• 대한약리학회지
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• 제19권1호
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• pp.93-99
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• 1983

Hydrocortisone 5 mg/kg which exerts minimal effect on the renal function and furosemide 1 mg/kg which induces moderate amount of diuresis were injected intraperitoneally to study their effects on the renal cyclic nucleotides content in rats. 1) The renal tissue levels of cAMP were significantly increased by administration of hydrocortisone, but there was no significant change in the furosemide group compared with that of saline treated control group. Moderate elevation in renal cAMP level was noted by the combined administration of hydrocortisone and furosemide, but this elevation was less than that of hvdrocortisone treated group. 2) The renal cGMP level did not show nay remarkable change after the administration of hydrocortisone, however, there were a significant increase by the administration of furosemide alone or combination of both drugs. The level of renal cGMP was higher and maintained longer in the combined treated group than furosemide treated group. The result of this experiment indicates that the potentiating effect of hydrocortisone on the diuretic action of furosemide nay be related to the renal levels of cGMP rather than that of cAMP.

• 대한약리학회지
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• 제32권1호
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• pp.83-91
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• 1996

본 연구에서는 Hydrocortisone이 적출 흰쥐 관류 부신에서 histamine에 의한 카테콜아민 (CA) 분비작용에 대한 영향을 관찰하고자 시도하였으며, 얻어진 연구 결과는 다음과 같다. Histamine (150ug)은 부신정맥내로 주입시 현저한 CA 분비작용을 나타내었다. 이러한 histamine의 CA 분비작용은 천연 글루코콜티코이드인 hydrocortisone (30uM)이나 합성 글루코콜티코이드인 dexamethasone (30uM)을 각각 20분간 전처치한 후에 현저히 증강되었다. Hydrocortisone에 의한 histamine의 CA 분비의 증강작용은 inositol trisphosphate 수용체 억제제인 heparin (3.56U/ml)으로 천처치시 뚜렷이 억제되었으나 adenylate cyclase의 강력한 활성화제인 forskolin (0.2uM)으로 전처치시 현저히 강화되었다. 이상과 같은 실험 결과를 종합한 결과, hydrocortisone (글루코콜티코이드)은 흰쥐 적출관류 부신에서 histamine의 CA 유리작용을 증강시킬 수 있으며, 이는 부신수질 크롬친화성 세포에서 inositol phosphate 뿐만 아니라 cyclic AMP의 축적작용과 관련성이 있는것으로 사료된다.

• 대한수의사회지
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• 제21권1호
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• pp.43-47
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• 1985

Striking effects of hydrocortisone were observed on the behaviour of Toxocara canis larvae in 2 months old dogs. Four cross-breed dogs were used in this studies and each dog was inoculated 3000 infective eggs. The larvae were recovered from 2 dogs (contro

• International Journal of Industrial Entomology and Biomaterials
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• 제1권1호
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• pp.41-45
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• 2000

The effect of topical application with hydrocortisone on economic parameters was analysed following treatment of last larval stadium. The treated larvae showed a significant increase in larval weight at higher concentrations along with other enhanced larval, cocoon and adult parameters. This suggests that hydrocortisone can be used effectively for commercial silkworm rearing. The larvas period was significantly increased in all the treated groups with increased female cocoon weights, its shell weights and male cocoon shell weight at 20$\mu\textrm{g}$/ml treated group. Filament length, weight and denier were increased significantly in all the treated groups. Moth emergence percentage, length of the ovariole, eggs per ovariole, fecundity and rind hatching percentage were unaffected when compared with that of the carrier control group. This suggests that hydrocortisone in addition to affecting larval growths also affect silk crop.

• Neonatal Medicine
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• 제18권1호
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• pp.82-88
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• 2011

