• Korean Circulation Journal
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• 제48권11호
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• pp.1014-1024
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• 2018

Background and Objectives: Intense exercise (IE) induced myocardial fibrosis (MF) showed contradictory findings in human studies, making the relationship between IE and the development of MF unclear. This study aims to demonstrate exercise induced MF is associated with cardiac damage, and inflammation is essential to the development of exercise induced MF. Methods: Sprague-Dawley rats were submitted to daily 60-minutes treadmill exercise sessions at vigorous or moderate intensity, with 8-, 12-, and 16-week durations; time-matched sedentary rats served as controls. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum cardiac troponin I (cTnI) concentration. After completion of the exercise protocol rats were euthanized. Biventricular morphology, ultrastructure, and collagen deposition were then examined. Protein expression of interleukin $(IL)-1{\beta}$ and monocyte chemotactic protein (MCP)-1 was evaluated in both ventricles. Results: After IE, right but not left ventricle (LV) MF occurred. Serum cTnI levels increased and right ventricular damage was observed at the ultrastructure level in rats that were subjected to long-term IE. Leukocyte infiltration into the right ventricle (RV) rather than LV was observed after long-term IE. Long-term IE also increased protein expression of proinflammation factors including $IL-1{\beta}$ and MCP-1 in the RV. Conclusions: Right ventricular damage induced by long-term IE is pathological and the following inflammatory response is essential to the development of exercise induced MF.

• Journal of Power Electronics
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• 제14권5호
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• pp.842-851
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• 2014

High efficiency standards are slowly being introduced with IE3 efficiency levels shortly becoming compulsory in many countries; IE4 efficiency levels being developed for future implementation. In this paper a review is carried out of the IE 60034-30 standard which covers standard line-start induction motors. Some design techniques that can be used to increase efficiency in order to meet the IE4 standards are discussed. This standard is now being replaced by the IE60034-30-1 standard which extends to other line start motors and also IE 60034-30-2 is being introduced to cover variable speed drives in order to address developing technology. The conclusion is that IE4 standards are obtainable but careful design is needed to reach this. Examples from the literature are given.

• 방사성폐기물학회지
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• 제13권3호
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• pp.171-180
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• 2015

본 연구는 고방사성해수폐액에 함유되어 있는 주요 고방사성 핵종인 Cs을 제거하기 위하여 IE911 (crystalline silicotitanate)에 의한 흡착 제거를 수행하였다. Cs의 효율적 흡착제거 및 2차 고체폐기물의 발생량을 최소화하기 위하여 IE911-Cs 흡착은 m/V (흡착제 질량/용액 부피) 비=2.5 g/L, 흡착시간은 1 시간 정도가 효과적이었다. 이때 Cs은 약 99%, Sr은 5% 이하가 각각 흡착되었다. 또한 IE911-Cs 흡착은 Langmuir 등온식 및 유사 (pseudo) 2차 속도 식으로 표현할 수 있으며, 흡착속도상수(k₂)는 Cs의 초기농도 및 입자크기 증가에 따라 감소하는데 반하여, m/V 비, 온도 및 교반속도 증가에 따라서는 증가하고 있다. IE911-Cs 흡착의 활성화에너지는 약 79.9 kJ/mol 로, IE911-Cs 흡착이 보다 강력한 결합 형태를 이룬 화학적 흡착임을 보여주고 있다. 그리고 음수 값의 Gibbs 자유에너지 및 엔탈피는 IE911-Cs의 흡착반응이 정반응의 발열반응이고, 저온에서 반응이 상대적으로 활발함을 의미하며, 음수 값의 엔트로피는 흡착된 Cs이 IE911에 균일하게 정렬되어 있음을 나타낸다.

