• 의료법학
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• 제11권1호
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• pp.297-329
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• 2010

The bioethics as a comprehensive and normative control method of life sciences including the technology of advanced medical care, on the one hand, it has modified the conditions for allowing the progress of life sciences. On the other hand, it has put the brakes on attempts of life sciences violating the dignity and value of human beings, natural order. Positively, bioethics presents ethical bases, suggests organization of the legal and institutional conditions, and enables elimination of the legal and institutional obstacles, for the progress of life sciences. Negatively, it has presented justifiable prospects and road maps of life sciences, not to take indiscreet and intemperate turn of violating the dignity and value of human beings, natural order, and its such roles must be carried on.

• BMB Reports
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• 제37권4호
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• pp.402-407
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• 2004

A human gene T-complex protein 10 like (TCP10L) was cloned in our lab. A previous study showed that it expressed specifically in the liver and testis. A transcription experiment revealed that TCP10L was a transcription factor with transcription inhibition activity. In this study, the human MAD4 was identified to interact with TCP10L by a yeast two-hybrid screen. This finding was confirmed by immunoprecipitation and subcellular localization experiments. As MAD4 is a member of the MAD family, which antagonizes the functions of MYC and promotes cell differentiation, the biological function of the interaction between TCP10L and MAD4 may be to maintain the differentiation state in liver cells. Also, we propose that the up-regulation of Myc is caused by the down-regulation of TCP10L in human hepatocarcinomas.

• 한국전자파학회논문지
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• 제25권4호
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• pp.442-450
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• 2014

본 논문은 피부를 포함하는 유방 모델에서 정합 액체의 전파 특성에 관한 연구 내용이다. 정합 액체의 분석을 위해 6개 타입의 정합 액체를 제안된 1-D 유방 모델에 적용하여 3~6 GHz의 주파수 대역에서 분석 연구를 수행하였다. 균일한 평면파가 1-D 유방 모델 내부의 복합 매질의 경계면에 입사되어 반사/투과되어 나타나는 전파 특성과 각 정합 액체의 전송 선로 손실을 분석하였다. 본 논문에서 연구한 방법은 유방암 진단 시스템, 인체 조직을 이용한 암 진단 분야 및 기타 의료기기 분야에 활용될 수 있으며, 본 논문에서는 유방암 진단 시스템에 적용하였다. 본 연구는 향후 유방암 진단 시스템에 적용될 적절한 정합 액체를 선정하고, 성능을 분석하는데 유용하게 적용될 수 있다.

• Food Science and Biotechnology
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• 제16권1호
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• pp.163-166
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• 2007

The cytotoxic effects of partially purified substances from Bacillus polylfermenticus SCD toward a variety tumor cell lines were studied. Cytotoxic activity was determined with regard to the A549 (human lung carcinoma), AGS (human stomach adenocarcinoma), DLD-1 (human colon adenocarcinoma), HEC-1-B (human uterus adenocarcinoma), SW-156 (human kidney carcinoma), and NIH/3T3 (murine normal fibroblast) cell lines using the MTT assay. Cytotoxic substances were partially purified through Diaion HP-20 columns and extracted with methanol or other organic solvents (n-hexane, chloroform, ethylacetate, and butanol). B. polyfermenticus SCD supernatant showed up to 60% inhibition of cell viability fer all five human cancer cell lines tested. When treated with 10 mg/mL of n-hexane, chloroform, ethylacetate, and butanol extract, HEC-1-B cells showed a 25,62,35, and 63% rate of inhibition respectively, and AGS cells showed a 72, 61, 44, and 67% rate of inhibition, respectively. At a concentration of 10 mg/mL, 100% methanol Diaion HP-20 extracts showed inhibition rates of 97.0% toward A-549 cells, 98.1% toward AGS cells, 81.6% toward DLD-1 cells, 83.5% toward HEC-1-B cells, and 92.7% toward SW-156 cells. These results indicate that partially purified fractions from B. polyfermenticus SCD have the potential to inhibit not only colon cancer cells, but also lung, stomach uterus, and kidney cancer cells. Further studies are needed to characterize the cytotoxic substances released in B. polyfermenticus SCD cultures.

• Human Ecology Research
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• 제62권2호
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• pp.369-383
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• 2024

The aim of this study was to develop and implement a program based on Cognitive Behavior Therapy (CBT) for female college students experiencing body dissatisfaction. To systematize the program development process, we adopted the service design method. First, we conducted In-Depth Interviews (IDIs) to identify the difficulties faced by six female college students who experience body dissatisfaction, and to determine what kind of help they needed. Second, content analysis of the findings revealed that female college students were experiencing emotional-behavior problems which derived from the discrepancy between their ideal body image and the reality. Third, a prototype of a cognitive reconstruction program was developed to help transform their perceived 'body distortion' to a rational cognitive concept and thus reduce maladaptive consequences of 'body dissatisfaction'. The overall program consisted of three therapeutic components and seven steps. Fourth, to assess the effectiveness of the program, survey and IDIs were conducted. The results revealed that it is appropriate to use a cognitive model to solve problems caused by body dissatisfaction, and that understanding and reconstructing one's own cognitive processes can be effective in reducing body dissatisfaction. However, based on feedback from participants, a number of revisions were proposed, such as including sufficient induction regarding the behavioral change.

