• Parasites, Hosts and Diseases
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• 제55권1호
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• pp.55-60
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• 2017

Fascioliasis is a foodborne zoonotic parasitic disease. We report 4 cases occurring in the same family, in whom diagnosis of acute fascioliasis was established after series of tests. One case was hospitalized with fever, eosinophilia, and hepatic lesions. MRI showed hypodense changes in both liver lobes. The remaining 3 cases presented with the symptom of stomachache only. Stool analysis was positive for Fasciola eggs in 2 adult patients. The immunological test and molecular identification of eggs were confirmed at the National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China. The results of serological detection were positive in all the 4 patients. DNA sequencing of PCR products of the eggs demonstrated 100% homology with ITS and cox1 of Fasciola hepatica. The conditions of the patients were not improved by broad-spectrum anti-parasitic drugs until administration of triclabendazole.

• 한국환경복원기술학회지
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• 제24권5호
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• pp.35-53
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• 2021

A field survey was carried out targeting 59 pine wilt disease control areas distributed in Andong, and the ecological characteristics of the areas affected by pine wilt disease were analyzed using vegetation information, ecological information, and land use information. Vegetation characteristics of Pine wilt disease affected forest area showed a 3-layer vegetation structure, high percentage of accidental occurrence species (37%) and secondary vegetation species (59.6%), appearing 12 taxa naturalized plants and 3 taxa ecosystem disturbance organisms designated by the Ministry of Environment. Ecological information of Pine wilt affected area showed frequent occurrence of water stress in south and west slopes, low lying grounds in mountains, and in well-drained soils. Also, surrounding the area has been used as roads, tombs, and cultivation where intensive human activities were the cause of disturbance and stress to the pine forest. It was analyzed that the pine forest in Andong city suffered extensive damage due to the onset of pine wilt disease while the pine trees were weakened due to continuous human activities. Conclusively, the spread and onset of pine wilt disease are worsened by artificial factors than natural environmental conditions.

• Journal of Ginseng Research
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• 제45권1호
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• pp.41-47
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• 2021

A wide range of studies have steadily pointed out the relation of oxidative stress to the primary and secondary causes of human disease and aging. As such, there have been multiple misconceptions about oxidative stress. Most of reactive oxygen species (ROS) generated from chronic diseases cause oxidative damage to cell membrane lipids and proteins. ROS production is increased by abnormal stimulation inside and outside in the body, and even though ROS are generated in cells in response to abnormal metabolic processes such as disease, it does not mean that they directly contribute to the pathogenesis of a disease. Therefore, the focus of treatment should not be on ROS production itself but on the prevention and treatment of diseases linked to ROS production, including types 1 and 2 diabetes, cancer, heart disease, schizophrenia, Parkinson's disease, and Alzheimer's disease. In this regard, Korean Red Ginseng (KRG) has been traditionally utilized to help prevent and treat diseases such as diabetes, cancer, inflammation, nervous system diseases, cardiovascular disease, and hyperlipidemia. Therefore, this review was intended to summarize in vivo animal and human clinical studies on the antioxidant activities of KRG and its components, ginsenosides.

• 혜화의학회지
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• 제12권2호
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• pp.85-103
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• 2004

From the studies on a few specific chapters of Tibetan Medical Painting, following conclusions were obtained. 1. The doctors of Tibet had to be not only academically and morally perfect, but he must show and have respect for his religion and his religous leaders and Gods. 2 The most main causes for all the disease that Tibetan Medicine resumed were hatred, delusion and ignorance of human mind which can make the physiological bile, wind, and phlegm to turn into pathological ones. 3. There is the classification of primary cause, which would be the human mind mentioned above, and the secondary cause which include dietary, behavior, seasonal problems, etc. 4. The Tibetans thought the digestive power is very important in the improvement or degravation of the disease. 5. More chapters were held for explaining the disease of fever, its clssification, stages, and cures which can indirectly show that the Tibetans might have thought it was very serious and could be very harmful. 6. The treatments for all the kinds of disease not only include medication and external therapy but also dietary and behavior regulations.

• IMMUNE NETWORK
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• 제5권2호
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• pp.99-104
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• 2005

Background: Malignant gliomas are the most common primary tumors in the central nervous system. Methods: We investigated the combined effect of PG490 and LPS on the induction of the apoptotic pathway in human astroglioma cells. Results: Treatment of U87 cells with combination of 50nM of PG490 and $50{\mu}g/ml$ of LPS resulted in increased internucleosomal DNA fragmentation, cleavage of PLC-${\gamma}1$, and downregulation of cIAP1 and XIAP. The combination of LPS and PG490 treatment-induced apoptosis is mediated through the activation of caspase, which is inhibited by the caspase inhibitor, z-VAD-fmk. Also, release of cytochrome c was found in PG490 and LPS-cotreated U87 cell. Conclusion: Taken together, combination of PG490 and LPS appears to be a potent inducer of apoptosis in astrogliaoma cells, and might have some benefit in the treatment of glioma patients.

