• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.1
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• pp.231-234
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• 2007

Dichlororinated bibenzyl compound (4) has been isolated from the New Zealand liverwort. This compound was elucidated using 1D/2D-NMR and mass spectral method. The compound (3) inhibited the growth of the Gram positive bacterium Bacillus subtilis ATCC 19659, (2 mm inhibition zone and 2 mm inhibition zone at 30 ${\mu}$g/disc), Candida albicans ATCC 14053, (2 mm inhibition zone and 2 mm inhibition zone at 30 ${\mu}$g/disc), and the dermatophytic fungi Trichophyton mentagrophytes ATCC 28185, (12 mm inhibition zone at 30 ${\mu}$g/disc) and Cladosporium resinae ATCC 52833 (2 mm inhibition zone at 30 ${\mu}$g/disc). This bibenzyl compound (4) exhibited antimicrobial activity.

• Applied Biological Chemistry
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• v.41 no.8
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• pp.608-610
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• 1998

To investigate the inhibitory activity of 2-hydroxy-3-amino-4-phenylbutyrate-harboring aminopeptidase N inhibitors, p-nitro-AHPA-peptide derivatives (1 and 2) and an AHPA-peptide derivative (3) were synthesized by chain elongation from C-terminal end using DCC/HOBt as a coupling reagent. The peptides $1{\sim}3$ exerted strong inhibitory activities against aminopeptidase N with $IC_{50}$ values of 1.8, 7.3 and $24.0\;{\mu}g/ml$, respectively, and cytotoxicity on cancer cell lines in vitro.

• Korean Journal of Child Studies
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• v.30 no.6
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• pp.535-548
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• 2009

The purpose of this study was to investigate relationships between adolescent's behavioral inhibition and social anxiety focused on the moderating effects of perceived parental rearing behaviors. Subjects were 749 7th through 9th grade students attending schools in Seoul and Gyeonggi Province. Major findings were that (1) boys' and girls' behavioral inhibition was an important factor predicting social anxiety; and (2) perceived parental rearing behaviors played the role of moderating variables on the influence of behavioral inhibition of boys' and girls' social anxiety. In the boys' group, perceived intrusion had a moderating effect on the relationships between behavioral inhibition and social anxiety; in the girls' group, perceived warmth and perceived granting of autonomy acted as moderating variables on social anxiety.

• Journal of Families and Better Life
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• v.18 no.1
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• pp.85-96
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• 2000

this study examined behavioral inhibition in relation to their mothers' value and attitudes toward children's inhibited behavior as a function of child sex. Data were collected via questionnaires from a sample of 483 7-to 8 year-olds and their mothers. Results showed that there were no significant differences in mother's value mothers' attitudes toward child behavior and child's behavioral inhibition according to child sex. However it was found that mothers' value was associated with attitudes toward child inhibition and behavioral inhibition in 7-to 8 year-olds girls. more specifically mothers who hold high traditional values were not concerned about girls' inhibited behavior and thus in turn had more inhibited girls. But the associations were not found for boys. the results indicated cultural effects on parenting attitudes as well as child inhibition.

• 한국신재생에너지학회:학술대회논문집
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• 2005.06a
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• pp.618-621
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• 2005

In this study, the phenomena of hydrate formation and inhibition were investigated according to varying the concentrations using methanol and ethylene glycol as chemical additives. The results reveal that the used additives display better inhibition effects compared to pure water by decreasing the formation temperature and the inhibition performance of methanol is superior to that of ethylene glycol. As a conclusion, the plugging phenomena of flowline in natural gas product ion. subsea and frozen field pipelines can be predicted by examining the hydrate formation and inhibition conditions. Specifically, the results of this study can be applied to the selection of the prevention criteria and method of hydrate formation.

• Natural Product Sciences
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• v.2 no.2
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• pp.137-142
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• 1996

This paper gives a description about the germination inhibition of American ginseng (Panax quinquefolium L.) seed coat. The existence of seed coat is one of the inhibitory factors which inhibit the embryo growth, particularly during the morphological after-ripening stage. The seed coat can obstruct the water absorption at the beginning of seed stratification, but it can not threaten seed germination. The inhibition of seed coat is not caused by the mechanical fetter neither. However, before splitting the seed coat, the inhibition of seed coat comes from both air-tight character and inhibitors, and after splitting the seed coat, the inhibition may come mainly from the inhibitors.