• 한국교육논총
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• 제40권2호
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• pp.1-16
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• 2019

지능정보사회는 사물, 지식, 계산을 키워드로 하는 새로운 세계이다. 이 세계에서 교육개혁의 철학적 조건은 무엇인가? 로빈슨과 애로니카(2015)는 현재의 교육개혁이 유기 농업이라는 상징을 중심으로 이루어져야 한다고 주장한바 여기에는 유기체로서의 인간의 존엄성에 대한 문제의식이 담겨 있다. 인간은 지능과 생명의 결합체이다. 인공지능의 개발은 안드로이드의 상호작용 증가에 따른 인간적 본질에 대한 물음을 제기한다. 현실적으로는 딥러닝으로 상징되는 인공지능의 발전이 교육개혁의 조건이 될 것이다. 반면 정보기술과 예술의 결합은 새로운 생명 이미지의 창출을 통해 인공생명의 문제, 곧 생명 자체에 관한 문제를 제기할 것이다. 인간적 본질에 대한 물음이 생명 자체에 관한 물음과 함께 회귀한다. 인공지능과 인공생명이 낳는 철학적 물음은 교육적 물음과 패러독스를 이루어 미래의 교육개혁에 난문(難問)을 던질 것이다.

• 공학교육연구
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• 제17권4호
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• pp.38-42
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• 2014

The principle of materialized world is the same as of human life. The human life is governed by the human mind composed of the copies of the materialized world. The stress is due to the human mind inside. The creativity is prevented by the copies in the human mind. The convergence is not easy due to the individual copy world which is different from each other. By subtraction of the copies inside the human, the creativity and convergence can be fulfilled. Syllabus of the lecture at KAIST is introduced. Students taking the lecture express the non-materialized world of human mind clearly after the subtraction the copies inside. The students who recognize the stress inside specifically can be free from the stress by discarding the copies inside.

• Genomics & Informatics
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• 제8권2호
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• pp.86-89
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• 2010

Closely related species share large genomic segments called syntenic regions, where the genomic elements such as genes are arranged co-linearly among the species. While synteny is an important criteria in establishing orthologous regions between species, non-syntenic regions may display species-specific features. As the first step in cataloging human- or primate- specific genomic elements, we surveyed human genomic regions that are not syntenic with any other non-primate mammalian genomes sequenced so far. Based on the data compiled in Ensembl databases, we were able to identify 10 such regions located in eight different human chromosomes. Interestingly, most of these highly human- or primate- specific loci are concentrated in subtelomeric or pericentromeric regions. It has been reported that subtelomeric regions in human chromosomes are highly plastic and filled with recently shuffled genomic elements. Pericentromeric regions also show a great deal of segmental duplications. Such genomic rearrangements may have caused these large human- or primate- specific genome segments.

• Journal of Life Science
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• 제10권2호
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• pp.12-13
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• 2000

A human-specific retroposon SINE-R.C2 has been derived from a human endogenous retrovirus HER V-K 10. It is absent in the genome of nonhuman primates and present within the third intron of the human C2 gene that is located in the class III region of the major histocompatibility complex. In the present study, we determined the regional location of the human C2 gene. The analysis of the Genebridge 4 radiation hybrid mapping panel using PCR amplification located the C2 gene between D6S1422 (10.1 cR) and CHLC.GATA4A03 (21.3) with a lod score of>3.0. This allowed us to localize C2 gene on the human chromosome 6 band p21.31.

• 한국가구학회지
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• 제23권4호
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• pp.364-371
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• 2012

I designed a dietary life kitchen utensils which is focused by the shape of split bamboo that has meaning of health and safety and the shaman who is the religion and incantation performer, and who solve problems, which are impossible to solve in common methods, by borrowing the power and granting the meaning which is connected with transcendent existence and principal. Having closest relation with human being's diet culture is being changed with adding beauty instead of the part of simple practical aspect in our normal life. I tried to show incantation effect with keeping the characteristic of kitchen utensils by granting the symbolic meaning of shamanism which is the shelter that is projected the desire of human beings. the materials were produced of an ebony and steel and varnished with lacquer for coloring. For hand shape, which is hard to treat in irregular forms, the religious image of shamanism was formed by casting which expresses the touch of an ebony and the cold characteristic of metal. an overall design doesn't detail excessively distort or largely transform the form of dietary utensils, keeps its individuality, and emphasizes the image by figuring a grip part which a human can see and a body can approach. in addition, I try to show a point that shamanism has affected human life for long time and symbolic meaning of bamboo-shape shows health and safety. And these things vest with each dietary life tools and should be the role of enzyme about the effect of human life.