• Journal of Veterinary Science
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• v.21 no.1
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• pp.7.1-7.13
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• 2020

Aging triggers cellular and molecular alterations, including genomic instability and organ dysfunction, which increases the risk of disease in mammals. Recently, due to the markedly growing number of aging dogs in the world, as much as 49% in total number of pet dogs, it is necessary to improve and maintain their quality of life by understanding of the biological effects of aging. Therefore, the aim of this study was to determine specific biomarkers in aging dogs as a means of defining a set of hematological/biochemical biomarkers that influence the aging process. Blood samples were collected from younger (1-3 years) and older (7-10 years) dogs of middle/large size. The hematological/biochemistry analysis was performed to evaluate parameters significantly associated with age. Enzyme-linked immunosorbent assay was used to target growth hormone (GH)/insulin growth factor-1 (IGF-1), one of the main regulators of the aging process. Declining levels of total protein and increased levels of glucose in young dogs was observed regardless of their body size. Notably, a significantly high concentration of GH and IGF-1 in the younger dogs compared to the older dogs was found in middle/large-sized dogs. GH and IGF-1 were also found at significantly high levels in large-sized dogs compared to middle-sized dogs, suggesting a similar trend to that of elderly humans. Consequently, glucose, total protein, GH, and IGF-1 were identified as potential biomarkers for regulating the aging process in large/middle-sized dogs. These findings provide an invaluable insight into the mechanism of aging for the field of aging research.

• Geomechanics and Engineering
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• v.33 no.6
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• pp.597-609
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• 2023

The instability and failure of engineered rock masses are influenced by crack initiation and propagation. Uniaxial compression and acoustic emission (AE) experiments were conducted on cracked sandstone. The effect of the crack's dip on the crack initiation was investigated using fracture mechanics. The crack propagation was investigated based on stress-strain curves, AE multi-parameter characteristics, and failure modes. The results show that the crack initiation occurs at the tip of the pre-fabricated crack, and the crack initiation angle increases from 0° to 70° as the dip angle increases from 0° to 90°. The fracture strength k_cr is derived varies in a U-shaped pattern as β increased, and the superior crack angle β_m is between 36.2 and 36.6 and is influenced by the properties of the rock and the crack surface. Low-strength, large-scale tensile cracks form during the crack initiation in the cracked sandstone, corresponding to the start of the AE energy, the first decrease in the b-value, and a low r-value. When macroscopic surface cracks form in the cracked sandstone, high-strength, large-scale shear cracks form, resulting in a rapid increase in the AE energy, a second decrease in the b-value and an abrupt increase in the r-value. This research has significant theoretical implications for rock failure mechanisms and establishment of damage indicators in underground engineering.

• Analyses & Alternatives
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• v.1 no.1
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• pp.44-64
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• 2017

Russia's push in the Asia-Pacific region stems from its interests that have the national, regional and global dimensions. In their turn, the aims of this policy are civilizational, geopolitical, economic and prospective, with a long-term outlook. In the course of their achievement, cooperation with Northeast Asia's countries will play one of the key roles owing to the factors of geographic proximity, Northeast Asia's economic potential, risk hedging and a growing influence Northeast Asia exerts upon the global development. A new cooperation paradigm between Russia and the states of Northeast Asia should be based upon establishing and cementing self-reproducing ties. This is the central aim of Russian initiatives in relations, with Japan, the Republic of Korea, Democratic People's Republic of Korea, Mongolia and China. However, numerous obstacles ranging from Russia's absence in the regional free trade agreements and supply-production chains of value-added production to the permanent international instability generated by Pyongyang's missile-nuclear developments hamper the practical implementation of this task. Realizing the necessity to give an additional impetus to this new cooperative paradigm, Russia has to develop directions with an apparent consolidating effect. The most promising may be the establishment of a permanent security forum based upon Northeast Asia Peace and Security Mechanism chaired by the Russian Federation. The urgency of this measure and its expected support stem from the necessity to strengthen security in Northeast Asia, a task neither the US-led hub-and-spoke system nor ASE-AN-led multilateral dialogue venues have been able to resolve. The issues addressed at the security forum must include the unification of approaches to North Korean nuclear issue and producing a document specifying actions of the claimants on the disputed maritime territories in the "direct contact" situations. At the expert level, Russia has elaborated on the idea to establish such a forum outlining the spectrum of the key directions of cooperation. With the urgency in the establishment of this dialogue venue, its agenda has to be coordinated with the agendas of the existing security systems presented by the US alliances and the ASE-AN-led multilateral negotiations. The practical implementation of this initiative will strengthen security in Northeast Asia as its challenges will be resolved in the pre-emptive way based on coordinated approaches. Therefore, Russia as the Eurasian state will be one of the role players in the advent of the Asian century.