• Korean Journal of Child Studies
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• v.22 no.2
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• pp.29-47
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• 2001

In this study of 79 3- and 4-year-old children, behavioral inhibition was assessed by their preschool teachers; mother-child attachment was assessed by the researchers in home visits; and mothers reported on their parenting and their child's emotionality at 6-12 months of age. Findings were that insecure attachment was related to high child's distress reactions to limitations (negative emotionality) in early infancy and to strong maternal rejection/hostility. Higher maternal sensitivity to child's inhibition was related to more secure attachment. Girls were more highly inhibited than boys. Smiling and laughter (positive emotionality) in early infancy was negatively related to child's inhibited behavior. Maternal sensitivity to child inhibition was positively related to child's inhibited behavior. Findings are consistent with Engfer's (1993) theory of gender differences in developmental paths into behavioral inhibition.

• YAKHAK HOEJI
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• v.43 no.3
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• pp.334-341
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• 1999

Thyroid peroxidase is a biochemical target protein for the antithyroid drugs. Ethanol extracts from one hundred and thirty seven natural products were screened for the inhibition of thyroid peroxidase activity. Thyroid peroxidase was purified from porcine thyroids, and the inhibition of peroxidase activity was evaluated using guaiacol oxidation (C-C coupling) assay. Twenty one natural products expressed a remarkable inhibition (>50%) of peroxidase activity at $330{\mu\textrm{g}}$ solid weight/m. The 50% inhibitory concentration ($IC_{50}$) of 70% ethanol extract from six potent natural products ranged from 3.1 to $31.2{\;}{\mu\textrm{g}}$ solid weight/m, in contrast to the range ($0.33~0.54{\;}{\mu\textrm{g}}/ml$) of $IC_{50}$ values fro catechin and epigallocatechin gallate as positive controls. Noteworthy, the extract of Camellia taliensis showed irreversible inhibition of the enzyme. It is suggested that extract from some natural products such as Camellia taliensis, Rheum undulatum or Euphorbia perinensis, exhibiting a potent inhibition of peroxidase activity, may be developed as sources of potent antithyroid agents.

• YAKHAK HOEJI
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• v.44 no.4
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• pp.358-361
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• 2000

Parameter focusing on the DNA topoisomerase-Iinhibition with X-substituted phenyl substituents in 1-(2-furyl)-3-phenylpropenone derivatives as inhibition material were analyzed. From the basis on the results the inhibition on DNA topoisomerase I suggested that the inhibition activities of X-substituted phenyl substitutents would depend largely on the net charge of $\beta$-carbon atom, LUMO energy (e.v.) and STERIMOL parameter B$_{5}$ (width) of X. Among them, non-substituent (X=H), 1 and 2,2-dichloro substituent, 4 showed the highest DNA topoisomerase-I inhibition activity.y.

• Development and Reproduction
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• v.16 no.4
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• pp.329-338
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• 2012

The proliferation of embryonic cells or adult stem cells in tissue is critically regulated during development and repair. How limited the proliferation of cells, so far, is not much explored. Cell-cell contact proliferation inhibition is known as a crucial mechanism regulating cell proliferation in vitro and in vivo. In this study we examined the characters of mouse subcutaneous adipose derived stem cells (msADSC) whether they lost or get contact inhibition during in vitro culture. The characters of msADSC growth after confluence were analyzed using confocal microscope and the expression profiles of contact inhibition related genes were analyzed according to the morphological changes using real-time PCR method. msADSC showed overlapping growth between them but not after passage 14. The cell shapes were also changed after passage 14. The expression profiles of genes which are involved in contact inhibition were modified in the msADSC after passage 14. The differentiation ability of msADSCs to adipocyte, chondrocyte and osteocyte was not changed by such changes of gene expression profiles. Based on these results, it is revealed that smADSC were characterized by getting of strong cell-cell contact inhibition after passage 14 but the proliferation and developmental ability were not blocked by the change of cell-cell contact proliferation inhibition. These finding will help to understand the growth of adipose tissue, although further studies are needed to evaluate the physiological meaning of the cell-cell contact proliferation inhibition during in vitro culture of msADSC.