• Journal of Korean Traditional Oncology
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• v.23 no.2
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• pp.11-25
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• 2018

Objective: The purpose of this study is to report the case of a patient with non-small cell lung cancer (NSCLC) with Programmed cell death protein 1 (PD-1) mutation treated by Integrative Medicine Therapy (IMT). Methods: A patient with metastatic NSCLC received pembrolizumab 200mg intravenously for every 3 weeks from July 2017. Repeat cycle every 3 weeks since July 2017. The patient has been treated with Integrative Medicine Therapy (IMT) since December 2016. The tumor size was measured by computed tomography (CT) and magnetic resonance imaging(MRI). Adverse events were evaluated by the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE), version 5.0. Results: After combined treatment, the extent of proximal portion of primary tumor in the left lower lobe was decreased and disease status was stable radiologically. No evidence of newly developed metastatic lesions in the brain since May 2017. The patient did not experience any adverse event according to NCI-CTCAE ver. 5.0. Conclusion: This case study suggests that Integrative Medicine Therapy (IMT) may contribute to tumor response, in conjunction with Pembrolizumab on the treatment of patients with NSCLC.

• Journal of Korean Medicine Rehabilitation
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• v.27 no.2
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• pp.93-99
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• 2017

Objectives The purpose of this study is to understand the condition of the Ease-West Integrative Care system in one of Korean Medical hospital, to develop more effective system, and to collect advance information for future research. Methods We analyzed patient's status, patient's composition and the ranking of the major disease code. In addition, we investigated the operating system of how Ease-West Integrative Care in hospitals is operating in order to grasp the actual situation is being done. Results As a result of analyzing the status, there was a balanced cooperation between the Korean Medicine and Western Medicine with a ratio of 0.86:1. The disease status from Korean Medicine to Western Medicine were mostly occupied by stroke patients and from Western Medicine to Korean Medicine fragment were mostly by musculoskeletal pain patients. Conclusions The results of this study showed that the Ease-West Integrative Care system of surveyed Korean Medical hospital has more integrated medical characteristics than previous studies in terms of quality and quantitative. Future research based on detailed data collection and review for a longer period is expected in the further.

• Journal of Acupuncture Research
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• v.37 no.4
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• pp.247-253
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• 2020

Background: Parkinson's disease(PD) affects not only motor symptoms, but also nonmotor symptoms. This study is a clinical trial to determine whether Qigong and acupuncture affect nonmotor symptoms of PD. Methods: A 2-arm parallel and randomized trial was performed with 21 participants who had received either Qigong meditation only [control group (CG)] or acupuncture and Qigong meditation [experimental group (EG)]. The participants' levels of the discomfort in nonmotor symptoms from Parkinson's disease were evaluated by using the Unified Parkinson's Disease Rating Scales (UPDRS 1) and Test of Smell Identification (TSI) before and after 12 treatments at baseline and 1 month after 12 treatments. Results: The both CG and EG showed improvements in the UPDRS 1 score after treatment by 5.6 ± 5.15 (p= 0.003; 74%) and 4.8 ± 3.80 (p = 0.004; 79%), respectively. The both CG and the EG did improvements in the TSI after treatment by 10.3 ± 4.37 (p < 0.001; 84%) and 12.6 ± 1.77 (p = 0.022; 100%), respectively. However, statistical differences were not observed between the CG and the EG using the UPDRS 1 and the TSI scores. Conclusion: The combination of Qigong and acupuncture and Qigong alone was shown to improve the nonmotor symptoms and olfactory function of PD. In the future, large-scale clinical studies on alternative treatment for PD and studies on mechanisms affecting nonmotor symptoms of acupuncture and Qigong are needed.

