• 대한수의학회지
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• 제26권1호
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• pp.117-124
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• 1986

The present study was undertaken to evaluate rosette formation and NK activity of splenic lymphocytes in 3-methylcholanthrene (MCA) treated mice. Mice were sensitized iv with 0.1ml of 1% sheep red blood cell (SRBC) suspension were treated with a single ip injection of olive oil alone or with different doses of MCA in oil at various time before or after sensitization, and were challenged at 4 days after SRBC. Rosette formation and NK activity of splenic lymphocytes were measured at 24 hours after challenge. Erythrocyte(E) rosette formation of splenic lymphocytes was significantly depressed in mouse treated with large dose of MCA (5~50mg) regardless of injecting time. But, there was no difference in the response between the treated with small dose of MCA (0.5mg). Whereas erythrocyte-antibody(EA) rosette or erythrocyte-antibody-complement(EAC) rosette forming cells were significantly depressed by MCA. Under small dose of MCA (0.5mg), any difference of NK activity was not observed in all course of injecting time. But, under large dose of MCA, the activity was markedly inhibited to about half the values seen in control and this suppression was transient, resulting that the normal level was reached again 19 days after MCA. These results, which conform with the predictions of immunosuppression hypothesis, suggest that MCA inhibits immunological responses including NK activity and thereby allows the outgrowth of antigenic neoplastic cells.

• Ocean and Polar Research
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• 제27권2호
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• pp.115-123
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• 2005

Recently, it has been observed in the East Sea that temperature increases below the thermocline, and dissolved oxygen increase in the intermediate layer but decrease below it. The layer of minimum dissolved oxygen deepens and the bottom homogeneous layer in oxygen becomes thinner. It emerges very probably that these changes are induced by the mode change of deep water formation associated with global warming. To further support this hypothesis, a one-dimensional model experiment is performed. First, a thermal profile is obtained by injecting a cold and high oxygen deep water into the bottom layer, say the bottom mode. Then, two thermal profiles are obtained from the bottom mode profile by assuming that either all the deep water introduce into the intermediate layer has been initiated, say the intermediate mode, or that only a part of the deep water has been initiated into the intermediate layer, say the intermediate-bottom mode. The results, from the intermediate-bottom mode experiment are closest to the observed results. They show quite well the tendency for oxygen to increase in the intermediate layer and the simultaneous thinning of the bottom homogeneous layer in oxygen. Therefore, it can be said that the recently observed slow variation of the thermal structure might be associated with changes in the deep water formation from the bottom mode to the intermediate-bottom mode.

• 유통과학연구
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• 제12권10호
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• pp.85-97
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• 2014

Purpose - This study aims to clarify through which process asset specificity and supplier development project (SDP) affect performance. Cooperation, partnership, the level of information exchange, and the importance of information sharing are considered significant variables as mediators related to the process. Finally, the performance formation model of the supply chain through asset specificity and supplier development project would be suggested as being a result of this study. Research design, data, and methodology - Data collection was as follows: questionnaires were distributed to 250 companies that have business ties with H Company. The empirical study to test our hypothesis was based on statistical analysis (using SPSS 19.0 and AMOS 19.0). The hypothesis of this paper is that the asset specificity and supplier development project variables have positive effects on the following variables: mediators such as cooperation and partnership (reliability and dependence); and the cooperation and partnership variables have a positive effect on the following variables: level of information sharing, the importance of information sharing, and level of information sharing; the importance of information sharing has a positive effect on supply chain performance. We tested our hypothesized model utilizing path analysis with latent variables. Results - First, it was found that asset specificity has significant positive effects on cooperation (H1), reliability (H2), and dependability (H3). Second, it was proved that the level of comprehension on the purpose of SDP has positive effects significantly on cooperation (H4), reliability (H5), and dependability (H6). Third, the hypotheses related to cooperation were all significantly accepted. The relationships of cooperation with the level (H7) and importance (H8) of information sharing were significant. Fourth, the hypotheses related to reliability were all significantly accepted. The relationships of reliability with the level (H9) and importance (H10) of information sharing were significant. In terms of dependability, however, the hypotheses were partially accepted. The effect of dependability was significant on the importance of information sharing (H12), but insignificant on the level of information sharing (H11). Finally, the causal relationships from the level of information sharing to SCM performance (H13) and from the importance of information sharing to SCM performance (H14) were both significantly accepted. Conclusion - First, with rapid changes in the business environment, enterprises should acquire the right information to properly implement SCM. For successful SCM, firms should understand the supplier development project. Second, asset specificity and the level of comprehension on SDP have significant effects both on cooperation and partnership (reliability and dependability). Third, mediators such as cooperation, reliability, and dependability significantly affect the level and importance of information sharing. Fourth, the level and importance of information sharing have significant impacts on SCM performance. This paper makes a meaningful contribution to further the understanding of how SDP affects SCM performance. Finally, successful SCM performance is achieved by information sharing through a collaborative environment and partnership (confidence & dependence) rather than by investing only in setting up an information system.

