• Title/Summary/Keyword: hub network

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Gene Co-expression Network Analysis Associated with Acupuncture Treatment of Rheumatoid Arthritis: An Animal Model

  • Ravn, Dea Louise;Mohammadnejad, Afsaneh;Sabaredzovic, Kemal;Li, Weilong;Lund, Jesper;Li, Shuxia;Svendsen, Anders Jorgen;Schwammle, Veit;Tan, Qihua
    • Journal of Acupuncture Research
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    • v.37 no.2
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    • pp.128-135
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    • 2020
  • Background: Classical acupuncture is being used in the treatment of rheumatoid arthritis (RA). To explore the biological response to acupuncture, a network-based analysis was performed on gene expression data collected from an animal model of RA treated with acupuncture. Methods: Gene expression data were obtained from published microarray studies on blood samples from rats with collagen induced arthritis (CIA) and non-CIA rats, both treated with manual acupuncture. The weighted gene co-expression network analysis was performed to identify gene clusters expressed in association with acupuncture treatment time and RA status. Gene ontology and pathway analyses were applied for functional annotation and network visualization. Results: A cluster of 347 genes were identified that differentially downregulated expression in association with acupuncture treatment over time; specifically in rats with CIA with module-RA correlation at 1 hour after acupuncture (-0.27; p < 0.001) and at 34 days after acupuncture (-0.33; p < 0.001). Functional annotation showed highly significant enrichment of porphyrin-containing compound biosynthetic processes (p < 0.001). The network-based analysis also identified a module of 140 genes differentially expressed between CIA and non-CIA in rats (p < 0.001). This cluster of genes was enriched for antigen processing and presentation of exogenous peptide antigen (p < 0.001). Other functional gene clusters previously reported in earlier studies were also observed. Conclusion: The identified gene expression networks and their hub-genes could help with the understanding of mechanisms involved in the pathogenesis of RA, as well understanding the effects of acupuncture treatment of RA.

Ancient Seaports on the Western Coast of India: The Hub of the Maritime Silk Route Network

  • DAYALAN, DURAISWAMY
    • Acta Via Serica
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    • v.3 no.2
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    • pp.49-72
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    • 2018
  • The extensive maritime trade network between the Harappan and Mesopotamian civilizations as early as the $3^{rd}$ millennium BCE is a testimony to the long maritime trade history of India. From the dawn of the historical epoch, the maritime trade network of India expanded extensively. The findings of a large number of coins, pottery, amphorae and other materials from Italy and various other European countries, west Asia, China, Korea, Africa, the Arabian Peninsula, Sri Lanka, Southeast Asia and Far-East countries in India, particularly in the coastal regions, are a testimony to the dynamic maritime trade of India with other countries in the early period. Similarly, pottery, sculptures, inscriptions and other materials of Indian origin are also found in those countries. The depiction of different types of ships on the coins, paintings, sculptures, seals and sealing, exhibit the variety of vessels used for navigation and other purposes in the early period. The over 7500 km-long coastline of India is well known for its seaports located at river mouths or outlets to the sea. The Periplus Maris Erythraei, Ptolemy, and Indian literary sources mention many seaports on the western coast of India. Interestingly, archaeological investigations in many of these port towns have yielded material evidence exhibiting their dominant role in transoceanic trade and commerce with many countries in the early period. This paper discusses in detail all the major ancient seaports on the western coast of India and their maritime trade activities. At the outset, the paper briefly deals with the Harappan's maritime network, their seaports and the type of ships of that period. Following this, the maritime trade network of India during the historical period with various countries in the east and west, the traces of Indian influence and materials abroad and foreign materials found in India, the products exported from India, the trade winds and navigational devices and the depiction of ships on the coins, paintings, and sculptures of the period are discussed in detail. After briefly highlighting the coastline of India and its favourable nature for safe anchorage of ships and the strategic position of the seaports of western India, an extensive account of the major ancient seaports of western India like Barygaza, Ashtacampra, Gundigar, Kammoni, Khambhat, Bardaxema, Suparaka, Calliena, Semylla, Sanjan, Naura, Tyndis, Muziris, Nelcynda and other seaports, and their maritime trade activities are given based on archaeological excavations and explorations, literature, epigraphy, foreign accounts, and numismatic evidence.

Analysis of Food Resources of 45 Fish Species in Freshwater Ecosystems of South Korea (Based on Literature Data Analysis) (국내 담수어류 45종의 먹이원 분석(문헌자료 분석을 중심으로))