• 기술혁신학회지
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• 제8권spc1호
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• pp.525-554
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• 2005

The purpose of this paper is to seek out the problems influencing on the operation of Institution Evaluation(IE) in Korea and suggest a better way for the evaluation based on the findings, expecially focusing on Government Research Institute(GRIs) in the field of Science and Technology. Unlike previous studies on IE of GRIs, this research is more oriented toward actual practices than design and theories of IE. Three categories are 1) purely system aspect, 2) system-operation aspect, and 3) environmental aspect. These three categories are classified into eight sub-categories: 1) the legal support and the legally enforceable provision, 2) the target area of evaluation, 3) the means and process of evaluation, 4) the criteria and indices for evaluation, 5) the expertise of evaluators, 6) the use of evaluation findings, 7) GRIs' support for IE, and 8) public support for IE. Summing up the findings of this study, the main factors that hamper the successful operation of the existing IE of GRIs in the field of Science and Technology was illuminated and the better way for the operation of IE was suggested.

• 한국지구과학회지
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• 제32권1호
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• pp.1-11
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• 2011

콘크리트 구조물의 안전진단을 위해 충격반향기법(Impact Echo method, IE)과 충격응답기법(Impulse Response method, IR)을 이용하여, 콘크리트 모형 하부의 공동 유무에 따른 탐사 결과를 분석하였다. 콘크리트 모형은 순수 콘크리트 부분과 철근+콘크리트 부분으로 나누고, 공동의 유무에 따라 각 기법의 적용에 의한 반응 변화를 관찰하였다. 이 연구에 앞서 수행한 GPR과 IE 및 IR 기법의 복합 적용 결과, IE 및 IR 기법이 철근의 영향을 크게 받지 않고 공동존재 여부에 따른 반응이 비교적 잘 나타나는 것으로 파악되었다. 본 연구에서는 선행 연구 결과를 토대로 IE와 IR 기법의 활용도를 높여서 보다 정확한 콘크리트 구조물의 안전진단 기법을 개발하고자 하였다. GPR과 같은 비파괴 조사 기법과 달리, IE 및 IR 기법은 측정이 이루어지는 위치를 정확히 알 수 있어 각 측점의 콘크리트 두께와 하부 공동의 반응을 보다 정확히 파악할 수 있는 장점이 있다. 연구 결과, IE 기법에서는 공진주파수보다 낮은 저주파수에서 나타나는 작은 피크 구간이 공동에 의한 반응으로 보이며, IR 기법에서는 주파수에 따른 운동성(mobility)과 동적 강성도(dynamic stiffness)의 변화를 통해 공동의 유무를 확인할 수 있었다. 이 연구에서 제안한 방법은 콘크리트 구조물의 보수 보강에 활용될 수 있을 것으로 예상된다.

• Restorative Dentistry and Endodontics
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• 제46권1호
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• pp.7.1-7.8
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• 2021

Objectives: The aim of the current study is to investigate the effect of different anticaries agents, such as experimental agents based on silver nanoparticles (SNPs) and silver diamine fluoride (SDF), on the micro-shear bond strength (μ-SBS) of composite resin applied to intact enamel (IE) or demineralized enamel (DE). Materials and Methods: Sixty dental enamel fragments were collected from human third molars and categorized into 6 groups (n = 10): positive control (IE), negative control (DE), IE + SDF, DE + SDF, IE + SNP and DE + SNP. Samples from DE, DE + SDF and DE + SNP groups were subjected to pH cycling; superficial microhardness test was performed to confirm demineralization. Resin composite build-ups were applied to the samples (0.75-mm diameter and 1-mm height) after the treatments (except for IE and DE groups); μ-SBS was also evaluated. Samples were analyzed under a stereomicroscope at 40× magnification to identify failure patterns. Data were subjected to one-way analysis of variance, followed by Tukey's and Dunnett's tests (p < 0.05). Results: There was no significant difference among the IE, IE + SNP, DE + SDF, and DE + SNP groups. The IE + SDF and DE groups recorded the highest and the lowest μ-SBS values, respectively. Adhesive-type failures were the most frequent for all treatments. Conclusions: Anticaries agents did not have a negative effect on the μ-SBS of composite resin when it was used on IE or DE.

