• Title/Summary/Keyword: human activities

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Cytotoxic Activities of Herbal Drugs against Human Cancer Cell Lines (I) (인체암세포주에 대한 천연자원의 세포독성 검색 (I))

  • Park, Jong-Dae;Kim, Shin-Il;Lee, You-Hui
    • Korean Journal of Pharmacognosy
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    • v.29 no.4
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    • pp.323-330
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    • 1998
  • For the search of new antineoplastic agents from natural resources, two hudred and one kinds of oriental medicinal drugs were extracted with petroleum ether/ether(1:1), ethyl acetate and methyl alcohol, successively and their cytotoxicities were evaluated against A549 (human lung carcinoma) and SK-OV-3 (human ovary adenocarcinoma) cell lines. Among them, thirty kinds of ether extracts, forty-one kinds of ethyl acetate extracts and nine kinds of methanol extracts showed significant cytotoxic activities (above 70% inhibition) against A549 cell lines at a concentration of $40\;{\mu}g/ml$. And also, twenty-four kinds of ether extracts, thirty-one kinds of ethyl acetate extracts and six kinds of methanol extracts showed significant cytotoxic activities against SK-OV-3 cell lines at the same concentration.

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The Impact of Human Resource Management Activities on the Compatibility and Work Results

  • NGUYEN, Duc Trung;HA, Van Dung;DANG, Truong Thanh Nhan
    • The Journal of Asian Finance, Economics and Business
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    • v.7 no.9
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    • pp.621-629
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    • 2020
  • This research focuses on determining the impact of human resource management activities on the compatibility and work results of employees of Ho Chi Minh Stock Exchange (HOSE) listed companies. The paper includes five parts: introduction, literature review, research methodology, research results, and conclusion and policy implications. The data are collected from the survey of 350 listed companies in HOSE, in which 315 survey notes filled with sufficient information are used for analysis. The paper employs both qualitative method and quantitative method. Group discussion of 10 experts is for qualitative research. Quantitative method performs analysis of Statistics, Cronbach's Alpha, EFA analysis, CFA analysis and SEM model. The results of the research clearly indicate that human resource management (HRM) activities are measured through improving the ability, improving the motivation and improving the opportunity. While compatibility is measured through suitability, connection and sacrifice; whereby HRM activities of ability improvement have a positive effect on the job suitability and connection; HRM activities of motivation improvement have a positive effect on the job suitability, connection and sacrifice; and HRM activities of opportunity improvement have a positive effect on the job suitability, sacrifice and connection; Finally, the job suitability, sacrifice and connection positively affect the work results of employees.

Associations between Japanese schoolchildren's involvement in at-home meal preparation, their food intakes, and cooking skills

  • Nozue, Miho;Ishida, Hiromi;Hazano, Sayaka;Nakanishi, Akemi;Yamamoto, Taeko;Abe, Aya;Nishi, Nobuo;Yokoyama, Tetsuji;Murayama, Nobuko
    • Nutrition Research and Practice
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    • v.10 no.3
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    • pp.359-363
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    • 2016
  • BACKGROUND/OBJECTIVES: This study aimed to examine the association of Japanese schoolchildren's involvement in at-home meal preparation with food intake and cooking skill. SUBJECTS/METHODS: We included 1,207 fifth-grade children aged 10-11 years and one parent of each child. A cross-sectional survey was used to collect data on involvement in at-home meal preparation. Correspondence analysis was used to classify involvement in at-home meal preparation into three groups: food-related activities (cooking only or with other activities such as shopping, table-setting, clean up, and dishwashing), non-food-related activities (table-setting and/or clean up), and no (helping) activities. Food intake was assessed using a food frequency questionnaire. Logistic regression models were used to examine involvement in at-home meal preparation associations. RESULTS: The sample consisted of 1,207 fifth-grade children. Vegetable intake was lower in the no (helping) activities group than the food-related activities group (95% CI; boys: 1.2, 5.1, girls: 2.0, 8.9). Fewer children in the non-food-related activities group reported they were able to make a portion of their meals compared with the food-related activities group (95% CI; boys: 1.6, 3.5; girls: 1.5, 3.2). CONCLUSIONS: Children in the food-related activities group showed more favorable food intake and cooking skills than children in the no (helping) activities or non-food-related activities group.

Replacement of the antifreeze-like domain of human N-acetylneuraminic acid phosphate synthase with the mouse antifreeze-like domain impacts both N-acetylneuraminic acid 9-phosphate synthase and 2-keto-3-deoxy-D-glycero-Dgalacto- nonulosonic acid 9-phosphate synthase activities

  • Reaves, Marshall Louis;Lopez, Linda Carolyn;Daskalova, Sasha Milcheva
    • BMB Reports
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    • v.41 no.1
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    • pp.72-78
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    • 2008
  • Human NeuNAc-9-P synthase is a two-domain protein with ability to synthesize both NeuNAc-9-P and KDN-9-P. Its mouse counterpart differs by only 20 out of 359 amino acids but does not produce KDN-9-P. By replacing the AFL domain of the human NeuNAc-9-P synthase which accommodates 12 of these differences, with the mouse AFL domain we examined its importance for the secondary KDN-9-P synthetic activity. The chimeric protein retained almost half of the ability of the human enzyme for KDN-9-P synthesis while the NeuNAc-9-P production was reduced to less than 10%. Data from the homology modeling and the effect of divalent ions and temperature on the enzyme activities suggest conformational differences between the human and mouse AFL domains that alter the shape of the cavity accommodating the substrates. Therefore, although the AFL domain itself does not define the ability of the human enzyme for KDN-9-P synthesis, it is important for both activities by aiding optimal positioning of the substrates.

