• Genomics & Informatics
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• 제10권2호
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• pp.106-109
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• 2012

Pulse rate is known to be related to diverse phenotypes, such as cardiovascular diseases, lifespan, arrhythmia, hypertension, lipids, diabetes, and menopause. We have reported two genomewide significant genetic loci responsible for the variation in pulse rate as a part of the Korea Association Resource (KARE) project, the genomewide association study (GWAS) that was conducted with 352,228 single nucleoride polymorphisms typed in 8,842 subjects in the Korean population. GJA1 was implied as a functionally causal gene for pulse rate from the KARE study, but lacked evidence of replication. To re-evaluate the association of a locus near GJA1 with pulse rate, we looked up this signal in another GWAS conducted in a Health Examinee-shared cohort of 3,703 samples. Not only we were able to confirm two pulse rate loci (1q32.2a near CD46 and 6q22.13c near LOCL644502) identified in the KARE GWAS, we also replicated a locus (6q22.31c) near GJA1 by the lookup in the Health Examinee GWAS. Considering that the GJA1-encoded protein is a major component of cardiac gap junctions, a functional study might be necessary to validate its genuine molecular biological role in the synchronized contraction of the heart.

• 감성과학
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• 제9권1호
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• pp.77-84
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• 2006

본 연구에서는 일상생활에서 진단 및 관리가 가능한 질병들을 모니터링 할 수 있는 스마트 의류의 개발에 목표를 두고, 그 기초적 개발 방향을 제시하고자 하였다. 이를 위하여 중요 건강 지표 및 요소 기술들을 고찰하고, 일반 소비자들에게 소구(遡求)할 수 있는 건강관리 개념의 스마트 의류에 대한 수요 조사를 실시하였다. 조사 결과 건강관리 지원형 스마트 의류에 대한 소비자들의 관심 및 선호도는 매우 높았고, 남 녀, 그리고 모든 연령대에 걸쳐 당뇨, 고혈압, 뇌졸중 등에 대한 위험성을 높게 인식하는 것으로 나타나, 이러한 질병의 진단 및 실시간 모니터링이 가능한 스마트 의류가 개발된다면 시장 가능성은 매우 높을 것으로 분석되었다. 본 연구에서 도출된 결과들은 건강관리 지원형 스마트 의류 개발에 있어서 중요한 지표가 될 것이다.

• Journal of Trauma and Injury
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• 제32권4호
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• pp.195-201
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• 2019

Purpose: This study was conducted to investigate the usefulness of a polyester urethane dural substitute (Neuro-Patch^®, B. Braun, Boulogne, France) as an anti-adhesion agent in subsequent cranioplasty by analyzing the use of Neuro-Patch^® during decompressive craniectomy in traumatic brain injury patients. Methods: We retrospectively analyzed patients with traumatic brain injury who underwent decompressive craniectomy followed by cranioplasty from January 2015 to December 2018. Patients were analyzed according to whether they received treatment with Neuro-Patch^® or not (Neuro-Patch^® group, n=71; control group, n=55). Patients' baseline characteristics were analyzed to identify factors that could affect cranioplasty results, including age, sex, hypertension, diabetes mellitus, use of antiplatelet agents or anticoagulant medication, the interval between craniectomy and cranioplasty, and the type of bone used in cranioplasty. The cranioplasty results were analyzed according to the following factors: operation time, blood loss, postoperative hospitalization period, surgical site infection, and revision surgery due to extra-axial hematoma. Results: No significant difference was found between the two groups regarding patients' baseline characteristics. For the cranioplasty procedures, the operation time (155 vs. 190 minutes, p=0.003), intraoperative blood loss (350 vs. 450 mL, p=0.012), and number of surgical site infections (4 vs. 11 cases, p=0.024) were significantly lower in the Neuro-Patch^® group than in the control group. Conclusions: The use of Neuro-Patch^® was associated with a shorter operation time, less blood loss, and a lower number of surgical site infections in subsequent cranioplasties. These results may provide a rationale for prospective studies investigating the efficacy of Neuro-Patch^®.

