• The Journal of the Korean life insurance medical association
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• v.28 no.1_2
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• pp.11-14
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• 2009

It is common to find cerebral infarct and hemorrhage without definite neurologic signs but with lesions on neuroimaging. These lesions are called silent lacunar infarct and cerebral microbleed. Silent lacunar infarct are frequently seen in the elderly and are associated with clinically apparent stroke and vascular dementia. Known stroke risk factors, such as hypertension, diabetes mellitus, smoking, hypercholesterolemia and heart problems may increase the risk of silent lacunar infarct. Metabolic syndrome, homocysteinemia, renal failure and intima media thickness(IMT) are also other risk factors of the silent lacunar infarct. Cerebral microbleed, lacunar infarct and intracerebral hemorrhage(ICH) have similar pathology and pathogenesis. So, cerebral microbleed are coexisted with lacunar infarct, leukoaraiosis, hypertensive ICH and vascular dementia. Cerebral microbleed are associated with volume and recurrence of ICH. Also cerebral microbleed may reflect baseline status of blood brain barrior disruption. Silent lacunar infarct and cerebral microbleed are very important to clinical management, but in the aspect of insurance medicine and independent medical examiners, these lesions are not subject of evaluation for handicap.

• The Research Journal of the Costume Culture
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• v.22 no.1
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• pp.167-182
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• 2014

This study researched the symbolic meaning of the costume colors in the independent film . The purpose of the study is to shed light on the relation between a film and the clothing color by exploring the symbolic meaning of costume colors as based on place images and as reflected in characters' internal psychological states and situations. The conclusions of this study are as follows. First, the colors primarily presented were neutral shades of black and white or dark, almost-black tones, representing the negative narrative structure and depicting the image of a human being. Second, a series of bright blue shades were presented to reflect the positive narrative structure of a human being returning successfully to reality. Third, the application of color, involving both the psychological aspect as well as the symbolism of color, was effectively delivered to the audience. Fourth, the emphasis on color in the smallest details of costumes was analyzed, and it was found that symbolic color effectively communicated the whole image of transformation as the story progressed, clearly delivered delicate emotional messages, and contained symbolism relating to particular places and situations.

• Journal of Agricultural Extension & Community Development
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• v.8 no.2
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• pp.201-208
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• 2001

The purpose of this study was to review the current studies on community attachment and its related variables to suggest directions for community attachment studies in Korea. Specific objectives of the study were to search the current studies on community attachment, to search for the significant variables related to community attachment, and to draw implications for community development in Korea. The major findings of the study were as follows; 1) Current studies on community attachment used individual characteristic variables such as length of residence in the community, age, size of population and density as major independent variables. 2) Studies on community attachment used community participation, social and cultural environment as major dependent variables, however, both independent variables and dependent variables were used interchangeably in many cases. 3) Recent studied on community attachment employed community economic and cultural variables, however, studies on community attachment in Korea was relatively limited in terms of quantity as well as quality. 4) Further research on community attachment should be conducted by utilizing various independent and dependent variables in various communities to increase the community attachment in rural and urban communities to further strengthen community development in Korea.

• Bulletin of the Korean Chemical Society
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• v.26 no.6
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• pp.916-920
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• 2005

Acetohydroxy acid synthase catalyzes the first common step in the biosynthesis of branched chain amino acids. AHAS plays two distinct metabolic roles, and is designated as anabolic AHAS and catabolic AHAS, depending on its function. Anabolic AHAS is FAD-dependent, while its catabolic counterpart is not. In this work, a conserved motif was identified in the $\beta$-domain of anabolic AHASs, but not in catabolic AHAS ($_{372}RFDDR_{376}$). In order to determine the functions of this motif, we replaced the motif with the corresponding sequence in FAD-independent AHAS, SPVEY. None of these three mutants (SPV, SPVE, and SPVEY) was detected with bound FAD. However, two of these mutants (SPVE and SPVEY) were active at a low level of specific activity. Although they exhibited pyruvate- and ThDP- dependent characteristics, the activity of the two active mutants appears to be FAD-independent. The SPVEY mutant was completely insensitive to the three tested herbicides, even at extremely high concentrations and is also somewhat more thermolabile than the wild type enzyme. The data provided in this work suggest that the RFDDR motif is a possible determinant of the FAD-dependent and herbicide-resistant properties of tobacco AHAS. The SPVEY mutant appears to exhibit catabolic AHAS-like activity.

• Journal of fish pathology
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• v.34 no.1
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• pp.17-22
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• 2021

Eukaryotic translation is initiated by either cap-dependent or cap-independent way, and the cap-independent translation can be initiated by the internal ribosomal entry site (IRES). In this study, to know whether the 5'UTR leader sequence of marine birnavirus (MABV) segment A and segment B can act as IRES, bicistronic vectors harboring a CMV promoter-driven red fluorescent gene (mCherry) and poliovirus IRES- or MABV's leader sequence-driven green fluorescent gene (eGFP) were constructed, then, transfected into a mammalian cell line (BHK-21 cells) and a fish cell line (CHSE-214 cells). The results showed that the poliovirus IRES worked well in BHK-21 cells, but did not work in CHSE-214 cells. In the evaluation of MABV's leader sequences, the reporter eGFP gene under the 5'UTR leader sequence of MABV's segment A was well-translated in CHSE-214 cells, indicating 5'UTR of MABV's segment A initiates translation in the cap-independent way and can be used as a fish-specific IRES system. However, the 5'UTR leader sequence of MABV's segment B did not initiate translation in CHSE-214 cells. As the precise mechanism of birnavirid IRES-mediated translation is not known, more elaborate investigations are needed to uncover why the leader sequence of segment B could not initiate translation in the present study. In addition, further studies on the host species range of MABV's segment A IRES and on the screening of other fish-specific IRESs are needed.

