• Korean Journal of Human Ecology
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• v.10 no.2
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• pp.189-203
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• 2001

The pulpous of this study is to investigated the kind and feature of the knots used in four categories, "living, clothing, ceremony, and decoration", after analysing and examining 42 knot remains of the folklore museum of On yang. The method were by old books and various kind's related books, history of knots and kind of knots investigated and analyze relics were actual proof investigation of real things and supplementary materials were photos, drawings, and museum's explanation used. The results are as is following ; First, a knot is twisted by two threads, formed in the process of twisting, become in equal shape, and made in symmetry. Second, In knot's names, there are sangkang, karakge, ankyongchip, jamjary, kukhwa, bol, byongary, memi, kkondiki, kong, yonbong which are easily seen in nature. Third, a knot was used in as living things in the era of the three Kingdoms, as a decoration such as Buddhism goods in Koryo. In the era of Cho sun, Because of the development of knot's kind and the variety of service, it was the target of restriction as a luxury. Fourth, as a result of investigating museum's relics, a knot was smaller than the chief object because that is a decoration. Fifth, there are 8 kinds for living and clothing which are simple knots "doramaetup, karakgemaetup, and sangtchokmaetup". Sixth, the complex knots such as kukhwamaetup, byongarymaetup, and 3bolkamkae emaetup are used on pangchang, chokja, nambawi, and chobawi. Seventh, there are 10 kinds for ceremony, the simple knots are twisted and the complex knots such as kukhwamaetp, maehwamaetup, nabimaetup, and sasaekgupoki are used. Eighth, there are 14 kinds for decoration, the simple knots such as doraemaetup, kakagemaetup, santchokmaetup, and ankyongchipmaetup and the applied knots such as kukhwamaetup, byongarymaemaetup, changkumaetup, nabimaetup, and seokssima etup are used. There are 42 knot remains in the folklore museum of On yang. Of them, there are 33 kinds in the present, 17 used. that is because only several knots have been used. Finally, to forget the knot's way, we will set up a plan to keep with it.

• Biomolecules & Therapeutics
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• v.18 no.4
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• pp.402-410
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• 2010

Although the overproduction of prostaglandin $E_2$ ($PGE_2$) in intestinal epithelial cells has been considered to be highly correlated with the colorectal carcinogenesis, the precise mechanism of action remains poorly elucidated. Accumulating evidence suggests that the PGE receptor (EP)-mediated signal transduction pathway might play an important role in this process. In the present study, we investigated the mechanism of action underlying $PGE_2$-mediated cell proliferation and the effect of resveratrol on the proliferation of human colon cancer cells in terms of the modulating $PGE_2$-mediated signaling pathway. $PGE_2$ stimulated the proliferation of several human colon cancer cells and activated growth-stimulatory signal transduction, including Akt and ERK. $PGE_2$ also increased the phosphorylation of GSK-$3{\beta}$, the translocation of ${\beta}$-catenin into the nucleus, and the expressions of c-myc and cyclin D1. Resveratrol, a cancer chemopreventive phytochemical, however, inhibited $PGE_2$-induced growth stimulation and also suppressed $PGE_2$-mediated signal transduction, as well as ${\beta}$-catenin/T cell factor-mediated transcription in human colon cancer cells. These findings present an additional mechanism through which resveratrol affects the regulation of human colon cancer cell growth.

• Anatomy and Cell Biology
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• v.51 no.4
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• pp.284-291
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• 2018

The role of androgens in the development of cardiovascular diseases remains controversial. The current study therefore sought to determine the changes in the histomorphology of the common carotid artery of the male rat in orchidectomy-induced hypogonadism. Twenty-two Rattus norvegicus male rats aged 2 months were used. The rats were randomly assigned into baseline (n=4), experimental (n=9), and control (n=9) groups. Hypogonadism was surgically induced in the experimental group by bilateral orchiectomy under local anesthesia. At experiment weeks 3, 6, and 9, three rats from each group (experimental and control) were euthanized, their common carotid artery harvested, and routine processing was done for paraffin embedding, sectioning, and staining. The photomicrographs were taken using a digital photomicroscope for morphometric analysis. Orchidectomy resulted in the development of vascular fibrosis, with a significant increase in collagen fiber density and decrease in smooth muscle and elastic fiber density. Moreover, there was development of intimal hyperplasia, with fragmentation of medial elastic lamellae in the common carotid artery of the castrated rats. Orchidectomy induces adverse changes in structure of the common carotid artery of the male rat. These changes may impair vascular function, therefore constituting a possible structural basis for the higher incidences of cardiovascular diseases observed in hypogonadism.