  • Ji, Chang Woo;Lee, Dae-Seong;Lee, Da-Yeong;Kwak, Ihn-Sil;Park, Young-Seuk
    • Korean Journal of Ecology and Environment
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    • v.53 no.4
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    • pp.311-323
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    • 2020
  • We analyzed food sources of 45 fish species in 28 genera of 12 families based on literature data in freshwater ecosystems of South Korea. The food sources of 45 fish species included in a total of 26 phyla, 42 classes, 94 orders, 189 families and 294 genera. Among them, animal food sources were 16 phyla, 24 classes, 54 orders, 126 families and 212 genera, whereas plant food sources were relatively small with 10 phyla, 18 classes, 42 orders, 63 families and 82 genera. The animal food sources were classified into Arthropod, Insecta, Diptera and Chironomidae according to taxa. Meanwhile, Bacillariophyta, Bacillariophyceae, Cymbellales and Cymbellaceae were the most abundant among the plant sources. Self-Organized Map (SOM) and network analysis were conducted the food sources were classified into taxonomic groups and the feeding types of fish : 45 fish species were divided into five groups, characterizing 1) fishvores, 2) invertebratevores, planktivores including 3) zooplankton and 4) phytoplankton, and 5) omnivores. The network analysis presented link association between fishes and food sources. Macroinvertebrate including diptera and ephemeroptera were revealed as hub food sources based on network analysis. This literature study would expect that the application model with the food source of fish could be utilized for the evaluation of the food network or chain in freshwater ecosystems.

Analysis of Demands on the International Development Cooperation Project of Regional Governments (지속가능한 지자체 국제협력사업 수요 분석)

  • Lee, Taek-Ku
    • Journal of the Korea Convergence Society
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    • v.9 no.4
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    • pp.201-208
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    • 2018
  • The purpose of this study is to analyze the demand for the science park development as a regional innovation hub to strengthen the internationalization capacity of local governments and to promote international exchange and cooperation based on public - private partnerships. For this, i)the main areas of interest and expectation for international exchange and cooperation, ii)preference for major projects, and iii)demand for development cooperation projects were identified, and it was figured out iv)what the core program is for cities of developing countries through network analysis using the UCINET program. Through these analysis, it was found that cities in developing countries wanted exchange and cooperation projects for the development of industrial and economic sectors. Especially, they wanted to develop industrial infrastructures and transfer advanced systems to foster regional strategic industries. In addition, the demand for the development of science park as a development cooperation project was found to be significant. Therefore it could be inferred that cities in developing countries want to develop a science park as a platform for regional development and industrial development, and to acquire development experience of advanced cities through continuous exchange and cooperation.

Searching for the Hub Module of fMRI Data with the Hypergraph Model (하이퍼그래프 모델을 이용한 fMRI Brain Network 의 허브 모듈 분석)

  • Kim, Joon-Shik;Lim, Byoung-Kwon;Kim, Eun-Sol;Yang, Jin-San;Zhang, Byoung-Tak
    • Proceedings of the Korean Information Science Society Conference
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    • 2010.11a
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    • pp.27-31
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    • 2010
  • 본 논문에서는 하이퍼그래프의 고유벡터를 척도로 하여 fMRI기반 Brain Network를 분석하여 중요한 허브노드를 찾는 방법론을 제시한다. 이 방법을 비디오게임을 수행하면서 촬영한 기능적 자기뇌영상(fMRI) 데이터인 PBAIC 2007 데이터셋에 대하여 그 유용성을 검증하였다. 이 데이터는 각 20분씩 세 세션을 촬영한 것이며 처음 두 세션에는 13가지의 감정 항목의 평가치가 각 스캔마다 주어진다. 한 피험자의 첫번째 세션 데이터로부터 13가지 감정 항목에 대하여 상관관계가 높은 각각의 복셀(voxel)들을 추출하였다. 이 13가지의 복셀들의 집합들을 각각 하이퍼에지로 보고 하이퍼그래프를 구성하였다. 하이퍼그래프로부 터 인접 행렬(adjacency matrix)를 구성한 후 고유치(eigenvalue)와 고유벡터(eigenvector)를 구하였다. 여기서 고유치가 가장 큰 고유벡터의 원소들은 각 복셀들의 중앙성(centrality), 즉 중요성을 나타내며 이로부터 감정과 관련된 중요한 허브 복셀들과 그들의 국소적 집합인 모듈을 찾았다. 모듈들은 감정 및 작업기억(working memory)과 관련된 뇌 영역들의 클러스터(cluster)로 추정된다.

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Delay and Channel Utilization Analysis of IEEE 802.12 VG-AnyLAN Medium Access Control under the Homogeneous Traffic Condition (동질 트래픽 조건에서 IEEE 802.12 VG-AnyLAN 매체접근제어의 지연시간과 채널이용율 해석)

  • Joo, Gi-Ho
    • The KIPS Transactions:PartC
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    • v.13C no.5 s.108
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    • pp.567-574
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    • 2006
  • VG-AnyLAN is a local area network standard developed by the IEEE 802.12 project. While preserving the frame format of IEEE 802.3, VG-AnyLAN adopts a new medium access control called Demand Priority where transmission requests of stations are arbitrated by a control hub in a round-robin manner. Unlike CSMA/CD which is the medium access control of IEEE 802.3, the Demand Priority, while providing the maximum bound on the packet delay, does not put the limit on the network segment size. In this paper, we analyze the delay and the channel utilization performances of the medium access control of IEEE 802.12 VG-AnyLAN. We develope an analytic model of the system under assumptions that each station generates traffic of the equal priority and that the packets are of fixed length. Using the analytic model, we obtain the recursive expression of the average channel utilization and the average access delay The numerical results obtained via analysis are compared to the simulation results of the system for a partial validation of our analysis.

