• Journal of Pharmaceutical Investigation
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• v.36 no.2
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• pp.115-121
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• 2006

The aim of this study was to develop new protein/peptide depot system instead of poly(DL-lactic acid-coglycolic acid) (PLGA) microspheres. Pullulan was chemically modified by the addition of acetic anhydride (pullulan acetate; PA) and then investigated as new depot system for protein/peptide delivery. PA microspheres (PAM) with lysozyme as a model protein were prepared by w/o/w double emulsion method. The microspheres had a mean size of 10-50 mm with a spherical shape. The size distributions reduced with increasing the degree of acetylation. The loading efficiency of lysozyme was also increased. Lysozyme aggregation behavior in the microsphere was monitored to estimate the change of protein stability during preparation step. The ratios of protein aggregation in PAMs are lower than that of PLGA microsphere, in particular, PA 5 showed lowest as about 16%. The result indicated that the increase of acetylation suppressed the aggregation of protein. The release profiles of lysozyme from PAMs were significantly different. High acetylation effectively improved lysozyme release kinetics by reducing initial burst release and extending continuous release over a period of time. To check the effect of preservation for structural stability of lysozyme, the activity of lysozyme released from PA 5 was also observed. The activity of lysozyme was maintained almost 100% for 25 day. Therefore, PAM may become to a useful carrier for delivery of protein/peptide drugs, if it will be supported by biocompatibility and biodegradability results.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.15 no.3 s.96
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• pp.341-345
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• 2005

Structural Dynamics Modification (SDM) is a very effective technique to improve structure's dynamic characteristics by adding or removing auxiliary structures, changing material properties and shape of structure. Among those of SDM technique, the method to change shape of structure has been mostly relied on engineer's experience and trial-and-error process which are very time consuming. In order to develop a systematic method to change structure shape, surface grooving technique is studied. In this work, the shape of base structure was modified to improve its dynamic characteristics such as natural frequencies via surface grooving technique. Grooving shape was formed by mergingthe neighboring small embossing elements after analyzing frequency increment sensitivities of all the neighboring emboss elements. For this process, Criterion Factor was introduced and the initial grooving was started from the element having highest strain energy and the grooving is expanded into neighboring element. The range of targeting grooving area to check its frequency variations restricted to their neighboring area to reduce the computation effort. This surface grooving technique was successfully applied to a hard disk drives (HDD) cover model to raise its natural frequency by giving some groove on its surface.

• Architectural research
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• v.16 no.3
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• pp.93-100
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• 2014

Existing BIM(Building Information Modeling) based energy evaluation tools cannot be utilized enough for the potential performance of BIM because most of them have not provided the integrated model for energy evaluation, assessment of the material, cost of the construction, and so on. This research aims to propose and develop a new application, EcoBIM, to support an integrated evaluation of the energy and cost efficiencies of the design alternatives within the design process. The proposed application functions as a BIM-based evaluation system that calculates energy-savings performance as well as the construction cost of the alternatives at the design stage. This study mainly focuses on the possibilities of developing the proposed technology. We also suggest an advanced design process using the proposed system, corresponding to changes of national regulations in Korea. This study deduce that EcoBIM can allow architects to make suitable decisions regarding energy- and cost-efficient designs. The proposed design process will allow architects not only to check the eco-friendly performance of design alternatives but also predict the operation cost in a certain period in the future. EcoBIM can prevent large-scale design changes required to obtain environmental certification and enable the owner to make an informed decision about the initial investment of construction according to the result of the analysis of the energy requirement at the design stage.

• Journal of Korea Society of Digital Industry and Information Management
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• v.9 no.2
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• pp.89-97
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• 2013

The green IT technology is being introduced in diverse sectors, especially in the data center and green computer sectors. Rack-type PCs, which have been developed by improving the computer hardware, are effective for data centers and large businesses, but they are not usually introduced in small organizations such as small and medium businesses and schools because they require high initial costs. Power-saving PC software enables the inexpensive power control, but the installation of the power-saving software in all computers in the organization is not an easy task. Computer users in the organization are usually not cooperative as they do not think the power-saving cost is directly related to themselves. In this paper, a technique wherein the server has a restriction in providing the IP address to the computers that has no power-saving software is proposed, so that users will cooperate in the PC power-saving system to avoid inconvenience. In order to provide restricted IP address periodically, the server makes a request of power-saving software installation check for user's PC. Proposed technique is more effective ways to save computer energy, because it does not depend on specific systems or organizations.