Study on the Antioxidative Activity of Human Milk (모유의 항산화능에 관한 연구)

  • 정해영;김정선;심경희;김명숙;김규원;이기영
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.24 no.5
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    • pp.651-657
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    • 1995
  • The antioxidative activity of each fraction in human milk was examined using H2O2 and FeSO4-induced lipid peroxidation of mouse liver homogenate in order to elucidate the antioxidative substances of human milk. High molecular weight(~>20KD) fraction had more antioxidative effect on lipid peroxidation than low molecular weight(~ <20KD) fraction. Furthermore, the changes of antioxidative enzyme activities were estimated during lactation to study the roles of human milk. The human milk showed high activities of catalase, glutathione(GSH) peroxidase and GSH S-transferase. These results suggest that the antioxidative activities may mostly be attributed to high molecular weight fraction containing catalase, GSH peroxidase and GSH S-transferase.

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Alterations in the Activities of Antioxidant Enzymes of Human Dermal Microvascular Endothelial Cells Infected with Orientia tsutsugamushi

  • Koh, Young-Sang
    • Journal of Microbiology
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    • v.39 no.2
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    • pp.142-145
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    • 2001
  • Changes in the Activities of several antioxidant enzymes in transformed human dermal microvascular endothelial Cells (HMEC-1) by infection with the obligate intracellular bacterium Orientia tsutsugamushi, the causative agent of scrub typhus, were investigated. The activities of glucose-6-phosphate dehydrogenase, catalase, and glutathione peroxidase were significantly decreased in HMEC-1 cells infected with Ο. tsutsugamushi. However, the level of superoxide dismutase increased slightly. Furthermore, Increased levels of intracellular peroxide was observed in HMEC-1 during infection. These results support the hypothesis that cells infected by this intracellular bacterium experience oxidant-mediated injury that may eventually contribute to cell death.

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A Study on the Relationships between Human Dimensions and Interior Space of the Residence Yunkyungdang (주택 연경당 내부공간과 인체치수와의 상관성 분석 연구)

  • 최상헌
    • Korean Institute of Interior Design Journal
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    • no.4
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    • pp.5-9
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    • 1995
  • In this study, the relationships between the interior space of the upper class residence of Korean late Chosun dynasty and human dimensions based on their life styles of that era are analized. As an object of the study, the interior space of Yunkyungdant in Changduk palace is selected. The major analytical frame works of this study are : the analysis of Space-Human Body System, the analysis of Space-Objects-Human Body System, and the analy-sis of Space-Objects-Human Body System, and the analy-sis of Space-Objects-Life Activities of Human Body System. As a result, it was verified that there are certain quantitative relationships between the interior space of the residence and the human dimensions of Koreans lived up to their life styles and activities of Chosun dynasty era, specialized as 'Confucian life style'.

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Waldorf and Theme-based Program Analyses of Five-year-olds' Activities of Early Childhood Educational Programs (발도르프 프로그램과 생활주제중심 프로그램 유형에 따른 5세 유아의 활동분석)

  • Moon, Chae-Lyun;Chong, Young-Sook
    • Korean Journal of Human Ecology
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    • v.16 no.2
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    • pp.237-250
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    • 2007
  • This study was to provide date for developing a effective educational program which would be helpful for teachers to understand children's daily activities more properly. From two kindergartens, 20 children were observed for 3 consecutive hours. The observer followed the target child, gathering data during 30-second "windows". This observation lasted for three hours per day and each child was observed 60 times. The proportion of major activities such as education, play, work, and conversation in children's daily activities was compared. Results showed that children of Waldorf program were more exposed to and engaged in play than children of Theme-based program, whereas children of theme-based program were exposed to and engaged in academic activities than those of Waldorf program.

The Factors Influenced Leisure Activities Participation in the Elderly (노인의 여가활동참여 결정요인에 관한 연구)

  • Park, Kyung-Rhan;Yi, Yeong-Sug
    • Korean Journal of Human Ecology
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    • v.16 no.3
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    • pp.465-477
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    • 2007
  • The purpose of this study was to investigate factors affecting leisure activities participation in the elderly. The factors considered were leisure opportunities, leisure motivation, leisure satisfaction and some background variables. Subjects were 291 elderly persons who completed the questionnaire assessing the variables in the study. The results of this study were as follows: 1) Leisure activities participation of the elderly was affected by leisure opportunities, leisure motivation, leisure satisfaction, gender, and education. 2) Leisure satisfaction influenced by leisure opportunities, motivation, health, and financial condition. 3) Leisure opportunities and motivation had effects on leisure activities participation indirectly via leisure satisfaction. 4) Also, status of health and financial condition of the elderly had an indirect effect on leisure activities participation via leisure motivation.