• The Journal of the Korea Contents Association
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• v.17 no.5
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• pp.461-469
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• 2017

The purpose of this study was to investigate college life adaptation and loneliness of non-traditional adult learners with nursing major. A cross-sectional survey was conducted on one hundred and ten participants from selected universities in G city. A structured questionnaire which included general characteristics, a College Life Adaptation Scale and a Revised UCLA Loneliness Scale was a study instrument. Descriptive statistics, independent t-test, one-way ANOVA, and Pearson correlation coefficients were used for data analysis. The average level of college life adaptation was 44.8, while the score for loneliness was found to be 40.3. There was a significant difference in college life adaptation according to perceived health status. Loneliness showed a significant difference according to grades. A significant positive correlation was observed between college life adaptation and loneliness. In other words, the greater the loneliness, the lower the adaptation to college life. Thus, the results suggest that Korean universities should pay close attention to psychological factors such as loneliness to improve the adaptation of non-traditional adult learners with varied backgrounds to college.

• Molecules and Cells
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• v.42 no.3
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• pp.237-244
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• 2019

Understanding the mechanisms of cancer drug resistance is a critical challenge in cancer therapy. For many cancer drugs, various resistance mechanisms have been identified such as target alteration, alternative signaling pathways, epithelial-mesenchymal transition, and epigenetic modulation. Resistance may arise via multiple mechanisms even for a single drug, making it necessary to investigate multiple independent models for comprehensive understanding and therapeutic application. In particular, we hypothesize that different resistance processes result in distinct gene expression changes. Here, we present a web-based database, CDRgator (Cancer Drug Resistance navigator) for comparative analysis of gene expression signatures of cancer drug resistance. Resistance signatures were extracted from two different types of datasets. First, resistance signatures were extracted from transcriptomic profiles of cancer cells or patient samples and their resistance-induced counterparts for >30 cancer drugs. Second, drug resistance group signatures were also extracted from two large-scale drug sensitivity datasets representing ~1,000 cancer cell lines. All the datasets are available for download, and are conveniently accessible based on drug class and cancer type, along with analytic features such as clustering analysis, multidimensional scaling, and pathway analysis. CDRgator allows meta-analysis of independent resistance models for more comprehensive understanding of drug-resistance mechanisms that is difficult to accomplish with individual datasets alone (database URL: http://cdrgator.ewha.ac.kr).

• Journal of the Korea Society of Computer and Information
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• v.28 no.7
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• pp.121-129
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• 2023

This study analyzed 247 data surveyed on 119 ambulance workers 268 in a G-Do. The variance of the multiple regression model on the effect of independent variables on life satisfaction factors was statistically significant. And transformational leadership is an independent variable that significantly affects life satisfaction factors. However, there is a slight difference in the perception of transactional satisfaction factors (p=.051) was not statistically significant, so the second research question raised in this study was rejected. Based on the results of this study, transformational leadership should be centered on improving 119 paramedics' life satisfaction in the relationship between the direct effects of leadership variables related to 119 paramedics' life satisfaction. By doing so, 119 paramedics' life satisfaction will increase and the ultimate improvement in the quality of first aid at the emergency site will be achieved by providing a foothold to demonstrate the potential capabilities of 119 paramedics. In addition, 119 paramedics need to recognize and promote the importance of life satisfaction recognized in their daily lives and workplaces, creating an environment that can demonstrate transformative leadership by carefully caring for 119 center heads, team leaders, and field seniors.

• Journal of the Korean Home Economics Association
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• v.34 no.4
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• pp.103-117
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• 1996

This study is a theoretical approach by literature about life style and housing life style. The purpose of this research is making an analysis model of housing life style which can be used as a conceptual framework in empirical study. the theme of‘Life style’was studied mainly in the area of consumerism and housing. Model was made to explore the sub-domain of new analysis model by the microsociological approach. As results, 1) Independent variable of housing life style research model must be selected to be possible of comparison in effect of objective and subjective variable and in effect of predictive function and well-being function of housing life style. 2) Sub-domain of housing life style must be consisted of value orientation of family life, consumption in house, consumer durables, furniture., and propensity to using space. 3) Conceptual model of housing life style must be tested in empirical study to know what is the housing adjustment behavior of individual family, to improve quality of housing life and to suggest housing policy for family as a consumer.

• The Journal of the Korean life insurance medical association
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• v.32 no.1
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• pp.8-14
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• 2013

Evidence-based medicine(EBM) or evidence-based health care has been used in clinical medicine. Recently, it also has been applied to areas of social medicine such as independent medical examination. Insurance medicine is one of social medicine, as for it's role is maintenance of sound insurance system or for insured of life insurance. Practical application of EBM to the insurance medicine are; confirming question, finding evidence, and evaluation that selected evidence is best or not in terms of practical aspect.