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Effect of Aging on the Xylene Metabolism in $CCl_4$-Induced Liver Damaged Rats

  • Kim, Hyun-Hee;Yoon, Chong-Guk
    • Biomedical Science Letters
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    • v.7 no.3
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    • pp.111-116
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    • 2001
  • To investigate an effect of aging on the xylene metabolism in liver damaged animals, a study was conducted. 50% carbon tetrachloride ($CCl_4$) in olive oil (0.1 ml/100 g body weight) was intraperitoneally given to 5-week and 12-week rats 12 times every other day and then one dose of 50% xylene in olive oil (0.25 ml/100 g body weight) was intraperitoneally given to the rats, and after 24 hr, the animals were sacrificed. On the basis of the functional findings in rat liver, ie, serum levels of alanine aminotransferase activity, liver protein and malonedialdehyde contents, 5-week rats showed less liver damage than 12-week rats. The increasing rate of urinary methylhippuric acid concentration to the control was significantly higher in 5-week rats than 12-week rats in case of xylene treatment after induction of liver damage. On the other hand, liver damaged 5-week rats showed significant rise of hepatic cytochrome P45O content compared with the liver damaged 12-week rats by the xylene treatment. And increasing rate of hepatic alcohol or aldehyde dehydrogenase activities to each liver damaged animals was higher tendency in 5-week rats than 12-week rats by the xylene treatment. In conclusion, 5-week rat showed greater metabolic rate of xylene than 10-week rats in case of liver injury because 5-week rats led to a slight liver damaged compared with 12-week rats.

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Iron Increases Susceptibilities of Pseudomonas aeruginosa to Ofloxacin by Increasing the Permeability

  • 김숙영;김진숙;남혜란;정유선;이연희
    • Korean Journal of Microbiology
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    • v.38 no.4
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    • pp.265-265
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    • 2002
  • Iron increased the susceptibilities of clinical isolates Pseudomonas aeruginosa to quinolones. In the presence of iron, increased susceptibilities to ofloxacin were observed in twenty-six out of thirty isolates and with no change in four isolates. In the case of norfloxacin, iran increased susceptibilities of twelve isolates but did not render any change in eighteen isolates. In the case of ciprofloxacin, iron decreased the MICs (Minimal Inhibitory Concentration) of twenty isolates, increased the MIC of one isolate, and did net change the MICs of nine isolates. To find out how iron increased susceptibility to ofloxacin, bacterial cells were grown in Muller Hinton (MH) media and succinate minimal media (SMM) to induce iran acquisition systems and the intracellular ofloxacin concentrations were assayed in the presence of iron. The addition of iron to the media decreased the MICs of cells whether they were grown in MH or SMM. Siderophores, carbonyl cyanide m-chlorophenylhydrazone (an inhibiter of proton motive force), and ouabain (an inhibitor of ATPase) did not decrease the effect of iron. Results suggested that the increase in the intracellular ofloxacin concentration by iron is accomplished not by decreasing the efflux but by increasing the of ofloxacin permeability.

Factors Influencing Social Capital through the Enhancement of a Lifelong Learning City: Youngcheon and Andong City Case Study (평생학습도시 관련변인의 사회자본 영향에 관한 연구: 안동시와 영천시의 사례)

  • Kim Nam-Sun;Ahn Hyun-Sook
    • The Korean Journal of Community Living Science
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    • v.17 no.2
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    • pp.113-124
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    • 2006
  • This study examines the factors influencing social capital within a lifelong learning city as discussed in the Youngcheon and Andong City case study. Data was collected from 205 leaners in Andong City and 194 learners in Youngchun City. The data was then analyzed by the SPSS WIN 12.0 program. The statistical techniques used for this study were frequency, percentile, 1-test, and regression. The major findings of this study were as follows: To begin with, the learners in LLC were more likely to have positive attitudes toward the construction of a lifelong learning city. Second, the leaners in LLC were more likely to have social capital including norm and network. Furthermore, the learning opportunity had a positive effect in increasing the trust between learners. Learning support and support systems also had influence in increasing the social network between learners. Finally, support systems had a positive effect in improving the norm between learners.