• Journal of Society of Preventive Korean Medicine
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• v.26 no.1
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• pp.11-23
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• 2022

Objectives : The aim of this study was to develop a clinical pathway (CP) model for the integrative treatment of non-invasive breast cancer, with western medicine and Korean traditional medicine. Methods : The checklist model was composed in four types according to the target patients: DCIS inpatients, DCIS outpatients, LCIS inpatients, LCIS outpatients. The vertical axis of the pathway consists of 11 categories of actions applied to the patient. The horizontal axis was in accordance with the flow of time, comprising three periods during inpatient care and seven periods during outpatient care. In addition, CP was also composed in flow chart form. The pathway model was developed through a literature review of clinical practice guidelines, conference publications, papers, books, and websites. Results : The integrative CP model for non-invasive breast cancer was developed. Conclusions : The goal of the CP suggested in this study was to improve non-invasive breast cancer patients' quality of life and to supplement conventional treatment, by alleviating the side effects. The model developed through this study could serve as the basis when developing CPs in a real-world integrative medical environment. This could lead to a reduction in cost and time for CP development, thus bringing about efficiency in the clinical setting.

• The Journal of Internal Korean Medicine
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• v.41 no.6
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• pp.1274-1281
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• 2020

Objective: This case report shows symptom improvements in stage IV metastatic colorectal cancer treated with a Korean medicine-based integrative cancer treatment (ICT). Methods: A 61-year-old male patient diagnosed with colorectal cancer in November 2017 and metastasis to the lung, peritoneum, and liver in September 2020 was treated with Integrative Cancer Treatment (ICT) for abdominal pain, abdominal discomfort, and anorexia for 1 month. Clinical outcomes were measured with the National Cancer Institute Common Terminology Criteria for Adverse Event (NCI-CTCAE), a numeral rating (NRS), the Eastern Cooperative Oncology Group (ECOG), and the Functional Assessment of Cancer Therapy-General (FACT-G) scales. Results: After treatment, the patient's abdominal pain was improved from NRS 8 to 1, and the ECOG score of the patient was improved from grade 3 to 2. Integrative Cancer Treatment. Also the score improved on the FACT-G test, and there were no serious side effects of grade 3 or higher according to the NCI-CTCAE. Conclusion: This case study suggests that Korean medicine-based ICT may help to improve abdominal pain and quality of life in patients with metastatic colorectal cancer.

• Journal of Korean Traditional Oncology
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• v.17 no.1
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• pp.45-53
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• 2012

Objective : We introduce a case of non-small cell lung cancer patient treated with allergen removed Rhus verniciflua Stokes. Methods : This patient started Allergen-removed Rhus Verniciflua Stokes from Feb 2010 right after his firstline chemotherapy, and maintained his Oriental medicine regimen until now. Results : It shows 12.0 months of progression-free-survival since starting point of maintenance chemotherapy, and 9.3 months of overall-survival since progression disease after 2nd chemotherapy, compared with 6.3 months of its known overall survival. Conclusion : Allergen removed Rhus verniciflua Stokes prolonged overall survival and slowed disease progression of a non-small cell lung cancer patient.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.28 no.4
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• pp.12-28
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• 2015

Objective : The purpose of this study is to analyse research trend on alopecia including androgenetic alopecia, alopecia areata, etc.Methods : We searched Pubmed, CNKI and OASIS on the title "alopecia" in recent 5 years.Results : We found 23 studies on Pubmed, 20 on CNKI, and 3 on OASIS about treatments of alopecia. The subjects of them were about 5α-reductase inhibitor, Minoxidil, steroids, immunosuppression, laser therapy, PRP, microneedling, stem cell, herbal medicine, integrative medicine, external treatments and syndrome differentiation.Conclusions : In recent studies in western medicine were about combination therapy or safety and presented validities and superiorities about new treatments. Integrative medicine, external treatment and researches about patients' characteristics were reported in TCM. Korean medicine has advantages of considering whole body and phychological problems.