• 한국식품영양과학회:학술대회논문집
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• 한국식품영양과학회 2004년도 Annual Meeting and International Symposium
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• pp.265-270
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• 2004

Coronary heart disease (CHD) has been the number one killer in western society for a long time, and CHD in most instances is due to atherosclerosis. One of the earliest events in atherogenesis is the intracellular accumulation of lipids, particularly cholesterol esters, in the aortic intima. The lipids presumably came from the uptake of plasma lipoproteins, particularly from LDL. These foam cells were identified as being predominantly as macrophages. Currently, it is believed that oxidation of low density lipoprotein (LDL) might contribute to the generation of foam cells. An outcome of the oxidation hypothesis is that the consumption of antioxidants would be beneficial. In this study, Boldine, an alkaloid of Peumus boldus was tested for their antioxidant potency both in, in vitro oxidation system and in mouse models. Boldine decreased the ex-vivo oxidation of Low-density lipoprotein (LDL). In vivo studies were performed to study the effect of these compounds on the atherosclerotic lesion formation in LDL r-/- mice. Three groups of LDL r-/- mice (N=12 each) were fed an atherogenic diet. Group 1 was given vehicle and group 2 and 3 were given 1 and 5 mg of Boldine/day in addition to the atherogenic diet. The results indicated that there was a decrease in lesion formation reaching a 40% reduction due to Boldine compared to controls. The in vivo tolerance of Boldine in humans (has been used as an herbal medicine in other diseases) should make it an attractive alternative to vitamin E.

• 한국콘텐츠학회논문지
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• 제7권10호
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• pp.221-228
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• 2007

창업보다 중요한 것은 어떻게 기업을 유지, 발전시키느냐의 문제이다. 그러므로 창업초기에 기업의 신뢰형성 문제는 이후 기업경영 성패를 좌우하는 요인이 되고 있다. 따라서 본 연구에서는 창업초기 인터넷 쇼핑몰에서의 신뢰형성에 영향을 주는 요인이 무엇인가를 분석하여 마케터들이 인터넷 쇼핑몰에 대한 성장전략 수립에 도움을 주고자 하였다. 선행연구를 통해 신뢰의 개념, 인터넷 환경 하에서의 소비자 구매행동과 신뢰형성 요인에 대한 요인들을 정리하였다 연구목적을 달성하기 위해 가설의 설정과 검증을 실시한 결과 정보품질, 웹디자인, 쇼핑 편의성이 초기신뢰에 영향요인으로 나타났다.

• 복식문화연구
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• 제16권1호
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• pp.181-203
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• 2008

This study suggests a model to identify relationships between Supply Chain Partnership(SCP) and the performance of Supply Chain Management(SCM) based on apparel companies and outsourcing suppliers of finished products that are in a position of getting into Supply Chain Level on apparel industry. This research model is based on an integrated model including a relationship between relationship formation factors and partnership strengthening factors in SCP; and supply chain performance a result of that relationship. The formation factors of SCP affect emotional elements(trust, commitment) of strengthening factors, and they, in turn, impact the performance of a supply chain through behavioral elements(collaboration, information sharing)16 hypotheses were formulated to research the degree of impact of SCP on supply chain performance. Theoretical and empirical research was executed in parallel to achieve the objectives of this study. Empirical research involved a research methodology using surveys. Survey target audiences were limited to designers and merchandisers over five years of experience with apparel companies and outsourcing suppliers for finished products operating mainly in Korea. SPSS 12.0 for Windows and AMOS 5.0 were used for data and statistical analysis. Reviewing the result of research model and identification of each hypothesis, total 11 from 16 hypotheses set by this research were selected, 5 hypotheses were dropped, and 4 meaningful paths were added.

