• PNF and Movement
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• 제14권3호
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• pp.157-176
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• 2016

Purpose: The purpose of this study was to share an experience about processes and lessons learned to execute evidence-based practice (EBP) in neurological physical therapy. Methods: The most important thing in applying EBP to practice is to search, find, and appraise the existing evidence. Many evidence databases are available, such as CENTRAL, PEDro, PUBMED, and EMBASE. However, the knowledge represented in these databases is not always perfect. The practice model is a set of processes to resolve client problems. Therapists should make hypothesis-focused decisions through EBP. Integrating clinical reasoning and evidence is most important when it comes to the execution of EBP. Results: The process of EBP consisted of following: coming up with clinical questions, followed by searching for, appraising, evaluating, and integrating evidence. To integrate EBP into practice, it is necessary to consider clinical expertise, patient value and preferences, as well as research wth the best evidence. We provided an example of a clinical case with a stroke patient to show how this process and framework concerning clinical reasoning through evidences can be integrateds. During this process, we also utilized information technology to improve EBP ability. Conclusion: We should recognize what manner of information is needed to resolve eash patient's problem, and we should search for this information efficiently. Then, we should judge the value of the information obtained as it applies, to the clinical setting.

• 한국측량학회지
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• 제20권3호
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• pp.273-282
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• 2002

GIS는 다양한 영역에서 유용한 도구로서 자리잡고 있으나, 한편으로는, 복잡한 문제를 해결하기 위해서는 GIS가 수학, 공학적인 모델링툴과 결합되는 것이 필요하다는 견해와 연구결과가 등장하고 있다. LP(Linear Programming)는 주어진 자원을 최적으로 배분하는 문제에 사용되는 수학적인 기법이다. LP는 공간적인 표현을 포함하지 않기때문에 GIS의 기능들과 결합될 때 그 유용성이 높아질 수 있다. 그러나 전통적인 LP는 명료하게 조건이 주어질 경우에만 적합한 방법이므로, 토지이용계획과 같이 결정요소가 명확한 값으로 주어질 수 없는 경우에는 현실적으로 적용하기 어려워진다. 이 연구에서는, 이와 같이 불명료한(fuzzy) 상황을 다루기 위해 Fuzzy logic을 사용한 fuzzy-LP를 개발하고, 이를 GIS와 통합하는 방법론을 제시한다. 통합시스템에서 GIS는 Fuzzy-LP과정으로 데이터를 공급하거나 Fuzzy-LP의 결과값을 표현하는데 이용된다. 이 시스템을 토지이용배분문제에 적용하는 경우를 예시하였다.

• 산업경영시스템학회지
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• 제38권4호
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• pp.168-176
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• 2015

Trends of integrating products and services lead to the emergence of Product-Service System (PSS). To implement and embody a PSS solution in new product development, a comprehensive design framework is allowed designers to facilitate the design factors of the PSS in complex business environments. A physical product, containing functionalities for services, is the role of medium between customers and a manufactures. Customers can access those metaphysical interfaces to utilize the product fully or expand its performances. The PSS is aiming to prolong its lifecycle while maintaining its expected quality. Since the quality can be represented as a measure which belongs to user's perspective, guaranteeing certain level of quality can be interpreted to sustaining customer satisfaction. The objective of this paper is to propose a PSS design framework to identify design factors for developing products and services by integrating object-oriented concepts and blueprinting in context of a business ecosystem. The proposed model is developed based on relationship products and services matching with their design factors. The products and the services are then brought together to form a PSS. Functions and processes can be categorized to identify the design factors in different levels using the object-oriented concepts. Objected-oriented concepts provide PSS analysis tools for describing a business process or a workflow process in the PSS. The blueprint is used to identify the relationships between the products functions and the service processes that are offered as part of a job. To demonstrate of the effectiveness of the proposed model, we use a case study involving a smart phone.

• 한국건설관리학회논문집
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• 제15권1호
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• pp.70-77
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• 2014

건설프로젝트의 성공적인 수행을 위해 의사소통, 협력, 정보공유 등을 포함한 구성원들 간의 협업은 반드시 필요하다. 그러나 프로젝트 조직 내의 협업과정이 성과에 미치는 영향에 대한 분석적인 시도는 부족하였다. 본 연구는 게임이론 기반의 에이전트기반 시뮬레이션을 활용하여 프로젝트 조직 내 협업과정을 보다 명시적으로 이해하는 방법을 제시하였다. 시뮬레이션의 결과로 구성원수준에서의 관계형성과 조직수준에서의 네트워크 발전양상을 관찰할 수 있었다. 본 연구는 프로젝트조직 내의 협업과정 분석방법 개발을 위한 기초연구이며, 향후 연구를 통해 조직 내 업무수행 프로세스, 생산작업 프로세스, 관리 프로세스 등의 부분과 결합하여 프로젝트 성과를 예측하는 방법으로 발전될 수 있을 것이다.

• Molecules and Cells
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• 제43권11호
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• pp.899-908
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• 2020

Intrinsically disordered proteins or regions (IDPs or IDRs) are widespread in the eukaryotic proteome. Although lacking stable three-dimensional structures in the free forms, IDRs perform critical functions in various cellular processes. Accordingly, mutations and altered expression of IDRs are associated with many pathological conditions. Hence, it is of great importance to understand at the molecular level how IDRs interact with their binding partners. In particular, discovering the unique interaction features of IDRs originating from their dynamic nature may reveal uncharted regulatory mechanisms of specific biological processes. Here we discuss the mechanisms of the macromolecular interactions mediated by IDRs and present the relevant cellular processes including transcription, cell cycle progression, signaling, and nucleocytoplasmic transport. Of special interest is the multivalent binding nature of IDRs driving assembly of multicomponent macromolecular complexes. Integrating the previous theoretical and experimental investigations, we suggest that such IDR-driven multiprotein complexes can function as versatile allosteric switches to process diverse cellular signals. Finally, we discuss the future challenges and potential medical applications of the IDR research.