• Journal of Oriental Neuropsychiatry
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• v.35 no.2
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• pp.177-189
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• 2024

Objectives: This study aimed to evaluate the impact of Resource Mindfulness on participants' emotional state, focusing on anxiety and stress reduction and to explore the importance of psychological resources in this process. The effectiveness of Resource Mindfulness was investigated through both quantitative and qualitative analyses, examining its influence on subjective distress, mindfulness, core emotions, and identification of personal resources. Methods: This study involved 27 participants, including Korean medicine students, psychological counselors, clinical psychologists, and Korean medicine specialists, who attended a 2-night, 3-day M&L psychological support education program from July 2 to July 4, 2022. Participants were informed of the study's purpose and procedures. They provided written consent. Quantitative measures included Subjective Units of Disturbance Scale (SUDS), Five Facet Mindfulness Questionnaire (FFMQ), and Core Seven-Emotions Inventory Short Form (CSEI-s). Qualitative analysis was conducted using the "Drawing the Rooms of the Mind" technique. Pre- and post-program assessments were conducted to compare changes in subjective distress, mindfulness, and core emotions. Data were analyzed using paired t-tests and qualitative content analysis methods. Results: Significant reductions in subjective distress and improvements in mindfulness components were observed. Core emotions showed significant decreases in negative emotions. Qualitative analysis revealed increased tranquility, relief, and confidence, with resourceful places often being nature-related. Conclusions: Resource Mindfulness effectively reduced anxiety and stress and enhanced self-awareness and self-efficacy. It is useful for managing various mental health issues. Further research is needed to generalize these findings.

• Journal of Acupuncture Research
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• v.40 no.3
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• pp.281-292
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• 2023

This study presents the cases of a 67-year-old female with an isolated left sacral fracture and a 69-year-old female with fractures in sacrum 1, 2, and the left pubic bone. Both patients exhibited marked improvement following integrative Korean medicine treatment, encompassing acupuncture, acupotomy, pharmacopuncture, herbal medicine, moxibustion, and cupping therapy. The treatment's efficacy was assessed using the numerical rating scale (NRS) scores, range of motion (ROM) in the lumbar spine, and alterations in gait and walking distance. Case 1 demonstrated an enhanced ROM and achieved independent walking after 29 days of treatment. Case 2 improved in both ROM and NRS score and could walk independently after 49 days of treatment. Significantly, radiological images showed notable changes in both cases following treatments. The study indicates that integrative Korean medicine treatment could provide clinical advantages to individuals suffering from sacral fractures.

• Journal of Ginseng Research
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• v.46 no.6
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• pp.750-758
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• 2022

Background: Mild cognitive impairment (MCI) is a transitional condition between normality and dementia. Ginseng is known to have effects on attenuating cognitive deficits in neurogenerative diseases. Ginsenosides are the main bioactive component of ginseng, and their protein targets have not been fully understood. Furthermore, no thorough analysis is reported in ginsenoside-related protein targets in MCI. Methods: The candidate protein targets of ginsenosides in brain tissues were identified by drug affinity responsive target stability (DARTS) coupled with label-free liquid chromatography-mass spectrometry (LC-MS) analysis. Network pharmacology approach was used to collect the therapeutic targets for MCI. Based on the above-mentioned overlapping targets, we built up a proteineprotein interaction (PPI) network in STRING database and conducted gene ontology (GO) enrichment analysis. Finally, we assessed the effects of ginseng total saponins (GTS) and different ginsenosides on mitochondrial function by measuring the activity of the mitochondrial respiratory chain complex and performing molecular docking. Results: We screened 2526 MCI-related protein targets by databases and 349 ginsenoside-related protein targets by DARTS. On the basis of these 81 overlapping genes, enrichment analysis showed the mitochondria played an important role in GTS-mediated MCI pharmacological process. Mitochondrial function analysis showed GTS, protopanaxatriol (PPT), and Rd increased the activities of complex I in a dose-dependent manner. Molecular docking also predicted the docking pockets between PPT or Rd and mitochondrial respiratory chain complex I. Conclusion: This study indicated that ginsenosides might alleviate MCI by targeting respiratory chain complex I and regulating mitochondrial function, supporting ginseng's therapeutic application in cognitive deficits.