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The gear shape and cross section of sweep at mouth of a bottom trawl (저층 트롤의 그물입구 형상과 소해 단면적)

  • Park, Hae-Hoon;Cho, Bong-Kon;Ko, Gwang-Su;Chang, Ho-Young
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.44 no.2
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    • pp.120-128
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    • 2008
  • Estimation of the gear shape and cross section of sweep at mouth of a bottom trawl net was described and applied to the field experiments obtained with the Scanmar system. The shape of the trawl net from wingend to the beginning of codend was assumed to be part of an elliptic cone of which the cross section was ellipse, and that of the float rope be of form $y_f=a_fx^{bf}$. In case of a bottom trawl with warp 180m long, the radius of ellipse, the cross section of sweep at mouth, the eccentricity of the ellipse, the inclination angle of float rope and the contribution of the side panel to net height were estimated in accordance with towing speed. The horizontal radius of the upper ellipse increased with increasing towing speed, the eccentricity of it became slightly bigger as increasing the towing speed which meant the shape of it being flat. And the inclination angle of the float rope was about between 7 and 12 degrees in case of the above bottom trawl.

Effect of Ball-milling on Hydrogen-reduction Behavior of WO3-CuO (WO3-CuO의 수소환원거동에 미치는 볼 밀링의 영향)

  • Kim, Dae-Gun;Shim, Woo-Seok;Kim, Young-Do
    • Korean Journal of Materials Research
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    • v.13 no.9
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    • pp.631-634
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    • 2003
  • To fabricate W-Cu nanocomposite powder, $WO_3$-CuO powder mixture was high-energetically ball-milled and subsequently hydrogen-reduced. The effect of ball-milling on the hydrogen-reduction behavior of$ WO_3$-CuO was investigated with non-isothermal hygrometric analysis during hydrogen-reduction. Increasing the ball-milling time, the reduction peak temperatures of humidity curves were shifted to low temperature. It was considered that the reduction temperature should be decreased because the specific surface area of each oxide considerably increased with increasing the ball-milling time. In case of ball-milling for 0 h, $WO_3$and CuO were independently hydrogen-reduced and W particles were nucleated on the surface of Cu adjacent to W by CVT. However, in case of ball-milling for 50 h, the aggregates of about 200-300 nm were observed. W particles of size below 30-50 nm were homogeneously distributed with Cu in the aggregates.

An Experimental Study on the Properties of the High Strength Crushed Sand Concrete Using Blast-Furnace Slag (고로슬래그를 사용한 고강도 부순모래 경화콘크리트의 물성에 관한 실험적 연구)

  • Choi, Young-Wha;Kim, Jong-In
    • Journal of the Korean Society of Industry Convergence
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    • v.8 no.3
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    • pp.169-176
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    • 2005
  • The purpose of this study is to develop the high strength crushed sand concrete in conditions of water binder ratios of 25, 30, 35% and blast-furnace slag substitutions of 0, 15, 30, 45%. Additionally, in case of water binder ratio of 30%, the maximum size of coarse aggregate is two kinds of 13, 19 mm. The conclusions of this study are as follows ; 1. The compressive strength appeared lower in early age as compared with that of plain concrete according to increasing of the blast-furnace slag substitution. But, the compressive strength was respectively 5, 6, 10% larger than that of plain concrete in case of 25, 30, 35% water binder ratios, 28 days, 30% blast-furnace slag substitution and 19mm coarse aggregate. 2. According to increasing of the blast-furnace slag substitution, the modulus of elasticity and the tensile strength of concrete increased. 3. The length change by the shrinkage increased when the larger coarse aggregate was used, and decreased according to higher blast-furnace slag substitution.

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Study on Nickel Plating of Leadframe using Pulse Technique (펄스법을 이용한 리드프레임의 니켈도금에 관한 연구)

  • Chung W.S.;Min B.S.;Lim J.J.;Chung U.C.
    • Journal of the Korean institute of surface engineering
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    • v.36 no.3
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    • pp.242-250
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    • 2003
  • Electrodeposition of Ni was carried out on copper substrate from Ni Sulfamate bath by DC and high frequency pulse current. During the electroplating, bath temperature was steady $60^{\circ}C$ , agitation was applied. Morphology and surface roughness of electrodeposits was investigated with the AFM. Crystalline structure of electrodeposits was investigated with XRD. Also, surface electric resistivity was investigated with 4-point probe. The result of crystalline structure by X-ray diffractometer, in the case of DC, <200> direction was dominant growing direction. But in the case of PC, the ratio of <200> direction vs. other direction decreased. As the pulse frequency increased, the enhanced properties of deposits were shown. With increasing frequency, the degree of surface properties increased DC more than that of PC, eg surface morphology, roughness and the degree of compactness of grains. With increasing duty cycle, the surface properties such as the degree of the morphology, roughness and electroconductivity was deteriorated.