• Journal of Chest Surgery
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• 제30권10호
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• pp.961-965
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• 1997

대전을지병원 흉부외과에서는 1991년 10월 부터 1996년 4월까지 27명의 관상동맥우회로술을 시행하였으며 심정지액을 사용한 A그룹과 사용하지않은 B그룹으로 구분하여 조사하였다. 남자는 17명, 여자는 10명 이었 으며 연령은 45세에서 76세까지 분포하였으며 평균연령은 65세였다. 술전 임상소견으로는 안전성 협심증 11 례,불안전성 협심증 13례, 심근경색후 협심증이 3례였다. 동반질환으로 고혈압 7례, 당뇨병 5례 및 기타질환 이 3례있었다. 환자당 평균 혈관문합수는 A군에서 2.0개소, B군에서는 2.83개소의 원위문합을 하였다. 대동 맥 차단시간은 A군에서 54.7분, B군에서는 18.5분이었다. 술중 혹은 술후 발생한 심근경색증은 A군에서 2례, B군에서 3례 였으며, 전체파망율은 4례론 14.8%이며 B군의 사망율은 8.3%였다.

• 사상체질의학회지
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• 제11권1호
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• pp.185-199
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• 1999

목 적 현대사회에 있어 생활전반에 걸쳐 편리화를 추구하는 사회환경과 식생활의 변화, 각종 스트레스 등으로 비만증은 급격히 늘어가며 심장병, 당뇨병, 고혈압, 동맥경화, 고지혈증, 지방간 등을 유발시킨다. 비만도 질병이기에 비만이 되기 쉬운 체질이 있을 것이고 비만인의 생활에도 체질적 특성이 있지 않을까 하여 이 연구를 하게 되었다. 방 법 (1) 연구대상 1999년 4월 l일 부터 1999년 5월 30일까지 부산진구 나라한의원에 내원한 여성 환자 101명을 대상으로 하였다. (2) 사상체질감별 환자 문진과 나라한의원에서 만든 사상체질감별 설문지를 통한 체질감별로 최종 확정했다. 결 과 (1) 비만증환자의 81.2%가 태음인, 15.8%가 소음인, 3%가 소양인이었다. (2) 소음인이 식사시간이 30분 이상인 경우가 유의성이 있었다. (3) 소음인이 초저녁잠이 많다는데 유의성이 있었다. (4) 태음인이 전체비만에서 유의성이 있었고 소음인에서는 복부비만과 하체비만에 유의성이 있었다.

• Journal of Yeungnam Medical Science
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• 제32권1호
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• pp.55-59
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• 2015

The widely used polyethylene glycol (PEG)-based solutions have been proven effective for bowel preparation when 4 L of the solution is administered before colonoscopy. However, large volumes of the solutions are generally poorly tolerated. A new PEG-based solution consisting of 2 L of PEG and a high dose of ascorbic acid has recently become available. Electrolyte abnormalities caused by PEG-based solutions have rarely been reported. We report on a case of acute severe hyponatremia with associated generalized tonic-clonic seizures after bowel preparation with a low-volume PEG plus ascorbic acid solution in a 74-year-old woman with no history of seizures. She took a beta blocker, an angiotensin-converting enzyme inhibitor, and glimepiride for hypertension and diabetes mellitus. She showed general weakness, nausea, agitation, muscle cramping, and seizures after ingestion of the PEG plus ascorbic acid solution. Her serum sodium level was 112 mEq/L. Her symptoms improved after intravenous administration of hypertonic saline. Physicians should pay attention to screening for electrolytes and development of neurological symptoms during bowel preparation.

• 디지털융복합연구
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• 제17권4호
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• pp.211-217
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• 2019

국내 만성질환 관리에서 모바일 헬스 적용이 임상적으로 유용하다는 보고가 증가됨에 따라, 본 연구는 텍스트 마이닝 기법을 적용하여 국내 외 학술지에 게재된 국내 만성질환자 대상 모바일 헬스 중재연구의 특성 및 중심 키워드의 변화를 파악하고자 시도된 이차분석연구이다. 분석대상 논문은 2005년부터 2018년까지 학술지에 게재된 최종 20편으로, 추출한 텍스트는 Microsoft Excel을 활용하여 논문별 분석을 실시하였고, Text Analyzer를 사용하여 주제어를 추출하였다. 연구결과, 모바일 헬스 중재 연구는 고혈압, 당뇨병, 뇌졸중 관상동맥질환자에 주로 적용되었다. 가장 많이 사용된 중재 유형은 애플리케이션 개발이었으며, 최근 연구에서는 주로 '유용성', '모바일 헬스', '결과측정' 등의 단어들이 가장 많이 출현하였다. 추후 만성질환자 대상 모바일 헬스 중재에 관한 국내 외 연구 모두를 포함하여 주제어 간의 연관성을 확인할 수 있는 사회연결망 분석방법을 적용하여 그 효용성을 확인해볼 것을 제안한다.