• Steel and Composite Structures
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• v.48 no.1
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• pp.27-41
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• 2023

Under the long-term effect of corrosive environment, many cold-formed steel (CFS) structures have serious corrosion problems. Corrosion leads to the change of surface morphology and the loss of section thickness, which results in the change of instability mode and failure mechanism of CFS structure. This paper mainly investigates the elastic local buckling behavior of corroded CFS columns. The surface morphology scanning test was carried out for eight CFS columns accelerated corrosion by the outdoor periodic spray test. The thin shell finite element (FE) eigen-buckling analysis was also carried out to reveal the influence of corrosion surface characteristics, corrosion depth, corrosion location and corrosion area on the elastic local buckling behaviour of the plates with four simply supported edges. The accuracy of the proposed formulas for calculating the elastic local buckling stress of the corroded plates and columns was assessed through extensive parameter studies. The results indicated that for the plates considering corrosion surface characteristics, the maximum deformation area of local buckling was located at the plates with the minimum average section area. For the plates with localized corrosion, the main buckling shape of the plates changed from one half-wave to two half-wave with the increase in corrosion area length. The elastic local buckling stress decreased gradually with the increase in corrosion area width and length. In addition, the elastic local buckling stress decreased slowly when corrosion area thickness was relatively large, and then tends to accelerate with the reduction in corrosion area thickness. The distance from the corrosion area to the transverse and longitudinal centerline of the plate had little effect on the elastic local buckling stress. Finally, the calculation formula of the elastic local buckling stress of the corroded plates and CFS columns was proposed.

• Journal of Life Science
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• v.26 no.2
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• pp.226-233
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• 2016

Vascular smooth muscle cell (VSMC) apoptosis has been identified in various vascular diseases, including atherosclerosis and restenosis after angioplasty, and has been known to precipitate atherosclerotic plaque instability and rupture. Oxysterols are known as inducers of apoptosis in VSMC, and 7-ketocholesterol (7KC) is the major nonenzymically formed oxysterol in atherosclerotic lesions. The precise mechanism underlying VSMC apoptosis is still poorly understood. In this study, we investigated whether 7KC causes apoptosis, and characterized its apoptotic mechanisms in primary cultured rat aortic VSMC. Cell viability was assessed by MTT assay and trypan blue assay. Apoptosis was assessed by flow cytometry, immunofluorescence, immunoprecipitation, and Western blot analyses. 7KC markedly decreased the VSMC viability in a time- and concentration-dependent manner, and increased the production of 4-hydroxynonenal (HNE), a major end-product of lipid peroxidation, which also decreased the VSMC viability. Pretreatment with 2,4-dinitrophenylhydrazine, a well-known reagent of lipid peroxidation-derived aldehydes, significantly restored the 7KC-decreased viability of VSMC. Furthermore, HNE, as well as 7KC, reduced the level of total Akt, a major mediator of cell survival. The 7KC-decreased level of total Akt was significantly restored by pretreatments with 2,4-dinitrophenylhydrazine and N-acetylcysteine. Lactacystin, a proteasome inhibitor, protected VSMC against apoptosis and Akt degradation, but did not inhibit HNE production. In the immunoprecipitation assay, 7KC increased HNE-modified Akt. From the results, it seems that, in atherosclerotic lesions, 7KC induces HNE production in VSMC, and this HNE binds to Akt, proceeding to proteasomal degradation of Akt, through which mechanism the atherosclerotic plaque instability may be facilitated.