목적: 본 연구에서는 부신기능부전과 연관된 저혈압의 임상적 특성과 hydrocortisone 투여에 대한 치료반응을 알아보고자 하였다. 방법: 2007년 1월 1일부터 2009년 8월 31일까지 분당서울대학교병원에서 출생하여 신생아집중치료실에 입원했던 재태주령 32주 미만의 미숙아 158명 중 미숙아 부신기능부전과 연관된 저혈압이 발생하였던 12명의 환아를 대상으로 하였고 이들의 임상적 특성과 hydrocortisone 투여 전과 후의 평균혈압, 소변량, 혈청 전해질 검사 소견을 비교하였다. 결과: 환아의 재태주령은 27.8${\pm}$2.5주, 출생체중은 1,110${\pm}$307g이었고 부신기능부전과 연관된 저혈압이 발생한 시기는 생후19${\pm}$7일, 월경 후 주령으로는 30.6${\pm}$2.4주이었고 당시 체중은 1,285${\pm}$365 g이었다. Dopamine 투여에도 저혈압이 발생한 미숙아는 hydrocortisone을 4.0 mg/kg/day의 스트레스 용량으로 시작해 2.2${\pm}$0.7일간 유지 후 감량하였으며 hydrocortisone 투여 전의 혈청 cortisol 농도는 11.6${\pm}$4.1 mg/dL이었다. Hydrocortisone 투여 당시와 2, 4, 6시간 후의 평균혈압은 25.0${\pm}$5.4 mmHg에서 35.0${\pm}$5.3 mmHg, 38.3${\pm}$8.0 mmHg 그리고 41.9${\pm}$6.5 mmHg 로 증가되다가 그 후로는 안정적으로 유지되었고 소변량도 hydrocortisone 투여 전에 0.9${\pm}$0.6 mL/kg/hr에서 치료 6시간 후 4.1${\pm}$3.4 mL/kg/hr로 증가되었다. 치료시작당시와 12시간 후의 dopamine 용량은 11.0${\pm}$2.9 ${\mu}g$/kg/min에서 8.0${\pm}$2.3 $\mu$g/kg/min로 감량되었고 24시간 후에는 5.5${\pm}$3.4 ${\mu}g$/kg/min까지 감량되었다. 혈청 $Na^+$ 농도는 hydrocortisone 투여 전 130${\pm}$4 mEq/L에서 투여 12시간 후 136${\pm}$4mEq/L로 증가되었고 혈청 $K^+$ 농도는 hydrocortisone 투여 전6.1${\pm}$1.1 mEq/L에서 투여 12시간 후 4.6${\pm}$0.6 mEq/L로 감소하였다. 결론: 미숙아에서 부신기능부전과 연관된 저혈압이 발생한 경우 hydrocortisone의 투여는 신속히 혈압을 상승시키고 소변량을 증가시켰으며 전해질 농도를 정상화시켰다.

• 치과방사선
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• 제21권2호
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• pp.203-220
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• 1991

The purpose of this study was to investigate the changes of morphology and structure of bone tissue, caused by administration of high-dose hydrocortisone, elcatonin and cyclophosphamide. In order to carry out experiment, 60 four-week old Sprague-Dawley strain rats weighing about 107 gms were selected and divided into experimental group and control group. The experimental group was subdivided into three groups, assigned fifteen rats for each group, by the different drugs administered. Each experimental group was then categorized as follows: hydrocortisone 30㎎/㎏ b.w. with daily subcutaneous injection, elcatonin 20U/㎏ b.w. with daily subcutaneous injection, and cyclophosphamide 100㎎/㎏ b.w. with a single intraperitoneal injection. Fifteen rats were injected daily with 5㎖/㎏ b.w. of normal saline solution subcutaneously in control group. Rats in control group and experimental group were serially sacrificed on the 6th, the 15th and the 22nd day after injection of normal saline, hydrocortisone, elcatonin and cyclophosphamide, respectively. Being sacrificed, both sides of mandibular condyles were removed and fixed with 10% neutral formaline. The one side of mandibular condyles was radiographed with soft X-ray apparatus. Thereafter, the obtained radiographs were observed, and the bone density of condylar head and condylar neck regions was measured by use of transferring video-based digital radiograph. The other side was further decalcified and embedded in paraffin as usual manner, then sectioned and stained with hematoxylin and eosin, observed by light microscope. The obtained results were as follows: 1. Sclerotic changes with regularly increased trabecular pattern were seen throughout experimental periods in hydrocortisone group. Increased the number of trabecular pattern with irregularity and periodic striation on the periphery of condylar head region were appeared with lapse of time in elcatonin group. In cyclophosphamide group, irregular trabecular pattern and stippled radiopacities on mandibular condyle were observed with lapse of time. 2. The bone density of condylar head region was increased in hydrocortisone group, decreased in elcatonin group, and tended to be decreased in cyclophosphamide group, compared with that of control group according to the experimental periods. 3. The bone density of condylar neck region tended to be rather increased in hydrocortisone group, elcatonin group and cyclophosphamide group, depending on the experimental periods. 4. In microscopic studies, there were irregular trabecular bonds and osteoblastic activity in hydrocortisone group and elcatonin group throughout experimental periods, degenerative cartilage and trabecular bones in the 6th day and densely calcified trabecular bones in the 22nd day in cyclophosphamide group.

• Toxicological Research
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• 제13권1_2호
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• pp.167-173
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• 1997

LBD-001, a recombinant human interferon $\gamma$ produced by genetically engineered yeast as a host system, was intravenously administered to pregnant female rabbits (New Zealand White strain) from day 6 to 18 of gestation at dose levels of $0.35 \times 10^6$, $0. 69 \times 10^6$, and $1.38 \times 10^6$ I.U./kg/day. Hydrocortisone sodium succinate (0.3 mg/kg/day) was also given in the same way. Teratological effects of the test agents on the organogenesis of fetuses and the development of offsprings (F1 rabbits) were investigated. The results were as followings: (1) No significant changes by the treatment of LBD-001 or hydrocortisone sodium succinate were observed in the body weights, the food and water consumption, the lactating or nurshing behaviors, and the autopsy of the pregnant rabbits. (2) No significant changes in the resorption rate, the fetal organogenesis, and the normal develpoment of offsprings (F1) by the treatment of LBD-001 or hydrocortisone sodium succinate were detected. The results show that LBD-001 at the dose of $1.38 \times 10^6$ I.U./kg/day or less and hydrocortisone sodium succinate at the dose of 0.3 mg/kg/day are neither teratogenic in the organogensis of the fetuses and the development of the offsprings (F1) nor toxic to the mother rabbits.