Smart Social Grid System using Interactive Sketch Map (인터랙티브 스케치맵을 활용한 스마트 소셜 그리드 시스템)

  • Kim, Jung-Sook;Lee, Hee-Young;Lee, Ya-Ree;Kim, Bo-Won
    • Journal of Korea Multimedia Society
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    • v.15 no.3
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    • pp.388-397
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    • 2012
  • Recently, one of the received attraction fields in web based service is 'Human Relationship Service' that is called SNS. This relationship map service is able to deliver information to user more easily and visually because it is intuitive data that is linked with offline real world. While past map service put physical real information in the map, present map service is evolving into new communicative platform that expresses social relationship beyond simple search platform that shows real world. In this paper, we propose smart social grid system using sketch map that is based on online map service structure. This system has features such as standardized interface provision for various SNS, use to governance hub tool in case of establishing a personal network through expanded social grid, a role of bridge to mashup software linked with other SNS, user environment construction that reproduces social grid data, and the faster service setup by improved search technology.

Design for Carbon Neutral Arboretum in Gwangju Metropolitan City (광주광역시 탄소중립 수목원 설계)

  • Kim, Hoon Hee
    • KIEAE Journal
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    • v.9 no.3
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    • pp.61-68
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    • 2009
  • Gwangju Metropolitan Government & Ministry of Environment have signed a model city in response to Climate Change agreement. The agreement calls for Gwangju to cut greenhouse gas emissions 10% below 2005 levels by 2015. Gwangju has seen this agreement as an opportunity to cut pollution and conserve the environment as well as to reinvigorate local economy. According to policy of Gwangju, Gwangju held design competition for Gwangju City Arboretum on march, 2009. The purpose of design competition was to give a wide publicity to Gwangju as Hub City of Asian Culture and construct carbon-neutral arboretum in accordance with the policy of 'Low-Carbon and Green Growth'. First of all, a design concept of arboretum is 'winding, round, overlay 'to reflect the landscape of Nam-do which is surrounded by mountains and river flows through the village. Second, the arboretum has five different places with these themes - Forest of Festivals, Health, Nature, Nostalgia, Education and Future. Each place has a symbolic theme park and different flow planning respectively. Third, the most critical point is that the arboretum is a carbon-neutral park. Gwangju arboretum will soon be developed in metropolitan sanitary landfill and constructed as the O2 arboretum based on low carbon strategy. Fourth, the O2 arboretum suggests specialized issue : 'Energy Saving', 'Recycling System', 'Green Network', 'Water System(rainwater maintenance and wetland development)'. Besides, main buildings(greenhouse, visitor center, Nam-do experience exhibition hall, and forest museum) is designed in consideration of harmony with topography character, surroundings. Also, planting will be a multilayer plant based on native landscape trees in consideration of function and the growth characteristics.

A study on the performance improvements of spread ALOHA with CLSP (CLSP를 이용한 대역확산 ALOHA 네트워크의 성능 향상에 관한 연구)

  • 김태중;김호준;박병훈;황금찬
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.22 no.11
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    • pp.2563-2571
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    • 1997
  • This paper presents a new CLSP/CC (Channel Load Sensing Protocol/Channel Clearance) in order to obtain better performance in spread slotted ALOHA networks. This proposed protocol can decrease a wasteful using of channel by prohibiting continuous transmissionof packets destroyed in previous slot, with little added system complexities. The performances of the proposed CLSP/CC, which include network throughput, average processing tiem and the number of mobile stations in retranmission state, are obtained and compared with those of existing CLSP by simulations in this paepr. As the resutls of simulations, the proposed CLSP/CC gets higher throughput and less average processing time, especially in the highly offered load. And CLSP/CC can obtain maximum network throughput at larger offered load than existing CLSP, so it enable to accommodate more mobile station or highly offered loads in slotted spread ALOHA networks.

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An Empirical Study on the Relationship between Corporate and Radical Innovation based on Patent Information (특허 정보를 이용한 기업의 급진적 혁신에 관한 실증연구)

  • Jeon, Suyeon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.10
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    • pp.471-479
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    • 2020
  • In this paper, we analyze features of radical innovative businesses using their patents. Although patents have been used to evaluate outcomes of businesses from the 1980s, it is challenging to use patents for radical innovations. We examined the possibility of taking advantage of patents for an indicator that represents a radical innovation in pharmaceutical industry. To this end, we collected FDA approval data from the U.S. Food and Drug Administration and patent data of 18 pharmaceutical companies. For analysis, we utilized the network centrality analysis and Wilcoxon signed ranked test, which is a non-parametric statistical hypothesis test used to compare two related samples. We observed that a radical innovative company typically cooperates with other research groups, such as universities and companies, and acts as a hub for connectivity in pharmaceuticals. Also, we found that there are differences in centrality between radical firms and non-radical firms. Thus, we expect that the results of this study will help in developing strategies for research and development of pharmaceutical companies and identifying factors affecting radical innovation in the future.