• Title/Summary/Keyword: human cases

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The Clinical Implication of MAGE Gene Detection in Bronchial Washing Fluid in Routine Practice (기관지 세척액 검사를 이용한 MAGE 유전자 검사의 임상적 의의)

  • Lee, Seung-June;Yun, Myung-Jae;Lee, Seong-Tae;Oh, Hye-Jin;Song, Sook-Hee;Sohn, In;Kim, Yeon-Jung;Han, Kyung-Hoon;Kim, Sun-Hee;Kim, Su-Hyun
    • Tuberculosis and Respiratory Diseases
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    • v.69 no.6
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    • pp.442-449
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    • 2010
  • Background: Melanoma antigen genes (MAGE) are expressed in many human malignant cells and are silent in normal tissues other than in testis and in placenta. But MAGE expression in benign lung diseases, such as pulmonary tuberculosis or cases with severe inflammation, needs further evaluation to overcome false-positive findings. We evaluated detection rates of the melanoma antigen genes (MAGE) RT-nested PCR in bronchoscopic washing samples from patients with benign lung disease, as well as in patients with malignancies. Methods: Bronchial washing fluid from 122 patients was used for cytological examination and MAGE gene detection using RT-nested-PCR of common A1-6 mRNA. We compared the results from the RT-nested PCR and the pathologic or bacteriologic diagnosis. We also analyzed the expression rate and false positive rate of MAGE gene. Results: Among 122 subjects, lung cancer was diagnosed in 23 patients and benign lung disease was diagnosed in 99 patients. In patients with lung cancer, the positive rate of MAGE expression was 47.8% (11/23) and in benign lung disease group, the expression rate was 14.1% (14/99). Among benign lung disease group, the expression rate of MAGE gene (25.0%) in patients with pulmonary tuberculosis (11/44) was especially high. Conclusion: MAGE A1-6 RT-nested PCR of bronchial washing fluid can be used as a complementary method in lung cancer, but that test results in a high false positive rate in tuberculosis patients.

Learning for Environment and Behavior Pattern Using Recurrent Modular Neural Network Based on Estimated Emotion (감정평가에 기반한 환경과 행동패턴 학습을 위한 궤환 모듈라 네트워크)

  • Kim, Seong-Joo;Choi, Woo-Kyung;Kim, Yong-Min;Jeon, Hong-Tae
    • Journal of the Korean Institute of Intelligent Systems
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    • v.14 no.1
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    • pp.9-14
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    • 2004
  • Rational sense is affected by emotion. If we add the factor of estimated emotion by environment information into robots, we may get more intelligent and human-friendly robots. However, various sensory information and pattern classification are prescribed for robots to learn emotion so that the networks are suitable for the necessity of robots. Neural network has superior ability to extract character of system but neural network has defect of temporal cross talk and local minimum convergence. To solve the defects, many kinds of modular neural networks have been proposed because they divide a complex problem into simple several subproblems. The modular neural network, introduced by Jacobs and Jordan, shows an excellent ability of recomposition and recombination of complex work. On the other hand, the recurrent network acquires state representations and representations of state make the recurrent neural network suitable for diverse applications such as nonlinear prediction and modeling. In this paper, we applied recurrent network for the expert network in the modular neural network structure to learn data pattern based on emotional assessment. To show the performance of the proposed network, simulation of learning the environment and behavior pattern is proceeded with the real time implementation. The given problem is very complex and has too many cases to learn. The result will show the performance and good ability of the proposed network and will be compared with the result of other method, general modular neural network.

Developing Local Biodiversity Strategies and Action Plans (지자체 생물다양성 관리전략 구축)

  • Kim, Geunhan;Kong, Seok-Jun;Kim, Min-Kyeong;Lee, Moung-Jin;Song, Jiyoon;Jeon, Seong-Woo
    • Journal of Environmental Policy
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    • v.13 no.2
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    • pp.3-20
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    • 2014
  • Due to habitat damage associated with climate change and human activities, biodiversity has decreased all over the world. In order to prevent further reduction in biodiversity, the international community has endeavored to establish a cooperative system, such as the Convention on Biological Diversity (CBD). Until now, most biodiversity strategic planning has been led by the national government. However, the National Biodiversity Strategy and Action Plan is conservative and its strategic plan is vague. Therefore, we propose a method for managing local biological resources called the Local Biodiversity Strategy and Action Plan. In order to provide the strategic plans and detailed plans for the Local Biodiversity Strategy and Action Plan, the report has examined several cases including Convention on Biological Diversity, Strategic Plan for Biodiversity 2011-2020, and the biodiversity strategies and action plans of the Republic of Korea and several other countries. As a result, the report demonstrates the survey and protection of bio-species, the designation and monitoring of conservation region, the management of the integrated eco-network, the establishment of biodiversity organizations and capacity building, the methods to promote networking and traditional knowledge, and the strategy for development in bioindustry. Consequently, the implementation of biodiversity management strategies by local governments will play a significant role in preserving and increasing biodiversity by realizing the goals of Strategic Plan for Biodiversity 2011-2020.