• 대한한방내과학회지
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• 제22권1호
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• pp.63-71
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• 2001

Objectives : Cordyceps Sinensis (CS) was tested for the effects of antioxidant enzymes and lipid peroxidation in the liver. Methods : We measured the changes in body weight, enzyme activity, lipid peroxide and the death rate in the hydrocortisone acetate-treated rats. Results : In vitro, CS didn't effect levels of lipid peroxide. the activities, and the ratio of type conversion of xanthine oxidase. In the hydrocortisone acetate-treated rats, lipid peroxide, the activities, the ratio of type conversion of xanthine oxidase, and the death rate all increased. But, glutathione peroxidase and superoxide dismutase decreased. In vitro, after CS was administered to hydrocortisone acetatetreated rats, the levels of lipid peroxide in the liver, and the death rate decreased. However, the activities, and the ratio of type conversion of xanthine oxidase decreased. The body weight, glutathione peroxidase, and superoxide dismutase in+creased. The effects of Sinensis Cordyceps Broth did better than the effects of Sinensis Cordyceps Mycelia. Conclusions : These results suggest that CS decrease the activities of free radical generating enzymes which form lipid peroxide and increase the activities of oxygen free radical scavenging enzymes.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1996년도 춘계학술대회
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• pp.278-278
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• 1996

Judging from hydrocortisone concentration in dosing area, the extent of absorption was reduced in the liposome-gel formulation. However, higher and sustained skin concentrations of hydrocortisone were achieved for the liposome-gel as compared to the ointment. Drug concentration in both viable and deep skin reached its maximum within 0.5 h after application of both formulations to both skin types. Drug concentrations in both skins from the ointment declined with time, while those from the liposome-gel were greatly sustained. The sustainment by the liposome-gel was more remarkable in the viable skin than in the deep skin. Drug concentration in the viable skin could be maintained at a nearly constant level for over 8 h by applying the liposome-gel. As a result, a 5-fold higher viable skin drug concentration was obtained from the liposome-gel than from the ointment at 8 h after the application to the SC-removed skin. However, the plasma concentration of hydrocortisone at 4 h from the liposome-gel was only one-fourth (p<0.01) the value from the ointment when the drug was applied to the SC-removed skin, consistent with. the lower urinary (one-third, p<0.05) and fecal (one-half, p＜0.05) excretion. Conclusions : Retarded diffusion of the drug from the skin to the systemic blood stream appears to be a potential factor in the sustained skin concentration of hydrocortisone from the liposome-gel, Interaction of hydrocortisone in the skin with phosphatidylcholine, a component of the liposomes and skin, may well be a factor in retarding the diffusion of the drug in the skin.

• 대한한의학회지
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• 제21권1호
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• pp.20-28
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• 2000

The purpose of this research is to investigate the synergistic effect of herb medicines with hydrocortisone and the regulation effect on the immune system of Onbitang and Dangguijakyaksan at the supernatant of PHA-P stimulated PBMC in the patients with minimal change nephrotic syndrome(MCNS). From the measurement of the concentration rate of IL-4, sCD23 and IL-13, the experiment yielded the following results : The Onbitang group showed a greater tendency to suppress IL-4 and IL-13 levels in MCNS group with no statistical significance. It showed very strong suppression in soluble CD23 compared with control group in MCNS group. The Dangguijakyaksan group, though not statistically significant, was inclined to suppress IL-4 level in MCNS group. It shows stronger suppression in sCD23 and IL-13 levels than these of control group in MCNS group. As for the synergistic effect, the group of hydrocortisone with herb medicines(Onbitang or Danguijakyaksan) produced more suppressive effect to IL-13 level in MCNS group than that of hydrocortisone-only group. They also tended to suppress sCD23 and IL-4 levels, though no statistical significance can be given. As to the suppressive effect of 1L-13 level, the group of Onbitang with hydrocortisone showed an increase of 22.6%, while the group of Dangguijakyaksan with hydrocortisone showed 14.7%. So Onbitang is more effective than Dangguijakyaksan. From the above results, a combinative treatment(herb medicines with hydrocortisone) can be an alternative method to substitute for steroid therapy. It can be a more effective therapy than steroid-only therapy because it is expected to reduce side effects and it shows more special effect to suppress IL-13 level. Based on the present results, further investigation concerning the serum IgE elevation is needed.