• 제목/요약/키워드: improvement of productivity

검색결과 1,515건 처리시간 0.04초

Doxorubicin Productivity Improvement by the Recombinant Streptomyces peucetius with High-Copy Regulatory Genes Cultured in the Optimized Media Composition

  • PARK, HEE-SEOP;KANG, SEUNG-HOON;PARK, HYUN-JOO;KIM, EUNG-SOO
    • Journal of Microbiology and Biotechnology
    • /
    • 제15권1호
    • /
    • pp.66-71
    • /
    • 2005
  • Doxorubicin is a clinically important anticancer polyketide compound that is typically produced by Streptomyces peucetius var. caesius. To improve doxorubicin productivity by S. peucetius, a doxorubicin pathway-specific regulatory gene, dnrI, was cloned into a high-copy-number plasmid containing a catechol promoter system. The S. peucetius containing the recombinant plasmid exhibited approximately 9.5-fold higher doxorubicin productivity compared with the wild-type S. peucetius. The doxorubicin productivity by this recombinant S. peucetius strain was further improved through the optimization of culture media composition. Based on the Fractional Factorial Design (FFD), cornstarch, $K_2HPO_4$, and $MgSO_4$ were identified to be the key factors influencing doxorubicin productivity. The Response Surface Method (RSM) results based on 20 independent culture conditions with varying amounts of key factors predicted the highest theoretical doxorubicin productivity of 11.1 mg/l with corn starch of 46.33 g/l, $K_2HPO_4$ of 4.63 g/l, and $MgSO_4$ of 9.26 g/l. The doxorubicin productivity of the recombinant S. peucetius strain with the RSM-based optimized culture condition was experimentally verified to be 11.46 mg/l, which was approximately 30.8-fold higher productivity compared with the wild-type S. peucetius without culture media optimization.

지능화된 크레인 터미널의 구현 (Implementation of Intelligent Crane Terminal)

  • 배종일;정동호;김도
    • 대한전기학회:학술대회논문집
    • /
    • 대한전기학회 2003년도 하계학술대회 논문집 D
    • /
    • pp.2761-2762
    • /
    • 2003
  • This paper is aimed to handle quick work for all the workers and to improve the productivity by adding more effective content in Crane Monitoring System. The contributing proportion of the increase of port productivity is more increasing concerning not only the port industry, but also all the informations of container crane which is the representative equipment by the rapid increase of the volume of freight of port. The basic of rapid service is the improvement of the productivity, the information of operation as to the productivity of crane for the quick handling within yard and especially the informations of breakdown and to handle breakdown as soon as possible has a great effect on the increase of productivity.

  • PDF

크레인의 모니터링 운영기법 (The Monitoring Operating Technique of A Crane)

  • 배종일;황용연;안두성
    • 대한전기학회:학술대회논문집
    • /
    • 대한전기학회 2007년도 제38회 하계학술대회
    • /
    • pp.1890-1891
    • /
    • 2007
  • This paper is aimed to handle quick work for all the workers and to improve the productivity by adding more effective content in Crane Monitoring System. The contributing proportion of the increase of port productivity is more increasing concerning not only the port industry, but also all the informations of container crane which is the representative equipment by the rapid increase of the volume of freight of port. The basic of rapid service is the improvement of the productivity, the information of operation as to the productivity of crane for the quick handling within yard and especially the informations of breakdown and to handle breakdown as soon as possible has a great effect on the increase of productivity.

  • PDF

코레일 신규채용기준의 유의성에 관한 연구 (An empirical study on the significance of employment criteria in KORAIL)

  • 인태명;박수명
    • 한국철도학회:학술대회논문집
    • /
    • 한국철도학회 2009년도 춘계학술대회 논문집
    • /
    • pp.1914-1923
    • /
    • 2009
  • KORAIL continuously drives practical reforms of change and originality both internally and externally for the purpose of adapting to rapidly changing circumstance and promote productivity of the organization. Various management strategies are needed to increase its productivity, yet the fist thing to be considered is to select talented human resources. A selection of the human resource should be conducted based on 3R(Right People, Right Place, Right Time). This study empirically analyzes through actual study how the method of new employment introduced on January 1, 2005 positively affects capability and productivity of each member of KORAIL. The area of this study is defined centering on the standard of new employment, capability of personnel, and productivity of the organization. Also, the improvement of new employment standard of KORAIL is suggested as significance of the standard was verified through survey of the standard, the capability and the productivity conducted to KORAIL working personnel.

  • PDF

Optimization of productivity in the rehabilitation of building linked to BIM

  • Boulkenafet Nabil;Boudjellal Khaled;Bouabaz Mohamed
    • Advances in Computational Design
    • /
    • 제8권2호
    • /
    • pp.179-190
    • /
    • 2023
  • In this paper, building information modelling (BIM) associated to the principle of significant items emerged at quantities and costs in the optimization of productivity related to the rehabilitation of the building where proposed and discussed. A quantitative and qualitative study related to the field of application based on some parameters such as pathology diagnosis, projects documents and bills of quantities were used for model development at the preliminary stage of this work. The study identified 14 quantities significant items specified to cost value based on the use of the 80/20 Pareto rule, through the integration of building information modelling (BIM) in the optimisation of labour productivity for rehabilitation of buildings. The results of this study reveal the reliability and the improvement of labour productivity using building information modelling process integrating quantities and cost significant items.