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A Study on Protection Depending on Mesh Size of Expanded Metal for Slope Reinforcement (사면보강용 Expanded Metal 격자크기에 따른 인발 특성 연구)

  • Ji, Younghwan;Kim, Kihwan;Kim, Sungho;Hwang, Yeongcheol;Lee, Seungho
    • Journal of the Korean GEO-environmental Society
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    • v.11 no.12
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    • pp.47-56
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    • 2010
  • The construction of new roads and the consistent extension of already-existing roads or the line-shape revision of those roads are increased with the governmental investment to SOC facilities currently. Accordingly, the road cut slopes are in the trend of rapidly increasing. As the road slope has increased, a lot of human and property damages has entailed consequently and in the local case, numerous studies have carried out aiming at minimizing this damages caused by the rockfall and landslide. In general, standard falling rock prevention facility has employed for most of the local road slope based on "Guide for Installation and Management of Road Safety Facilities" published by MLTM(the Ministry of Land, Transport, and Maritime Affairs) but profound doubt has raised as to whether this rockfall prevention facility would function properly enough to prevent rockfall efficiently without any damages in case of actual occurrence of rockfall. In addition, it is a reality that in most cases, such work is relied on overseas technology as a whole as the local technical level is low and in case of rockfall prevention net, it is judged that a study on rockfall prevention net that is able to endure more powerful rockfall energy is required as the problem including net bursting is taken place as a result of enough bearing force being failed to be demonstrated due to its partial weak point(not uniformly made). Under this background, in this study, three kinds of model depending on mesh size of expanded metal that is considered to have an adoptability as rockfall prevention net, as target are selected and characteristics depending on mesh size of expanded metal is intended to be researched through a pull-out test performance by using pull-out test equipment rockfall prevention net.

A Study on KSNP Environmental Color Design (개선형 한국 표준 원자력 발전소의 친환경 색채디자인 연구)

  • Kim, Yeon-Jung
    • Archives of design research
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    • v.17 no.4
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    • pp.233-240
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    • 2004
  • Living in the modern age with well-developed scientific technologies, all of us are enjoying convenient lives because of 'energy'. Korea, poor in resources, is importing a large portion of its energy sources from abroad but energy consumption shows an upward tendency due to the continuing economic growth and the improvement of living conditions. The atomic energy is considered a self-reliant, alternative energy source like our country. However, it is necessary to educate the people on and publicize atomic power generation in the face of the widespread negative recognition that the atomic power plant is a hazardous facility. The study approaches to these matters with a human-friendly and environment-friendly coloring plan in the perspective of environment coloring plan. The study aims to minimize negative images of the atomic power, while highlighting its friendly and positive images so as to enhance the confidence of the people on the atomic power and to create a clean image for the atomic power. For this goal, the study examined and analyzed cases of Japanese nuclear power plants and domestic nuclear power plants, and also carried out an on-site survey in the sites in which nuclear power plants would be constructed to extract concrete colors through the analyses of their natural environment and actual conditions. The study also carried out a survey of residents in the regions to induce their participation, and reflected the survey results to the coloring plan. The study is expected to create a stable and friendly image of the nuclear power plant through materializing its environment-friendly image and remove negative recognition that the people have on the nuclear power plant. It also attempted an external environment-coloring plan a s a strategic means for positive publicity and through this, is expected to ultimately contribute to the creation of the new images of nuclear ower plants.

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Development of the optical cases which have many functions by injection molding. (사출성형에 의한 다기능 안경집 개발)

