• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.4
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• pp.691-696
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• 2011

In order to the neuroprotective effect of electroacupuncture (EA), the present study examined the effects of electroacupuncture inacupoint ST36 (Stomach 36) on trimethyltin chloride (TMT)-induced cognitive impairments rat using the Morris water maze (MWM) task and immunohistochemistry staining. The rats were randomly divided into the following groups: naive rat (Normal), TMT injection rat (Control), TMT injection + EA treated rat inacupoint ST36 (ST36) and TMT injection + EA treated rat in non-acupoint, base of tail (Non-AC). Electroacupuncture (2Hz, 2mA, and 10 minutes)was applied either to the acupuncture point ST36 or the nonacupuncture point in the tail for the last 14 days. In the water maze test, the animals were trained to find a platform in a fixed position during 4d and then received 60s probe trial on the $5^{th}$ day following removal of platform from the pool. Rats with TMT injection showed impaired learning and memory of the tasks and treatment with EA in acupoint ST36 (P<0.05) produced a significant improvement in escape latency to find the platform after $2^{nd}$ day and retention trial in the Morris water maze. Consistent with behavioral data, treatment with EA in acupoint ST36 also significantly increased expression of Choline acetyltransferase (ChAT) and Acetylcholinesterase (AChE) immunoreactive neurons in the hippocampus compared to the Control group. These results demonstrated that EA in acupoint ST36 has a protective effect against TMT-induced neuronal and cognitive impairments. The present study suggests that EA in acupoint ST36 might be useful in the treatment of TMT-induced learning and memory deficit.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.22 no.12
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• pp.1735-1745
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• 1998

Oil-film surface flow visualizations and three-dimensional flow measurements using a straight five-hole probe have been conducted for a circular impinging jet which is normally oriented to the crossflow in a channel. Throughout the experiments, the ratio of channel height to injection hole diameter, H/D, is fixed to be 1.0, and blowing ratio is varied to be 1.0, 2.0, 3.0 and 4.0. From the surface flow visualizations for both top wall(target plate) and bottom wall, impinging jet region on the target plate can be clearly identified, and for the small value of H/D = 1.0, presence of the bottom wall changes the near-hole flow structure, significantly. The three-dimensional flow measurements show that in the dawnstream region of the injection hole, there exist a pair of counter-rotating vortices, called "scarf vortices", and the strength of the vortices strongly depends on the blowing ratio. In addition, a new flow model in the flow symmetry plane has been proposed for H/D = 1.0.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.20 no.4
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• pp.1363-1375
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• 1996

Oil-film flow visualizations and three-dimensional flow measurements using a five-hole probe have been conducted to investigate three-dimensional flow characteristics and total pressure losses of a row of film-cooling jets injected in spanwise direction. For several span-to-diameter ratios, experiments are performed in the case of three velocity ratios of 0.5, 1.0 and 1.5. The flow measurements show that downstream flow due to the injection is characterized by a single streamwise vortex instead of a pair of counter-rotating vortices, which appear in the case of streamwise injection, and the vortex strength strongly depends on the velocity ratio. Regardless of the velocity*y ratio, presence of the spanwise film-cooling jets always produces total pressure loss, which is pronounced when the velocity ratio is large. It has also been found that the production of the total pressure loss is closely related to the secondary vortical flow. In addition, effects of the span-to-diameter ratio on the flow and total pressure loss are discussed in detail.

• Proceedings of the KSME Conference
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• 2003.11a
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• pp.712-716
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• 2003

In the present study, the gas injection system based on air-water model was designed to investigate the behavior characteristics of bubbles injected into a ladle. The parameters such as gas volume fraction and bubble rise velocity were exprementally measured in a gas-liquid flow region. To measure gas volume fraction, an electo-conductivity probe was used and bubble rise velocity was obtained by a high speed CCD camera. Gas volume fraction was symmetric to the axis of nozzle secured on the bottom of a ladle. The bubble rise velocity was calculated for two different experimental conditions. That is, gas flow conditions were following two case: 1) Q = $0.63{\times}10^{-4}$ $m^{3}/s$, 2) $1.26{\times}10^{-4}$ $m^{3}/s$. As a gas injected into the liquid ladle, the liquid-phase region is circulated by bubbles' behavior. The bubble rise velocity was influenced of the circulation flow of liquid phase. As a result, the bubble rise velocity was appeared higher middle region of ladle than near the nozzle.

• YAKHAK HOEJI
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• v.41 no.5
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• pp.607-614
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• 1997

Flurbiprofen- and flurbiprofen axetil-loaded microemulsions composed of soybean oil, poloxamer 407, glycerine and water were prepared by generator-type homgenizer and ultrasoni c probe system. The particle size of microemulsions was measured by the dynamic light scattering method. The pharmacokinetics and organ distribution of flurbiprofen were investigated after intravenous injection of flurbiprofen solution, flurbiprofen-loaded microemulsion and flurbiprofen axetil-loaded microemulsions equivalent to 10mg/kg of flurbiprofen to rats. Blood samples were collected from the anterior ciliary artery of rats for 24hr, and flurbiprofen in plasma and organs was analyzed by HPLC. Stable microemulsions were prepared. Even though there is a little change in droplet size just after the preparation, no creaming and no separation were occured during the storage period for 6 months at 4, 21, 37 and 45$^{\circ}C$. Pharmacokinetic parameters and organ distribution of flurbiprofen after intravenous injection of flurbiprofen- and flurbiprofen axetil-loaded microemulsions emulsified with poloxamer 407 were not significantly different from those of commercial lipid microemulsion emulsified with lecithin. Therefore, it is concluded that flurbiprofen- and flurbiprofen axetil-loaded microemulsion prepared with poloxamer 407 could be used as a parenteral formulation.