• Journal of Conservation Science
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• v.26 no.1
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• pp.95-107
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• 2010

Biochemical research was carried out on 4 human skeletal remains from historical lime-layered tombs assigned to the Joseon Dynasty in Oknam-ri, Seocheon. The preservation of femur was evaluated by stereoscopic microscopy and scanning electron microscopy. Most of specimens showed good histological preservation. The histological results proved to be a good potentiality for biochemical analysis using bio-molecules. The amelogenin gene and mitochondrial DNA (mtDNA) analyses revealed that three specimens perhaps have maternal consanguinity due to sharing with mtDNA haplogroup D4b1, and two specimens buried in the same tomb were a couple in Gatjaegol site. Carbon and nitrogen stable isotope analysis indicated that four deads diet were built around C3 plant as rice, barley, wheat and bean. In this study we characterized genetic and diet features from the social stratum who could make lime-layered tombs during period of the Joseon Dynasty. The results suggest that biochemical research using the human skeletal remains from the Joseon Dynasty has the great potential and reasonable value for archaeology, anthropology, and population genetics.

• Journal of the Korea Society of Computer and Information
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• v.26 no.2
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• pp.79-88
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• 2021

In this paper, we propose a API Gateway technique for the expansion of human resource management module, one of the ERP functions. The institution has introduced ERP (Enterprise Resource Planning) based on its efforts to transform all human and physical resources into business competitiveness and its response to the digital knowledge informatization environment, and listed it as multiple success factors. Human resource management is one of the factors that have been dealt with. However, ERP's Human Resources Management Module remains in the role of functional personnel management. How to utilize human resources begins with navigating and recognizing human resources. The proposed API Gateway technique leverages blockchain networks to design and implement APIs for human resource sharing and navigation, including the possibility of extending ERP's human resource management module. Secondly, it was designed and implemented using a smart contract that behaves like an API for preventing information forgery. The proposed method will not only be used as a tool that can actively utilize human resources, but will also be a complete resource for utilizing big data technology.

• 한국문화재보존과학회:학술대회논문집
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• 2003.03a
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• pp.49-50
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• 2003

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.16 no.1
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• pp.10-16
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• 2013

The field of stem cell research has been rapidly expanding. Although the clinical usefulness of research remains to be ascertained through human trials, the use of stem cells as a therapeutic option for currently disabling diseases holds fascinating potential. Many pediatric gastrointestinal tract diseases have defect in enterocytes, enteric nervous system cells, smooth muscles, and interstitial cells of Cajal. Various kinds of therapeutic trials using stem cells could be applied to these diseases. This review article focuses on the recent achievements in stem cell applications for pediatric gastrointestinal tract diseases.

• Proceedings of the Optical Society of Korea Conference
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• 2009.10a
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• pp.153-154
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• 2009

In this study, a new accommodation-dependent crystalline lens with a constant volume and homogeneous refractive index is developed. The human lens parameters, such as curvature and thickness, are calculated at the central parts of the lens, and the asphericity is adjusted at the peripheral parts of the lens due to accommodation. We propose a accommodating schematic eye which is suitable for easy paraxial calculations because the refractive index of the lens remains uniform and constant.

• Journal of the Ergonomics Society of Korea
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• v.1 no.2
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• pp.25-29
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• 1982

The job design was frequently tried in many enterprises in order to give workers the job satisfaction, but there remains obscure about what kinds of human factors in job yield the satisfaction. This study is concerned with an experimental method for job design to account for such findings that work with conveyor gave workers unsatisfaction, and that enlarged job of work resulted in high job satisfaction.

• Biomolecules & Therapeutics
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• v.24 no.4
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• pp.380-386
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• 2016

Silymarin from milk thistle (Silybum marianum) has been reported to show an anti-cancer activity. In previous study, we reported that silymarin induces cyclin D1 proteasomal degradation through NF-${\kappa}B$-mediated threonine-286 phosphorylation. However, mechanism for the inhibition of Wnt signaling by silymarin still remains unanswered. Thus, we investigated whether silymarin affects Wnt signaling in human colorectal cancer cells to elucidate the additional anti-cancer mechanism of silymarin. Transient transfection with a TOP and FOP FLASH luciferase construct indicated that silymarin suppressed the transcriptional activity of ${\beta}$-catenin/TCF. Silymarin treatment resulted in a decrease of intracellular ${\beta}$-catenin protein but not mRNA. The inhibition of proteasome by MG132 and $GSK3{\beta}$ inhibition by SB216763 blocked silymarin-mediated downregulation of ${\beta}$-catenin. In addition, silymarin increased phosphorylation of ${\beta}$-catenin and a point mutation of S33Y attenuated silymarin-mediated ${\beta}$-catenin downregulation. In addition, silymarin decreased TCF4 and increased Axin expression in both protein and mRNA level. From these results, we suggest that silymarin-mediated downregulation of ${\beta}$-catenin and TCF4 may result in the inhibition of Wnt signaling in human colorectal cancer cells.