  • 한두희
    • Proceedings of the KAIS Fall Conference
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    • 2000.10a
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    • pp.226-229
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    • 2000
  • 일반적으로 안경집은 일회적으로 사용하고 버리는 것이라 생각하는 사람이 많다. 안경집을 주로 생산하고 있는 대동사출금형과의 공동 노력으로 다기능성 안경집을 개발한 것을 소개한다. 일상적인 고정관념을 버리면 편리하고 기능성이 높은 제품을 만들 수 있다는 신념으로 개발한 결과 어린이나 젊은이들이 졸아할 문방구 겸용 안경집을 개발할 수 있었다. 완구는 소비자가 일상적으로 많이 접촉하기 때문에 곰팡이나 세균이 서식하지 않도록 항균 세라믹을 이용하여 항균처리하였다. 또한 상온에서 인체에 이로운 원적외선이 방출될 수 있도록 고안하였다. 단순한 색상의 무료함을 줄이기 위하여 어린이나 젊은이들이 좋아하는 상용화된 캐릭터를 사용하여 제품의 다양화를 꾀하였고, 4개의 조각으로 만들어 어린이들이나 젊은이들이 조립할 수 있도록 하여 흥미를 더할 수 있도록 하였다. 또한 소비자들이 선호하는 색을 알아보기 위하여 기존의 안경집을 활용하여 색상성호도 조사를 실시하였다. 젊은층은 자극적이고 화려한 색깔을 선호하는 한편 기성세대는 무난한 색깔을 선호하였다. 또한 콘택트 렌즈를 착용하는 경우에도 안경을 사용하는 경우가 많다. 이 경우 콘택트 렌즈와 안경을 따로 가지고 다녀야 하는 불편이 있다. 이에 착안하여 안경과 콘택트 렌즈를 겸용으로 사용하는 소비자를 위하여 안경과 콘택트 렌즈를 동시에 담을 수 있는 안경집을 개발(실용신안 출원번호:8928)하였다. 이 고안은 콘택트 렌즈를 안경집에 보관하기 위한 것으로 콘택트렌즈가 식염수에 잠겨 보관된 렌즈캡을 안경집내에 별도로 삽입되는 케이스에 수납하도록 구성하여 안경과 함께 콘택트 렌즈를 보관해 휴대하는 안경집 보관용 콘택트 렌즈 케이스에 관한 것으로 이것의 특징은 뚜껑이 열리고 닫히도록 구성된 안경집에 있어서 뚜껑 안쪽에 거울이 마련되고 뚜껑이 연결되는 선단부 안쪽에 끼움홈과 체결홈이 형성된 체결부를 갖는 안경집과 이것에 결합되는 체결구가 마련되어 개폐되는 커버가 형성된 케이스로 구성된다.로 금형설계 및 제작기간을 단축하고자 한다.ere demonstrated in rats after i.c.v., intraperitoneally and orally administration, respectively. The antiepileptical effects by the combination of compounds from ginseng; were compared with the iuluence of Rg1, Rb1, Rc and with the well known antiepileptical drugs such as carbamazepine, valproic acid. The base for the research is obtained by using the WAG/Rij strain (Luijtelaar, Coenen, Kuznetcova), an excellent genetic model for human generalized absence epilepsy. The improving action of gensinosides was effectively demonstrated on the model of electrical kindling of amygdala of WAG/Rij rats with genetically determined absences, and the influences of ginsenosides on the slow wave discharges have also been being investigated. The different characteristics of a kindling process exerted in the sex-different region of the amygdala and demonstrated that the level of sex steroids and content of neurosteroids in amygdaloid tissue ca

Analysis and Application of Nursing Management Practicum Case Simulation for Developing Performance-Centered Education (성과중심 교육과정 개발을 위한 간호관리실습 사례시뮬레이션 적용 및 내용 분석)

  • Lim, Ji Young;Ko, Gug Jin
    • The Journal of the Korea Contents Association
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    • v.17 no.9
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    • pp.235-254
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    • 2017
  • The purpose of this study was to develop a nursing management case simulation (NMCS) framework based on the five components of nursing management process and to apply it to clinical nursing practice of nursing college students. The subjects of this study were NMCS reports submitted by the 4th grade 105 nursing students of an university. The research tool is a simulation framework for nursing management practice. It reflects the brainstorming and debriefing process used in the previous simulation exercise based on the five elements of planning, organization, human resource management, directing and control of the nursing management process respectively. As a result of the study, 32 nursing management cases were found to have 79.6% correct rate, 11.6% concept error rate, and 5.6% classification error rate in the first brainstorming and debriefing process for the five components of nursing management process. On the other hand, in the second brainstorming and debriefing process, 94.6% correct rate, 0.0% concept error rate, and 4.4% classification error rate. Based on these results, the NMCS framework developed in this study can be applied to the nursing management theory and practice course of nursing college students as well as simulation based job training and maintenance educations for clinical nurses. Therefore, we propose follow-up studies in various clinical nursing settings and a longitudinal cohort study to investigate the effect of nursing management job skills of nursing college students after graduation.