• Journal of Electrochemical Science and Technology
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• v.13 no.1
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• pp.100-111
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• 2022

This paper presents a simple and inexpensive method to fabricate chemically and mechanically resistant hot electron-emitting composite electrodes on reusable substrates. In this study, the hot electron emitting composite electrodes were manufactured by doping a polymer, nylon 6,6, with few different brands of carbon particles (graphite, carbon black) and by coating metal substrates with the aforementioned composite ink layers with different carbon-polymer mass fractions. The optimal mass fractions in these composite layers allowed to fabricate composite electrodes that can inject hot electrons into aqueous electrolyte solutions and clearly generate hot electron- induced electrochemiluminescence (HECL). An aromatic terbium (III) chelate was used as a probe that is known not to be excited on the basis of traditional electrochemistry but to be efficiently electrically excited in the presence of hydrated electrons and during injection of hot electrons into aqueous solution. Thus, the presence of hot, pre-hydrated or hydrated electrons at the close vicinity of the composite electrode surface were monitored by HECL. The study shows that the extreme pH conditions could not damage the present composite electrodes. These low-cost, simplified and robust composite electrodes thus demonstrate that they can be used in HECL bioaffinity assays and other applications of hot electron electrochemistry.

• The Journal of Korean Physical Therapy
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• v.9 no.1
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• pp.89-96
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• 1997

The purpose of this study was to determine the effect of Ga-Al-As (Gallium-Aluminum-Arsenid) laser radiation on the tail-flick latency in rat. Thirty Sprague-Dawley male and female rats Were divided into five groups : that is control, laser 15sec radiation, laser 30sec radiation, laser 60sec radiation, and Tramadol Hcl injection groups. The continuous Ga-Al-As laser with, wave length 780-830nm and diameter of probe in the 3mm, averse output of 100mw radiation was applied to the meridian point(Gv 1 : Governing vessel) of the rats. Tail-flick latency were measured with hot plate at $55^{\circ}C$ : before treatment and immediately, 30 minutes, 1 hour, 2 hours, 24 hours, 24 hours and 48 hours after treatment. The result were as follows ; 1. The tail-flick latency according to time varition, control group was not significance. 2. The tail-flick latency according to time varition, laser 15 sec irradiate rats in post-treared was significance(P<0.05). 3. The tail-flick latency according to time varition, laser 30 sec irradiate rats group was not significance. 4. The tail-flick latency according to time varition, laser 60 sec irradiate rats in post 30 minute was significance(P<0.05). 5. The tail-flick latency according to time varition, Tramadol Hcl injection rats in post-treated (P<0.05), post 30 minute(P<0.05), post 60 minute (P<0.01) and 2 hour(P<0.05) was significance. This study suggest that Ga-Al-As (Gallium-Aluminum-Arsenid) laser applied to meridian point of the rat with 15 sec, 30 sec, and 60 set radiation could induc no analgesic effect, but Tramadol Hcl injection rat is good analgesic effect.

• Journal of Biosystems Engineering
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• v.28 no.5
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• pp.465-468
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• 2003

A microdialysis coupled flow injection amperometric biosensor was calibrated to measure the concentration of glucose using 7 standard samples from 10ml to 70ml of glucose solution. The output of the sensor increased linearly with an increase in the glucose concentration with an $R^2$ correlation of 0.99. The amperometric biosensor was then applied to measure the. glucose concentration of 2 commercial samples(Orange and Pineapple juice) and the results compared with HPLC. Around 12% error was observed in glucose concentration measurements of the samples analyzed. The sensor has potential in rapid measurement once the calibration is done. Potential for on-line sensing is also discussed.

• Proceedings of the KOSOMBE Conference
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• v.1998 no.11
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• pp.129-130
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• 1998

In this paper, We designed the ECG-NIBP-$SpO_2$ patient monitor. This production can measure Electrocardiograph, Heart Rate, Noninvasive Blood Pressure, and Oxygen Saturation for Noninvasive Mehod and can display each information. These informations were implemented by the electrodes of ECG part, the cuff of NIBP module and the finger probe with light sensor of $SpO_2$ without injection of needle or catheter. In addition, We developed a new analysis algorithm and measurement technique for NIBP and $SpO_2$ to observe patient's conditions correctly.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2002.02a
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• pp.3-10
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• 2002

In this study on machine measuring system based on solid feature was developed. This system was applied with injection mold using 3 dimensional solid modeler for verification. Developed program include pre-processor, main processor, and post processor. In pre-processor there are functions which check intersection, simulate motion of probe and calculate measuring time. Main processor generates measuring path and output NC code in Unigraphics. In post-processor functions that include evaluation of undercut or overcut and display of measuring procedure are offered. In addition analysis module for quality control of measured data on manufactured product was developed with geometric and dimensional tolerance concept. As the result developed program could get stability of system, precision of product, rapidity and cost down of manufacturing process compared with before measuring process.