• 대한바이러스학회지
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• 제29권2호
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• pp.137-144
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• 1999

Transformation efficiency, virus multiplication and foreign gene expression were characterized in the insect cells transformed with Autographa californica nuclear polyhedrosis virus (AcNPV) immediate early 1 gene (IE1). Transformation efficiency of insect cells by AcNPV IE1 gene vector horboring foreign gene was approximately 8-fold higher in the Sf9 cells transformed previously with AcNPV IE1 gene than in the normal Sf9 cells. Virus multiplication and foreign gene expression of recombinant baculovirus in the Sf9 cells transformed with AcNPV IE1 gene were similar to those of the normal Sf9 cells. These results suggest that transformed cells displaying foreign gene product by using AcNPV IE1 gene promoter will be useful for the diverse applications of insect cells.

• International Journal of Industrial Entomology and Biomaterials
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• 제3권1호
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• pp.43-49
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• 2001

We have cloned and characterized an immediate early-1 gene, iel, which is activated immediately upon entrance of the viral genome into the cell nucleus, from Bombyx mori nuclear polyhedrosis virus (BmNPV) K1 strain. This gene encodes a protein 584 amino acids with a predicted molecular weight of 67 kDa. The promoter and coding regions of BmNPV-K1 ie1 showed high homology with Autographa californica nuclear polyhedrosis virus and BmNPV T3 strain. The BmNPV-K1 ie1 was different from amino acid sequence at 4 positions in BmNPV T3. The location of ie1 gene in the BmNPV-K1 genome was confirmed by Southern blot analysis and its expression patterns at the transcriptional level in the infected cells were confirmed by Nerthern hybridization analysis.

• 산업공학
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• 제20권1호
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• pp.1-10
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• 2007

The main purpose of this research is to find out whether curriculums of industrial engineering (IE) departments meet the demand of IE graduates working in various fields. The research was conducted as an online questionnaire survey selecting IE Graduates working in industries as practising engineers. 1,324 participants were validated among 1,477 participants. 13 fields were selected and used in the survey. Those were; 1) Mathematical statistics, 2) Computer, 3) Purchase, 4) Production system, 5) Logistics, 6) Marketing, 7) Monetary, 8) Experiment methods, 9) Operations Research (OR), 10) Human Factors, 11) Quality, 12) Engineering management, and 13) Information systems. Using the 5-scale Likert rating, each education subject was assessed both in terms of its usefulness in practices and the amount it being taught in school. As a result, courses such as motion/time study, linear programming that IE has traditionally focused showed less usefulness in practices while it is taught in relatively large amount in schools. However, courses such as 6 sigma, CRM which are closely related to industrial practices showed high usefulness in practices compared with low degree of teaching in school. This was the first ever large scalesurvey conducted for IE graduates in Korea. The result of survey displayed many helpful information on current status and future direction of IE education in Korea.

• International Journal of Industrial Entomology and Biomaterials
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• 제15권2호
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• pp.131-135
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• 2007

Open reading frame 4 of Bombyx mori nucleopolyhedrovirus (BmNPV), designated as Bm4, is a gene whose function is completely unknown. With the recently developed BmNPV bacmid and a modified pFastBac1 whose polyhedrin promoter was replaced with ie1 promoter, a recombinant bacmid expressing Bm4-EGFP fusion protein under the control of ie1 promoter in BmN cells was successfully constructed. The result not only showed that the polyhedrin promoter can be replaced efficiently with other promoters to direct the expression of foreign gene in BmN cells by using Bac-to-Bac/BmNPV baculovirus expression system but also laid the foundation for rescue experiment of Bm4 deletion mutant due to the ability of ie1 promoter to direct gene expression throughout the infection cycle.