A Study on dental hygienist subjectivity toward relationship with inaccessible patients: the cases of Seoul, Gyeonggi province and Incheon (치과위생사가 경험한 어려운 환자와의 관계에 대한 주관성 연구 -서울, 경기, 인천 지역을 중심으로-)

  • Han, Kyung-Soon;Kim, Young-Nam;Lee, Myeong-Ju
    • Journal of Korean society of Dental Hygiene
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    • v.5 no.2
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    • pp.279-296
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    • 2005
  • The purpose of this study was to examine what types of experiences dental hygienists underwent with patients who were unapproachable in an effort to find out the latter group's needs and expectations, explore how to treat them of different personality type, and provide better dental services in response to their needs. To attain the purpose, Q-methodology was employed, which made a subjective and systematic assessment of human subjectivity. There were three types of subjectivity among dental hygienists in conjunction with their experiences with patients who were hard to please. Each group whose subjectivity was different also had a different preference for patients, which was not exclusive to one another but unique. Type 1 was "avoiding patients who showed off". Dental hygienists of this type found it unpleasant to treat patients who boasted of their background, position or relations with the head of hospital and wanted to be given special treatment. They avoided those patients, since giving special treatment to specific patients was likely to do damage to others. They believed that better medical services could be provided through mutual concern and good manners between medical personnels and patients. Dental hygienists of type 2 considered it hard to treat patients who were picky and looked at treatment or its outcome negatively. Those who had to be separated from others on account of possible cross-infection or who called for special decontamination methods of dental instruments were also difficult to deal with. Dental hygienists of this type could be said to "avoid picky patients", as they preferred to fare with patients by offering good, faithful treatment rather than by giving special treatment. Dental hygienists of type 3 believed that smooth and successful treatment hinged on mutual trust, confidence and collaboration between medical personnels and patients. According to them, patients who choose a specific hospital or a particular medical team at their own option have to cooperate if necessary, listen carefully to medical personnels and treat them without any hostility or bias. Therefore, they could be said to "avoid patients who were not cooperative".

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Analysis on Current States of Multimedia Interface Design Research (멀티미디어 인터페이스 디자인의 연구 경향 분석)

  • 정승녕;정경원
    • Archives of design research
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    • v.12 no.2
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    • pp.171-182
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    • 1999
  • This study aims to clarify the nature and properties of multimedia interface design, and to identify direction of multimedia interface design research. It also focuses on forecasting boundaries and major trends in current researches on multimedia interface design. The two jargons, 'interface' and 'interaction', are distinguished clearly to show the definition and boundary of multimedia interface. The multidisciplinary nature of multimedia interface design is identified as a result of examination and analysis on major researches. Nine research cases have been selected and categorized into two directions as the theoretical approach and the technical approach. Major characteristics of each case are examined in terms of subjects and methodologies. Findings on current states of the multimedia interface design research are: $\circled1$increasing importance of contextuality; $\circled2$emerging tendency for perceiving the content as one of interacting subjects; $\circled3$providing idiomatic interface context; and $\circled4$paying much attention to the meaning of minor actions. Those findings can be possible as a result of expansion of boundary of multimedia content with rapid distribution of multimedia in recent years. The study concludes that further researches can be activated on the basis of the concept of content-based multimedia interface.

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Estimation of the Relative Risk of the Elderly with Different Evacuation Velocity in a Toxic Gas Leakage Accident (독성물질 누출 시 대피 속도 차이에 따른 고령자의 상대적 위험도 산정)

  • Lee, H.T.;Kwak, J.;Park, J.;Ryu, J.;Lee, J.;Jung, Seungho
    • Journal of the Korean Society of Safety
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    • v.34 no.6
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    • pp.13-21
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    • 2019
  • Leakage accidents in businesses dealing with hazardous chemicals can have a great impact on the workers inside the workplace, as well as residents outside the workplace. In fact, there were cases where hazardous chemicals leaked from many businesses. As a result, the Chemicals Control Act(CCA) was enacted in 2015, the Ministry of Environment introduced an Off-site Risk Assessment(ORA). The purpose of the ORA is to secure safety from the installation of the design of the workplace facilities so that chemical accidents of hazardous chemical handling facilities do not cause human or physical damage outside the workplace. In general, the ORA qualitatively determines where a protected facility is within the scope of the accident scenario. However, elderly who belong to the sensitive group is more sensitive than the general group under the same chemical accident effect, and the extent of the damage is serious. According to data from the Korea National Statistic Office, the number of elderly people is expected to increase steadily. Therefore, a quantitative risk analysis considering the elderly is necessary as a result of a chemical accident. In this study, accident scenarios for 14 locations were set up to perform emergency evacuation due to toxic gas leakage of Cl2(Chlorine) and HF(Hydrogen Fluoride), and the effects of exposure were analyzed based on the evacuation velocity difference of age 20s and 60s. The ALOHA(Areal Locations of Hazardous Atmospheres) program was used to calculate the concentration for assessing the effects. The time of exposure to toxic gas was calculated based on the time it took for the evacuation to run from the start point to the desired point and a methodology was devised that could be applied to the risk calculation. As a result of the study, the relative risk of the elderly, the sensitive group, needs to be determined.