• Applied Chemistry for Engineering
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• v.31 no.1
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• pp.97-102
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• 2020

Recently, various degradation mechanisms of lithium secondary battery cathode materials have been revealed. As a result, many studies on overcoming the limitation of cathode materials and realizing new electrochemical properties by controlling the degradation mechanism have been reported. Li-rich layered oxide is one of the most promising cathode materials due to its high reversible capacity. However, the utilization of Li-rich layered oxide has been restricted, because it undergoes a unique atomic structure change during the cycle, in turn resulting in unwanted electrochemical degradations. To understand an atomic structure deterioration mechanism and suggest a research direction of Li-rich layered oxide, we deeply evaluated the atomic structure of 0.4Li₂MnO₃_0.6LiNi_1/3Co_1/3Mn_1/3O₂ Li-rich layered oxide during electrochemical cycles, by using an atomic-resolution analysis tool. During a charge process, Li-rich materials undergo a cation migration of transition metal ions from transition metal slab to lithium slab due to the structural instability from lithium vacancies. As a result, the partial structural degradation leads to discharge voltage drop, which is the biggest drawback of Li-rich materials.

• Journal of the Korean earth science society
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• v.37 no.4
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• pp.187-199
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• 2016

The purpose of this study is to investigate the formation mechanism of landspout by using the Cloud Resolving Storm Simulator (CReSS). The landspout occurred over Ilsan, Goyang City, the Republic of Korea on June 10, 2014 with the damage of a private property. In synoptic environment, a cold dry air on the upper layers of the atmosphere, and there was an advection with warm and humid air in the lower atmosphere. Temperature differences between upper and lower layers resulted in thermal instability. The storm began to arise at 1920 KST and reached the mature stage in ten minutes. The cloud top height was estimated at 9 km and the hook echo was appeared at the rear of a storm in simulation result. Model results showed that the downburst was generated in the developed storm over the Ilsan area. This downburst caused the horizontal flow when it diverged near the surface. The horizontal flow was switched to updraft at the rear of storm, and the rear-flank downdrafts (RFDs) current occurred from simulation result. The RFDs took down the vertical flow to the surface. After then, the vertical vorticity could be generated on the surface in simulation result. Subsequently, the vertical vorticity was stretched to form a landspout. The cyclonic vorticity of echo hook from simulation was greater than $3{\times}10^{-2}s^{-1}$(height of 360 m) and landspout diameter was estimated at 1 km.

• Journal of Veterinary Clinics
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• v.16 no.2
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• pp.309-320
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• 1999

