• 제목/요약/키워드: imported malaria

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전이 학습을 이용한 VGG19 기반 말라리아셀 이미지 인식 (Malaria Cell Image Recognition Based On VGG19 Using Transfer Learning)

  • ;김강철
    • 한국전자통신학회논문지
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    • 제17권3호
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    • pp.483-490
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    • 2022
  • 말라리아는 기생충에 의해 발생하는 질병으로 전 세계에 퍼져있다. 말라리아 셀을 인식하는데 일반적으로 두꺼운 혈흔과 얇은 혈흔 검사 방법이 사용되지만 이러한 방법은 많은 수작업 계산이 필요하여 효율성과 정확성이 매우 낮을 뿐만 아니라 빈민국에는 병리학자가 부족하여 말라리아 치명율이 높다. 본 논문에서는 특징 추출기, 잔류 구조와 완전 연결층으로 구성되고, 전이 학습을 이용한 말라리아셀 이미지를 인식하는 모델을 제안한다. VGG-19 모델의 사전 학습된 파라미터가 사용될 때 일부 컨볼루션층의 파라미터는 고정되고, 모델의 데이터에 맞추기 위하여 미세조정이 사용된다. 그리고 제안된 모델과 비교하기 위하여 잔류 구조가 없는 말라리아셀 인식 모델을 구현한다. 실험 결과 잔류 구조를 사용한 모델이 잔류 구조가 없는 모델에 비하여 성능이 우수 하였으며, 최신 논문과 비교하여 가장 높은 97.33%의 정확도를 보여주었다.

비무장지대 부근에서 발생한 양성 삼일열 말라리아 환자 2례 (Two vivax malaria cases detected in Korea)

  • 조승열;공윤;박실무;이준승;임영애;채석래;고원규;이종수;심재철;신학균
    • Parasites, Hosts and Diseases
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    • 제32권4호
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    • pp.281-284
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    • 1994
  • On .lune and .truly 1994, two cases of vivax wl,Blaria were consecutively diagnosed at the Yongsan Hospital, Chung-Ang University in Seoul. The first patient was a soldier sewing in western parts of the demilitarized zone (DMZ) while the second case was a resident of a village near DMZ. Neither patients had history of being abroad. Republic of Korea (ROK) has been free of malaria since the mid-1970s except for imported cases. The two ivfn malaria cases, together with an additional patient detected in 1993, occurred in relatively small areas near DMZ. This necessitated an epidemiologic surveillance. When medical records and blood smears in the areas were examined, no other cases were found. Of 7,723 mosquitoes collected by a black light trap for ho nights in June, 7,066 (91.5%) were Anopheles sinensis. In order to evaluate a significance of the recent malaria occurrence, a surveillance system should be operated in the areas.

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국내 기생충 질환의 현황 및 전망

  • 채종일
    • 한국건강관리협회지
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    • 제1권1호
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    • pp.26-32
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    • 2003
  • The current status and future prospects of parasitic infections in Korea is briefly reviewed. Soil-transmitted helminth infections including ascariasis, trichuriasis, and hookworm infections decreased remarkably. owing to the national control activities excuted by the Korea Association of Health Promotion(formerly Korea Association of parasite Eradication) using mass heath education. Important recent trends include reemergence of vivax malaria since 1993, persistence of food-borne trematode infections including clonorchiasis and intestinal trematode infections, increased detection of zoonotic parasitosis, close-up of infection with opportunistic parasites including cryptosporidiosis, toxoplasmosis, and pneumosytosis, increase of imported tropical infectious disease, appearance of new parasitic disease such as gymnophalloidiasis, and increase of accidental infections with free-living amoebae. These trends represent greatly changed overall patterns of parasitic infections in Korea.