• Pediatric Infection and Vaccine
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• 제19권3호
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• pp.89-110
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• 2012

Meningococcal Disease, manifesting as meningitis and septicemia, is a life-threatening bacterial infection that results in significant morbidity and mortality, particularly in childhood. Its epidemic potential and limited opportunities for clinical intervention due to its rapid course present unique public health and clinical challenges. Incidence is highest in infants and young children, with a secondary peak of risk in adolescents. Approximately 10% of cases are fatal and survivors can be left with serious and permanent sequelae including amputations, hearing loss and cognitive impairment. Transmission is only from human-to-human, by infected respiratory tract secretions or saliva and therefore crowding poses a tremendously elevated risk for disease development. Military recruits and university students are at high risk due to the high carriage rate in adolescents, their behavior patterns and close contact. Menveo$^{(R)}$ (Novartis Vaccines and Diagnostics), a novel quadrivalent meningococcal conjugate vaccine directed against meningococcal serogroups A, C, W-135 and Y, has been shown to be immunogenic and well tolerated in all age groups and was recently licensed for use in Korea. Recent cases and deaths among military recruits drew public attention to their elevated risk and the Korean government has recommended vaccination of all new military recruits. Many Korean students seek to attend school, university, or language institutes in countries where routine meningococcal vaccination is required - clinicians should be aware of such requirements to ensure that students are vaccinated prior to arrival in the destination country.

• 생태와환경
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• 제50권4호
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• pp.374-380
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• 2017

Pine wilt disease (PWD) is one of the hazardous pine tree diseases in whole world. In Korea, PWD has been spreading since it was first observed in Busan in 1988. Dispersion of PWD is mainly mediated by its vectors such as Japanese pine sawyer. In this study, we characterized environmental condition including meteorological factors, geographical factors, and land use factors influencing on the occurrence of PWD. The occurrence data of PWD were collected at 153 sites where were the initial occurrence sites of PWD in local government regions such as city, Gun, or Gu scale. We used Akaike Information Criterion (AIC) to evaluate the relative importance of environmental variables on the discrimination of occurrence or absence of PWD. The results showed that altitude, slope, and distance to road were the most influential factors on the occurrence of PWD, followed by distance to building. Finally, our study presented that human activities highly influenced on the long term dispersal of PWD.

• 대한방사선기술학회지:방사선기술과학
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• 제43권3호
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• pp.195-208
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• 2020

Artificial intelligence(AI) is a field of computer science that is defined as allowing computers to imitate human intellectual behavior, even though AI's performance is to imitate humans. It is grafted across software-based fields with the advantages of high accuracy and speed of processing that surpasses humans. Indeed, the AI based technology has become a key technology in the medical field that will lead the development of medical image analysis. Therefore, this article introduces and discusses the concept of deep learning-based medical imaging analysis using the principle of algorithms for convolutional neural network(CNN) and back propagation. The research cases application of the AI based medical imaging analysis is used to classify the various disease(such as chest disease, coronary artery disease, and cerebrovascular disease), and the performance estimation comparing between AI based medical imaging classifier and human experts.

• IMMUNE NETWORK
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• 제13권6호
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• pp.257-263
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• 2013

Although pathogenesis of human rheumatoid arthritis (RA) remains unclear, arthritogenic T cells and downstream signaling mediators have been shown to play critical roles. An increasing numbers of therapeutic options have been added for the effective control of RA. Nevertheless, there is still a category of patients that fails treatment and suffers from progressive disease. The recently developed immunosuppressant CP-690550, a small molecule JAK kinase inhibitor, has been implicated as an important candidate treatment modality for autoimmune arthritis. In this study, we evaluated the therapeutic effect of CP-690550 on established arthritis using an SKG arthritis model, a pathophysiologically relevant animal model for human RA. CP-690550 treatment revealed remarkable long-term suppressive effects on SKG arthritis when administered to the well-advanced disease (clinical score 3.5~4.0). The treatment effect lasted at least 3 more weeks after cessation of drug infusion, and suppression of disease was correlated with the reduced pro-inflammatory cytokines, including IL-17, IFN-${\gamma}$, and IL-6 and increased level of immunoregulatory IL-10.

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2008년도 제49회 학술심포지움 및 국제학술대회
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• pp.85.2-85.2
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• 2008