• 한국해양학회지:바다
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• 제18권1호
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• pp.21-31
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• 2013

생태모델은 생태계 구성 요소간의 관계를 수치적으로 표현하여 생태계 내에 존재하는 다양한 요인들의 시간에 따른 내재적 변동과 외부 조건의 변화에 따른 반응을 예측하는데 유용한 도구다. 해양 생태모델은 학제간 공동 연구결과를 토대로, 보다 체계적이고 종합적인 접근 방법을 통해, 최근 수 십 년 동안 많은 발전을 이룩하였다. 이 글은 해양 생태모델의 이론적 배경을 살피고, 모델 수립 시 고려해야 할 사항 및 최근 동향에 대하여 소개한다.

• Molecules and Cells
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• 제39권10호
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• pp.722-727
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• 2016

Cardiomyopathy is a major cause of death worldwide. Based on pathohistological abnormalities and clinical manifestation, cardiomyopathies are categorized into several groups: hypertrophic, dilated, restricted, arrhythmogenic right ventricular, and unclassified. Dilated cardiomyopathy, which is characterized by dilation of the left ventricle and systolic dysfunction, is the most severe and prevalent form of cardiomyopathy and usually requires heart transplantation. Its etiology remains unclear. Recent genetic studies of single gene mutations have provided significant insights into the complex processes of cardiac dysfunction. To date, over 40 genes have been demonstrated to contribute to dilated cardiomyopathy. With advances in genetic screening techniques, novel genes associated with this disease are continuously being identified. The respective gene products can be classified into several functional groups such as sarcomere proteins, structural proteins, ion channels, and nuclear envelope proteins. Nuclear envelope proteins are emerging as potential molecular targets in dilated cardiomyopathy. Because they are not directly associated with contractile force generation and transmission, the molecular pathways through which these proteins cause cardiac muscle disorder remain unclear. However, nuclear envelope proteins are involved in many essential cellular processes. Therefore, integrating apparently distinct cellular processes is of great interest in elucidating the etiology of dilated cardiomyopathy. In this mini review, we summarize the genetic factors associated with dilated cardiomyopathy and discuss their cellular functions.

• Applied Microscopy
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• 제25권1호
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• pp.65-74
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• 1995

개의 교핵내의 GABA를 함유한 억제성 신경세포의 연접부위를 전자현미경을 이용한 면역세포화학적 방법으로 조사하였다. 반응산물은 신경원의 핵부위나 가지돌기에서 관찰되었으며, 반응산물을 포함하고 있지 않은 신경종말이 이들과 비대칭형 연접을 형성하였다. 그 외에도 많은 수의 GABA성 신경종말이 관찰되었으며, 이들은 반응산물을 함유하지 않은 가지돌기와 대칭형 또는 비대칭형 연접을 형성하였다. 한편 축삭돌기-축삭돌기 연접에서는 연접후 유축사돌기 (axon-like processes)가 GABA-양성이었다. 이와 같은 관찰은 개의 교핵에 존재하는 억제성 개재신경원이 여러 수입계로부터의 정보를 통합하고, 이를 소뇌피질이나 소뇌핵에 전달함으로써, 대뇌-교핵-소뇌계의 신경경로에서 조절기능을 담당함을 뒷받침하는 것이다.

• International Journal of Internet, Broadcasting and Communication
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• 제13권1호
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• pp.194-200
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• 2021

This study proposes a plan to construct an integrated platform that reduces manufacturing costs and efficiently produce by integrating the systems of main producers, production subcontractors, and raw material subcontractors for the production of food packaging containers. The production plan of food packaging containers and raw materials is established in real time between the main producers, production subcontractors, and raw material subcontractors in consideration of the demand characteristics of each product. It establishes basic information that all processes from the production planning stage to the forwarding stage of the product are linked to each other. The progress of each producer of interlinked processes is shared in real-time to improve productivity and quality of food packaging containers and raw materials and reduce manufacturing costs. By monitoring the system of the main producer and the production subcontractor in real time, the production of food packaging containers is performed in a timely manner, thereby improving productivity. The application of the plan-do-check-action (PDCA) process, which includes planning, execution, evaluation and improvement in the production operation processes of the main producer, production subcontractor and raw material subcontractor, enables improved production compliance rate. The contents of the main producers, production subcontractors, and raw material subcontractors are managed in real time, then a converged production management system is established through the platform proposed in this study to ensure timely supply and demand of raw materials without delay in ordering.

• 한국정밀공학회지
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• 제14권10호
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• pp.75-84
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• 1997

This paper describes the development of an integrating method for process planning and scheduling activities for block assembly in shipbuilding. A block is composed of several steel plates and steel sections with the predetermined shapes according to the ship design. The parts which constitute the block are manufac- tured by cutting and/or bending operations, which are termed as machining operation in this paper. The machining operation is the first process for block assembly which influences the remaining block assembly processes. Thus process planning and scheduling for machining operation to manufacture parts for block are very important to meet the assembly schedule in the shipyard. An integrating method for process plan- ning and scheduling is developed by introducing the concept of distributed process planning and scheduling composed of initial planning, alternative planning and final planning stages. In initial planning stage, nesting parts information and machining emthods are generated for each steel plate. In alternative plan- ning stage, machine groups are selected and workcenter dispatching information is generated. In final planning stage, cutting sequences are determined. The integrated system is tested by case study. The result shows that the integrated system is more efficient than existing manual planning system.