• 성인간호학회지
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• 제22권5호
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• pp.499-508
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• 2010

Purpose: Cardiovascular risk factor modification is important for patients with coronary artery disease to prevent poor progression of the disease. Without an understanding and an awareness of risk factors, patients with coronary artery disease are not able to reduce their risk by the lifestyle modification. The aims of this study were to assess patient's awareness of risk factors and to identify predictors of awareness of risk factors. Methods: A descriptive correlational study using a cross-sectional survey method was performed. The sites of the study were three hospitals in Seoul, Korea. The sample consisted of 214 subjects. The awareness of risk factors and other subjects' characteristics were measured by a questionnaire developed for this study. Results: A range of subjects (gender: 72.0%; hyperlipidemia: 51.9%; hypertension: 40.7%; obese: 37.4%; age: 35.5%; smoking: 22.4%; diabetes: 19.2%; family history: 18.2%) were not able to accurately identify the risk factors. Among predictors, gender (${\beta}$=-.17) and diabetics (${\beta}$=-.25) had statistically significant influences on awareness of risk factors. Conclusion: Our findings highlight the lack of awareness of risk factors for coronary artery disease. The findings have important implications for nursing practice in terms of guiding educational strategies for the modification of risk factors for coronary heart disease.

• Journal of Korean Neurosurgical Society
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• 제49권2호
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• pp.92-96
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• 2011

Objective : We retrospectively evaluated the prognostic factors that can influence long-term survival in patients who suffered acute large cerebral infarction. Methods : Between June 2003 and October 2008, a total of 178 patients were diagnosed with a large cerebral infarction, and, among them, 122 patients were alive one month after the onset of stroke. We investigated the multiple factors that might have influenced the life expectancies of these 122 patients. Results : The mean age of the patients was $70{\pm}13.4$ years and the mean survival was $41.7{\pm}2.8$ months. The mean survival of the poor functional outcome group ($mRS{\geq}4$) was $33.9{\pm}3.3$ months, whereas that of the good functional outcome group ($mRS{\leq}3$) was $58.6{\pm}2.6$ months (p value=0.000). The mean survival of the older patients (270 years) was $29.7{\pm}3.4$ months, whereas that of the younger patients (<70 years) was much better as $58.9{\pm}3.2$ months (p value=0.000). Involvement of ACA or PCA territory in MCA infarction is also a poor prognostic factor (p value=0.021). But, other factors that are also known as significant predictors of poor survival (male gender, hypertension, heart failure, atrial fibrillation, diabetes mellitus, a previous history of stroke, smoking, and dyslipidemia) did not significantly influence the mean survival time in the current study. Conclusion : Age (older versus younger than 70 years old) and functional outcome at one month could be critical prognostic factors for survival after acute large cerebral infarction. Involvement of ACA or PCA territory is also an important poor prognostic factor in patients with MCA territorial infarction.

• Journal of Acupuncture Research
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• 제24권5호
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• pp.43-52
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• 2007

Objective : The purpose of this study is to present the epidemiological data on stroke patients admitted to Department of Acupuncture & Moxibustion, Kang-Nam Korean Medicine Hospital Kyunghee University and comparison to past stroke patient studies. Methods : Research was conducted by surveys and charting of patients with a stroke admitted to Department of Acupuncture & Moxibustion Gang-Nam Korean Medicine Hospital Kyunghee University from Jan. 1. 2005 to Dec. 31. 2006. Results : There was 2.3 times more cerebral infarction than cerebral hemorrhage and 1.5 times more female patients. Older patients showed more infarction than hemorrhage. Patient range was mostly in the 70year old range. Preceding diseases were hypertension>diabetes>hyperlipidemia. Gait condition improved during hospitalization. Most patients were admitted after 61 days of stroke onset and hospitalization period exceeded 71days. 76% of patients received treatment from other medical facilities before admittance. Most patients came from western medicine hospitals. Triglyceride levels were high at 32.3% at the time of admittance. The most common symptom in admission time was headache. Conclusion : Acute stroke patients decreased, long term patients increased, and patients who came from other medical facilities increased.