the Korean Chemical Society
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    • v.38 no.4
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    • pp.295-301
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    • 1994
  • The Ru(Ⅲ), Ni(Ⅱ), Cu(Ⅱ), and Pd(Ⅱ) complexes of N$_4$-polydentate ligands(meso-Me$_6$-[14]-ane, rac-Me$_6$-[14]-ane, and cyclam) have been prepared and their catalytic activity and selectivity in the oxidation of olefins in the presence of oxidant such as NaOCl, H$_2$O$_2$, t-BuOOH, and PhIO studied. The oxidations of cyclohexene, 1-hexene, cyclooctene, 1-octene, and styrene as substrates have been investigated gas chromatographically. The Ru(Ⅲ)-N$_4$ complexes showed high selectivity for epoxide in the catalyzed oxidation of olefins with NaOCl. The catalytic activities of Ru(Ⅲ)-N$_4$ complexes were discussed in terms of the flexibility of N$_4$-polydentate ligands, the Ru(Ⅲ)-Cl bond interaction and the steric effect of oxidants. The oxidation of 1-octene using PhIO as oxidant was carried out to verify. The Pd(Ⅱ) complex turned out to be more active catalyst than the Ni(Ⅱ) complexes.

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