Medial patellar luxation in dogs is one of the most common patellar problems presented to the veterinary practitioner. It is observed in toy and miniature breed and the majority of cases is a congenital form. Because of extensor mechanism's instability, it causes deformity and disorder in the growth of the affected limb when the luxation is left without treatment As lameness is not easily detectable in puppies, early diagnosis and correction are essential for therapy. Up to now, there has not been any reports refering to the diagnostic methods and the optimal age for correction in young dogs. Thirteen 45-90 days old puppies, have grade I and/or II medial patellar luxation. Only by palpation, all 13 dogs were diagnosed of patelar luxation. Skyline radiographic view was useful to interpret patellar morphology and depth of trochlear groove only above 60 days old. However, it was difficult to make definite diagnosis patellar luxation. The caudocranial and lateral radiographic view as well as ultrasonographic skyline view were not showed of patellar luxation. 2 puppies had unilateral patellar luxation and 11 puppies had bilateral patellar luxation which more serious on the left than on the right. Only 3 puppies among 11 puppies with bilateral patellar luxation were observed of lameness degree 1. Regardless of grade of patellar luxation and lameness, we performed trochlear chondroplasty using a U-shape sculpture blade to minimize cartilage injury, transposition of tibia tuberosity with No. 1 Supramid to align extensor mechanism and lateral imbrication. After surgery, we examined the operated animal daily for 10 days and on 15, 30 and 60 days after surgery respectively. After operation, pain and fever became normal on 7 days, swelling on 10 days, respectively. On 10 days after surgery, dogs showed normal standing position, and normal walking was observed in 15 days after surgery. In force plate analysis, the operated legs were normal weight bearing at 30 days after operation. After surgery, not only patellar luxation and clinical signs have been gradually reduced but also bone growth have become normal without showing growth physeal plate injury. The survival rate of puppies over 62 days old was 100%, while 42-45 days old 37.5%. The above results suggest that optimal age for surgical correction of congenital medial patellar luxation is recommended over 60 days old. In conclusion, combination of trochlear chondroplasty, transposition of tibia tuberosity, and lateral retinacular imbrication is appropriate for over 60 days old puppies to efficiently correct patellar luxation.

• Journal of Korean Society of Steel Construction
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• v.24 no.3
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• pp.337-348
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• 2012

This study investigated the characteristics of bifurcation and the instability due to the initial imperfection of the space truss, which is sensitive to the initial conditions, and the calculated buckling load by the analysis of Eigen-values and the determinant of tangential stiffness. A two-free nodes model, a star dome, and a three-ring dome model were selected as case studies in order to examine the unstable phenomenon due to the sensitivity to Eigen mode, and the influence of the rise-span ratio and the load parameter on the buckling load were analyzed. The sensitivity to the imperfection of the two-free nodes model changed the critical path after reaching the limit point through the bifurcation mode, and the buckling load level was reduced by the increase in the amount of imperfection. The two sensitive buckling patterns for the model can be explained by investigating the displaced position of the free node, and the asymmetric Eigen mode was a major influence on the unstable behavior due to the initial imperfection. The sensitive mode was similar to the in-extensional mechanism basis of the simplified model. Since the rise-span ratio was higher, the effect of local buckling is more prominent than the global buckling in the star dome, and bifurcation on the equilibrium path occurring as the value of the load parameter was higher. Additionally, the buckling load levels of the star dome and the three-ring model were about 50-70% and 80-90% of the limit point, respectively.

• Journal of the Korean earth science society
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• v.34 no.7
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• pp.645-661
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• 2013

The synoptic, thermodynamic, and dynamic characteristics of a heavy snowfall event that occurred in Seoul metropolitan area on 27 to 28 December 2010 was investigated. During this period there was a distinctive case that was identified as a polar low. We analyzed surface and upper level weather charts, snowfall amount, sea surface temperature, satellite imagery, sounding, and the National Center for Environmental Prediction global $1^{\circ}{\times}1^{\circ}$ reanalysis data. The polar low developed in an area where there was strong baroclinicity in the lower level aided by strong conditional instability due to 925 hPa warm air advection and 700 hPa cold air advection. The development mechanism of polar low is due, in part, to the tropopause folding, which advected stratospheric air increasing potential vorticity in mid-level and inducing cyclonic vorticity and convergence in low-level. Eventually clouds developed and there were snowfall total of 10 cm in Seoul metropolitan area and as much as 20 cm in southern parts of Korea. During the snowfall development, there was a $-45^{\circ}C$ cold core at 500 hPa and shortwave maintained $3-5^{\circ}$ separation with surface trough, which favored the development of polar low located in the warm sector and cyclonic advection area. The height of the dynamical tropopause lowered to 700 hPa during the peak development and increase in potential vorticity allowed strong vertical motion to occur. Overall, there was a close relationship between the development of snowfall and tropopause undulation. The heaviest snowfall occurred east of the tropopause folding where strong cyclonic vorticity, vertical motion, and moisture advection all coincided while the polar low was passing through the Korean peninsula.