• Journal of Yeungnam Medical Science
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• 제17권1호
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• pp.1-11
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• 2000

Inhibition of cyclooxygenase(COX), and thus prevention of the formation of prostaglandins, provided a unifying explanation of the therapeutic and toxic actions of nonsteroidal anti-inflammatory drugs (NSAIDs). Recently, the discovery of the two isoforms of COX was made by molecular biologists studying neoplastic transformation in chick embryo cells. The constitutive enzyme, COX-1, is obviously responsible for the production of prostaglandins involved in housekeeping functions such as maintenance of integrity of the gastric mucosa, renal blood flow and platelet aggregation. The inducible form of COX (COX-2) is responsible for the formation of prostaglandins that pathologically affects inflammation, pain and fever. Clearly, all the experimental and clinical data support the hypothesis that the beneficial effects of NSAIDs are due to inhibition of the COX-2 enzyme, whereas the gastrotoxicity is due to inhibition of COX-1. The cox-2/COX-1 ratios of the NSAIDs in common use have been measured and compared with epidemiological data on their side effects. There is little evidence to suggest that one NSAID is clearly more effective than another, But substantial individual variability is present with respect to the pharmacology and pharmacokinetics of these drugs: therefore it is essential to adjust the dosage and choose specific drug to the patient's response.

• 대기
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• 제18권4호
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• pp.417-427
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• 2008

In this paper, we analyzed the physical and thermodynamic characteristics of fog by using the integrated water vapor (IWV) from Global Positioning System (GPS) networks and the regular observation data of meteorological stations in GPS sites. The cases of a radiation and an advection fog were selected as samples, the conversions of water substance from the water vapor to cloud water in fog were detected by the Bulk Water-Continuity Model, and the pattern analysis is adapted on GPS IWV, temperature, wind and relative humidity. Under the specific hypothesis (saturation and stable), GPS IWV could detect quantitatively the phase changing between the water vapor and cloud water content with condensation/evaporation during the formation and dissipation of fog. After it reaches to the saturation, the relative humidity can be a limited indicator for fog. However, GPS IWV can detect the status change of fog even after the saturation. It has indicated that GPS IWV could be a new observing technique for the processes of the fog formation and the dissipation.

• 한국과학교육학회지
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• 제32권5호
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• pp.823-840
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• 2012

과학교육과정에서 과학의 본성은 교육의 중심에 있었으며, 특히 과학영재교육에서의 중요성은 더욱 크다고 할 수 있다. 그럼에도 불구하고 과학영재들의 과학의 본성에 대한 개념구조가 어떻게 형성되어있는지의 연구는 많지 않다. 이 연구에서는 언어 네트워크 분석법을 통해 중학교 과학영재의 사실, 가설, 이론, 법칙 그리고 과학적인 것의 의미에 대한 이들의 인식을 탐색하는 것을 목표로 하였다. 연구 목적 달성을 위해 개방형 검사지에서 얻은 응답들을 언어 네트워크 분석법을 통해 분석하였다. 연구 참여자들의 총 110명의 대학부설 과학영재교육원 소속 중학교 과학영재들이 연구에 참여하였으며 이들의 응답에 의해 5가지의 언어 네트워크를 얻었다. 네트워크 분석결과 이들이 인식하고 있는 사실은 증명여부와 실제성 문제, 가설은 잠정성과 불확실성, 이론은 실험에 의해 증명된 가설이라는 통념, 법칙은 절대성과 권위를 상징하는 언어들, 과학적인 것은 사실근거, 증명 가능여부, 정확하고 논리적인 이론체계 동반을 가장 중요한 인식의 핵으로 하고 있었다. 통합네트워크 분석결과, 연구에 참여한 중학교 과학영재들은 절대주의적이고 논리-실증주의적인 과학관을 형성하고 있는 것을 알 수 있었다. 이 연구에 활용된 언어 네트워크 분석법은 학습자의 보이지 않는 특정 내용을 어떤 방식으로 인식하여 개념구조를 형성하고 있는지 시각화하고, 학습자 개개인 및 지식별 통합적 정신모형을 구축하는데 유용할 것으로 기대된다.

• 대한간호학회지
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• 제12권2호
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• pp.1-26
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• 1982