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Genetic Diversity and Natural Selection in 42 kDa Region of Plasmodium vivax Merozoite Surface Protein-1 from China-Myanmar Endemic Border

  • Zhou, Xia;Tambo, Ernest;Su, Jing;Fang, Qiang;Ruan, Wei;Chen, Jun-Hu;Yin, Ming-Bo;Zhou, Xiao-Nong
    • Parasites, Hosts and Diseases
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    • 제55권5호
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    • pp.473-480
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    • 2017
  • Plasmodium vivax merozoite surface protein-1 (PvMSP1) gene codes for a major malaria vaccine candidate antigen. However, its polymorphic nature represents an obstacle to the design of a protective vaccine. In this study, we analyzed the genetic polymorphism and natural selection of the C-terminal 42 kDa fragment within PvMSP1 gene ($PvMSP1_{42}$) from 77 P. vivax isolates, collected from imported cases of China-Myanmar border (CMB) areas in Yunnan province and the inland cases from Anhui, Yunnan, and Zhejiang province in China during 2009-2012. Totally, 41 haplotypes were identified and 30 of them were new haplotypes. The differences between the rates of non-synonymous and synonymous mutations suggest that $PvMSP1_{42}$ has evolved under natural selection, and a high selective pressure preferentially acted on regions identified of $PvMSP1_{33}$. Our results also demonstrated that $PvMSP1_{42}$ of P. vivax isolates collected on China-Myanmar border areas display higher genetic polymorphisms than those collected from inland of China. Such results have significant implications for understanding the dynamic of the P. vivax population and may be useful information towards China malaria elimination campaign strategies.

홍천읍 송화선(宋化善) 장기(掌記)를 통해 본 20세기 초 한국의 생활 문화 연구 (A study on Living Culture of Korea through accounting records written by Song, Whasun at Hongcheon-Up in early 20th century)

  • 조임선;이은진
    • 패션비즈니스
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    • 제21권1호
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    • pp.148-165
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    • 2017
  • An assortment of daily supplies have been documented in and accounting book that Hwa-sun Song, a wholesale dealer in Hongcheon, Gangwon-do, sent to Young-hui Sin, a customer. This study analyzed a total of 163 documentations in the accounting book between 1910 to 1916, which includes types of daly supplies, trading volume, and prices, maintained accounting between. Consequently, we are able to indentify companies that produced the applicable goods, names of products, units by which goods were counted, and the lowest and highest prices prevailing, along with kinds of goods patronized in everyday life in Hongcheon in the early 20th century. Paper had the maximum trading volume. The second, most traded were cigarettes, a symbol of the new culture. These were traded under various brand names, such as Kkotpyo, Guksyu, Sanhopyo, Syonghak, and Joil. Foodstuffs, were the third most traded items, including fish, fruits, sugar, Waeddeok, Chilwaeddeok, Color candies and Okchyun candies. Our results indicate that the snack food business had developed since the 19th century. Lighting equipment, oil, candles, matches as well as traditional oil lamps and flints cornered the fourth largest stock being traded. Medications were fifth, with prescriptions written for Insohwan, Hoechyungsan and Siungo, including quinine, a medicine for malaria. Other trades included kitchen appliances such as soup bowls, porcelain bowls, kettles, and drinking cups, and a variety of daily supplies such as mirrors, mats, umbrellas, Geumjiwaemil, hair oil imported from Japan, and soap.

Aspartic proteases of Plasmodium vivax are highly conserved in wild isolates

  • Na, Byoung-Kuk;Lee, Eung-Goo;Lee, Hyeong-Woo;Cho, Shin-Hyeong;Bae, Young-An;Kong, Yoon;Lee, Jong-Koo;Kim, Tong-Soo
    • Parasites, Hosts and Diseases
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    • 제42권2호
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    • pp.61-66
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    • 2004
  • The plasmepsins are the aspartic proteases of malaria parasites. Treatment of aspartic protease inhibitor inhibits hemoglobin hydrolysis and blocks the parasite development in vitro suggesting that these proteases might be exploited their potentials as antimalarial drug targets. In this study, we determined the genetic variations of the aspartic proteases of Plasmodium vivax (PvPMs) of wild isolates. Two plasmepsins (PvPM4 and PvPM5) were cloned and sequenced from 20 P. vivax Korean isolates and two imported isolates. The sequences of the enzymes were highly conserved except a small number of amino acid substitutions did not modify key residues for the function or the structure of the enzymes. The high sequence conservations between the plasmepsins from the isolates support the notion that the enzymes could be reliable targets for new antimalarial chemotherapeutics.