컨테이너 크레인의 CMS에 관한 연구 (A Study of Crane Monitoring System for Container Crane)

  • 김영호;손정기;정동호;배종일;이권순;이만형
    • 한국항해항만학회:학술대회논문집
    • /
    • 한국항해항만학회 1998년도 추계학술대회논문집:21세기에 대비한 지능형 통합항만관리
    • /
    • pp.145-151
    • /
    • 1998
  • This paper is aimed to handle quick work for all the workers and to improve the productivity by adding more effective content in Crane Monitoring System. This contributing proportion of the increase of port productivity is more increasing concerning not only the port industry, but also all the informations of container crane which is the representative equipment by the rapid increase of the volume of freight of port. The basic of rapid service is the improvement of the productivity, the information of operation as to the productivity of crane for the quick handling within yard and especially the informations of breakdown and to handle breakdown as soon as possible has a greate effect on the increase of productivity.

  • PDF

PLC를 이용한 RMQC 모니터링 기법 (RMQC Monitoring Method via PLC)

  • 김영호;정동호;배종일;이동철
    • 대한전기학회:학술대회논문집
    • /
    • 대한전기학회 2000년도 하계학술대회 논문집 D
    • /
    • pp.3189-3191
    • /
    • 2000
  • This paper is aimed to handle quick work for all the workers and to improve the productivity by adding more effective content in Crane Monitoring System. The contributing proportion of the increase of port productivity is more increasing concerning not only the port industry, but also all the informations of container crane which is the representative equipment by the rapid increase of the volume of freight of port. The basic of rapid service is the improvement of the productivity, the information of operation as to the productivity of crane for the quick handling within yard and especially the informations of breakdown and to handle breakdown as soon as possible has a great effect on the increase of productivity.

  • PDF

기업의 노동생산성 향상을 위한 분석연구 (An Analytical Study for the Labor Productivity Improvement of Enterprise)

  • 김종래
    • 산업경영시스템학회지
    • /
    • 제4권4호
    • /
    • pp.35-42
    • /
    • 1981
  • This paper grasped the labor productivity actual condition by the standard of per unit working hour and production about the main products of our country's industrial the main materials and could understand the average of our country's labor productivity as compared this with the labor productivity actual condition of Japan. As the point at issue of analitical result. 1. Low a matter of thinking about productivity. 2. Have a lot of difficult problem in an industrial part. 3. Have the point at issue on technical development and accumulation. 4. Have the point at issue on management. As a countermeasure about these. 1. must convert the way of use of industrial policy. 2. must make a housing development and special serialization of a small and medium enterprise. 3. must establish an organic technical development system. 4. must grope the policy of management rationalization.

  • PDF

크레인의 모니터링 기법에 관한 연구 (A Study for Monitoring Method of Crane)

  • 김영호;이영일;박종웅;배종일;김영식
    • 제어로봇시스템학회:학술대회논문집
    • /
    • 제어로봇시스템학회 2000년도 제15차 학술회의논문집
    • /
    • pp.206-206
    • /
    • 2000
  • This paper is ai ed to handle quick work for all the workers and to improve the productivity by adding more effective content in Crane Monitoring System. The contributing proportion of the increase of port productivity is more increasing concerning not only the port industry, but also all the informations of container crane which is the representative equipment by the rapid increase of the volume of freight of port. The basic of rapid service is the improvement of the productivity, the information of operation as to the productivity of crane for the quick handling within yard and especially the informations of breakdown and to handle breakdown as soon as possible has a great enect on the increase of productivity.

  • PDF

건설 하도급 생산성 개선 방안 연구 (A Study on the Improvement for Productivity of Construction Subcontract)

  • 이태식;정보건
    • 한국건설관리학회:학술대회논문집
    • /
    • 한국건설관리학회 2001년도 학술대회지
    • /
    • pp.337-340
    • /
    • 2001
  • 건설시장의 구조를 보면 발주자로부터를 낙찰 받은 하도급자는 이를 3차 하도까지 주고 있다. 이렇듯 원도급자가에게 하도를 줌으로써 결과물 생성을 하도급자가 맡게 된다. 현장 생산성에 직접 관계를 맺고 있는 하도급에 대한 연구가 부족한 것으로 보인다. 건설업의 특성상 한 프로젝트에 각 분야의 하도급업자가 참가한다. 프로젝트에 참여하는 하도급자의 품질 및 작업을 향상 시킨다면 작게는 한 업체의 생산성이 향상되는 것이지만, 이것이 점차 넓어지면서 프로젝트 전체의 생산성을 향상 시킬수 있는 것이다. 이런 점에서 하도급 생산성에 대한 이해를 하고 분석함으로써 하도급생산성 향상 방안을 제시하고자 한다.

  • PDF