Study on the Characteristics of Electroplated Solder: Comparison of Sn-Cu and Sn-Pb Bumps (무연 도금 솔더의 특성 연구: Sn-Cu 및 Sn-Pb 범프의 비교)

  • 정석원;정재필
    • Journal of the Korean institute of surface engineering
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    • v.36 no.5
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    • pp.386-392
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    • 2003
  • The electroplating process for a solder bump which can be applied for a flip chip was studied. Si-wafer was used for an experimental substrate, and the substrate were coated with UBM (Under Bump Metallization) of Al(400 nm)/Cu(300 nm)Ni(400 nm)/Au(20 nm) subsequently. The compositions of the bump were Sn-Cu and eutectic Sn-Pb, and characteristics of two bumps were compared. Experimental results showed that the electroplated thickness of the solders were increased with time, and the increasing rates were TEX>$0.45 <\mu\textrm{m}$/min for the Sn-Cu and $ 0.35\mu\textrm{m}$/min for the Sn-Pb. In the case of Sn-Cu, electroplating rate increased from 0.25 to $2.7\mu\textrm{m}$/min with increasing current density from 1 to 8.5 $A/dm^2$. In the case of Sn-Pb the rate increased until the current density became $4 A/dm^2$, and after that current density the rate maintains constant value of $0.62\mu\textrm{m}$/min. The electro plated bumps were air reflowed to form spherical bumps, and their bonded shear strengths were evaluated. The shear strength reached at the reflow time of 10 sec, and the strength was of 113 gf for Sn-Cu and 120 gf for Sn-Pb.

Comparative Studies on Lighting Environment and Energy Performance depending on the Transmittance of Window and Slat Angle of Blind (창호의 투과율과 블라인드 슬랫각도에 따른 빛환경 및 에너지성능 비교 연구)

  • Sim, Se-Ra;Yoon, Jong-Ho;Shin, U-Cheul
    • 한국태양에너지학회:학술대회논문집
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    • 2011.11a
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    • pp.256-263
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    • 2011
  • Recently, curtain wall structure is constructed according to increasing high rise building. Glass is usually used in opening of curtain wall structure and window area ratio is finally increased. Excessive Daylighting and solar radiation by large window area ratio cause discomfort glare and add to cooling load in the case of office that is heavy on lighting and cooling. Therefore, this study suggests to use low transmittance window for solve those problems. Indoor lighting environment and building energy performance were analyzed by increasing transmittance from 10% to 90% and comparing fixed venetian blind. Consequently, the range of transmittance that is possible to daylighting and prevent discomfort glare. Secondary energy consumption is efficient in the case that transmittance is the range of from 20% to 50%, primary energy consumption is nice on from 20% to 40%. If those result put together, the range of window transmittance from 30% to 50% is proper in the office in lighting environment and energy consumption aspects.

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Tribological Behaviors Against Counterpart Materials of Ti-Si-N Coating Layers Prepared by a Hybrid Coating System (하이브리드 코팅시스템에 의해 제조된 Ti-Si-N 코팅막의 상대재에 대한 마모거동 연구)

  • 박옥남;박종현;윤석영;권식철;김광호
    • Journal of the Korean institute of surface engineering
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    • v.36 no.2
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    • pp.116-121
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    • 2003
  • Ti-Si-N coating layers were deposited onto WC-Co substrates by a hybrid system of arc ion plating (AIP) and sputtering techniques. The tribological behaviors of Ti-Si-N coating layers with various Si contents were investigated by the dry sliding wear experiments, which were conducted at three different sliding speeds, 0.1, 0.3, 0.5 m/s, against the steel and alumina balls. In the case of steel ball, the average friction coefficient slightly decreased with increasing the sliding speed regardless of Si content due to adhesive wear behavior between coating layer and steel ball. At constant sliding speed, the average friction coefficient decreased with increase of Si content. On the contrary, in the case of alumina ball, the average friction coefficient increased with increasing the sliding speed regardless of Si content, indicating that the abrasive wear behavior was more dominant when the coating layers slide against alumina ball. Through these experimental results, it was found that the tribological behaviors of Ti-Si-N coating layers were effected by factors such as Si content, sliding speed, and kinds of counterpart materials rather than the hardness of coating layer.