• Journal of the Korean Society of Safety
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• v.36 no.1
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• pp.86-94
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• 2021

Lecture rooms are crowded with many attendees. Moreover, they rely significantly on the natural ventilation through windows for removing and controlling indoor contaminants such as CO₂. With the aim of broadening the understanding of the characteristics of natural ventilation phenomena in lecture rooms, the average individual CO₂ release rates of attendees were measured during the course of a lecture and compared with previously reported CO₂ release rates. In addition, the effects of natural ventilation through windows on the time-variant CO₂ concentrations in the center of the lecture room were measured and analyzed. Moreover, details about the overall and regional CO₂ concentrations, as well as the air flows in the lecture room, were simulated and analyzed with computational fluid dynamics software, Fluent 2020 R2. It was found that the average individual CO₂ release rates were slightly slower than previously reported rates. The local CO₂ concentrations in the lecture room for regions with a high density of attendees increased over a short period of time, although the natural ventilation was already started by opening the windows. The overall CO₂ concentration in the lecture room rapidly decreased in the early stage of ventilation, but declined very slowly after a longer period of ventilation time. Therefore, in order to enhance the efficiency of a lecture room's natural ventilation, it is recommended to homogeneously distribute the attendees in the lecture room, and to frequently open the windows for short periods of time.

• Korean Journal of Clinical Pharmacy
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• v.6 no.2
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• pp.19-23
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• 1996

Carbamazepine is an anticonvulsant drug that has been shown to be as effective as phenytoin or phenobarbital in treatment of grand mal and complex partial seizures and is also approved as the drug of choice for treatment of the pain associated with trigerminal neuralgia. And the therapeutic or toxic effects of carbamazepine are better related to plasma concentration than to dosage, which can be attributed to interindividual variability in the pharmacokinetics. A slow rate of carbamazepine dissolution in the gastrointestinal tract is believed to be the cause of its relatively slow and erratic rate of absorption. For these reasons pharmacokinetic evaluation of newly formulated carbamazepine is neccessary. In this study, the bioequivalence in carbamazepine between the $TegretoI^{TM}$ CR tablet (Geigy Co.) and $Carmazepine^{TM}$ CR tablet (Myung In Co.) was evaluated. 12 normal volunteers (age $21\~27$ years old) was divided into two groups, and a randomized cross-over study was employed. The pharmacokinetic parameters ($C_{max},\;T_{max}$ and AUC) obtained of oral administration of each formulatim of carbamazepine 400 mg were evaluated and ANOVA was utilized for the statistical analysis of parameters. $C_{max}\;is\;8.26{\pm}3.1{\mu}g/ml\;(C.V.\;37.3\%)\;in\;TegretoI^{TM}\;and\;9.39\{pm}2.9{\mu}g/ml\;(C.V.\;30.5\%)$ in $Carmazepine^{TM},\;T_{max}\;is\;28.0{\pm}5.9\;hrs(C.V.\;21.1\%)$ in $Tegretol^{TM}\;and\;24.0{\pm}7.2\;hrs(C.V.\;30.2\%)$ in $Carmazepine^{TM}$ and AUC is $786.4{\pm}360.5{\mu}g{\cdot}hr/ml\;(C.V.\;45.8\%)$ in $TegretoI^{TM}\;and\;792.8{\pm}228.6{\mu}g{\cdot}hr/ml\;(C.V.\;28.8\%)$ in $Carmazepine^{TM}$, respectively. As the result of the data, two formulations are bioequvalent, and the lower C.V. of $Carmazepine^{TM}$ in every individual can be merit.