The main purpose of this study was to test the effect of the structured information on the sleep amount of the patients undergoing open heart surgery. This study has specifically addressed to the Following two basic research questions: (1) Would the structed in formation influence in the reduction of sleep disturbance related to anxiety and Physical stress before and after the operation? and (2) that would be the effects of the structured information on the level of preoperative state anxiety, the hormonal change, and the degree of behavioral change in the patients undergoing an open heart surgery? A Quasi-experimental research was designed to answer these questions with one experimental group and one control group. Subjects in both groups were matched as closely as possible to avoid the effect of the differences inherent to the group characteristics, Baseline data were also. collected on both groups for 7 days prior to the experiment and found that subjects in both groups had comparable sleep patterns, trait anxiety, hormonal levels and behavioral level. A structured information as an experimental input was given to the subjects in the experimental group only. Data were collected and compared between the experimental group and the control group on the sleep amount of the consecutive pre and post operative days, on preoperative state anxiety level, and on hormonal and behavioral changes. To test the effectiveness of the structured information, two main hypotheses and three sub-hypotheses were formulated as follows; Main hypothesis 1: Experimental group which received structured information will have more sleep amount than control group without structured information in the night before the open heart surgery. Main hypothesis 2: Experimental group with structured information will have more sleep, amount than control group without structured information during the week following the open heart surgery Sub-hypothesis 1: Experimental group with structured information will be lower in the level of State anxiety than control group without structured information in the night before the open heart surgery. Sub-hypothesis 2 : Experimental group with structured information will have lower hormonal level than control group without stuctured information on the 5th day after the open heart surgery Sub-hypothesis 3: Experimental group with structured information will be lower in the behavioral change level than control group without structured information during the week after the open heart surgery. The research was conducted in a national university hospital in Seoul, Korea. The 53 Subjects who participated in the study were systematically divided into experimental group and control group which was decided by random sampling method. Among 53 subjects, 26 were placed in the experimental group and 27 in the control group. Instruments; (1) Structed information: Structured information as an independent variable was constructed by the researcher on the basis of Roy's adaptation model consisting of physiologic needs, self-concept, role function and interdependence needs as related to the sleep and of operational procedures. (2) Sleep amount measure: Sleep amount as main dependent variable was measured by trained nurses through observation on the basis of the established criteria, such as closed or open eyes, regular or irregular respiration, body movement, posture, responses to the light and question, facial expressions and self report after sleep. (3) State anxiety measure: State Anxiety as a sub-dependent variable was measured by Spi-elberger's STAI Anxiety scale, (4) Hormornal change measure: Hormone as a sub-dependent variable was measured by the cortisol level in plasma. (5) Behavior change measure: Behavior as a sub-dependent variable was measured by the Behavior and Mood Rating Scale by Wyatt. The data were collected over a period of four months, from June to October 1981, after the pretest period of two months. For the analysis of the data and test for the hypotheses, the t-test with mean differences and analysis of covariance was used. The result of the test for instruments show as follows: (1) STAI measurement for trait and state anxiety as analyzed by Cronbachs alpha coefficient analysis for item analysis and reliability showed the reliability level at r= .90 r= .91 respectively. (2) Behavior and Mood Rating Scale measurement was analyzed by means of Principal Component Analysis technique. Seven factors retained were anger, anxiety, hyperactivity, depression, bizarre behavior, suspicious behavior and emotional withdrawal. Cumulative percentage of each factor was 71.3%. The result of the test for hypotheses show as follows; (1) Main hypothesis, was not supported. The experimental group has 282 minutes of sleep as compared to the 255 minutes of sleep by the control group. Thus the sleep amount was higher in experimental group than in control group, however, the difference was not statistically significant at .05 level. (2) Main hypothesis 2 was not supported. The mean sleep amount of the experimental group and control group were 297 minutes and 278 minutes respectively Therefore, the experimental group had more sleep amount as compared to the control group, however, the difference was not statistically significant at .05 level. Thus, the main hypothesis 2 was not supported. (3) Sub-hypothesis 1 was not supported. The mean state anxiety of the experimental group and control group were 42.3, 43.9 in scores. Thus, the experimental group had slightly lower state anxiety level than control group, howe-ver, the difference was not statistically significant at .05 level. (4) Sub-hypothesis 2 was not supported. . The mean hormonal level of the experimental group and control group were 338 ㎍ and 440 ㎍ respectively. Thus, the experimental group showed decreased hormonal level than the control group, however, the difference was not statistically significant at .05 level. (5) Sub-hypothesis 3 was supported. The mean behavioral level of the experimental group and control group were 29.60 and 32.00 respectively in score. Thus, the experimental group showed lower behavioral change level than the control group. The difference was statistically significant at .05 level. In summary, the structured information did not influence the sleep amount, state anxiety or hormonal level of the subjects undergoing an open heart surgery at a statistically significant level, however, it showed a definite trends in their relationships, not least to mention its significant effect shown on behavioral change level. It can further be speculated that a great degree of individual differences in the variables such as sleep amount, state anxiety and fluctuation in hormonal level may partly be responsible for the statistical insensitivity to the experimentation.