• Transactions of the Korean Society of Mechanical Engineers
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• v.19 no.7
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• pp.1604-1618
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• 1995

In the process of mechanical assembly design, assembly modeling systems have been used mainly for the design verification before manufacturing by enabling to check the interference and/ or the dynamic and kinematic performance. However, the conventional assembly modeling systems have a shortcoming that they can not be used in the initial design stage but can be used only after the design is fully completed. In other words conventional assembly modeling systems provide bottom-up modeling which means that the detailed modeling of components must precede the definition of relationships between them. To resolve this problem, an assembly modeling system is proposed to provide a top-down modeling environment in which components and assembly can be modeled simultaneously. To this end, an assembly data structure suitable for top-down assembly modeling has been established. Feature positioning Module(FPM) using geometric constraints has been also developed. The Sekective Solving Method proposed for FPM is based on the priority between the constraint equations and enables the designer's intent expressed by geometric constraints to be maintained throughout the whole modeling process. Finally, the feature based modeling technique using two-level features has been developed. Two-level features include an abstract model and a detailed model in a merged form in non-manifold data frame.

• Proceedings of the KSME Conference
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• 2000.04b
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• pp.220-227
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• 2000

The purpose of this study is to develop the non-gravity fluidized dryer. In this non-gravity fluidized dryer the fluidized zone is produced by two paddles in mixer, which maximizes the surface area of materials and then heated air through the guiding panels dehumidify them. This can conduct the drying process quickly and control moisture contents to lower limits. The ventilation system is closed loop system, which can be changeable to open system, and can be used as a multi-purposed dryer in which mixing, drying, granulating and cooling process is conducted. In order to develop non-gravity fluidized dryer, in the first the fundamental experiments performed to mixing accuracy and then the other parts of dryer and control system were examined to check whether they were designed properly and operated harmoniously with mixer. Also the preparatory experiments were fulfilled to examine the efficiency and reliability of dryer. Lastly, on the basis of preparatory experiments in case the initial moisture contents, desired moisture contents, heated air velocity and heating temperature were vary, performance test for the non-gravity fluidized dryer carried out.

• The KSFM Journal of Fluid Machinery
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• v.15 no.6
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• pp.51-57
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• 2012

Performance evaluation of a compressor is conducted to develop 500W class ultra-micro gas turbine (UMGT) for power generation. The performance evaluation is essential to check the performance of the components of UMGT, a radial turbine, a centrifugal compressor, an angular combustor and a shaft, which have been already designed in previous researches. The purpose of this study is to introduce the development process of the performance testing equipments of the UMGT and to present the results of compressor performance test. For the performance evaluation of the compressor, two test equipments are developed and the initial test equipment uses commercial static air bearings with long shaft. In the improved test equipment, static air bearing is improved to increase rotating speed and compressed nitrogen gas is used for utility gas of the static air bearing to supply compressed air in a stable and steady way. To increase rotating speed to 320,000 rpm, 80% speed of design speed, compressed air is provided to the turbine. The performance map of the compressor with the 50%, 60%, 70%, 80% speed of design point is presented. The results of the performance test of compressor show a good agreement with the results of 3D CFD.

• Journal of Korean Society of Water and Wastewater
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• v.29 no.1
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• pp.107-122
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• 2015

The purpose of this study is to analyze the structural stability of pavement due to water infiltration at the road with infiltration trench as using the FEM(finite element analysis). Five cases for FEM is divided considering the amount of rainfall and rain duration time. The results of FEM show that the more rainfall in a short period time is faster the change of moisture content. Also, it is the proportional relationship between and changing area of moisture content of more than 40% due to rainfall. Case 3 and 4 are necessary to check the installation of infiltration trench because of moisture content of more than 40%, recovery time of initial moisture content, and changing area of more than 40%. Case 1,2, and 5 have no a significant effect on road pavement structure due to lower moisture content and shorter duration time of higher moisture content.

• Journal of Biosystems Engineering
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• v.32 no.2 s.121
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• pp.102-108
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• 2007

Heat pump systems are recognized to be heating and cooing systems. In this study, to check the practical application possibility of heat pump systems as low temperature storage systems and get basic data, apples of a long term storage items were stored and performance of low temperature storage and quality changes of apples were evaluated. Cooling coefficient of performance of the system was from 1.1 to 1.3. Although ambient air temperature varied widely from $-13^{\circ}C$ to $29.6^{\circ}C$ during low temperature storage period from January to June, the average temperature of low temperature storage chamber was $1.1^{\circ}C$ at setting temperature of $1.5^{\circ}C$. Sucrose of apples stored by the heat pump decreased from initial sucrose of 15.4% (Brix number) to final sucrose of 14.3%. Weight loss ratio of apples was 9.7% and internal and external view of apples after low temperature storage were very satisfactory with the naked eye.

• Special Issue of the Society of Naval Architects of Korea
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• 2011.09a
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• pp.112-116
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• 2011

The noise analysis is usually carried out in the early structure design stage for the main areas in a vessel such as an accommodation, an engine room, HVAC System and etc. If the analysis results are higher than the noise limits based on guideline, appropriate countermeasures are established to reduce noise levels and applied to the vessel. But excessive noise induced the main or auxiliary equipment and high pressure steam system is very difficult to check in the initial design stage, and local noise problems frequently appear in actual vessels. This paper deals with excessive noise of the engine control room on LNG carrier. It includes the cause analysis of excessive noise, the countermeasure, and verification. Also, it proves suitability of the countermeasure through the on-board test.